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2. FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress

Author

Brunner, Andrä, Li, Qiuzhen, Fisicaro, Samuele, Kourtesakis, Alexandros, Viiliäinen, Johanna, Johansson, Henrik J, Pandey, Vijaya, Mayank, Adarsh K, Lehtiö, Janne, Wohlschlegel, James A, Spruck, Charles, Rantala, Juha K, Orre, Lukas M, and Sangfelt, Olle

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Hematology, Genetics, Cancer, Rare Diseases, Breast Cancer, Women's Health, 2.1 Biological and endogenous factors, Humans, Cell Survival, Chromatin, Cyclin E, DNA Damage, DNA Repair, DNA Replication, Fanconi Anemia, Fanconi Anemia Complementation Group D2 Protein, Neoplasms, CYCLIN E, DNA damage, FANCD2, FBXL12, Fanconi anemia, SCF ubiquitin ligase, cancer vulnerability, replication stress, therapeutic target, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the pivotal pathway protein FANCD2 by CHK1 triggers its FBXL12-dependent proteasomal degradation, facilitating FANCD2 clearance at stalled replication forks. This promotes efficient DNA replication under conditions of CYCLIN E- and drug-induced replication stress. Reconstituting FANCD2-deficient fibroblasts with phosphodegron mutants failed to re-establish fork progression. In the absence of FBXL12, FANCD2 becomes trapped on chromatin, leading to replication stress and excessive DNA damage. In human cancers, FBXL12, CYCLIN E, and FA signaling are positively correlated, and FBXL12 upregulation is linked to reduced survival in patients with high CYCLIN E-expressing breast tumors. Finally, depletion of FBXL12 exacerbated oncogene-induced replication stress and sensitized cancer cells to drug-induced replication stress by WEE1 inhibition. Collectively, our results indicate that FBXL12 constitutes a vulnerability and a potential therapeutic target in CYCLIN E-overexpressing cancers.

Published
2023

3. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

Author

Shen, Jia Z, Qiu, Zhixin, Wu, Qiulian, Finlay, Darren, Garcia, Guillermina, Sun, Dahui, Rantala, Juha, Barshop, William, Hope, Jennifer L, Gimple, Ryan C, Sangfelt, Olle, Bradley, Linda M, Wohlschlegel, James, Rich, Jeremy N, and Spruck, Charles

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Immunotherapy, Human Genome, Genetics, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Adult, Cell Line, Tumor, Cell Proliferation, Cell Survival, DNA Breaks, Double-Stranded, DNA Replication, Drug Resistance, Neoplasm, F-Box Proteins, Female, Gene Expression Regulation, Neoplastic, Histones, Humans, Immune Checkpoint Inhibitors, Immunity, Interferons, Lysine, Male, Methylation, Middle Aged, Neoplasm Proteins, Neoplasms, Nucleosomes, Repetitive Sequences, Nucleic Acid, Signal Transduction, Transcription, Genetic, Treatment Outcome, FBXO44, H3K9me3, SUV39H1, immunotherapy, repetitive elements, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Repetitive elements (REs) compose ∼50% of the human genome and are normally transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi screen, we identified FBXO44 as an essential repressor of REs in cancer cells. FBXO44 bound H3K9me3-modified nucleosomes at the replication fork and recruited SUV39H1, CRL4, and Mi-2/NuRD to transcriptionally silence REs post-DNA replication. FBXO44/SUV39H1 inhibition reactivated REs, leading to DNA replication stress and stimulation of MAVS/STING antiviral pathways and interferon (IFN) signaling in cancer cells to promote decreased tumorigenicity, increased immunogenicity, and enhanced immunotherapy response. FBXO44 expression inversely correlated with replication stress, antiviral pathways, IFN signaling, and cytotoxic T cell infiltration in human cancers, while a FBXO44-immune gene signature correlated with improved immunotherapy response in cancer patients. FBXO44/SUV39H1 were dispensable in normal cells. Collectively, FBXO44/SUV39H1 are crucial repressors of RE transcription, and their inhibition selectively induces DNA replication stress and viral mimicry in cancer cells.

