59 results on '"Sangüeza OP"'
Search Results
2. Chronic Painful Vegetative Plaques on the Buttocks: Answer.
- Author
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Muñoz de Toro M, Masatkar V, Blankenship HT, Ahn C, and Sangüeza OP
- Subjects
- Humans, Buttocks pathology
- Abstract
Competing Interests: The authors declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
3. Lymphangitic Melanomatosis: Case Report of Intralymphatic Spread of Melanoma in a 66-year-old Man.
- Author
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Srivatsa S, Smith CJ, Sangüeza OP, Miedema J, Collichio FA, and Googe PB
- Subjects
- Aged, Humans, Male, Lymphangitis complications, Melanoma pathology
- Abstract
Abstract: Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
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4. Progressive Hyperpigmentation on the Face in a Skin of Color Woman: Answer.
- Author
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Gosch ME, McMichael AJ, Niehaus AG, and Sangüeza OP
- Subjects
- Female, Humans, Skin, Black or African American, Hyperpigmentation diagnosis
- Abstract
Competing Interests: M. Gosch, A. Niehaus, and O. P. Sangüeza: No conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
5. Progressive Hyperpigmentation on the Face in a Skin of Color Woman: Challenge.
- Author
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Gosch ME, McMichael AJ, Niehaus AG, and Sangüeza OP
- Abstract
Competing Interests: M. Gosch, A. Niehaus, and O. P. Sangüeza: No conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
6. Mucinous Syringometaplasia: Case Report and Review of the Literature.
- Author
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Macías-Alonso B, Solís-Ledesma G, Sánchez-Tadeo MT, Jarquin-Guillermo NE, Velázquez-Espinosa OA, and Sangüeza OP
- Subjects
- Adult, Epidermis pathology, Female, Humans, Male, Metaplasia, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms pathology, Skin Neoplasms surgery, Warts pathology
- Abstract
Abstract: Mucinous syringometaplasia is a rare and poorly recognized entity that usually presents as a warty tumor in acral regions. It is more frequent in men, and the age of presentation is variable. Typically, it has been reported as a solitary lesion with a warty appearance that occasionally can drain serous material. The affected sites include head, neck, breast, acral regions, and buttocks. The evolution over time is variable. The pathogenesis has not been elucidated. Diagnosis is established through histopathology, the characteristic feature is an epidermal invagination, which creates a structure similar to a "pore" at the dermal level. The clinical differential diagnosis is mainly with a viral wart, but it can also resemble basal cell carcinomas and other adnexal tumors. The treatment is surgical, and no recurrences have been reported to date. We describe the case of a 25-year-old woman who presented with a lesion on one of her eyelids. A shave removal of the lesion was performed, and the diagnosis was established by histopathologic examination., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
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7. Keratotic Papules and Plaques on Lower Limbs: Answer.
- Author
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Roque Quintana B, Quickenborne CF, Ali SM, and Sangüeza OP
- Abstract
Competing Interests: The authors declare no conflicts of interest.
- Published
- 2021
- Full Text
- View/download PDF
8. Keratotic Papules and Plaques on Lower Limbs: Challenge.
- Author
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Roque Quintana B, Quickenborne CF, Ali SM, and Sangüeza OP
- Abstract
Competing Interests: The authors declare no conflicts of interest.
- Published
- 2021
- Full Text
- View/download PDF
9. Morphea With Keloidal Features: A Case Report and Review of the Literature.
- Author
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Yu D, Ibarra BS, Akkurt ZM, Ahn C, and Sangüeza OP
- Subjects
- Adult, Antibodies, Antinuclear blood, Biopsy, Diagnosis, Differential, Erythema pathology, Female, Humans, Hyperpigmentation pathology, Keloid diagnosis, Keloid pathology, Scleroderma, Localized drug therapy, Scleroderma, Localized diagnosis, Scleroderma, Localized pathology, Skin pathology
- Abstract
Keloidal morphea is a rare variant of scleroderma, which often can be clinically confused with keloid or scar formation. We report a 34-year-old woman with a medical history of asthma and Raynaud's phenomenon, presented for the evaluation and management of multiple erythematous hyperpigmented annular plaques reportedly developed after taking trimethoprim/sulfamethoxazole. An initial skin biopsy showed findings supportive of a drug eruption. She was treated with oral prednisone and achieved some improvement. She presented 1 year later with enlargement of the plaques and emergence of new lesions. Skin biopsies revealed an unremarkable epidermis with marked fibrosis of the mid-to-deep dermis with sparing of the papillary dermis, and superficial and deep perivascular and perieccrine lymphoplasmacytic inflammation. Verhoeff-Van Gieson staining demonstrated the loss of elastin fibers within the fibrotic areas of the biopsy specimens, which supported the diagnosis of keloidal morphea. Her laboratory tests were positive for antinuclear antibody (greater than 1:1280). She continued treatment with oral prednisone and topical steroids, and she showed improvement. This case highlights the importance of differentiating keloidal scleroderma from a hypertrophic scar or keloid to reveal an underlying systemic process. A correlation of clinical and histopathological findings is paramount to reach a correct diagnosis, ensure appropriate treatment, and monitor for comorbid disease.
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- 2020
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10. Dermatofibrosarcoma Protuberans.
- Author
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Allen A, Ahn C, and Sangüeza OP
- Subjects
- Dermatofibrosarcoma genetics, Dermatofibrosarcoma pathology, Dermatologic Surgical Procedures, Humans, Imatinib Mesylate therapeutic use, Margins of Excision, Oncogene Proteins, Fusion genetics, Oncogene Proteins, Fusion metabolism, Skin Neoplasms genetics, Skin Neoplasms pathology, Translocation, Genetic genetics, Antineoplastic Agents therapeutic use, Dermatofibrosarcoma therapy, Mohs Surgery, Skin Neoplasms therapy
- Abstract
Dermatofibrosarcoma protuberans (DFSP) is an uncommon dermal neoplasm that exhibits a high rate of local recurrence and infiltrative behavior, but has a low risk of metastasis. It arises as a slowly progressive, painless pink or violet plaque. Histologically, DFSP is characterized by a monomorphous spindle cell proliferation in a storiform pattern. The gold standard of treatment is surgical resection with negative margins. In cases where obtaining clear margins is not possible, radiation and systemic therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to be effective., (Published by Elsevier Inc.)
- Published
- 2019
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11. Hypopigmented Macules as Manifestation of Lichen Planus and Lichen Planopilaris.
