37 results on '"Sandrine Jean"'
Search Results
2. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children
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Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau, and Mehdi Oualha
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Shock ,Children ,Acute myocarditis ,Multisystem inflammatory syndrome ,SARS-CoV-2 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. Results 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25–55); troponin, 269 ng/mL (31–4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1–10). All children had highly elevated C-reactive protein (> 94 mg/L) and procalcitonin (> 1.6 ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n = 20, skin rash, n = 10; conjunctivitis, n = 6; cheilitis, n = 5; adenitis, n = 2), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated. All children received intravenous immunoglobulin (2 g per kilogram) with adjuvant corticosteroids (n = 2), IL 1 receptor antagonist (n = 1) or a monoclonal antibody against IL-6 receptor (n = 1). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge. Conclusions Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral to an expert center is recommended. A delayed and inappropriate host immunological response is suspected. While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment.
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- 2020
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3. Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells
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Anne Trinh, Raeeka Khamari, Quentin Fovez, François-Xavier Mahon, Béatrice Turcq, Didier Bouscary, Patrice Maboudou, Marie Joncquel, Valérie Coiteux, Nicolas Germain, William Laine, Salim Dekiouk, Sandrine Jean-Pierre, Veronique Maguer-Satta, Bart Ghesquiere, Thierry Idziorek, Bruno Quesnel, Jerome Kluza, and Philippe Marchetti
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Synthetic lethality ,Metabolic addiction ,LSC ,Metabolic stress ,Stem-like cells ,Internal medicine ,RC31-1245 - Abstract
Objective: Long-term treatment with tyrosine kinase inhibitors (TKI) represents an effective cure for chronic myeloid leukemia (CML) patients and discontinuation of TKI therapy is now proposed to patient with deep molecular responses. However, evidence demonstrating that TKI are unable to fully eradicate dormant leukemic stem cells (LSC) indicate that new therapeutic strategies are needed to control LSC and to prevent relapse. In this study we investigated the metabolic pathways responsible for CML surviving to imatinib exposure and its potential therapeutic utility to improve the efficacy of TKI against stem-like CML cells. Methods: Using complementary cell-based techniques, metabolism was characterized in a large panel of BCR-ABL+ cell lines as well as primary CD34+ stem-like cells from CML patients exposed to TKI and L-Asparaginases. Colony forming cell (CFC) assay and flow cytometry were used to identify CML progenitor and stem like-cells. Preclinical models of leukemia dormancy were used to test the effect of treatments. Results: Although TKI suppressed glycolysis, compensatory glutamine-dependent mitochondrial oxidation supported ATP synthesis and CML cell survival. Glutamine metabolism was inhibited by L-asparaginases such as Kidrolase or Erwinase without inducing predominant CML cell death. However, clinically relevant concentrations of TKI render CML cells susceptible to Kidrolase. The combination of TKI with Lasparaginase reactivates the intinsic apoptotic pathway leading to efficient CML cell death. Conclusion: Targeting glutamine metabolism with the FDA-approved drug, Kidrolase in combination with TKI that suppress glycolysis represents an effective and widely applicable therapeutic strategy for eradicating stem-like CML cells.
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- 2022
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4. Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d’Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies
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Philippe Le Conte, Nicolas Terzi, Guillaume Mortamet, Fekri Abroug, Guillaume Carteaux, Céline Charasse, Anthony Chauvin, Xavier Combes, Stéphane Dauger, Alexandre Demoule, Thibaut Desmettre, Stephan Ehrmann, Bénédicte Gaillard-Le Roux, Valérie Hamel, Boris Jung, Sabrina Kepka, Erwan L’Her, Mikaël Martinez, Christophe Milési, Élise Morawiec, Mathieu Oberlin, Patrick Plaisance, Robin Pouyau, Chantal Raherison, Patrick Ray, Mathieu Schmidt, Arnaud W. Thille, Jennifer Truchot, Guillaume Valdenaire, Julien Vaux, Damien Viglino, Guillaume Voiriot, Bénédicte Vrignaud, Sandrine Jean, Eric Mariotte, and Pierre-Géraud Claret
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Asthma ,Severe exacerbation ,Guidelines ,Emergency ,Intensive Care ,Pediatric ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in adult and pediatric patients. Results The guidelines were related to 5 areas: diagnosis, pharmacological treatment, oxygen therapy and ventilation, patients triage, specific considerations regarding pregnant women. The literature analysis and formulation of the guidelines were conducted according to the Grade of Recommendation Assessment, Development and Evaluation methodology. An extensive literature research was conducted based on publications indexed in PubMed™ and Cochrane™ databases. Of the 21 formalized guidelines, 4 had a high level of evidence (GRADE 1+/−) and 7 a low level of evidence (GRADE 2+/−). The GRADE method was inapplicable to 10 guidelines, which resulted in expert opinions. A strong agreement was reached for all guidelines. Conclusion The conjunct work of 36 experts from 3 scientific societies resulted in 21 formalized recommendations to help improving the emergency and intensive care management of adult and pediatric patients with SAE.
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- 2019
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5. Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation.
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Marie-Philippine Clair, Jérôme Rambaud, Adrien Flahault, Romain Guedj, Julia Guilbert, Isabelle Guellec, Amélie Durandy, Maryne Demoulin, Sandrine Jean, Delphine Mitanchez, François Chalard, Chiara Sileo, Ricardo Carbajal, Sylvain Renolleau, and Pierre-Louis Léger
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Medicine ,Science - Abstract
Extracorporeal membrane oxygenation support is indicated in severe and refractory respiratory or circulatory failures. Neurological complications are typically represented by acute ischemic or hemorrhagic lesions, which induce higher morbidity and mortality. The primary goal of this study was to assess the prognostic value of cerebral tissue oxygen saturation (StcO2) on mortality in neonates and young infants treated with ECMO. A secondary objective was to evaluate the association between StcO2 and the occurrence of cerebral lesions.This was a prospective study in infants < 3 months of age admitted to a pediatric intensive care unit and requiring ECMO support.The assessment of cerebral perfusion was made by continuous StcO2 monitoring using near-infrared spectroscopy (NIRS) sensors placed on the two temporo-parietal regions. Neurological lesions were identified by MRI or transfontanellar echography.Thirty-four infants
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- 2017
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6. Les jeunes familles au coeur des transformations des quartiers péricentraux : le cas d’Ahuntsic à Montréal
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Sandrine Jean and Annie Bilodeau
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quartier péricentral ,familles ,transformations ,modes de vie ,offre commerciale ,parc ,sociabilité publique ,peri-central neighbourhoods ,families ,lifestyles ,shops ,parks ,public sociability ,Political science (General) ,JA1-92 ,Sociology (General) ,HM401-1281 - Abstract
L’embourgeoisement des quartiers centraux a fait couler beaucoup d’encre au cours des dernières décennies. Le rôle joué par les familles dans les processus de transformations des quartiers demeure cependant méconnu. Nous étudions les transformations du quartier Ahuntsic comme quartier péricentral montréalais, un type de quartier en transformation peu exploré dans la littérature, face à l’arrivée de familles avec de jeunes enfants. Les résultats présentés sont le fruit d’une enquête conduite à Ahuntsic entre 2010 et 2012 où ont été menées : 1) une trentaine d’observations d’espaces publics (parcs, installations sportives, centres communautaires et bibliothèques) ; 2) plus d’une quarantaine d’entrevues courtes avec des résidents et usagers de ces espaces ; ainsi que 3) plus d’une vingtaine d’entrevues approfondies auprès de familles avec de jeunes enfants. L’arrivée de familles avec de jeunes enfants participe à la transformation du quartier à travers leur occupation de l’espace public, leurs habitudes de consommation et leurs relations sociales. Deux principaux changements sont observés. Premièrement, les familles ont des attentes spécifiques à l’égard des commerces, des parcs et des installations sportives dans le quartier. Deuxièmement, elles ont des rapports de voisinage et des pratiques de sociabilité quotidienne qui altèrent les dynamiques locales et participent au maintien de leur mode de vie urbain, précédant l’arrivée des enfants. Les changements qu’occasionne l’arrivée de familles avec de jeunes enfants invitent à repenser la place et le rôle des familles dans les quartiers péricentraux, de même qu’à une production renouvelée et inclusive de la ville.