Published
2021

4. A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Author

Cheung, Belamy B., Kleynhans, Ane, Mittra, Rituparna, Kim, Patrick Y., Holien, Jessica K., Nagy, Zsuzsanna, Ciampa, Olivia C., Seneviratne, Janith A., Mayoh, Chelsea, Raipuria, Mukesh, Gadde, Satyanarayana, Massudi, Hassina, Wong, Iris Poh Ling, Tan, Owen, Gong, Andrew, Suryano, Aldwin, Diakiw, Sonya M., Liu, Bing, Arndt, Greg M., Liu, Tao, Kumar, Naresh, Sangfelt, Olle, Zhu, Shizhen, Norris, Murray D., Haber, Michelle, Carter, Daniel R., Parker, Michael W., and Marshall, Glenn M.

Published
2021
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6. PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma

Author

Vidarsdottir, Linda, Azimi, Alireza, Das, Ishani, Sigvaldadottir, Ingibjorg, Suryo Rahmanto, Aldwin, Petri, Andreas, Kauppinen, Sakari, Ingvar, Christian, Jönsson, Göran, Olsson, Håkan, Frostvik Stolt, Marianne, Tuominen, Rainer, Sangfelt, Olle, Pokrovskaja Tamm, Katja, Hansson, Johan, Grandér, Dan, Egyházi Brage, Suzanne, and Johnsson, Per

Published
2021
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7. Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

Author

Mehtonen, Juha, Teppo, Susanna, Lahnalampi, Mari, Kokko, Aleksi, Kaukonen, Riina, Oksa, Laura, Bouvy-Liivrand, Maria, Malyukova, Alena, Mäkinen, Artturi, Laukkanen, Saara, Mäkinen, Petri I., Rounioja, Samuli, Ruusuvuori, Pekka, Sangfelt, Olle, Lund, Riikka, Lönnberg, Tapio, Lohi, Olli, and Heinäniemi, Merja

Published
2020
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9. Supplementary Table S3 from Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Author

Borgenvik, Anna, primary, Holmberg, Karl O., primary, Bolin, Sara, primary, Zhao, Miao, primary, Savov, Vasil, primary, Rosén, Gabriela, primary, Hutter, Sonja, primary, Garancher, Alexandra, primary, Rahmanto, Aldwin Suryo, primary, Bergström, Tobias, primary, Olsen, Thale Kristin, primary, Mainwaring, Oliver J., primary, Sattanino, Damiana, primary, Verbaan, Annemieke D., primary, Rusert, Jessica M., primary, Sundström, Anders, primary, Bravo, Mar Ballester, primary, Dang, Yonglong, primary, Wenz, Amelie S., primary, Richardson, Stacey, primary, Fotaki, Grammatiki, primary, Hill, Rebecca M., primary, Dubuc, Adrian M., primary, Kalushkova, Antonia, primary, Remke, Marc, primary, Čančer, Matko, primary, Jernberg-Wiklund, Helena, primary, Giraud, Géraldine, primary, Chen, Xingqi, primary, Taylor, Michael D., primary, Sangfelt, Olle, primary, Clifford, Steven C., primary, Schüller, Ulrich, primary, Wechsler-Reya, Robert J., primary, Weishaupt, Holger, primary, and Swartling, Fredrik J., primary

Published
2023
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10. Supplementary Data from Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Author

Borgenvik, Anna, primary, Holmberg, Karl O., primary, Bolin, Sara, primary, Zhao, Miao, primary, Savov, Vasil, primary, Rosén, Gabriela, primary, Hutter, Sonja, primary, Garancher, Alexandra, primary, Rahmanto, Aldwin Suryo, primary, Bergström, Tobias, primary, Olsen, Thale Kristin, primary, Mainwaring, Oliver J., primary, Sattanino, Damiana, primary, Verbaan, Annemieke D., primary, Rusert, Jessica M., primary, Sundström, Anders, primary, Bravo, Mar Ballester, primary, Dang, Yonglong, primary, Wenz, Amelie S., primary, Richardson, Stacey, primary, Fotaki, Grammatiki, primary, Hill, Rebecca M., primary, Dubuc, Adrian M., primary, Kalushkova, Antonia, primary, Remke, Marc, primary, Čančer, Matko, primary, Jernberg-Wiklund, Helena, primary, Giraud, Géraldine, primary, Chen, Xingqi, primary, Taylor, Michael D., primary, Sangfelt, Olle, primary, Clifford, Steven C., primary, Schüller, Ulrich, primary, Wechsler-Reya, Robert J., primary, Weishaupt, Holger, primary, and Swartling, Fredrik J., primary