- Author
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Arnold D, Hoffman MB, Onajin O, Sangüeza OP, and McMichael A
- Subjects
- Black or African American, Humans, Lichen Planus complications, Lichen Planus pathology, Male, Middle Aged, Scalp Dermatoses complications, Scalp Dermatoses pathology, Hypopigmentation etiology, Lichen Planus diagnosis, Scalp Dermatoses diagnosis
- Abstract
Lichen planus (LP) is an idiopathic inflammatory disease of the skin, hair, nails, and mucous membranes. Classic cutaneous LP is characterized by violaceous flat-topped papules that typically favor the extremities. LP on the scalp, otherwise known as lichen planopilaris, classically presents with scarring alopecia, perifollicular erythema and follicular prominence. Although LP pigmentosus presents primarily as hyperpigmentation, there is only one previous report of hypopigmented LP. In this report, the authors report 2 cases of LP that presented primarily as hypopigmented macules in 2 African American men. The first patient presented with hypopigmented macules on face and scalp as well as trunk and extremities. The second patient presented with hypopigmented macules on scalp with associated alopecia. Histopathological examination from both patients showed features of LP. The authors propose a new variant of LP that presents acutely as hypopigmented lesions.
- Published
- 2019
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12. Malignant Sweat Gland Tumors.
- Author
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Ahn CS and Sangüeza OP
- Subjects
- Biopsy, Diagnosis, Differential, Disease Management, Humans, Immunohistochemistry, Neoplasm Grading, Neoplasm Staging, Sweat Gland Neoplasms etiology, Sweat Gland Neoplasms therapy, Sweat Gland Neoplasms diagnosis
- Abstract
Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
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13. Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases.
- Author
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Santos-Briz A, Calle A, Linos K, Semans B, Carlson A, Sangüeza OP, Metze D, Cerroni L, Díaz-Recuero JL, Alegría-Landa V, Mascaró JM, Moreno C, Rodríguez-Peralto JL, and Requena L
- Subjects
- Adolescent, Adult, Aged, B-Lymphocytes pathology, Biopsy, Dendritic Cells metabolism, Dendritic Cells pathology, Dermatomyositis complications, Female, Humans, Interleukin-3 Receptor alpha Subunit metabolism, Male, Middle Aged, Muscle, Skeletal pathology, Panniculitis complications, T-Lymphocytes, Helper-Inducer pathology, Young Adult, Dermatomyositis metabolism, Dermatomyositis pathology, Panniculitis metabolism, Panniculitis pathology
- Abstract
Background: Panniculitis occurring in dermatomyositis is uncommon, with only a few cases described in the literature, most of them as case reports., Objective: This report describes the clinicopathological and immunohistochemical findings in a series of 18 patients with panniculitis associated with dermatomyositis., Methods: In each patient, we collected the clinical data of the cutaneous lesions as well as the characteristic clinical and laboratory findings. A series of histopathologic findings was recorded in the biopsy of each patient. A panel of antibodies was used in some cases to investigate the immunophenotype of the infiltrate. Data of treatment and follow-up were also collected., Results: Of the 18 patients, 13 were female and 5 were male, ranging in age from 13 to 74 years (median, 46.4 years). In addition to panniculitis, all patients presented pathognomonic cutaneous findings of DM and reported proximal muscle weakness prior to the diagnosis of panniculitis. Muscle biopsy was performed in 17 patients and MRI in one, all with the diagnosis of inflammatory myopathy. None of the patients presented any associated neoplasia. Panniculitis lesions were located in the upper or lower limbs. Histopathology showed a mostly lobular panniculitis with lymphocytes as the main component of the infiltrate. Most cases showed also numerous plasma cells and lymphocytes surrounding necrotic adipocytes (rimming) were frequently seen. Lymphocytic vasculitis and abundant mucin interstitially deposited between collagen bundles of the dermis were also frequent findings. Late-stage lesions showed hyaline necrosis of the fat lobule and calcification. Immunohistochemistry demonstrated that most lymphocytes of the infiltrate were T-helper lymphocytes, with some B lymphocytes in the lymphoid aggregates and small clusters of CD-123-positive plasmacytoid dendritic cells in the involved fat lobule., Conclusion: Panniculitis in dermatomyositis is rare. Histopathologic findings of panniculitis dermatomyositis are identical to those of lupus panniculitis. Therefore, the final diagnosis requires clinic-pathologic correlation., (© 2018 European Academy of Dermatology and Venereology.)
- Published
- 2018
- Full Text
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14. Pediatric Patient With Chronic Generalized Blisters: Challenge.
- Author
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Martinez-Rosales K, Torres-Alvarez B, and Sangüeza OP
- Published
- 2017
- Full Text
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15. Pediatric Patient With Chronic Generalized Blisters: Answer.
- Author
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Martinez-Rosales K, Torres-Alvarez B, and Sangüeza OP
- Subjects
- Adrenal Cortex Hormones therapeutic use, Biopsy, Child, Fluorescent Antibody Technique, Direct, Humans, Immunosuppressive Agents therapeutic use, Lupus Erythematosus, Cutaneous drug therapy, Lupus Erythematosus, Cutaneous immunology, Lupus Erythematosus, Systemic drug therapy, Lupus Erythematosus, Systemic immunology, Male, Remission Induction, Skin drug effects, Skin immunology, Skin Diseases, Vesiculobullous drug therapy, Skin Diseases, Vesiculobullous immunology, Treatment Outcome, Lupus Erythematosus, Cutaneous pathology, Lupus Erythematosus, Systemic pathology, Skin pathology, Skin Diseases, Vesiculobullous pathology
- Published
- 2017
- Full Text
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16. Melanocytic Nevi of Special Sites.
- Author
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Ahn CS, Guerra A, and Sangüeza OP
- Subjects
- Biopsy, Female, Humans, Male, Nevus, Pigmented pathology, Skin Neoplasms pathology
- Abstract
Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Now, additional anatomical sites with known site-related atypia include the ear, conjunctivae, scalp, breast, flexural skin, legs, and back and shoulder. This continuing medical education article presents a review of the histopathological characteristics of special site nevi based on anatomic location. It is imperative for dermatologists, pathologists, and dermatopathologists to distinguish benign melanocytic nevi with site-related atypia from malignant melanoma to avoid unnecessary surgical intervention or treatment.
- Published
- 2016
- Full Text
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17. Is Tumor of Follicular Infundibulum a Reaction to Dermal Scarring?
