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114 results on '"Sandra Karanović"'

1. A Trial of Finerenone in a Patient with Primary Aldosteronism

Author

Sandra Karanović Štambuk

Subjects
arterial hypertension, finerenone, mineralocorticoid receptor antagonists, primary aldosteronism, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introduction: Primary aldosteronism (PA), a common secondary cause of arterial hypertension, is treated either surgically or pharmacologically with mineralocorticoid receptor antagonists (MRAs). These drugs, while effective, can cause allergic reactions and have side effects, including menstrual cycle disorders in women. Finerenone is a new, highly selective, nonsteroidal MRA with excellent side-effect profile, primarily intended to slow the progression of diabetic kidney disease and improve cardiovascular outcomes in these patients. No data are available so far on its effect on patients with PA. Case Presentation: A case of a female patient with confirmed primary aldosteronism, in whom adrenal vein sampling failed twice is presented. The patient developed a skin allergic reaction to spironolactone and experienced prolonged vaginal bleedings with eplerenone, which was attributed to the drug’s affinity for progesterone receptors. A trial of finerenone was initiated, resulting in mild increase in plasma renin activity and serum potassium, and somewhat control of blood pressure, but far from optimal blood pressure control, normokalemia, or unsuppression of plasma renin activity. Conclusion: This case highlights the challenges of managing PA and describes an attempt of treatment with finerenone to which this patient unfortunately did not adequately respond.

Published
2024
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2. Residual Renal Function: A Double-Edged Sword

Author

Sandra Karanović Štambuk, Margareta Fištrek-Prlić, and Bojan Jelaković

Subjects
cardiovascular risk, nephrotic syndrome, pharmacologic nephrectomy, residual renal function, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introduction: Nephrotic syndrome may persist despite end-stage kidney disease and result in dyslipidaemia, thrombosis and a significantly increased cardiovascular risk. Treatment of refractory nephrotic syndrome includes surgical bilateral nephrectomy, renal artery embolization and pharmacologic nephrectomy. Case Presentation: We present a case of a haemodialysis patient with refractory nephrotic syndrome who underwent pharmacologic nephrectomy. The procedure decreased the patient‘s cardiovascular risk and enabled the patient to become a candidate for kidney transplantation. Conclusion: In certain situations residual renal function may be harmful. In such instances, nephrectomy should be considered. Pharmacologic nephrectomy using nephrotoxic drugs is a non-invasive approach with least potential complications.

Published
2024
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4. Arterial Hypertension and Risk of Mortality in Patients with COVID-19 Infection

Author

Nikolina Bukal, Melanija Kolarić, Ines Golubić, Josipa Josipović, Vedran Premužić, Ana Jelaković, Sandra Karanović, Nikolina Bašić Jukić, and Bojan Jelaković

Subjects
arterial hypertension, covid-19 infection, renin-angiotensin system, Medicine
Abstract

COVID-19 is currently a major global health concern. Among many unanswered questions related to COVID-19, some of the most debated ones are those concerning arterial hypertension. Arterial hypertension is a major risk factor for mortality worldwide and its importance has been emphasised even further in light of COVID-19. The most common antihypertensive drugs are ACE inhibitors and angiotensin II type-I receptor blockers. SARS-CoV-2 utilises the angiotensin-converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin–angiotensin system (RAS). In terms of arterial hypertension and COVID-19, there are three main issues which have been the focus of extensive debates. First, is arterial hypertension a predisposing factor for COVID-19 infection? Second, does arterial hypertension affect the severity of COVID-19 infection and increase the risk of all-cause and cardiovascular mortality? And finally, how important is the interaction of COVID-19 infection and the renin–angiotensin system for clinical outcomes? Is RAS blockade beneficial or harmful? The aim of this brief review was to provide substantiated answers to these questions.