Published
2023
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11. Supplementary Figure Legends from Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Author

Borgenvik, Anna, primary, Holmberg, Karl O., primary, Bolin, Sara, primary, Zhao, Miao, primary, Savov, Vasil, primary, Rosén, Gabriela, primary, Hutter, Sonja, primary, Garancher, Alexandra, primary, Rahmanto, Aldwin Suryo, primary, Bergström, Tobias, primary, Olsen, Thale Kristin, primary, Mainwaring, Oliver J., primary, Sattanino, Damiana, primary, Verbaan, Annemieke D., primary, Rusert, Jessica M., primary, Sundström, Anders, primary, Bravo, Mar Ballester, primary, Dang, Yonglong, primary, Wenz, Amelie S., primary, Richardson, Stacey, primary, Fotaki, Grammatiki, primary, Hill, Rebecca M., primary, Dubuc, Adrian M., primary, Kalushkova, Antonia, primary, Remke, Marc, primary, Čančer, Matko, primary, Jernberg-Wiklund, Helena, primary, Giraud, Géraldine, primary, Chen, Xingqi, primary, Taylor, Michael D., primary, Sangfelt, Olle, primary, Clifford, Steven C., primary, Schüller, Ulrich, primary, Wechsler-Reya, Robert J., primary, Weishaupt, Holger, primary, and Swartling, Fredrik J., primary

Published
2023
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13. Supplementary Table 1 from FBXW7/hCDC4 Is a General Tumor Suppressor in Human Cancer

Author

Akhoondi, Shahab, primary, Sun, Dahui, primary, von der Lehr, Natalie, primary, Apostolidou, Sophia, primary, Klotz, Kathleen, primary, Maljukova, Alena, primary, Cepeda, Diana, primary, Fiegl, Heidi, primary, Dofou, Dimitra, primary, Marth, Christian, primary, Mueller-Holzner, Elisabeth, primary, Corcoran, Martin, primary, Dagnell, Markus, primary, Nejad, Sepideh Zabihi, primary, Nayer, Babak Noori, primary, Zali, Mohammad Reza, primary, Hansson, Johan, primary, Egyhazi, Susanne, primary, Petersson, Fredrik, primary, Sangfelt, Per, primary, Nordgren, Hans, primary, Grander, Dan, primary, Reed, Steven I., primary, Widschwendter, Martin, primary, Sangfelt, Olle, primary, and Spruck, Charles, primary

Published
2023
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15. Data from FBXW7/hCDC4 Is a General Tumor Suppressor in Human Cancer

Author

Akhoondi, Shahab, primary, Sun, Dahui, primary, von der Lehr, Natalie, primary, Apostolidou, Sophia, primary, Klotz, Kathleen, primary, Maljukova, Alena, primary, Cepeda, Diana, primary, Fiegl, Heidi, primary, Dofou, Dimitra, primary, Marth, Christian, primary, Mueller-Holzner, Elisabeth, primary, Corcoran, Martin, primary, Dagnell, Markus, primary, Nejad, Sepideh Zabihi, primary, Nayer, Babak Noori, primary, Zali, Mohammad Reza, primary, Hansson, Johan, primary, Egyhazi, Susanne, primary, Petersson, Fredrik, primary, Sangfelt, Per, primary, Nordgren, Hans, primary, Grander, Dan, primary, Reed, Steven I., primary, Widschwendter, Martin, primary, Sangfelt, Olle, primary, and Spruck, Charles, primary

Published
2023
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16. Mechanistic Study of Wee1 Kinase Inhibition with AZD1775 Exposes Drug Targetable Vulnerabilities in Acute B-Lymphoblastic Leukemia

