1. Reference percentiles of FEV1 for the Canadian cystic fibrosis population: comparisons across time and countries.
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Sang-Ook Kim, Corey, Mary, Stephenson, Anne L., Strug, Lisa J., and Kim, Sang-Ook
- Subjects
CYSTIC fibrosis ,EXPIRATORY flow ,LUNG physiology ,CANADIANS ,PATIENTS ,DISEASES ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,REFERENCE values ,RESEARCH ,SEX distribution ,STATURE ,TIME ,EVALUATION research ,ACQUISITION of data ,FORCED expiratory volume - Abstract
Background: Forced expiratory volume in 1 s (FEV1) indicates lung health in cystic fibrosis (CF). FEV1 is commonly communicated as a per cent predicted of a healthy individual sharing the same age, sex, race and height. CF-specific reference equations are complementary and calibrate a patient's FEV1 to that of their CF peers.Objectives: (1) To derive Canadian CF-specific FEV1 reference percentiles (FEV1%iles), (2) characterize how they have changed over time and (3) compare the Canadian FEV1%iles to those for USA and European CF populations.Method: CF FEV1%iles are calculated using the Canadian CF Registry and quantile regression.Results: The Canadian FEV1%iles demonstrated better lung function in more recent time periods within Canada, especially below the 50% percentile and in males. When compared to USA and European FEV1%iles for the same time period, Canadian FEV1%iles were higher.Conclusion: CF-specific FEV1%iles can provide useful information about changes in lung health. An online calculator (available at cfpercentile.Research: sickkids.ca) makes these FEV1%iles accessible. [ABSTRACT FROM AUTHOR]- Published
- 2018
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