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- 2016
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7. Extracorporeal membrane oxygenation for immunocompromised children with acute respiratory distress syndrome: a French referral center cohort
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Jean-Eudes Piloquet, Yohan Soreze, Sandrine Jean, Jérôme Rambaud, Pierre-Louis Leger, Isabelle Guellec, Julien Jegard, Julia Guilbert, Julie Starck, Blandine Robert, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), and Rambaud, Jerome
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ARDS ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Extracorporeal ,Extracorporeal Membrane Oxygenation ,children ,Intensive care ,Extracorporeal membrane oxygenation ,medicine ,Humans ,Child ,Survival rate ,Referral and Consultation ,Retrospective Studies ,Respiratory Distress Syndrome ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,business.industry ,medicine.disease ,veno-arterial ECMO ,3. Good health ,immunocompromised ,Respiratory failure ,Life support ,Cohort ,Pediatrics, Perinatology and Child Health ,Quality of Life ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,veno-venous ECMO - Abstract
International audience; Background: Immunocompromised children are likely to develop a refractory acute respiratory distress syndrome (ARDS). The usefulness of providing extracorporeal life support (ECLS) to these patients is a subject of debate. The aim of our study was to report the outcomes and to compare factors associated with mortality between immunocompromised and non-immunocompromised children supported with veno-venous ECMO. Methods: We performed a retrospective monocentric study in the French pediatric ECMO center of Armand Trousseau Hospital, including all pediatric patients aged from 1 month to 18 years requiring ECLS for ARDS. Results: Between 2007 and 2018, one hundred and eleven (111) patients underwent ECMO for respiratory failure; among them twenty-five (25) were immunocompromised. Survival rate at 6 months after intensive care discharge was significantly lower for immunocompromised patients compared to non-immunocompromised ones (41.7% vs. 62.8%; p = 0.04). ARDS severity was similar between the 2 groups. Fungal pneumonias were reported only in immunocompromised patients (12.5% versus 0% in the control group; p = 0.001). Bleeding complications were significantly more frequent in the immunocompromised group and blood product transfusions were also more frequently required in this group. Conclusion: Six months after intensive care discharge, survival rate of immunocompromised children supported with ECMO for pediatric ARDS is lower than for nonimmunocompromised patients. But, the expectation for a favorable outcome is real and it is worth it if their condition is likely to be compatible with a good long-term quality of life.
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- 2022
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8. Managing liminal time in the fly-in fly-out work camp
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Sandrine Jean and Sara Dorow
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Fly-in fly-out ,FIFO (computing and electronics) ,Computer science ,Strategy and Management ,media_common.quotation_subject ,05 social sciences ,0507 social and economic geography ,sync ,General Social Sciences ,computer.software_genre ,Arts and Humanities (miscellaneous) ,Work (electrical) ,Management of Technology and Innovation ,0502 economics and business ,Operating system ,Liminality ,050703 geography ,computer ,050203 business & management ,media_common - Abstract
Fly-in fly-out (FIFO) work camps are built and organized to ensure that long-distance rotational workers are fed, housed, and mobilized in sync with the pressing yet unpredictable rhythms of resource extraction. Positioned thus ‘betwixt and between’ the complex relations of work and life (Johnsen and Sørensen, 2015), the work camp is a generative yet hitherto neglected example of the temporal operations of permanent liminality (Bamber et al., 2017). But what does this mean for workers? If camp does the liminal work of managing the temporal challenges of the resource-based mobility regime, how do FIFO workers experience and respond to its inevitable lived consequences? Drawing on rare qualitative fieldwork in Canada’s Athabasca Oil Sands, we explain the effects of camp time—disorientation, monotony, and entrapment—and examine the temporal tactics workers deploy to manage those effects, from embracing and disrupting internal camp routines to aligning and syncing with outside and future-oriented temporalities. We argue that workers’ tactics make them ‘competent liminars’ (Borg and Söderlund, 2015) of camp time, which is, in turn, crucial to the latter’s disciplining function within the FIFO mobility regime. Our findings invite renewed attention to the temporal mediation accomplished by liminal people and places, especially in organizational contexts aimed at institutionally harnessing social time to productive imperatives.
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- 2022
9. Usefulness of implementation of a protective mechanical ventilation bundle during extracorporeal membrane oxygenation for pediatric acute respiratory distress syndrome
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Julien JEGARD, Yael LEVY, Isabelle GUELLEC, Julia GUILBERT, Yohann SOREZE, Jean-Eudes PILOQUET, Julie STARCK, Sandrine JEAN, Pierre-Louis LÉGER, and Jerome RAMBAUD
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Pediatrics, Perinatology and Child Health - Abstract
Defining the best ventilatory settings under ECMO remains a challenging question. Despite a well-defined ARDS treatment before ECMO initiation, there is no recommendation on how to ventilate a patient under ECMO for P-ARDS. Only a few descriptive studies are available on ventilatory settings during respiratory ECMO. We aim at evaluating the usefulness of a protective ventilation bundle under ECMO and its capacity to reduce the ventilatory pressure in our ECMO center.We performed a monocentric retrospective study from January 2007 to December 2018. All children aged from 1 month to 18 years old and requiring an extracorporeal membrane oxygenation for a refractory acute respiratory distress syndrome were included. A protective mechanical ventilation under ECMO bundle has been developed in 2014. We compare the period 1 (before 2014) to the period 2 (after 2014).Eighty-three patient had been included during the study. We reported a significant increase of PEEP and mean pressure respectively at day 3, day 7 and day 14 of ECMO during the period 2. Conversely, the driving pressure were significantly lower in the period 2 at day 3 (p: 0.009), day 7 (p:0.001) and day 14 (p: 0.001). We also shown a strong increase in the use of prone positioning during ECMO in the period 2 (p: 0.01). There was no significant effect of our bundle on the length of mechanical ventilation, of hospitalization and on the survival rate.The implementation of a protective mechanical ventilation bundle during ECMO is usefulness to apply for lower ventilatory pressure and higher use of prone positioning. Nonetheless, the lack of power of our study prevents us from showing its efficacy on outcome criteria.