Author

Malyukova, Alena, primary, Lahnalampi, Mari, additional, Falqués, Ton, additional, Pölönen, Petri, additional, Sipola, Mikko, additional, Mehtonen, Juha, additional, Teppo, Susanna, additional, Viiliäinen, Johanna, additional, Lohi, Olli, additional, Hagstroem-Andersson, Anna, additional, Heinäniemi, Merja, additional, and Sangfelt, Olle, additional

Published
2022
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17. Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Author

Borgenvik, Anna, primary, Holmberg, Karl O., additional, Bolin, Sara, additional, Zhao, Miao, additional, Savov, Vasil, additional, Rosén, Gabriela, additional, Hutter, Sonja, additional, Garancher, Alexandra, additional, Rahmanto, Aldwin Suryo, additional, Bergström, Tobias, additional, Olsen, Thale Kristin, additional, Mainwaring, Oliver J., additional, Sattanino, Damiana, additional, Verbaan, Annemieke D., additional, Rusert, Jessica M., additional, Sundström, Anders, additional, Bravo, Mar Ballester, additional, Dang, Yonglong, additional, Wenz, Amelie S., additional, Richardson, Stacey, additional, Fotaki, Grammatiki, additional, Hill, Rebecca M., additional, Dubuc, Adrian M., additional, Kalushkova, Antonia, additional, Remke, Marc, additional, Čančer, Matko, additional, Jernberg-Wiklund, Helena, additional, Giraud, Géraldine, additional, Chen, Xingqi, additional, Taylor, Michael D., additional, Sangfelt, Olle, additional, Clifford, Steven C., additional, Schüller, Ulrich, additional, Wechsler-Reya, Robert J., additional, Weishaupt, Holger, additional, and Swartling, Fredrik J., additional

Published
2022
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18. FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Author

Suryo Rahmanto, Aldwin, Savov, Vasil, Brunner, Andrä, Bolin, Sara, Weishaupt, Holger, Malyukova, Alena, Rosén, Gabriela, Čančer, Matko, Hutter, Sonja, Sundström, Anders, Kawauchi, Daisuke, Jones, David TW, Spruck, Charles, Taylor, Michael D, Cho, Yoon‐Jae, Pfister, Stefan M, Kool, Marcel, Korshunov, Andrey, Swartling, Fredrik J, and Sangfelt, Olle

Published
2016
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19. Deregulation of Cyclin E and Genomic Instability

Author

Spruck, Charles H., Smith, Adrian P. L., Reed, Susanna Ekholm, Sangfelt, Olle, Keck, Jaimie, Strohmaier, Heimo, Méndez, Juan, Widschwendter, Martin, Stillman, Bruce, Zetterberg, Anders, Reed, Steven I., Li, Jonathan J., editor, Li, Sara A., editor, and Llombart-Bosch, Antonio, editor

Published
2005
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20. Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Author

Borgenvik, Anna, Holmberg, Karl O., Bolin, Sara, Zhao, Miao, Savov, Vasil, Rosén, Gabriela, Hutter, Sonja, Garancher, Alexandra, Rahmanto, Aldwin Suryo, Bergström, Tobias, Olsen, Thale Kristin, Mainwaring, Oliver, Sattanino, Damiana, Verbaan, Annemieke D., Rusert, Jessica M., Sundström, Anders, Ballester Bravo, Mar, Dang, Yonglong, Wenz, Amelie S., Richardson, Stacey, Fotaki, Grammatiki, Hill, Rebecca M., Dubuc, Adrian M., Kalushkova, Antonia, Remke, Marc, Čančer, Matko, Jernberg Wiklund, Helena, Giraud, Geraldine, Chen, Xingqi, Taylor, Michael D., Sangfelt, Olle, Clifford, Steven C., Schueller, Ulrich, Wechsler-Reya, Robert J., Weishaupt, Holger, Swartling, Fredrik J., Borgenvik, Anna, Holmberg, Karl O., Bolin, Sara, Zhao, Miao, Savov, Vasil, Rosén, Gabriela, Hutter, Sonja, Garancher, Alexandra, Rahmanto, Aldwin Suryo, Bergström, Tobias, Olsen, Thale Kristin, Mainwaring, Oliver, Sattanino, Damiana, Verbaan, Annemieke D., Rusert, Jessica M., Sundström, Anders, Ballester Bravo, Mar, Dang, Yonglong, Wenz, Amelie S., Richardson, Stacey, Fotaki, Grammatiki, Hill, Rebecca M., Dubuc, Adrian M., Kalushkova, Antonia, Remke, Marc, Čančer, Matko, Jernberg Wiklund, Helena, Giraud, Geraldine, Chen, Xingqi, Taylor, Michael D., Sangfelt, Olle, Clifford, Steven C., Schueller, Ulrich, Wechsler-Reya, Robert J., Weishaupt, Holger, and Swartling, Fredrik J.