- Author
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Baquerizo Nole KL, Lopez-Garcia DR, Teague DJ, Al Sayyah A, Mansoori P, Salim Al Alshehri H, and Sangüeza OP
- Subjects
- Adult, Aged, Aged, 80 and over, Cicatrix complications, Female, Humans, Incidental Findings, Male, Middle Aged, Neoplasms, Adnexal and Skin Appendage complications, Retrospective Studies, Skin Neoplasms complications, Cicatrix pathology, Hair Follicle, Neoplasms, Adnexal and Skin Appendage pathology, Neoplasms, Multiple Primary pathology, Skin Neoplasms pathology
- Abstract
Tumor of follicular infundibulum (TFI) is currently believed to be a benign epithelial neoplasm with follicular differentiation. It has been suggested that TFI is associated with dermal scarring, but further investigation is needed to confirm this correlation. To approach this question, a retrospective study was presented, a total of 67 cases (64 lesions) were found in a search covering cases over a 10-year period. Overall, the presence of histological dermal scarring was noted in 34 of 64 (53.13%) cases. Of the cases where TFI was an incidental finding, the presence of dermal scarring was noted in 13 of 18 (72.22%) cases. Meanwhile, of the cases where TFI was the main diagnosis, the presence of dermal scarring was noted in 12 of 34 (35.29%) cases. This suggests that TFI may, in some cases, represent an epidermal reaction pattern to dermal scarring.
- Published
- 2015
- Full Text
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18. Mycosis fungoides: an updated review of clinicopathologic variants.
- Author
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Ahn CS, ALSayyah A, and Sangüeza OP
- Subjects
- Humans, Immunohistochemistry, Phenotype, T-Lymphocytes, Helper-Inducer chemistry, Antigens, CD analysis, Biomarkers, Tumor analysis, Mycosis Fungoides chemistry, Mycosis Fungoides pathology, Skin Neoplasms chemistry, Skin Neoplasms pathology
- Abstract
Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. Although it was first described in 1833, our understanding of this disease has continued to evolve. From a diagnostic perspective, the diagnosis of MF can be challenging particularly in the early stages of the disease, because of overlap between the histological features of early MF lesions and many other inflammatory dermatoses. Furthermore, there has been an emergence of numerous clinicopathologic and immunohistochemical variants of MF reported in the literature. Although the prognostic significance of some of the rare variants is still not fully understood, certain variants, such as folliculotropic and bullous MF, have demonstrated less indolent clinical courses compared with classic MF and necessitate aggressive therapeutic measures. Thus, it is important for dermatologists and dermatopathologists to be knowledgeable of the widely varied clinical, histological, and immunohistochemical presentations of MF to arrive at a prompt and accurate diagnosis and initiate appropriate treatment.
- Published
- 2014
- Full Text
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19. Update on vascular neoplasms.
- Author
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Sangüeza OP
- Subjects
- Cell Cycle Proteins, Claudins genetics, Claudins metabolism, Hemangioma, Capillary pathology, Humans, Neoplasms, Vascular Tissue genetics, Neoplastic Syndromes, Hereditary pathology, Nuclear Proteins genetics, Nuclear Proteins metabolism, Proto-Oncogene Proteins c-myc genetics, Proto-Oncogene Proteins c-myc metabolism, RNA Splicing Factors, Sarcoma, Kaposi pathology, Skin Neoplasms genetics, Neoplasms, Radiation-Induced pathology, Neoplasms, Vascular Tissue metabolism, Neoplasms, Vascular Tissue pathology, Perivascular Epithelioid Cell Neoplasms pathology, Skin Neoplasms metabolism, Skin Neoplasms pathology
- Abstract
This article provides an update on vascular neoplasms. New immunohistochemical markers for the diagnosis of vascular neoplasms tumor 1, infantile hemangiomas, myopericytomas, perivascular epithelial cell tumors, acquired elastotic hemangiomas, vascular proliferations in radiated skin, and new histopathologic variants of AIDS-related Kaposi sarcoma are explored., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
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20. Composite B-cell and T-cell lineage post-transplant lymphoproliferative disorder of the lung with unusual cutaneous manifestations of mycosis fungoides.
- Author
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Mills KC, Sangüeza OP, Beaty MW, Raffeld M, and Pang CS
- Subjects
- Adolescent, B-Lymphocytes pathology, B-Lymphocytes virology, Cell Lineage, Epstein-Barr Virus Infections genetics, Epstein-Barr Virus Infections immunology, Gene Rearrangement, Humans, Kidney Transplantation adverse effects, Lung Diseases genetics, Lymphoproliferative Disorders genetics, Male, Mycosis Fungoides genetics, Receptors, Antigen, T-Cell genetics, Skin Neoplasms genetics, T-Lymphocytes pathology, Immunocompromised Host, Lung Diseases immunology, Lymphoproliferative Disorders immunology, Mycosis Fungoides immunology, Skin Neoplasms immunology
- Abstract
We present the case of a 17-year-old male kidney transplant recipient who presented initially with dermatologic symptoms and was found to have histologic changes in the skin that were consistent with mycosis fungoides. Shortly after this diagnosis was made, imaging studies demonstrated multifocal interstitial and airspace consolidation in both lungs. Physical examination revealed no lymphadenopathy or hepatosplenomegaly, but an open lung biopsy revealed an Epstein-Barr virus (EBV)-negative monomorphic T-cell posttransplant lymphoproliferative disorder (PTLD) with a concomitant EBV-positive B-cell PTLD involving the same lesion of the lung. Polymerase chain reaction analysis demonstrated clonal T-cell receptor gene rearrangements in both the skin and the lung biopsies. Interestingly, 1 clone was shared between the skin and lung while a second clone was present only in the lung. To our knowledge, this is the first reported case of a PTLD presenting in the skin in which there was a subsequent discovery of composite, bilineal B- and T-cell PTLD of the lung.
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- 2012
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21. Erythematous lesions on the back of a man: challenge. Erythema ab igne.
- Author
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Cardona LF, Parsons AC, and Sangüeza OP
- Subjects
- Humans, Male, Middle Aged, Reflex Sympathetic Dystrophy therapy, Back pathology, Burns, Electric etiology, Burns, Electric pathology, Erythema etiology, Erythema pathology, Transcutaneous Electric Nerve Stimulation adverse effects
- Published
- 2011
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22. A 41-year-old woman with a scaly erythematous plaque admixed with erosions on the groin, back, and legs: challenge. Nutritional deficiency.