Published
2022
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5. Outcome in Elderly Patients with Anca – Associated Glomerulonephritis Managed with Immunosuppressive Treatment

Author

Karlo Kurtov, Mario Laganović, Sandra Karanović, Živka Dika, Ema Ivandić, Marijana Živko, Jelena Kos, Margareta Fištrek, Bojan Jelaković, and Ivana Vuković Brinar

Subjects
Antineutrophil Cytoplasmic antibodies, Glomerulonephritis, Elderly, Immunosuppression, Mortality, Kidney failure, Medicine
Abstract

The most common cause of rapidly progressive glomerulonephritis in elderly, antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN), demands immunosuppressive therapy (IS) regimen in a multi-morbid disease burdened population. Our aim was to assess outcome differences in two age groups. The study included a total of 38 ANCA-GN renal limited patients (18 men) treated from 1990 to 2018, of which 11 were 65 years of age and older (median 70, min. - max. 66 - 79 years), and 27 younger than 65 (median 55, min. - max. 23 - 64 years). All patients were treated with mono/combination of IS. Most commonly applied IS in elderly was combination of IV cyclophosphamide and corticosteroids (CS) (in 9 [81.8%]), while in younger it was a combination of CS and cyclophosphamide or rituximab (59.2%). Older patients had comparable mortality (3, [14.8%] vs. 4, [27.3%]; P = 0.369), malignancies (1, [3.7%] vs. 1, [9.1%]; P = 0.5) and infectious complications (10, [46.7%] vs. 7, [63.6%]; P = 0.388). Ten patients at the end of the follow up were at renal replacement therapy (RRT ), with no difference between age groups (6, [22.2%] vs. 4, [36.4%]; P = 0.369). Interestingly, from initial need for RRT , half of the younger and older patients recovered with IS. Our findings give more credit to the current paradigm to treat elderly ANCA-GN patients with IS therapy due to the similar outcome of elderly as younger ones.

Published
2021
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6. Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy

Author

Vedran Premužić, Vanja Ivković, Ninoslav Leko, Želimir Stipančić, Sandra Karanović, Ana Jelaković, Ivana Vuković Brinar, Živka Dika, and Bojan Jelaković

Subjects
Balkan endemic nephropathy, aristolochic acid nephropathy, arterial stiffness, chronic hemodialysis, chronic kidney disease, pulse wave velocity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in lower CV mortality. A total of 186 hemodialysed (HD) patients (90 BEN, 96 non-BEN; 67.3 + 13.0 years) were enrolled and followed-up for 25 months. Brachial blood pressure (BP) and pulse wave velocity (PWV) were determined before mid-week dialysis. BEN patients were older (72.1 ± 37.1 vs. 62.8 ± 15.1; p < 0.001), had shorter duration of HT prior commencement of HD than non-BEN patients (36 vs. 84 months; p < 0.001). There were no differences in BP, but BEN patients were treated with less antihypertensive drugs (p < 0.01). BEN patients had lower PWV values at baseline and at the end of follow-up period despite being chronologically older (p < 0.001). Baseline PWV > 10 m/s was associated with higher risk for CV mortality (aHR 1.8 [1.4, 2.4]). In multivariate analyses BEN was predictor of lower PWV. During the follow-up period significantly less CV deaths were observed in BEN vs. on-BEN patients (12 vs. 31; p = 0.001). CV mortality adjusted for other risk factors was significantly lower in BEN group (aHR 0.2 [0.1, 0.5]). Overall BEN patients had longer mean survival time on HD (22.3 vs. 18.2 months; p < 0.001). Observed slower vascular aging (i.e., lower PWV) in BEN patients compared to other ESRD patients is related to the later onset of HT and milder stages of HT during predialytic clinical course and better control of BP and phosphate during HD.