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- 2022
10. Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia
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Florence Zylbersztejn, Iryna Byelinska, Sandrine Jeanpierre, Léa Barral, Kevin Geistlich, Mario Flores-Violante, Thibault Voeltzel, Etienne Paubelle, Mael Heiblig, Vincent Alcazer, Gregoire Le Meur, Gaelle Fossard, Amine Belhabri, Ivan Cruz-Moura, Olivier Hermine, Sylvain Lefort, and Véronique Maguer-Satta
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Published
- 2024
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11. Le rôle des groupes religieux dans la fabrique du lien social: l'action des Églises évangéliques montréalaises auprès des personnes immigrantes
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Frédéric Dejean, Myriam Richard, and Et Sandrine Jean
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Political science ,General Medicine - Published
- 2019
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12. L’expérience de la diversité dans les quartiers de classe moyenne à Montréal
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Sandrine Jean
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Social Sciences and Humanities ,Parks ,parques ,Energy Engineering and Power Technology ,Public Spaces ,sociabilidad ,convivialité ,Families ,diversidad étnica ,barrio de clase media ,sociabilité ,Conviviality ,Ethnic Diversity ,Montreal ,Jean ,Sociability ,General Engineering ,quartiers de classes moyennes ,convivialidad ,parcs ,familles ,familias ,Middle Class Neighborhood ,espacios públicos ,Sciences Humaines et Sociales ,diversité ethnique ,Montréal ,espaces publics - Abstract
Les tensions sociales et politiques concernant la question de l’immigration qui secouent le Québec sont plus que jamais d’actualité. Alors que plusieurs travaux ont porté sur les attitudes face à l’immigration, nous proposons un regard ethnographique sur l’expérience de la diversité dans deux quartiers dits de « classe moyenne » de la grande région de Montréal. L’observation concrète des interactions interethniques dans les espaces publics ainsi que des entrevues qualitatives approfondies auprès de familles « natives » et d’origine immigrante avec de jeunes enfants nous permettent d’avancer que les espaces publics, plus particulièrement les parcs de quartier, apparaissent comme des lieux particulièrement privilégiés des familles dans l’expérience de la diversité et l’apprivoisement de la différence. Bien que la convivialité l’emporte sur l’aversion dans ces espaces publics, certains inconforts demeurent, surtout lorsqu’ils engagent des marqueurs religieux ou touchent à l’éducation des enfants. La sociabilité publique et la participation dans les réseaux communautaires, tant des « natifs » que des immigrants, permettent de dépasser certaines tensions et favorisent des rapprochements vers une cohabitation interethnique urbaine inclusive., The social and political tensions related to immigration in Quebec are more relevant than ever. While several studies have focused on attitudes towards immigration, this article provides an ethnographic study of the experience of diversity in two « middle class » neighborhoods of the Greater Montreal. The empirical observation of interethnic interactions in public spaces and in-depth qualitative interviews with « native » and immigrant families with young children support that public spaces, especially neighborhood parks, stand as privileged places in families’ experience of diversity. Although conviviality outweighs aversion in these public spaces, some tensions remains, especially with regard to religious markers and the education of children. Public sociability and participation by both « natives » and immigrants in community networks help in overcoming some of these discomforts and promote an inclusive interethnic urban cohabitation., Las tensiones sociales y políticas sobre la cuestión de la inmigración que sacuden a Quebec son más que nunca de actualidad. Si bien varios trabajos se han centrado en las actitudes frente a la inmigración, nosotros proponemos un enfoque etnográfico sobre la experiencia de la diversidad en dos barrios llamados de « clase media » en la gran región de Montreal. La observación concreta de las interacciones interétnicas en los espacios públicos, así como entrevistas de fondo entre familias « nativas » y de origen inmigrante con hijos jóvenes nos han permitido postular que los espacios públicos, y en particular los parques del barrio, se presentan como lugares particularmente privilegiados por las familias en la experiencia de la diversidad y familiarización con la diferencia. Aunque la convivialidad prevalezca sobre la animadversión en dichos espacios públicos, siguen sintiéndose ciertas incomodidades, sobre todo cuando se trata de indicadores religiosos o que conciernen a la educación de los hijos. La sociabilidad pública y la participación en las redes comunitarias, tanto de « nativos » como de inmigrantes, permiten rebasar ciertas tensiones y favorecer vinculaciones hacia una cohabitación urbana interétnica incluyente.
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- 2018
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13. Extracorporeal Membrane Oxygenation Can Save Lives in Children With Heart or Lung Failure After Liver Transplantation
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Laurent Dupic, Christophe Chardot, Carmen Capito, Mehdi Oualha, Florence Lacaille, Sylvain Renolleau, Sandrine Jean, Philippe Pouard, and Olivier Bustarret
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Inotrope ,medicine.medical_specialty ,medicine.medical_treatment ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,030204 cardiovascular system & hematology ,Liver transplantation ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Intensive care ,medicine ,Extracorporeal membrane oxygenation ,Lung ,business.industry ,General Medicine ,Oxygenation ,medicine.disease ,Surgery ,Systemic inflammatory response syndrome ,surgical procedures, operative ,medicine.anatomical_structure ,030228 respiratory system ,Heart failure ,Cardiology ,business - Abstract
The risk of cardiac or lung failure after liver transplantation (LT) is significant. In rare cases, the usual intensive care techniques fail to maintain organ oxygenation with a risk of multiorgan dysfunction. Although extracorporeal membrane oxygenation (ECMO) is a difficult and risky procedure, it can be proposed as life-saving. Four children with either acute pulmonary (three) or cardiac (one) failure after LT, and the criteria that decided the use of ECMO (level of ventilation and results, dosage of inotropic drugs, cardiac ultrasound, blood lactate) were retrospectively reported. These patients, 1-11 years old, were treated with either veno-arterial (three) or veno-venous (one) ECMO. Two experienced a full recovery, with 3 and 6 years of follow-up. Two died of systemic inflammatory response syndrome (SIRS) due to ECMO, and relapse of heart failure due to the underlying disease. Although our patients' survival was only 50%, we showed that ECMO can be useful in children after LT. It should be considered before the development of irreversible multiorgan failure.