- Author
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Smith B, Curtis A, Parsons A, Yosipovitch G, and Sangüeza OP
- Subjects
- Adult, Back, Biopsy, Deficiency Diseases complications, Deficiency Diseases metabolism, Female, Groin, Humans, Leg, Pellagra pathology, Polycythemia Vera pathology, Deficiency Diseases diagnosis, Niacin deficiency, Pellagra etiology, Polycythemia Vera etiology, Skin pathology, Zinc deficiency
- Published
- 2010
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23. Papular mycosis fungoides: two new cases of a recently described clinicopathological variant of early mycosis fungoides.
- Author
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Martorell-Calatayud A, Botella-Estrada R, Sanmartín-Jimenez O, Requena C, Guillén-Barona C, and Sangüeza OP
- Subjects
- Clobetasol therapeutic use, Female, Glucocorticoids therapeutic use, Humans, Immunohistochemistry, Middle Aged, Mycosis Fungoides drug therapy, PUVA Therapy, Skin Neoplasms drug therapy, Treatment Outcome, Mycosis Fungoides pathology, Skin Neoplasms pathology
- Abstract
Background: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. In early stages of the disease many different clinicopathologic variants have been observed. Currently, a papular variant of MF which is characterized by a good prognosis has been described., Objective and Methods: Because only seven cases have been reported in the literature, clinical and morphological data of this variant are not well established. We report the clinical and histopathological characteristics of two new patients with papular mycosis fungoides and review the previous cases reported in the literature., Results: The two cases of this early variant of MF were characterized by the presence of papules which, unlike the papules of lymphomatoid papulosis, did not show a tendency for spontaneous resolution. Histologic examination confirmed the diagnosis of MF in all cases. Immunohistochemical staining for CD30 was negative in all two cases. Follow-up data of our two patients confirmed the non-aggressive behavior of the disease, confirming that the lesions were not manifestations of advanced MF., Conclusion: Papular MF is a new variant of early MF characterized by a good prognosis in the long term follow- up. Thus, it should be added to the long list of clinicopathologic subtypes of MF.
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- 2010
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24. [Advances in molecular biology and their application in the diagnosis and treatment of melanoma].
- Author
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Martorell-Calatayud A, Requena C, Botella-Estrada R, and Sangüeza OP
- Subjects
- Genes, p16, Humans, Melanoma genetics, Molecular Diagnostic Techniques, Skin Neoplasms genetics, Melanoma diagnosis, Melanoma drug therapy, Skin Neoplasms diagnosis, Skin Neoplasms therapy
- Abstract
Even though malignant melanoma accounts for 4 % of all skin cancers, it is the type responsible for most deaths. The pathogenesis of melanoma is currently not well understood, although an interaction of environmental and genetic factors doubtlessly plays a role. Molecular biology in medicine has progressed increasingly rapidly in recent years. In dermatology, application of molecular biology techniques to the study of malignant melanoma has led to important advances in our knowledge of the main molecular pathways implicated in its development. These findings not only can improve our knowledge of the pathogenesis of the disease but may also have practical implications. Thus, molecular characterization of malignant melanoma may be of great help in differentiating between benign and malignant melanocytic lesions when histopathological features prove insufficient as is the case, for example, in Spitz nevus and spitzoid melanoma. In addition, knowledge of the abnormal molecular pathways in different malignant melanoma lesions can point to new therapeutic targets for treating patients with melanomas with distant metastases, in whom current chemotherapy has failed to extend life expectancy. At present, lack of availability is the main barrier to use of these techniques in dermatology--they are often limited to research, so not generally available in most hospitals. This problem will, however, be overcome when the molecular patterns become standardized, allowing a prognostic and therapeutic characterization of this important disease.
- Published
- 2009
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25. Challenge. What is your diagnosis? Answer. Primary nodal diffuse large B-cell lymphoma with secondary cutaneous involvement.
- Author
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Walsh SN, Kerchner K, and Sangüeza OP
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Aspirin therapeutic use, Clopidogrel, Coronary Artery Disease complications, Coronary Artery Disease drug therapy, Coronary Artery Disease surgery, Diuretics therapeutic use, Exanthema etiology, Humans, Hydrochlorothiazide therapeutic use, Lisinopril therapeutic use, Lymphoma, Large B-Cell, Diffuse complications, Male, Platelet Aggregation Inhibitors therapeutic use, Skin Neoplasms complications, Sotalol therapeutic use, Stents, Ticlopidine analogs & derivatives, Ticlopidine therapeutic use, Lymphoma, Large B-Cell, Diffuse pathology, Skin Neoplasms pathology
- Published
- 2009
- Full Text
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26. PEComas: a review with emphasis on cutaneous lesions.
- Author
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Walsh SN and Sangüeza OP
- Subjects
- Actins metabolism, Antigens, Neoplasm metabolism, Biomarkers, Tumor metabolism, Epithelioid Cells metabolism, Female, Humans, Melanoma-Specific Antigens, Middle Aged, Neoplasm Proteins metabolism, Perivascular Epithelioid Cell Neoplasms metabolism, Perivascular Epithelioid Cell Neoplasms surgery, Skin Neoplasms metabolism, Skin Neoplasms surgery, Desmin metabolism, Epithelioid Cells pathology, Perivascular Epithelioid Cell Neoplasms pathology, Skin Neoplasms pathology
- Abstract
The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC). Morphologically, analogous lesions found in other locations are composed of the unifying cell, the perivascular epithelioid cell (PEC). PEC tumors (or PEComas), other than AML, CCST, and LAM, are not associated with TSC and typically occur in middle-aged adult females. These neoplasms are composed of nests and fascicles of clear to granular epithelioid and/or spindled cells with a consistent arrangement around blood vessels. Characteristically, the cells express both melanocytic (usually HMB45) and myogenic (typically actin) markers. Although the most common sites are the gastrointestinal and genitourinary tracts, approximately 23 cases, to date, of PEComas arising in the skin have been reported. Primary cutaneous PEComas also have a predilection for adult females and most often present as a painless mass on the extremities. In contrast to other sites, the myogenic marker most commonly expressed in PEComas of the skin is desmin. Most reported cutaneous PEComas follow a benign course, however, a malignant case has been reported. Surgical excision is currently the mainstay of treatment.
- Published
- 2009
- Full Text
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27. New and improved features at the American Journal of Dermatopathology.
- Author
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Sangüeza OP
- Subjects
- Dermatology, Pathology, Periodicals as Topic
- Published
- 2009
- Full Text
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28. Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review.