Published
2018
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7. Variation in Presentation and Presence of DNA Adducts and p53 Mutations in Patients with Endemic Nephropathy - an Environmental Form of the Aristolochic Acid Nephropathy

Author

Sandra Karanović, Ivana Vuković Lela, Bojan Jelaković, Kathleen G. Dickman, Anamarija Kovač Peić, Damir Dittrich, Matej Knežević, Vesna Matijević, Andrea S. Fernandes, and Frederick Miller

Subjects
Aristolochic acid, Endemic nephropathy, Urothelial cell cancer, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Background: Endemic nephropathy (EN) and associated urothelial cell cancers (UUC) are an environmental form of aristolochic acid nephropathy where the most probable rout of ingestion of aristolochic acid (AA) was made by bread contaminated with AA, leading to chronic dietary intoxication. Clinical courses of three members of the same family, similarly exposed to toxin, who exhibited different clinical courses of the disease are presented. Methods: Questionnaires on AA exposure were taken. Tissue samples were obtained during therapeutic nephrouretectomies. Histopathology, immunohistochemical detection of p53, p53 mutation screening in tumor DNA and analysis on the presence of aristolactam (AL)-DNA adducts were performed. Results: Case 1 had UUC with typical EN histopathological signs, whereas Case 2 had bilateral UUCs with typical EN histopathological signs. In contrast, the patient in Case 3 initially showed renal insufficiency, complicated afterwards by right UUC, and later on by left UUC with histopathological end-stage chronic changes but without typical EN changes. AA-DNA adducts and specific p53 mutational spectra (A:T→ T:A transversion) were found in tissues of cases 1 and 2. Conclusion: Diverse clinical courses seem to be related not to differences in exposure but to differences in metabolic activation or detoxification of AA and/or DNA repair resulting from different genetic polymorphisms.

Published
2013
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10. Arterijska hipertenzija i bubrežna bolest - neočekivana komplikacija

Author

Mario Podrug, Narcisse Nasri, Sandra Karanović Štambuk, Bojan Jelaković, Mario Laganović, Ivana Vuković-Brnar, and Jelena Kos

Abstract

Arterial hypertension and chronic kidney disease are mutually interconnected. Uncontrolled arterial hypertension along with diabetes is one of the two most common causes of end-stage chronic kidney disease. On the other hand, chronic kidney disease, as well as renal artery stenosis, results in the development of arterial hypertension. Hypertensive crisis with target-organ damage, also known as a hypertensive emergency, is a serious arterial hypertension complication which is however becoming less frequent. It requires urgent parenteral antihypertensive treatment adjusted to the values of arterial hypertension and accompanying clinical signs. Damage can manifest on numerous organ systems primarily eyes, brain, cardiovascular system, and the kidneys. This is a case report of a patient who presented with hypertensive crisis and kidney damage and was eventually diagnosed with abdominal aortic dissection expanding into the renal arteries, but without typical clinical presentation of stabbing pain. MSCT aortography, despite the risk of progression of renal damage due to the effect of contrast agent, allowed us to set definitive diagnosis and clarify the aetiology of kidney damage and resistant arterial hypertension.

Published
2022
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11. Supplementary Figure legends from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Jiri Zavadil, Bojan Jelaković, Arthur P. Grollman, Magali Olivier, Kathleen G. Dickman, Adriana Heguy, Andrea Fernandes, Viktoria S. Sidorenko, Shahrokh F. Shariat, James McKay, Igor Dolgalev, Damir Dittrich, Maja Mišić, Krešimir Karlović, Catherine Voegele, Florence Le Calvez-Kelm, Nathalie Forey, Stephanie Villar, Geoffroy Durand, Evanguelos Xylinas, Karla Tomić, Maude Ardin, Sandra Karanović, and Xavier Castells

Abstract

Supplementary Figure legends

Published
2023
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12. Supplementary Figure S1 from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Jiri Zavadil, Bojan Jelaković, Arthur P. Grollman, Magali Olivier, Kathleen G. Dickman, Adriana Heguy, Andrea Fernandes, Viktoria S. Sidorenko, Shahrokh F. Shariat, James McKay, Igor Dolgalev, Damir Dittrich, Maja Mišić, Krešimir Karlović, Catherine Voegele, Florence Le Calvez-Kelm, Nathalie Forey, Stephanie Villar, Geoffroy Durand, Evanguelos Xylinas, Karla Tomić, Maude Ardin, Sandra Karanović, and Xavier Castells

Abstract

Supplementary Figure S1. Identification of AA signature by ultra-low coverage sequencing reads.

