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5 results on '"Sandra Primus"'

1. Culturomics: bacterial species isolated in 3 healthy donors for faecal microbiota transplantation in Clostridium difficile infection

Author

Luca Masucci, Gianluca Quaranta, Domenico Nagel, Sandra Primus, Lucio Romano, Rosalia Graffeo, Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota, and Maurizio Sanguinetti

Subjects
Culturomics, Faecal microbiota transplantation, Clostridium difficile, Microbiology, QR1-502
Abstract

Background. Clostridium difficile infections are the main cause of nosocomial acquired diarrhea, because of prolonged antibiotic regimens. In the last years, mortality has increased due to recurrent infections caused by metronidazole and vancomicin resistant hypervirulent C. difficile strain 027. Faecal Microbiota Transplantation (FMT) is an infusion of faecal material obtained from healthy donors. This procedure reduces mortality in recurrent C. difficile infections (CDI). In this study we identified bacterial species obtained from donors’ stool samples using culturomics. Materials and methods. Three donors were selected for FMT in three recipients affected by CDI. Faces obtained for FMT underwent culturomics, applying 17 different culture methods. Results and conclusions. Several different bacteria were isolated from donors. In two donors 4 potentially pathogenic bacteria were isolated; this suggests the use of culturomics for donors’ screening or for selection of bacteria to infuse.

Published
2017
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4. Clostridium difficile: trend in an Italian Tertiary Care Hospital during fifteen years, 2002-2016

Author

Sandra Primus, Rosalia Graffeo, Andrea Tamburrano, Domenico Nagel, Gianluca Quaranta, Giovanni Cammarota, Klaus Eisendle, Maurizio Sanguinetti, Brunella Posteraro, Luca Masucci, Carola Maria Archibusacci, Nicola Nicolotti, Lucio Romano, and Patrizia Mazzella

Subjects
Diarrhea, medicine.medical_specialty, Cross Infection, Time Factors, business.industry, Clostridioides difficile, Bacterial Toxins, MEDLINE, General Medicine, Clostridium difficile, Tertiary care hospital, Anti-Bacterial Agents, Repressor Proteins, Tertiary Care Centers, Enterotoxins, Bacterial Proteins, Italy, Emergency medicine, medicine, Clostridium Infections, Humans, business
Published
2019

5. Culturomics: bacterial species isolated in 3 healthy donors for faecal microbiota transplantation in Clostridium difficile infection

Author

Domenico Nagel, Giovanni Cammarota, Luca Masucci, Maurizio Sanguinetti, Gianluca Quaranta, Antonio Gasbarrini, Lucio Romano, Gianluca Ianiro, Sandra Primus, and Rosalia Graffeo

Subjects
Culturomics, medicine.drug_class, Faecal microbiota transplantation, Antibiotics, lcsh:QR1-502, Pathogenic bacteria, General Medicine, Clostridium difficile, Biology, biology.organism_classification, medicine.disease_cause, lcsh:Microbiology, Microbiology, Metronidazole, Diarrhea, Immunology, medicine, medicine.symptom, Bacteria, medicine.drug
Abstract

Background. Clostridium difficile infections are the main cause of nosocomial acquired diarrhea, because of prolonged antibiotic regimens. In the last years, mortality has increased due to recurrent infections caused by metronidazole and vancomicin resistant hypervirulent C. difficile strain 027. Faecal Microbiota Transplantation (FMT) is an infusion of faecal material obtained from healthy donors. This procedure reduces mortality in recurrent C. difficile infections (CDI). In this study we identified bacterial species obtained from donors’ stool samples using culturomics. Materials and methods. Three donors were selected for FMT in three recipients affected by CDI. Faces obtained for FMT underwent culturomics, applying 17 different culture methods. Results and conclusions. Several different bacteria were isolated from donors. In two donors 4 potentially pathogenic bacteria were isolated; this suggests the use of culturomics for donors’ screening or for selection of bacteria to infuse.

Published
2017

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