- Author
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Papalas JA, Balmer NN, Wallace C, and Sangüeza OP
- Subjects
- Aged, Histiocytoma, Benign Fibrous metabolism, Humans, Immunohistochemistry, Male, Ossification, Heterotopic metabolism, Skin Neoplasms metabolism, Giant Cells pathology, Histiocytoma, Benign Fibrous pathology, Ossification, Heterotopic pathology, Osteoclasts pathology, Skin Neoplasms pathology
- Abstract
Dermatofibromas are fibrohistiocytic lesions with numerous histologic variants. Ossifying dermatofibroma with osteoclast-like giant cells is an uncommon variant that has only rarely been reported. We report another case of ossifying dermatofibroma with osteoclast-like giant cells and describe the immunohistochemical expression pattern of these rare lesions. A 72-year-old male presented with a 3.5-cm subcutaneous nodule on the posterior right shoulder of several years duration. The excision specimen showed a large, dermal-based, well-circumscribed, nonencapsulated heterogenous spindle cell proliferation. Large islands of spindled cells arranged in a storiform pattern were separated by broad fibrous bands. Collections of multinucleated giant cells were present predominantly at the periphery of the spindle cell islands. In addition, small islands of bone with osteoblastic rimming were present multifocally, concentrated in the central portion of the lesion. The spindle cells express factor XIIIA, smooth muscle actin, and CD68 on immunohistochemical stains, confirming a fibrohistiocytic origin. There was no immunohistochemical expression for S100 protein, panmel, CD57, cytokeratin, neuron-specific enolase, or CD34. A broad differential diagnosis, including variants of melanoma and osteosarcoma, should be considered when analyzing cutaneous lesions with a fibrohistiocytic component admixed with giant cells and metaplastic bone.
- Published
- 2009
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29. Localized palmar vancomycin-induced linear IgA bullous dermatosis occurring at supratherapeutic levels.
- Author
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Walsh SN, Kerchner K, and Sangüeza OP
- Subjects
- Aged, Anti-Bacterial Agents administration & dosage, Antibodies, Anti-Idiotypic analysis, Bacteremia drug therapy, Biopsy, Complement C3 metabolism, Diagnosis, Differential, Epidermis metabolism, Epidermis pathology, Fluorescent Antibody Technique, Direct, Follow-Up Studies, Hand Dermatoses immunology, Hand Dermatoses pathology, Humans, Immunoglobulin A immunology, Immunoglobulin A metabolism, Male, Skin Diseases, Vesiculobullous immunology, Skin Diseases, Vesiculobullous pathology, Staphylococcal Infections drug therapy, Vancomycin administration & dosage, Anti-Bacterial Agents adverse effects, Hand Dermatoses chemically induced, Skin Diseases, Vesiculobullous chemically induced, Vancomycin adverse effects
- Published
- 2009
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30. Intralymphatic histiocytosis. A clinicopathologic study of 16 cases.
- Author
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Requena L, El-Shabrawi-Caelen L, Walsh SN, Segura S, Ziemer M, Hurt MA, Sangüeza OP, and Kutzner H
- Subjects
- Aged, Aged, 80 and over, Dermis blood supply, Eyelid Diseases pathology, Female, Histiocytes metabolism, Histiocytes pathology, Histiocytosis metabolism, Humans, Male, Membrane Glycoproteins metabolism, Middle Aged, Phosphoglucomutase metabolism, Dermis pathology, Hemangioendothelioma pathology, Histiocytosis pathology, Lymphatic Vessels pathology, Vascular Neoplasms pathology
- Abstract
Intralymphatic histiocytosis is a rare condition characterized by the presence of dilated lymphatic vessels containing aggregates of mononuclear histiocytes (macrophages) within their lumina. The phenomenon seems to occur almost exclusively within the reticular dermis. Although its pathogenesis remains uncertain, there has been speculation about the possible relationship between intralymphatic histiocytosis and intravascular reactive angioendotheliomatosis. In addition, several examples historically have been associated with rheumatoid arthritis. We describe our experience with 16 cases of intralymphatic histiocytosis. Clinically, the lesions were located predominantly on the upper and lower limbs, and they consisted of asymptomatic and poorly demarcated erythematous plaques and livedo reticularis-like lesions. They were characterized histopathologically by dilated vascular structures involving the reticular dermis. Some of these dilated vessels had empty lumina, whereas others contained variable number of mononuclear histiocytes. An inflammatory response of variable intensity from case to case was also present in the adjacent dermis. The dilated vessels exhibited thin walls with irregular shapes, and a single discontinuous layer of flat endothelial cells lined their lumina. Immunohistochemically, the endothelial cells lining the dilated lumina expressed immunoreactivity for CD31, CD34, podoplanin, D2-40, Lyve-1, and Prox-1, which confirmed their nature as lymphatic endothelial cells. Intralymphatic mononuclear histiocytes expressed CD68 (PGM1), although some cases also had variable immunoexpression for myeloperoxidase, CD31, and podoplanin. In the 4 cases that employed double immunohistochemistry, with podoplanin + CD68 (PGM1) or with Lyve-1 + CD68 (PGM1), each marker highlighted their specific target cells unequivocally; the endothelial cells expressed podoplanin or Lyve-1 immunoreactivity, and intralymphatic histiocytes showed CD68 (PGM1) immunoexpression. Our findings expand on the previously described morphologic and immunohistochemical features of intravascular histiocytosis. We also discuss the possible relationship between intralymphatic histiocytosis and the so-called reactive intravascular angioendotheliomatosis.