Abstract

Relapse is the leading cause of death in patients with medulloblas-toma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification. In paired primary-recurrent patient samples, SOX9-positive cells accumulated in medulloblastoma relapses. SOX9 expression anti-correlated with MYC expression in murine and human medulloblastoma cells. However, SOX9-positive cells were plastic and could give rise to a MYC high state. To follow relapse at the single-cell level, an inducible dual Tet model of medulloblastoma was developed, in which MYC expression was redirected in vivo from treatment-sensitive bulk cells to dormant SOX9-positive cells using doxycycline treatment. SOX9 was essential for relapse initiation and depended on suppression of MYC activity to promote therapy resistance, epithelial-mesenchymal transition, and immune escape. p53 and DNA repair pathways were downregulated in recurrent tumors, whereas MGMT was upregulated. Recurrent tumor cells were found to be sensitive to treatment with an MGMT inhibitor and doxorubicin. These findings suggest that recurrence-specific targeting coupled with DNA repair inhibition comprises a potential therapeutic strategy in patients affected by medulloblastoma relapse.Significance: SOX9 facilitates therapy escape and recurrence in medulloblastoma via temporal inhibition of MYC/MYCN genes, revealing a strategy to specifically target SOX9-positive cells to prevent tumor relapse.

Published
2022
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24. A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

Author

Shen, Jia Z., primary, Qiu, Zhixin, additional, Wu, Qiulian, additional, Zhang, Guoxin, additional, Harris, Rebecca, additional, Sun, Dahui, additional, Rantala, Juha, additional, Barshop, William D., additional, Zhao, Linjie, additional, Lv, Deguan, additional, Won, Kwang-Ai, additional, Wohlschlegel, James, additional, Sangfelt, Olle, additional, Laman, Heike, additional, Rich, Jeremy N., additional, and Spruck, Charles, additional

Published
2022
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25. TMOD-25. LATENT SOX9-POSITIVE CELLS BEHIND MYC-DRIVEN MEDULLOBLASTOMA RELAPSE

Author

Borgenvik, Anna, primary, Bolin, Sara, additional, Savov, Vasil, additional, Holmberg, Karl O, additional, Zhao, Miao, additional, Rosén, Gabriela, additional, Hutter, Sonja, additional, Garancher, Alexandra, additional, Rahmanto, Aldwin Suryo, additional, Bergström, Tobias, additional, Mainwaring, Oliver, additional, Sattanino, Damiana, additional, Verbaan, Annemieke D, additional, Rusert, Jessica, additional, Sundström, Anders, additional, Dang, Yonglong, additional, Wenz, Amelie, additional, Richardson, Stacey, additional, Fotaki, Grammatiki, additional, Giraud, Geraldine, additional, Hill, Rebecca, additional, Dubuc, Adrian, additional, Kalushkova, Antonia, additional, Remke, Marc, additional, Cancer, Matko, additional, Jernberg-Wiklund, Helena, additional, Chen, xingqi, additional, Taylor, Michael D, additional, Sangfelt, Olle, additional, Clifford, Steven, additional, Schüller, Ulrich, additional, Wechsler-Reya, Robert, additional, Weishaupt, Holger, additional, and Swartling, Fredrik, additional

Published
2021
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33. CDK-mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