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- 2017
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14. Place de l’assistance respiratoire et circulatoire extracorporelle de courte durée (ECMO), post-cardiotomie exclue, dans la prise en charge des défaillances graves du nouveau-né et de l’enfant
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Jérôme Rambaud, A. Durandy, M. Demoulin, P. L. Léger, Alain Amblard, Ricardo Carbajal, Julia Guilbert, Sandrine Jean, and I. Guellec
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Gynecology ,medicine.medical_specialty ,Critically ill ,business.industry ,medicine.medical_treatment ,030208 emergency & critical care medicine ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Pediatrics, Perinatology and Child Health ,Critical illness ,Emergency Medicine ,Extracorporeal membrane oxygenation ,medicine ,business - Abstract
Resume L’assistance respiratoire et circulatoire extracorporelle (ECMO), hors situation postoperatoire d’une cardiotomie, correspond a l’ensemble des techniques de reanimation utilisees chez le nouveau-ne comme chez l’enfant, ayant pour objectif la suppleance cardiaque et pulmonaire. L’ECMO comprend differentes modalites techniques selon le type de defaillance d’organe pris en charge. Les principales indications des ECMO sont a la fois respiratoires (syndrome de detresse respiratoire aigu, asthme aigu grave, pleuropneumopathie hypoxemiante, inhalation meconiale et hypertension arterielle pulmonaire) et hemodynamiques (choc cardiogenique, choc septique refractaire, arret cardiorespiratoire refractaire). Les principales contre-indications sont la prematurite
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- 2017
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15. Communication, informations et place des parents en réanimation polyvalente pédiatrique : revue de la littérature
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L. de Saint Blanquat, C. Pierron, Sandrine Jean, Hélène Chappuy, and Agathe Béranger
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Service (business) ,MEDLINE ,Health literacy ,Context (language use) ,Comprehension ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,030225 pediatrics ,Intensive care ,General partnership ,Pediatrics, Perinatology and Child Health ,medicine ,Anxiety ,030212 general & internal medicine ,medicine.symptom ,Psychology - Abstract
Pediatric intensive care units (PICUs), whose accessibility to parents raises controversy, often operate under their own rules. Patients are under critical and unstable conditions, often in a life-threatening situation. In this context, the communication with the parents and their participation in the unit may be difficult. Information is a legal, deontological, and moral duty for caregivers, confirmed by the parents' needs. But the ability to enforce them is a challenge, and there is a gap between the theory and the reality. The communication between the parents and the physicians starts at the admission of the child with a family conference. According to the Societe de reanimation de langue francaise (SRLF), the effectiveness of the communication is based on three criteria: the patients' comprehension, their satisfaction and their anxiety and depression. It has been shown that comprehension depends on multiple factors, related on the parents, the physicians, and the medical condition of the child. Regarding the parents' participation in the organization of the service, the parents' presence is becoming an important factor. In the PICU, the parents' status has evolved. They become a member of the care team, as a partner. The best interest of the child is always discussed with the parents, as the person knowing the best their child. This partnership gives them a responsibility, which is complementary to the physician's one, but does not substitute it.
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- 2017
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16. Nosocomial Infections in Neonates Supported by Extracorporeal Membrane Oxygenation: First French Retrospective Study
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Julia Guilbert, Ricardo Carbajal, Pierre Louis Leger, Romain Guedj, Maryne Demoulin, Isabelle Guellec, Jérôme Rambaud, Sandrine Jean, Cecile Allioux, Service de réanimation néonatale et pédiatrique [CHU Trousseau], CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
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medicine.medical_specialty ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,business.industry ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,030208 emergency & critical care medicine ,Retrospective cohort study ,Critical Care and Intensive Care Medicine ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Nosocomial infection ,030228 respiratory system ,Emergency medicine ,medicine ,Extracorporeal membrane oxygenation ,Original Article ,ECMO ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
How to cite this article: Rambaud J, Allioux C, Jean S, Guilbert J, Guellec I, Demoulin M, et al. Nosocomial Infections in Neonates Supported by Extracorporeal Membrane Oxygenation: First French Retrospective Study. Indian J Crit Care Med 2019;23(9):392–395.
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- 2019
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17. Successful extracorporeal membrane oxygenation transport of a 4‐month‐old brain‐dead infant for organ donation: A case report
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Alain Amblard, Anna Deho, Sandrine Jean, Erik Hervieux, Claire Leblanc, Nancy Pracros, Mathieu Genuini, Noëlla Lodé, Pierre-Louis Leger, and Pascale Philippe-Chomette
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Brain dead ,Transplantation ,medicine.medical_specialty ,business.industry ,Septic shock ,medicine.medical_treatment ,030232 urology & nephrology ,Authorization ,030230 surgery ,medicine.disease ,03 medical and health sciences ,surgical procedures, operative ,0302 clinical medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Extracorporeal membrane oxygenation ,Referral center ,Organ donation ,Parental consent ,Intensive care medicine ,business ,Donor pool - Abstract
A 4-month-old infant was declared brain-dead 2 days after being initiated on venoarterial ECMO for a refractory septic shock. All brain death diagnostic criteria were fulfilled according to French law, and parental consent was given for organ donation. The hospital where ECMO was initiated had no authorization for organ procurement, and the donor was then transferred to the local referral center for child organ recovery with our mobile ECMO team to maintain organ perfusion. The kidneys were recovered and successfully transplanted to a child who is now well and alive. Although the transport elements of this case report are of limited relevance to an international audience as no other country, to our knowledge, has this particular organization, it does show excellent collaboration between teams to realize the goal of organ donation for this family. This is the first case describing a successful inter-hospital transport for organ procurement of a brain-dead infant on ECMO. Brain-dead pediatric patients undergoing ECMO can be considered as potential organ donors to expand the donor pool.
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- 2019
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18. Neighbourhood attachment revisited: Middle-class families in the Montreal metropolitan region
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Sandrine Jean
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Middle class ,media_common.quotation_subject ,05 social sciences ,0211 other engineering and technologies ,0507 social and economic geography ,021107 urban & regional planning ,Gender studies ,02 engineering and technology ,Emotional Bonds ,Environmental Science (miscellaneous) ,Metropolitan area ,Urban Studies ,Globalization ,Geography ,Cultural diversity ,050703 geography ,Neighbourhood (mathematics) ,media_common - Abstract
Migration, mobility, globalisation and individualisation have transformed the way people relate to space by affecting their physical, social and emotional bonds to place. Yet, does it mean that place attachment is due to wane and that the neighbourhood does not matter nowadays? The article is tackling this question by addressing the underexplored neighbourhood attachment and the residential choices of young middle-class families in Montreal Census Metropolitan Area. Empirical results are drawn from in-depth interviews with immigrant and non-immigrant households in a comparative perspective between a peri-urban and near-suburban neighbourhood in recent ethnic transition. We explore three types of neighbourhood attachment: physical and social as underlined in the literature, but we also suggest the importance of accounting for the symbolic dimension of neighbourhood attachment. Findings reveal how families display neighbourhood attachment through an extensive use of neighbourhood amenities (physical), embedded social ties (social) and distinctive lifestyles convergent with the representations of middle-class family life (symbolic). Unlike narratives of middle-classes’ place detachment and withdrawal from neighbourhood life, our case study of ‘middle’ middle-class neighbourhoods suggest that the neighbourhood preserves its importance, but that neighbourhood attachment takes different forms and that these forms differ among urban and suburban families. It is argued that what residents believe urban and suburban life should be and their values and identities associated with it needs further investigation, given their considerable role in neighbourhood attachment and residential choices of middle-classes families.