- Published
- 2009
- Full Text
- View/download PDF
31. It seems that it was yesterday.
- Author
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Sangüeza OP
- Subjects
- Dermatology trends, History, 20th Century, Pathology trends, Periodicals as Topic trends, Dermatology history, Pathology history, Periodicals as Topic history
- Published
- 2009
- Full Text
- View/download PDF
32. Fungal foes: Lacazia loboi.
- Author
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Elston DM and Sangüeza OP
- Subjects
- Animals, Brazil, Humans, Paracoccidioides isolation & purification, Bottle-Nosed Dolphin microbiology, Mycoses microbiology, Paracoccidioides immunology, Paracoccidioidomycosis microbiology
- Published
- 2009
33. Synchronous verrucous carcinoma and cutaneous T-cell lymphoma.
- Author
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Parsons AC, Sheehan DJ, and Sangüeza OP
- Subjects
- Adult, Carcinoma, Verrucous drug therapy, Humans, Lymphoma, T-Cell, Cutaneous drug therapy, Male, Neoplasms, Second Primary drug therapy, Skin Neoplasms drug therapy, Carcinoma, Verrucous pathology, Lymphoma, T-Cell, Cutaneous pathology, Neoplasms, Second Primary pathology, Skin Neoplasms pathology
- Published
- 2008
- Full Text
- View/download PDF
34. Interstitial granulomatous dermatitis secondary to acute promyelocytic leukemia.
- Author
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Swing DC Jr, Sheehan DJ, Sangüeza OP, and Woodruff RW
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biopsy, Needle, Blood Chemical Analysis, Bone Marrow pathology, Disease Progression, Female, Follow-Up Studies, Hip, Humans, Immunohistochemistry, Leukemia, Promyelocytic, Acute drug therapy, Risk Assessment, Severity of Illness Index, Treatment Failure, Dermatitis etiology, Dermatitis pathology, Leukemia, Promyelocytic, Acute complications, Leukemia, Promyelocytic, Acute diagnosis
- Published
- 2008
- Full Text
- View/download PDF
35. A linear orofacial macule.
- Author
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Walsh SN, Jorizzo JL, Haverstock C, and Sangüeza OP
- Subjects
- Administration, Oral, Adolescent, Biopsy, Needle, Drug Therapy, Combination, Follow-Up Studies, Humans, Hypopigmentation pathology, Immunohistochemistry, Lichen Sclerosus et Atrophicus diagnosis, Lip, Male, Methotrexate administration & dosage, Prednisone administration & dosage, Lichen Sclerosus et Atrophicus drug therapy, Lichen Sclerosus et Atrophicus pathology, Mouth Mucosa pathology
- Published
- 2008
- Full Text
- View/download PDF
36. Ossifying plexiform tumor: report of two new cases.
- Author
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Walsh SN and Sangüeza OP
- Subjects
- Adult, Aged, Diagnosis, Differential, Female, Fibroma pathology, Humans, Immunohistochemistry, Neurothekeoma pathology, Skin Neoplasms metabolism, Fingers pathology, Ossification, Heterotopic pathology, Skin Neoplasms pathology
- Abstract
Ossifying plexiform tumor is a cutaneous lesion that microscopically resembles cellular neurothekeoma but has abundant central ossification as the prominent feature and has only been previously described in a single case report. We detail 2 additional examples, both arising on the finger of adult women (36 and 76 years old). Clinically, the lesions were described as a raised flesh-colored "extraosseous" mass, averaging 1.1 cm in greatest dimension. Histological examination showed an unencapsulated well-delineated dermal tumor with thin fibrous bands separating lobules and fascicles of epithelioid to spindled cells that were embedded in a somewhat loose myxoid matrix. Present within the center of the lobules were large irregular foci of mature bone, some lined by osteoblasts. After excision, these lesions have not recurred or persisted in a limited follow-up duration (9 and 2 months). In concordance with the only other case report of a 30-year-old woman with a left thumb mass, ossifying plexiform tumor has occurred exclusively on the digits of adult women. Although it is possible that ossifying plexiform tumor could represent an ossifying variant of cellular neurothekeoma, we believe it is a lesion sui generis, and hope its recognition will allow for an accurate diagnosis and distinction from other cutaneous ossifying lesions.
- Published
- 2008
- Full Text
- View/download PDF
37. Cutaneous epithelioid angiomatous nodule: a case series and proposed classification.
- Author
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Sangüeza OP, Walsh SN, Sheehan DJ, Orland AF, Llombart B, and Requena L
- Subjects
- Adolescent, Adult, Aged, Diagnosis, Differential, Female, Hemangioendothelioma pathology, Hemangioendothelioma, Epithelioid pathology, Humans, Male, Middle Aged, Retrospective Studies, Skin blood supply, Skin pathology, Epithelioid Cells pathology, Skin Neoplasms pathology
- Abstract
Cutaneous epithelioid angiomatous nodule is a peculiar and recently recognized vascular proliferation. Clinically, these lesions affect different areas of the body and histologically are characterized by a well-circumscribed, mainly unilobular, solid proliferation of endothelial cells with prominent epithelioid features. The cytoplasm is abundant and eosinophilic, and many of the neoplastic cells contain prominent vacuoles. Inflammatory infiltrates are variable. All the cases reported thus far have followed a benign course. We report 10 additional cases of this curious entity, including 2 which presented in an eruptive fashion and 5 that were located on the head and neck. We also discuss the histological differential diagnoses with other epithelioid proliferations and propose categorization within the spectrum of epithelioid hemangioma.
- Published
- 2008
- Full Text
- View/download PDF
38. Spontaneous regression of langerhans cell histiocytosis in a neonate with multiple bony lesions.
- Author
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McElligott J, McMichael A, Sangüeza OP, Anthony E, Rose D, and McLean TW
- Subjects
- Female, Humans, Infant, Newborn, Radiography, Remission, Spontaneous, Bone Diseases diagnostic imaging, Histiocytosis, Langerhans-Cell diagnostic imaging, Skin Diseases diagnostic imaging
- Abstract
We report the case of a newborn with Langerhans cell histiocytosis involving the skin and multiple bones. All lesions resolved without therapy. This case underscores the benefits of a conservative approach in the absence of risk organ involvement.
- Published
- 2008
- Full Text
- View/download PDF
39. The importance of avoiding electrosurgical artifact at the margins of melanoma excisions.
- Author
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Sheehan DJ, Sangüeza OP, and Feldman SR
- Subjects
- Aged, Artifacts, Humans, Male, Electrosurgery, Head and Neck Neoplasms surgery, Melanoma surgery, Scalp, Skin Neoplasms surgery