Author

Cepeda, Diana, Ng, Hwee-Fang, Sharifi, Hamid Reza, Mahmoudi, Salah, Cerrato, Vanessa Soto, Fredlund, Erik, Magnusson, Kristina, Nilsson, Helén, Malyukova, Alena, Rantala, Juha, Klevebring, Daniel, Viñals, Francesc, Bhaskaran, Nimesh, Zakaria, Siti Mariam, Rahmanto, Aldwin Suryo, Grotegut, Stefan, Nielsen, Michael Lund, Szigyarto, Cristina Al-Khalili, Sun, Dahui, Lerner, Mikael, Navani, Sanjay, Widschwendter, Martin, Uhlén, Mathias, Jirström, Karin, Pontén, Fredrik, Wohlschlegel, James, Grandér, Dan, Spruck, Charles, Larsson, Lars-Gunnar, and Sangfelt, Olle

Published
2013
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39. MBRS-10. QUIESCENT SOX9-POSITIVE CELLS BEHIND MYC DRIVEN MEDULLOBLASTOMA RECURRENCE

Author

Bolin, Sara, primary, Savov, Vasil, additional, Borgenvik, Anna, additional, Rosén, Gabriela, additional, Olausson, Karl Holmberg, additional, Zhao, Miao, additional, Garancher, Alexandra, additional, Rahmanto, Aldwin Suryo, additional, Hutter, Sonja, additional, Mainwaring, Oliver, additional, Rusert, Jessica, additional, Sundstrom, Anders, additional, Richardson, Stacey, additional, Fotaki, Grammatiki, additional, Hill, Rebecca M, additional, Dubuc, Adrian M, additional, Kalushkova, Antonia, additional, Remke, Marc, additional, Čančer, Matko, additional, Jernberg-Wiklund, Helena, additional, Ramaswamy, Vijay, additional, Chen, Xingqi, additional, Taylor, Michael D, additional, Sangfelt, Olle, additional, Schüller, Ulrich, additional, Clifford, Steve C, additional, Wechsler-Reya, Robert J, additional, Weishaupt, Holger, additional, and Swartling, Fredrik J, additional

Published
2020
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41. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

Author

Brunner, Andrä, primary, Suryo Rahmanto, Aldwin, additional, Johansson, Henrik, additional, Franco, Marcela, additional, Viiliäinen, Johanna, additional, Gazi, Mohiuddin, additional, Frings, Oliver, additional, Fredlund, Erik, additional, Spruck, Charles, additional, Lehtiö, Janne, additional, Rantala, Juha K, additional, Larsson, Lars-Gunnar, additional, and Sangfelt, Olle, additional

Published
2020
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42. Author response: PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

Author

Brunner, Andrä, primary, Suryo Rahmanto, Aldwin, additional, Johansson, Henrik, additional, Franco, Marcela, additional, Viiliäinen, Johanna, additional, Gazi, Mohiuddin, additional, Frings, Oliver, additional, Fredlund, Erik, additional, Spruck, Charles, additional, Lehtiö, Janne, additional, Rantala, Juha K, additional, Larsson, Lars-Gunnar, additional, and Sangfelt, Olle, additional

Published
2020
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43. Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1 positive pediatric leukemia identifies drug-targetable transcription factor activities

Author

Mehtonen, Juha, primary, Teppo, Susanna, additional, Lahnalampi, Mari, additional, Kokko, Aleksi, additional, Kaukonen, Riina, additional, Oksa, Laura, additional, Bouvy-Liivrand, Maria, additional, Malyukova, Alena, additional, Laukkanen, Saara, additional, Mäkinen, Petri I., additional, Rounioja, Samuli, additional, Ruusuvuori, Pekka, additional, Sangfelt, Olle, additional, Lund, Riikka, additional, Lönnberg, Tapio, additional, Lohi, Olli, additional, and Heinäniemi, Merja, additional

Published
2020
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44. PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma

Author

Vidarsdottir, Linda, primary, Azimi, Alireza, additional, Sigvaldadottir, Ingibjorg, additional, Rahmanto, Aldwin Suryo, additional, Petri, Andreas, additional, Kauppinen, Sakari, additional, Ingvar, Christian, additional, Jönsson, Göran, additional, Olsson, Håkan, additional, Stolt, Marianne Frostvik, additional, Tuominen, Rainer, additional, Sangfelt, Olle, additional, Tamm, Katja Pokrovskaja, additional, Hansson, Johan, additional, Grandér, Dan, additional, Brage, Suzanne Egyházi, additional, and Johnsson, Per, additional

Published
2020
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