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- 2016
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19. Management of severe asthma exacerbation: guidelines from the Societe Francaise de Medecine d'Urgence, the Societe de Reanimation de Langue Francaise and the French Group for Pediatric Intensive Care and Emergencies
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Erwan L'Her, Patrick Ray, Stéphane Dauger, Elise Morawiec, Damien Viglino, Pierre-Géraud Claret, Guillaume Valdenaire, Eric Mariotte, Mathieu Oberlin, Mikaël Martinez, Robin Pouyau, Alexandre Demoule, Guillaume Voiriot, Patrick Plaisance, Sabrina Kepka, Christophe Milési, Anthony Chauvin, Chantal Raherison, Boris Jung, M. Schmidt, Céline Charasse, Bénédicte Vrignaud, Stephan Ehrmann, Thibaut Desmettre, Xavier Combes, Guillaume Mortamet, Fekri Abroug, Valérie Hamel, Jennifer Truchot, Sandrine Jean, Arnaud W. Thille, Nicolas Terzi, Philippe Le Conte, Guillaume Carteaux, Julien Vaux, Bénédicte Gaillard-Le Roux, CHU de Nantes, Centre hospitalier universitaire de Nantes (CHU Nantes), PHU3, Faculté de Médecine, Service de réanimation médicale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Grenoble, University of Grenoble-Alpes, HP2, 38000, Grenoble, Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Fattouma Bourguiba [Monastir] (HFB), Service d'anesthésie-réanimation SAMU94-SMUR94 [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Bordeaux (UB), Hôpital des Enfants - Groupe hospitalier Pellegrin - CHU de Bordeaux, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), AP-HP Hôpital universitaire Robert-Debré [Paris], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université de Tours (UT), CHU Toulouse [Toulouse], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Strasbourg, CHRU Brest - Service de Réanimation Médicale (CHU - BREST - Réa Med), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), centre hospitalier du Forez, 42605, Montbrison, centre hospitalier Le Corbusier, 42700, Firminy, France., Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Structure des Urgences, Centre hospitalier de Cahors, Service des Urgences, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Service d'Urgence [AP-HP Hôpital Lariboisière, Paris], Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), CHU Bordeaux [Bordeaux], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital Lariboisière-Fernand-Widal [APHP], Hôpital Henri Mondor, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique Médicale et Service d'Urgences Pédiatriques, Hôpital Mère-Enfant, CHU Trousseau [APHP], Hémostase et biologie vasculaire, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2 ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), MORNET, Dominique, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Université de Tours, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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medicine.medical_specialty ,Exacerbation ,Severe asthma ,[SDV]Life Sciences [q-bio] ,Review ,Guidelines ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology ,Intensive care ,Medicine ,030212 general & internal medicine ,Asthma ,Pediatric ,business.industry ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Intensive Care ,Severe exacerbation ,lcsh:RC86-88.9 ,medicine.disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,030228 respiratory system ,Emergency medicine ,Emergency ,business - Abstract
Background The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in adult and pediatric patients. Results The guidelines were related to 5 areas: diagnosis, pharmacological treatment, oxygen therapy and ventilation, patients triage, specific considerations regarding pregnant women. The literature analysis and formulation of the guidelines were conducted according to the Grade of Recommendation Assessment, Development and Evaluation methodology. An extensive literature research was conducted based on publications indexed in PubMed™ and Cochrane™ databases. Of the 21 formalized guidelines, 4 had a high level of evidence (GRADE 1+/−) and 7 a low level of evidence (GRADE 2+/−). The GRADE method was inapplicable to 10 guidelines, which resulted in expert opinions. A strong agreement was reached for all guidelines. Conclusion The conjunct work of 36 experts from 3 scientific societies resulted in 21 formalized recommendations to help improving the emergency and intensive care management of adult and pediatric patients with SAE.
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- 2019
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20. Incidence and risk factors of ventilator-associated pneumonia in neonatal intensive care unit: a first French study
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Yohan Soreze, Jérôme Rambaud, Julia Guilbert, Ricardo Carbajal, Guillaume Geslain, Romain Guedj, Isabelle Guellec, Pierre-Louis Leger, Sandrine Jean, Cécile Valentin, and Maryne Demoulin
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0301 basic medicine ,Male ,Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,030106 microbiology ,Population ,03 medical and health sciences ,Risk Factors ,Intensive Care Units, Neonatal ,Medicine ,Humans ,Prospective Studies ,education ,Prospective cohort study ,education.field_of_study ,business.industry ,Mortality rate ,Incidence (epidemiology) ,Incidence ,Ventilator-associated pneumonia ,Infant, Newborn ,Infant ,Pneumonia, Ventilator-Associated ,medicine.disease ,respiratory tract diseases ,Pneumonia ,Low birth weight ,Anesthesiology and Pain Medicine ,Female ,France ,medicine.symptom ,business - Abstract
BACKGROUND Ventilator-associated pneumonia (VAP) is a severe intensive complication and remains under estimated in neonatal intensive care unit (NICU). Center for Disease Control defined criteria for adults and pediatrics without neonatal criteria. The objective of this article was to evaluate the rate, the risks factors and the outcome of neonates suffering from ventilator-associated pneumonia in a French NICU. METHODS We conducted a prospective observational study within a one-year period in our NICU. Three hundred and eighty-one neonates under 28 days of age were included. Data analyses were performed using Fischer exact-test, Kolgomorov analysis, Mann-Whitney test and logistic regression. RESULTS Seventeen patients were diagnosed with ventilator-associated pneumonia. Incidence rate of VAP was 8.8 per 1000 invasive mechanical ventilator days. The median age at diagnosis was 20 days (range: 4-45). Extremely low birth weight (under than 1000 grams) were significantly associated with VAP (OR=4.31 [95% CI: 1.38-13.39]). Newborns suffering from VAP had a significantly longer duration of invasive ventilation (median: 16 days [range 4-75] versus 3 days [range 1-28], P
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- 2018
21. Provided information and parents' comprehension at the time of admission of their child in pediatric intensive care unit
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Charlotte Pierron, Hélène Chappuy, Naïm Bouazza, Laure de Saint Blanquat, Agathe Béranger, and Sandrine Jean
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Adult ,Male ,Parents ,medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,Time Factors ,Medical information ,Intensive Care Units, Pediatric ,03 medical and health sciences ,0302 clinical medicine ,Professional-Family Relations ,030225 pediatrics ,Health care ,Medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Pediatric intensive care unit ,business.industry ,Critically ill ,030208 emergency & critical care medicine ,Middle Aged ,Wait time ,Active participation ,Comprehension ,Family medicine ,Pediatrics, Perinatology and Child Health ,Female ,France ,business - Abstract
This study evaluated the first interaction (FI) between parents and health care providers at the time of admission of a child in pediatric intensive care unit (PICU), and explored the extent to which parents understood the medical information. This prospective study took place in three French university-affiliated PICUs. Forty-two parents of 30 children were interviewed. The physician and nurse who took care of the child completed a questionnaire. We evaluated parents' comprehension (excellent, fair, or poor) by comparing parents' and physicians' responses to six items: diagnosis, affected organ, reason for hospitalization, prognosis, treatments, and further investigations. Parent-physician FI occurred within 24 h of child's admission. Two thirds of the parents were dissatisfied to wait before receiving information. Most of the parents had an excellent comprehension of the affected organ (n = 25/28, 89.3%) and prognosis (n = 26/30, 86.7%). Two thirds of the parents understood the reason for hospitalization (n = 18/28, 64.3%) and diagnosis (n = 19/30, 63.3%). Less than half the parents understood child's treatments (n = 10/30, 33.3%) and further investigations (n = 8/21, 38.1%). When a nurse delivered information on treatment, parental comprehension improved (p = 0.053).Parents complained of their wait time before receiving information. Most of them had an excellent comprehension. An improved communication between nurses and physicians is mandatory, and the active participation of nurses to give information to the parents should be encouraged. What is known: • In pediatric intensive care unit, health care providers deliver information to parents on their child's condition, which fosters the trust between them to build a partnership. • Various guidelines exist to help health care providers communicate with parents in PICU, but never mention the specific time of admission. What is new: • Even though parents could wait before entering the unit, they all received information on their child's condition within 24 hours after admission. • Parents understood the information well, and nurses improved the parental comprehension of the treatments by reformulating.