- Published
- 2007
- Full Text
- View/download PDF
40. Transglutaminases: the missing link in nephrogenic systemic fibrosis.
- Author
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Parsons AC, Yosipovitch G, Sheehan DJ, Sangüeza OP, Greenberg CS, and Sane DC
- Subjects
- Antigens, CD metabolism, Antigens, Differentiation, Myelomonocytic metabolism, Biopsy, Case-Control Studies, Contrast Media adverse effects, Factor XIIIa metabolism, Female, Fibroblasts enzymology, Fibroblasts pathology, Fibrosis chemically induced, Gadolinium adverse effects, Histiocytes enzymology, Histiocytes pathology, Humans, Male, Middle Aged, Skin Diseases chemically induced, Skin Diseases pathology, Syndrome, Renal Insufficiency enzymology, Skin enzymology, Skin pathology, Skin Diseases enzymology, Transglutaminases metabolism
- Abstract
Nephrogenic systemic fibrosis (NSF), also known as nephrogenic fibrosing dermopathy (NFD), occurs in renal failure patients after gadolinium contrast exposure. The fibrosis of the dermis and subcutaneous septae accompanies fibrosis of other organs, including the heart, liver, lungs, and muscle. The fibrotic skin demonstrates increased dermal collagen, fibroblasts, and mucin. The mechanism by which gadolinium is associated with fibrosis is not known. We tested the hypothesis that upregulation of transglutaminases contributes to the fibrosis seen in the organs, including skin, of renal failure patients exposed to gadolinium contrast. We performed immunohistochemical studies using antibodies to transglutaminase-2, factor XIIIa, transglutaminase isopeptide, and the histiocyte marker CD68 on five archived skin biopsies of NSF. The results indicate that the dermal fibroblasts and histiocytes of NSF express transglutaminase-2, CD68, factor XIIIa, and transglutaminase isopeptide, indicating increased expression and/or activation of transglutaminases in NSF. We recommend further research into the use of transglutaminase inhibitors in the treatment and prevention of NSF.
- Published
- 2007
- Full Text
- View/download PDF
41. Proliferating trichilemmal tumors: a review of the literature.
- Author
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Satyaprakash AK, Sheehan DJ, and Sangüeza OP
- Subjects
- Carcinoma, Squamous Cell diagnostic imaging, Epidermal Cyst diagnostic imaging, Head and Neck Neoplasms diagnostic imaging, Humans, Radiography, Retrospective Studies, Skin Neoplasms diagnostic imaging, Carcinoma, Squamous Cell pathology, Epidermal Cyst pathology, Head and Neck Neoplasms pathology, Scalp, Skin Neoplasms pathology
- Abstract
Background: Proliferating trichilemmal tumors (PTTs) are uncommon lesions whose histologic hallmark is the presence of trichilemmal keratinization. PTT is thought to originate from the trichilemmal cyst (TC) and have the potential for malignant transformation, at which point it is termed a malignant proliferating trichilemmal tumor (MPTT). These lesions may cause considerable morbidity and even mortality, and recurrence after simple local excision is common., Objective: The objective was to review the clinical presentation, histopathologic characteristics, malignant potential, and treatment options for PTT., Methods: The English literature was reviewed regarding PTT, TC, and MPTT., Results: PTT generally presents as a subepidermal tumor on the scalp in women over the age of 60. Histologic findings may be used to differentiate PTT from TC and MPTT. Complete surgical excision is recommended; additional radiotherapy and/or chemotherapy may be used for lesions with increased invasive potential., Conclusion: Adequate treatment of PTT requires skilled histopathologic examination for proper diagnosis; histologic appearance may not correlate with clinical behavior. After surgical excision, long-term clinical follow-up for evidence of metastatic disease is judicious.
- Published
- 2007
- Full Text
- View/download PDF
42. Mycosis fungoides: new insights into an old problem.
- Author
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Sangüeza OP and Lu D
- Subjects
- Hair Follicle pathology, Humans, Mucinosis, Follicular pathology, Mycosis Fungoides classification, Mycosis Fungoides complications, Skin Neoplasms classification, Skin Neoplasms complications, T-Lymphocytes pathology, Mucinosis, Follicular complications, Mycosis Fungoides pathology, Skin Neoplasms pathology
- Published
- 2002
- Full Text
- View/download PDF
43. Postirradiation pseudosclerodermatous panniculitis.
- Author
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Carrasco L, Moreno C, Pastor MA, Izquierdo MJ, Fariña C, Martín L, Sangüeza OP, and Requena L
- Subjects
- Adult, Aged, Breast Neoplasms radiotherapy, Female, Humans, Middle Aged, Radionuclide Imaging, Panniculitis diagnostic imaging, Panniculitis pathology
- Abstract
Pseudosclerodermatous panniculitis is an unusual variant of panniculitis that results as a complication of megavoltage radiotherapy. Four women developed this unusual entity on the anterior chest and abdominal skin after receiving megavoltage therapy for either breast carcinoma or painful bone metastases from breast carcinoma. Histopathologically, the epidermis and dermis of the involved area showed little or no evidence of radiodermatitis. The main findings were confined to the subcutaneous tissue and consisted of thickened, sclerotic septa composed of both thick and thin collagen bundles, and a lobular panniculitis characterized by lipophagic granulomas and scattered lymphocytes and plasma cells. Additionally, one of the cases showed markedly dilated vascular spaces with the appearance of lymphatics in the upper part of the dermis. Pseudosclerodermatous panniculitis after irradiation is an unusual cutaneous complication of megavoltage radiotherapy that should be distinguished from subcutaneous metastatic disease, cellulitis, or connective tissue diseases involving the subcutaneous fat. The differential diagnosis can be established on the basis of the characteristic histopathologic features of postirradiation pseudosclerodermatous panniculitis.
- Published
- 2001
- Full Text
- View/download PDF
44. Update on the histologic findings of cutaneous infections.
- Author
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Sangüeza OP, Fleet SL, and Requena L
- Subjects
- Dermatomycoses pathology, Helminthiasis pathology, Humans, Prototheca, Protozoan Infections pathology, Scabies pathology, Skin Diseases, Bacterial pathology, Virus Diseases pathology, Skin Diseases, Infectious pathology
- Published
- 2000
45. Angiocentric cutaneous T-cell lymphoma of childhood (hydroa-like lymphoma): a distinctive type of cutaneous T-cell lymphoma.