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- 2017
22. Ville ou banlieue?
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Sandrine Jean
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Social Sciences and Humanities ,Montreal ,suburbs ,choix résidentiels ,young families ,lifestyles ,General Medicine ,banlieue ,residential choices ,jeunes familles ,modes de vie ,middle class ,Sciences Humaines et Sociales ,classe moyenne ,Montréal - Abstract
Bon an, mal an, environ 20 000 personnes quittent la Ville de Montréal pour s’établir en banlieue. Dans ce contexte de concurrence pour attirer les jeunes ménages, nous nous sommes penchés sur les choix résidentiels de familles de la classe moyenne en faveur de la ville centrale ou de la banlieue. Cinquante et une entrevues approfondies ont été menées en 2011-2012 dans deux quartiers de la région métropolitaine de Montréal, l’un représentant la banlieue, Vimont-Auteuil, l’autre la ville centrale, Ahuntsic. Au-delà du prix des logements, les choix résidentiels des familles sont liés aux représentations de la ville et de la banlieue, aux usages du quartier et du chez-soi, à leur mobilité quotidienne, leur identité, et en somme leurs modes de vie. Les images négatives de la vie de famille en ville véhiculées par les banlieusards de même que la vision stéréotypée de la banlieue dépeinte par les urbains donnent à penser que l’opposition ville/banlieue est loin d’être caduque, du moins dans les représentations que s’en font encore aujourd’hui les jeunes familles de la classe moyenne., Year after year, about 20,000 people leave the City of Montreal to settle in the suburbs. In light of the competition facing communities to attract young families, we examine the residential choices of middle class families for either the city or the suburbs. Some 51 interviews were conducted between 2011 and 2012 in two districts of the Montreal metropolitan area, one representing the suburbs – Vimont-Auteuil – and the other representing the city – Ahuntsic. Beyond housing prices, residential choices of families are determined by their notions of the city and suburbs, to uses made of a neighbourhood and home, to their daily mobility patterns, their identity, and their overall lifestyle. Negative images of family life in the city held by those living in the suburbs as well as a stereotyped view of the suburbs on the part of urban dwellers suggest that the city/suburb dichotomy is far from obsolete, at least in the representations held by today’s young middle class families.
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- 2014
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23. La diversité ethnique croissante des quartiers de classe moyenne dans la métropole montréalaise : des jeunes familles perplexes
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Annick Germain and Sandrine Jean
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General Medicine - Abstract
L’impact de la diversite ethnoculturelle croissante sur les metropoles canadiennes a suscite de nombreux travaux. On a toutefois moins etudie le cas des quartiers de classe moyenne ou cette transition ethnoculturelle est recente. Nous nous sommes penchees sur la lecture que font de ces changements les jeunes familles, immigrantes ou non, soit des menages particulierement sensibles au choix d’un milieu de vie adequat pour elever leurs enfants. Une cinquantaine d’entrevues ont ete menees aupres de familles frequentant des lieux publics (parcs et bibliotheques) dans deux quartiers de la region metropolitaine de Montreal, l’un en banlieue, l’autre dans la ville centrale. Si la diversite ethnique croissante de leur quartier ne semble pas avoir pese d’emblee sur leurs choix residentiels, les propos recueillis temoignent neanmoins de leur perplexite quant aux transformations de leur milieu de vie, et ce, au-dela d’experiences urbaines differenciees entre banlieues et ville centre. Les ecoles, les bibliotheques, de meme que les activites culturelles et de loisirs organisees dans les parcs, s’averent egalement nevralgiques pour ces jeunes familles comme lieux de construction du rapport a l’autre.
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- 2014
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24. Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation
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Isabelle Guellec, Jérôme Rambaud, Delphine Mitanchez, Amélie Durandy, Marie-Philippine Clair, François Chalard, Adrien Flahault, Chiara Sileo, Sylvain Renolleau, Pierre-Louis Leger, Maryne Demoulin, Ricardo Carbajal, Julia Guilbert, Romain Guedj, and Sandrine Jean
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Male ,medicine.medical_treatment ,lcsh:Medicine ,Blood Pressure ,030204 cardiovascular system & hematology ,Pathology and Laboratory Medicine ,Pediatrics ,Jugular Vein ,Vascular Medicine ,Diagnostic Radiology ,0302 clinical medicine ,Medicine and Health Sciences ,Prospective Studies ,Brain Damage ,Respiratory system ,Prospective cohort study ,lcsh:Science ,Oxygen saturation (medicine) ,Ultrasonography ,Cerebral Ischemia ,Multidisciplinary ,Spectroscopy, Near-Infrared ,Radiology and Imaging ,Brain ,Prognosis ,Magnetic Resonance Imaging ,Survival Rate ,Chemistry ,Neurology ,Circulatory system ,Physical Sciences ,Cardiology ,Female ,medicine.symptom ,Anatomy ,Research Article ,Chemical Elements ,medicine.medical_specialty ,Imaging Techniques ,Brain damage ,Research and Analysis Methods ,Veins ,03 medical and health sciences ,Extracorporeal Membrane Oxygenation ,Signs and Symptoms ,Diagnostic Medicine ,030225 pediatrics ,Internal medicine ,Intensive Care Units, Neonatal ,medicine ,Extracorporeal membrane oxygenation ,Humans ,Survival rate ,business.industry ,lcsh:R ,Infant, Newborn ,Infant ,Biology and Life Sciences ,Oxygen ,Blood pressure ,Brain Injuries ,Cardiovascular Anatomy ,Lesions ,Blood Vessels ,lcsh:Q ,business - Abstract
Objectives Extracorporeal membrane oxygenation support is indicated in severe and refractory respiratory or circulatory failures. Neurological complications are typically represented by acute ischemic or hemorrhagic lesions, which induce higher morbidity and mortality. The primary goal of this study was to assess the prognostic value of cerebral tissue oxygen saturation (StcO2) on mortality in neonates and young infants treated with ECMO. A secondary objective was to evaluate the association between StcO2 and the occurrence of cerebral lesions. Study design This was a prospective study in infants < 3 months of age admitted to a pediatric intensive care unit and requiring ECMO support. Measurements The assessment of cerebral perfusion was made by continuous StcO2 monitoring using near-infrared spectroscopy (NIRS) sensors placed on the two temporo-parietal regions. Neurological lesions were identified by MRI or transfontanellar echography. Results Thirty-four infants
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- 2017
25. Extracorporeal Membrane Oxygenation Can Save Lives in Children With Heart or Lung Failure After Liver Transplantation
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Sandrine, Jean, Christophe, Chardot, Mehdi, Oualha, Carmen, Capito, Olivier, Bustarret, Philippe, Pouard, Sylvain, Renolleau, Florence, Lacaille, and Laurent, Dupic
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Graft Rejection ,Heart Failure ,Male ,Infant ,Systemic Inflammatory Response Syndrome ,Liver Transplantation ,Extracorporeal Membrane Oxygenation ,Fatal Outcome ,Liver ,Recurrence ,Feasibility Studies ,Humans ,Female ,Child ,Respiratory Insufficiency ,Immunosuppressive Agents ,Liver Failure ,Ultrasonography - Abstract
The risk of cardiac or lung failure after liver transplantation (LT) is significant. In rare cases, the usual intensive care techniques fail to maintain organ oxygenation with a risk of multiorgan dysfunction. Although extracorporeal membrane oxygenation (ECMO) is a difficult and risky procedure, it can be proposed as life-saving. Four children with either acute pulmonary (three) or cardiac (one) failure after LT, and the criteria that decided the use of ECMO (level of ventilation and results, dosage of inotropic drugs, cardiac ultrasound, blood lactate) were retrospectively reported. These patients, 1-11 years old, were treated with either veno-arterial (three) or veno-venous (one) ECMO. Two experienced a full recovery, with 3 and 6 years of follow-up. Two died of systemic inflammatory response syndrome (SIRS) due to ECMO, and relapse of heart failure due to the underlying disease. Although our patients' survival was only 50%, we showed that ECMO can be useful in children after LT. It should be considered before the development of irreversible multiorgan failure.