- Author
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Magaña M, Sangüeza P, Gil-Beristain J, Sánchez-Sosa S, Salgado A, Ramón G, and Sangüeza OP
- Subjects
- Child, Child, Preschool, Herpesviridae Infections complications, Herpesvirus 4, Human isolation & purification, Humans, In Situ Hybridization, Lymphoma, T-Cell, Cutaneous pathology, Lymphoma, T-Cell, Cutaneous virology, Male, Skin pathology, Skin Neoplasms pathology, Skin Neoplasms virology, Tumor Virus Infections complications, Lymphoma, T-Cell, Cutaneous classification, Skin Neoplasms classification
- Abstract
Background: Angiocentric cutaneous T-cell lymphomas of childhood (ACTCLC) are an unusual type of T-cell lymphomas that present with a vesiculopapular eruption mimicking hydroa vacciniforme. Most patients have been children from Asia and Latin America., Objective: The purpose of this study was to describe four cases of ACTCLC; to discuss its clinical, histopathologic, and immunohistochemical features; to consider its possible relationship to the Epstein-Barr virus (EBV); and to clarify its classification within the spectrum of angiocentric lymphomas., Methods: The clinical, histopathologic, and immunohistochemical features of four cases of ACTCLC were identified and analyzed. In addition in situ hybridization for EBV was performed in all cases., Results: The clinical features were similar to previous cases reported under different names, such as hydroa-like lymphomas, edematous, scarring vasculitic panniculitis. Histologically, all showed angiocentric infiltrates composed mainly of T cells. In all cases there were variable numbers of CD30+ cells. The EBV was present in three of the cases., Conclusion: ACTCLC is a distinct type of T-cell lymphoma. It affects mainly children, and the EBV appears to play a role in the pathogenesis of this disease.
- Published
- 1998
- Full Text
- View/download PDF
46. Neoplasms with neural differentiation: a review. Part II: Malignant neoplasms.
- Author
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Sangüeza OP and Requena L
- Subjects
- Adult, Biomarkers, Tumor analysis, Epithelioid Cells pathology, Female, Granular Cell Tumor pathology, Humans, Immunohistochemistry, Male, Melanoma chemistry, Melanoma pathology, Middle Aged, Neoplasms, Muscle Tissue, Nerve Sheath Neoplasms chemistry, Neurilemmoma pathology, Neuroectodermal Tumors, Primitive pathology, Neurofibromatosis 1 complications, Neurofibrosarcoma chemistry, Neurofibrosarcoma complications, Neurofibrosarcoma pathology, Peripheral Nervous System Neoplasms chemistry, Cell Differentiation, Nerve Sheath Neoplasms pathology, Peripheral Nervous System Neoplasms pathology
- Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) encompass a wide and unusual group of neoplasms with features of neural differentiation. They most commonly present as spindle cell neoplasms and it can be difficult to differentiate them from other spindle cell neoplasms such as leiomyosarcomas, fibrosarcomas and synovial sarcomas. Strict criteria need to be applied in order to make the diagnosis of MPNSTs. Helpful features include contiguity with a nerve or an association with von Recklinghausen disease. The use of immunohistochemical stains may also help to confirm the diagnosis. Markers such as S-100 protein, neurofilament, epithelial membrane antigen and Leu-7 (CD57) are frequently used to assess neural differentiation in these neoplasms. In addition to the spindle cell pattern, MPNSTs may also display an epithelioid pattern. Rarely, other elements may be seen including glands in the so-called glandular MPNST or muscle in triton tumors. In more unusual cases cartilage, adipose tissue and even bone are present. Also included in the group of MPNSTs are the peripheral neuroepithelial tumor, neurotropic or desmoplastic melanomas and malignant granular cell tumors. MPNSTs are highly aggressive tumors and should be treated accordingly.
- Published
- 1998
- Full Text
- View/download PDF
47. Malignant glomus tumor of the thumb: a case report.
- Author
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Wetherington RW, Lyle WG, and Sangüeza OP
- Subjects
- Adult, Female, Glomus Tumor surgery, Humans, Glomus Tumor pathology, Thumb
- Abstract
Glomangiosarcoma is a rare malignant variant of the glomus tumor (GT). It has been reported in different anatomical locations, with only 1 report of its localization to the hand, despite the fact that its benign counterpart is most frequently found there. There is only 1 report of glomangiosarcoma that has metastasized. Special attention should be paid to GTs that are not well circumscribed, since the possibility of persistence and malignant transformation is increased in these lesions. The treatment of choice for glomangiosarcomas is wide local excision.
- Published
- 1997
- Full Text
- View/download PDF
48. Metastatic Crohn's disease.
- Author
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Sangüeza OP, Davis LS, and Gourdin FW
- Subjects
- Adult, Aged, Anal Canal pathology, Crohn Disease pathology, Diagnosis, Differential, Forearm pathology, Granuloma diagnosis, Granuloma pathology, Humans, Male, Perineum pathology, Sarcoidosis diagnosis, Sarcoidosis pathology, Scrotum pathology, Skin Diseases pathology, Crohn Disease diagnosis, Skin Diseases diagnosis
- Abstract
Metastatic Crohn's disease is the term used for granulomatous lesions of Crohn's disease involving sites other than the gastrointestinal tract. Metastatic Crohn's disease has been considered uncommon, when in actuality it may simply be underdiagnosed or misdiagnosed since the clinical findings can be different. We report on three patients with this condition: one with generalized plaques, another with perineal and perianal ulcerations, and a third with a painless forearm nodule.
- Published
- 1997
- Full Text
- View/download PDF
49. Epstein-Barr virus. A serial killer or an innocent bystander?
- Author
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Sangüeza OP
- Subjects
- Herpesviridae Infections immunology, Herpesvirus 4, Human immunology, Humans, Lymphoproliferative Disorders immunology, Tumor Virus Infections immunology, Herpesviridae Infections etiology, Herpesvirus 4, Human pathogenicity, Lymphoproliferative Disorders etiology, Tumor Virus Infections etiology
- Published
- 1997
50. Erythema elevatum diutinum: a clinicopathological study of eight cases.
- Author
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Sangüeza OP, Pilcher B, and Martin Sangüeza J
- Subjects
- Adult, Female, Granuloma pathology, Humans, Male, Middle Aged, Skin Diseases, Vascular pathology, Erythema pathology
- Abstract
Erythema elevatum diutinum (EED) is a rare cutaneous condition that initially presents as leukocytoclastic vasculitis (LCCV) of the skin and later resolves with fibrosis. In addition to the LCCV, EED may show features reminiscent of other entities. For example, it may mimic lesions of dermatofibroma, granuloma annulare, granuloma faciale, or dermatitis herpetiformis. For this study, we reviewed the clinical records and 13 skin biopsies in eight patients with EED. One of the patients had concurrent pityriasis rubra pilaris, and another developed lesions of EED following and at the sites of mosquito bites; these associations have not been noted previously. In addition to such typical histopathological features as diffuse dermal involvement by neutrophils, eosinophils, and leukocytoclastic vasculitis, we also found two unusual patterns. The first was characterized by palisaded necrotizing granulomas, as previously described and associated with Churg-Strauss granuloma; the second condition simulated a pyogenicgranuloma--like lesion.
- Published
- 1997
- Full Text
- View/download PDF
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