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- 2016
26. Les représentations sociales de la ruralité et l’urbanité québécoise contemporaine. Une approche par la cartographie conceptuelle
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Sandrine Jean
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youth ,Social Sciences and Humanities ,social representation ,urbanité ,urbanity ,jeunes ,Sciences Humaines et Sociales ,concept mapping ,General Medicine ,représentations sociales ,cartographie conceptuelle ,ruralité ,rurality - Abstract
Au Québec, les reconfigurations sociospatiales des territoires remettent en question la permanence de la distinction ville-campagne et nous invitent à réétudier les réalités rurales et urbaines. Pour saisir les nouvelles frontières qui se profilent entre les régions rurales et urbaines, cet article vise à faire ressortir les grandes représentations de la ruralité et de l’urbanité contemporaine qui circulent dans l’espace social québécois grâce à la méthode de la cartographie conceptuelle. Ces représentations ont émergé de quatre groupes de discussion avec des jeunes urbains de Montréal et des jeunes ruraux du Bas-Saint-Laurent. Notre étude permet d’identifier le caractère asymétrique des rapports entretenus entre la campagne et la ville. La cartographie conceptuelle montre, de façon générale, une certaine incompréhension des caractéristiques spécifiques de la ruralité de la part des urbains, alors que les réalités urbaines semblent généralement mieux comprises, tant par les urbains que par les ruraux., In Quebec, the socio-spatial reconfigurations of territories call the conventional city-country distinction into question and invite us to reexamine the actual reality of rural and urban areas. To capture the new characteristics that are taking shape in rural-urban relations, this article highlights the representations of rurality and urbanity that currently predominate in the Quebec social space, mainly by means of the method of concept mapping. The representations emerged from four discussion groups held with urban youth from Montreal and rural youth from Bas-Saint-Laurent. Our study identified an asymmetry in the relations between the country and the city, in the sense that the attributes of rurality are generally rather poorly understood by urban youth, while urban realities appear to be better understood by both urban and rural youth.
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- 2012
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27. Transportation of children on extracorporeal membrane oxygenation: one-year experience of the first neonatal and paediatric mobile ECMO team in the north of France
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Katia Kessous, I. Guellec, Sandrine Jean, Alain Amblard, P. L. Leger, Noella Lode, M. Larroquet, I. Casadevall, J. Guilbert, Ricardo Carbajal, Jérôme Rambaud, and H. Walti
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pain medicine ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Intensive Care Units, Pediatric ,03 medical and health sciences ,0302 clinical medicine ,Extracorporeal Membrane Oxygenation ,030225 pediatrics ,Anesthesiology ,Extracorporeal membrane oxygenation ,Medicine ,Humans ,Intensive care medicine ,Child ,business.industry ,Infant, Newborn ,Infant ,Infant newborn ,Transportation of Patients ,Child, Preschool ,Female ,France ,business - Published
- 2015
28. Mise en place de la première unité mobile d’assistance circulatoire et respiratoire pédiatrique et néonatale en Île-de-France
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Noella Lode, Jérôme Rambaud, M. Larroquet, H. Walti, L. Alix-Seguin, Sandrine Jean, I. Guellec, A. Durandy, M. Demoulin, Ricardo Carbajal, J. Guilbert, P. L. Leger, and Alain Amblard
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business.industry ,Emergency Medicine ,Medicine ,business - Published
- 2016
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29. Sexual Health of Adolescents in Quebec Residential Youth Protection Centres
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Élise Roy, Gilles Lambert, Claude Tremblay, Sandrine Jean, Jean-Yves Frappier, Joanne Otis, and Nancy Haley
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Male ,medicine.medical_specialty ,Adolescent ,Substance-Related Disorders ,Sexual Behavior ,law.invention ,Gonorrhea ,Alcohol intoxication ,Risk-Taking ,Condom ,law ,Surveys and Questionnaires ,medicine ,Prevalence ,Humans ,Sex organ ,Psychiatry ,Suicidal ideation ,Reproductive health ,Pregnancy ,Chlamydia ,business.industry ,Public Health, Environmental and Occupational Health ,Quebec ,General Medicine ,Chlamydia Infections ,medicine.disease ,Mental health ,Adolescent Health Services ,Female ,medicine.symptom ,Quantitative Research ,business ,Demography - Abstract
OBJECTIVES: To document risk behaviours and prevalence of chlamydia and gonorrhoea infections among adolescents aged 14 to17 years entering care in Quebec Youth Protection Centres (YPC). METHODS: From July 2008 to May 2009, adolescents residing in six YPCs completed a questionnaire during a face-to-face interview. Questions covered sexual and substance use behaviours prior to admission, as well as other health issues affecting respondents’ mental and physical health. Urine samples were tested for Chlamydia trachomatis genital infection (CTGI) and Neisseria gonorrhoea genital infection (NGGI). RESULTS: Among 578 participants aged 14 to 17 years, 89% had had consensual sexual relations. Sexual risk behaviours included early sexual initiation (66% at
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- 2013
30. Conjugacy Classes of Series in Positive Characteristic and Witt Vectors
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Sandrine Jean, DMI, XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), TN, and Vieceli, Yolande
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Combinatorics ,Algebra and Number Theory ,Conjugacy class ,Series (mathematics) ,Geometry ,Witt vector ,ComputingMilieux_MISCELLANEOUS ,Mathematics - Abstract
Soit k la cloture algebrique de F p et K le corps local des series formelles a coefficients dans k. Le but de cet article est de decrire l'ensemble y n des classes de conjugaison des series d'ordre p n pour la loi de composition. Ce travail concerne les series formelles reversibles a coefficients dans un corps de caracteristique p qui sont d'ordre p n pour la loi de composition. Dans le but d'explorer la conjecture de Oort, je donne une description des classes de conjugaison des series au moyens de vecteurs de Witt de longueur finie. Nous developpons certains outils permettant de constuire une bijection entre un ensemble A n de vecteurs de Witt et un ensemble X n de couples constitues d'une extension L/K cyclique totalement ramifiee de degre p n et d'un generateur du groupe de Galois. Nous pouvons definir pour chaque element de A n une suite de sauts de ramification. Nous pouvons egalement decrire une seconde bijection entre y n et les orbites A n sous une certaine action de groupe. Les sauts de ramification d'une serie appartenant a Y n peuvent etre retrouves grâce aux composantes du vecteur de Witt correspondant dans A n .
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- 2009
31. Sexual Heath of Adolescents in Quebec Youth Protection Centers
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Gilles Lambert, Claude Tremblay, Élise Roy, Jean-Yves Frappier, Joanne Otis, Nancy Haley, and Sandrine Jean
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Environmental protection ,Political science ,Environmental health ,Pediatrics, Perinatology and Child Health - Published
- 2012
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32. P1-S2.29 Risky sexual practices among youth in Quebec Care Centers
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Gilles Lambert, Claude Tremblay, Jean-Yves Frappier, Sandrine Jean, Nancy Haley, Élise Roy, and Joanne Otis
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medicine.medical_specialty ,Pregnancy ,Chlamydia ,business.industry ,Reproductive medicine ,Human sexuality ,Dermatology ,Quarter (United States coin) ,medicine.disease ,law.invention ,Infectious Diseases ,Condom ,law ,medicine ,Health education ,Psychiatry ,business ,Demography ,Adolescent health - Abstract
Background Adolescents in Youth Protection facilities are a vulnerable population, with difficult life trajectories; many of their behaviours are health compromising. Method Youth aged 14–17, living in semi-urban and urban youth centers in Quebec were recruited on a volunteer basis to participate in the study. Socio-demographic, drug use, sexual behaviours and health service utilisation data were obtained using a structured, face-to-face interview. A urine sample was collected to test for chlamydia and gonorrhoea. Results Between July 2008 and May 2009, 578 youth were interviewed—(♂—58 %); median age—♂—16; ♀—15. The majority of youth were sexually active (89%); two thirds experienced voluntary coitarche before 14 years of age. Median number of lifetime partners was 6 (♂—8, ♀—5). Over a third (41%) reported group sexual activities. A large proportion of youth experienced 50% or more of their sexual activities under the influence of alcohol—18%, cannabis—37%, other drugs—18%. Lifetime history of “never or rarely” using condoms was 24.7% for vaginal relations and 42.1% for anal relations (♂—33%, ♀—55%). Protection used during last vaginal activity was—double protection (condom and another contraceptive method)—25%; condom only—32%; contraceptive method without condom—20%; no protection—24%. A quarter of girls (28%) and boys (27%) reported an unplanned pregnancy (lifetime). Prevalence of chlamydia was—girls 9%, boys 1.9%. No cases of gonorrhoea were documented. Conclusions Youth in Quebec care centers report many risky sexual behaviours, often associated with drug and alcohol use. Only a quarter of youth used protection to prevention both STIs and pregnancy during their last sexual activity. Their sejour in residential care is an opportune moment to screen these youth for risk behaviours that may compromise their future health and to provide them with personalised prevention education and health services adapted to their reality.
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- 2011
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33. Éditorial : Que nous apprennent les enfants qui n'apprennent pas ?
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Sandrine Jean-Calmettes, Marika Bergès-Bounes, and Jean Bergès
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- 2002
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34. Interview du Dr Florence Veber sur le « Plan d'action pour les enfants atteints d'un trouble spécifique du langage »
- Author
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Sandrine Jean-Calmettes and Marika Bergès-Bounes
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- 2002
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35. The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission
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Sandrine Jeanpierre, Kawtar Arizkane, Supat Thongjuea, Elodie Grockowiak, Kevin Geistlich, Lea Barral, Thibault Voeltzel, Anissa Guillemin, Sandrine Gonin-Giraud, Olivier Gandrillon, Franck-Emmanuel Nicolini, Adam J. Mead, Véronique Maguer-Satta, and Sylvain Lefort
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Chronic myelogenous leukemia arises from the transformation of hematopoietic stem cells by the BCR-ABL oncogene. Though transformed cells are predominantly BCR-ABL-dependent and sensitive to tyrosine kinase inhibitor treatment, some BMPR1B+ leukemic stem cells are treatment-insensitive and rely, among others, on the bone morphogenetic protein (BMP) pathway for their survival via a BMP4 autocrine loop. Here, we further studied the involvement of BMP signaling in favoring residual leukemic stem cell persistence in the bone marrow of patients having achieved remission under treatment. We demonstrate by single-cell RNA-Seq analysis that a sub-fraction of surviving BMPR1B+ leukemic stem cells are co-enriched in BMP signaling, quiescence and stem cell signatures, without modulation of the canonical BMP target genes, but enrichment in actors of the Jak2/Stat3 signaling pathway. Indeed, based on a new model of persisting CD34+CD38- leukemic stem cells, we show that BMPR1B+ cells display co-activated Smad1/5/8 and Stat3 pathways. Interestingly, we reveal that only the BMPR1B+ cells adhering to stromal cells display a quiescent status. Surprisingly, this quiescence is induced by treatment, while non-adherent BMPR1B+ cells treated with tyrosine kinase inhibitors continued to proliferate. The subsequent targeting of BMPR1B and Jak2 pathways decreased quiescent leukemic stem cells by promoting their cell cycle re-entry and differentiation. Moreover, while Jak2-inhibitors alone increased BMP4 production by mesenchymal cells, the addition of the newly described BMPR1B inhibitor (E6201) impaired BMP4-mediated production by stromal cells. Altogether, our data demonstrate that targeting both BMPR1B and Jak2/Stat3 efficiently impacts persisting and dormant leukemic stem cells hidden in their bone marrow microenvironment.
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- 2020
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36. L’urbanité québécoise contemporaine
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Sandrine Jean
- Subjects
espaces urbains québécois ,Social representation ,Social Sciences and Humanities ,jeunes ,General Engineering ,urban spaces ,Sciences Humaines et Sociales ,concept mapping ,Bas-Saint-Laurent ,Représentations sociales ,cartographie conceptuelle ,youths - Abstract
Les reconfigurations sociospatiales des territoires québécois nous forcent à réétudier l’urbain et la façon dont il est représenté aujourd’hui. Cet article vise à faire ressortir les grandes représentations de l’urbanité contemporaine qui circulent dans l’espace social québécois grâce à la méthode de la cartographie conceptuelle. Par l’entremise de deux groupes de discussion, une gamme de représentations sociales véhiculées par de jeunes Montréalais et de jeunes Bas-Laurentiens a été répertoriée et mise sous forme de cartes conceptuelles. Des divergences et des similitudes quant aux représentations de la vie en ville sont apparues en confrontant les régimes discursifs des urbains et des ruraux. Les retombées de cette recherche pourraient se traduire par la mise en oeuvre de politiques gouvernementales davantage adaptées aux réalités actuelles de l’urbanité., The socio-territorial reconfiguration of Quebec province forces us to re-examine the very nature of urban space and the way it is represented today. The aim of this article is to shed light on current social representation of urbanity by applying the method of concept mapping. Via two “focus groups”, it was possible to index a range of social representations, provided by youths originating from Montreal and from Bas-Saint-Laurent. These were then put into conceptual maps. An analysis of discursive frameworks allowed us to identify divergences and similarities in the perception of urban space by these two groups. The results of this research could be used to set up government policies that are better adapted to present-day urban reality.
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37. Introduction
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Gabrielle Désilets and Sandrine Jean
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