Published
2023
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13. Supplemental Material (for review only) File - Supplementary Tables 1-5. from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Jiri Zavadil, Bojan Jelaković, Arthur P. Grollman, Magali Olivier, Kathleen G. Dickman, Adriana Heguy, Andrea Fernandes, Viktoria S. Sidorenko, Shahrokh F. Shariat, James McKay, Igor Dolgalev, Damir Dittrich, Maja Mišić, Krešimir Karlović, Catherine Voegele, Florence Le Calvez-Kelm, Nathalie Forey, Stephanie Villar, Geoffroy Durand, Evanguelos Xylinas, Karla Tomić, Maude Ardin, Sandra Karanović, and Xavier Castells

Abstract

Supplementary Table S1: Clinicopathological and epidemiological patient data and urothelial tumor sample description. Supplementary Table S2: Complete list of annotated SBS identified in all LC-WES analyzed urothelial tumors (HiSeq2500 data only). Supplementary Table S3: GO and KEGG Classification of genes mutated by non-synonymous A:T>T:A mutations. Supplementary Table S4: List of cancer driver genes found recurrently mutated in the EN and Taiwan UTUC sample sets. Supplementary Table S5: GO and KEGG classification of the recurrently mutated cancer driver genes (see Figure 3B).

Published
2023
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14. Supplementary Methods from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Jiri Zavadil, Bojan Jelaković, Arthur P. Grollman, Magali Olivier, Kathleen G. Dickman, Adriana Heguy, Andrea Fernandes, Viktoria S. Sidorenko, Shahrokh F. Shariat, James McKay, Igor Dolgalev, Damir Dittrich, Maja Mišić, Krešimir Karlović, Catherine Voegele, Florence Le Calvez-Kelm, Nathalie Forey, Stephanie Villar, Geoffroy Durand, Evanguelos Xylinas, Karla Tomić, Maude Ardin, Sandra Karanović, and Xavier Castells

Abstract

Supplementary Methods

Published
2023
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15. Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

Author

Kathleen G. Dickman, Ivana Vuković Brinar, Damir Dittrich, Elisa Venturini, Fran Borovečki, Sandra Karanović, Daniel S. Lee, Stephanie Villar, Želimir Stipančić, Magali Olivier, Karla Tomić, Bojan Jelaković, Jiri Zavadil, Claire Renard, Arthur P. Grollman, Krešimir Karlović, Adam Lorch, Zuojian Tang, Neda Slade, and Maude Ardin

Subjects
Cancer Research, Proteome, Aristolochic acid, Context (language use), Biology, medicine.disease_cause, upper tract urothelial carcinoma, aristolochic acid nephropathy, urinary biomarkers, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, microRNA, Clinical Medical Sciences, Biomarkers, Tumor, medicine, Humans, Exome, RNA, Messenger, 030304 developmental biology, Carcinoma, Transitional Cell, 0303 health sciences, Tissue microarray, Cancer, Basic Medical Sciences, Prognosis, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Gene expression profiling, MicroRNAs, Urinary Bladder Neoplasms, Oncology, chemistry, 030220 oncology & carcinogenesis, Mutation, Cancer research, Aristolochic Acids, Carcinogenesis, Follow-Up Studies
Abstract

Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe. We applied an integrative multiomics analysis of UTUCs, corresponding unaffected tissues and of patient urines. Quantitative microRNA (miRNA) and messenger ribonucleic acid (mRNA) expression profiling, immunohistochemical analysis by tissue microarrays and exome and transcriptome sequencing were performed in UTUC and nontumor tissues. Urinary miRNAs of cases undergoing surgery were profiled before and after tumor resection. Ribonucleic acid (RNA) and protein levels were analyzed using appropriate statistical tests and trend assessment. Dedicated bioinformatic tools were used for analysis of pathways, mutational signatures and result visualization. The results delineate UTUC-specific miRNA:mRNA networks comprising 89 miRNAs associated with 1, 862 target mRNAs, involving deregulation of cell cycle, deoxyribonucleic acid (DNA) damage response, DNA repair, bladder cancer, oncogenes, tumor suppressors, chromatin structure regulators and developmental signaling pathways. Key UTUC- specific transcripts were confirmed at the protein level. Exome and transcriptome sequencing of UTUCs revealed AA-specific mutational signature SBS22, with 68% to 76% AA-specific, deleterious mutations propagated at the transcript level, a possible basis for neoantigen formation and immunotherapy targeting. We next identified a signature of UTUC- specific miRNAs consistently more abundant in the patients' urine prior to tumor resection, thereby defining biomarkers of tumor presence. The complex gene regulation programs of AAN-associated UTUC tumors involve regulatory miRNAs prospectively applicable to noninvasive urine-based screening of AAN patients for cancer presence and recurrence.

Published
2022

16. Assessment of microvascular reactivity in randomly selected adult population EHUH study Croatian scientific foundation

Author

Petar Šušnjara, Ana Stupin, Marija Matasin, Zivka Dika, Ivana Jukić, Bojan Jelaković, B. Krtalic, Luka Kolar, Sandra Karanović, Leon Perić, Ines Drenjančević, Ana Jelaković, and Ivo Vincetić

Subjects
Croatian, Gerontology, Physiology, business.industry, Adult population, Foundation (engineering), language.human_language, skin microvascular reactivity, laser Doppler flowmetry, anthropometric parameters, blood pressure, Internal Medicine, language, Medicine, Cardiology and Cardiovascular Medicine, Reactivity (psychology), business
Abstract

Objective. To assess the forearm skin microvascular reactivity and anthropometric parameters in randomly selected population and seek the differences between a group of people who had elevated blood pressure at the time of measurement and those who were normotensive. Design and method. Total of 148 randomly selected individuals (50 men/98 women) participated in this study. The exclusion criteria were less than 1l of urine collected at 24h, and creatinine values below the reference values. Forthy eight individuals included in this study had arterial hypertension (HT) and 44 had normal arterial blood pressure values (NT). Post-occlusive reactive hyperemia (PORH) in skin microcirculation following 1 minute of vascular occlusion period was assessed using laser Doppler flowmetry. Anthropometric parameters, blood pressure, heart rate were measured, and 24-hour urine was collected to sodium excretion and creatinine measurement. P< 0, 05 was considered statistically significant. Results. Sistolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressure were significantly higher, while PORH was significantly lower in HT group compared to NT individuals. HT had higher body mass index (BMI) and waist circumference, while there were no differences in heart rate between HT and NT group. In HT individuals, PORH was negatively associated with waist circumference (r=-0, 438), and positively associated with heart rate (r=0, 316). Sodium excretion was positively associated with DBP (r=0, 361). In NT group, PORH was negatively associated with SBP (r=-0, 362) and MAP (r=-0, 37). SBP and MAP were positively associated with BMI (r=0, 484, r=0, 312) and waist circumference (r=0, 421, r=0, 319). Sodium excretion was positively associated with BMI (r=0, 546) and waist circumference (r=0, 523). Analyzes of all individuals together showed that PORH was negatively associated with BMI (r=-0, 253), SBP (r=-0, 274) and MAP (r=-0, 24), while BMI was positively associated with SBP (r=0, 359), DBP (r=0, 219) and MAP (r=0, 312). Conclusions. High blood pressure attenuated microvascular function. Arterial blood pressure is related to obesity (BMI, waist circumference).

Published
2021

17. ESTIMATED PULSE WAVE VELOCITY (EPWV) DISTRIBUTION IN A COHORT STUDY – EH-UH STUDY (CROATIAN SCIENTIFIC FOUNDATION)

Author

Marija Matasin, Bojan Jelaković, Luka Katic, Sandra Karanović, Vedran Premuzic, Ivan Pećin, Tajana Zeljkovic Vrkic, Jelena Kos, Luka Blagus, Zivka Dika, Vito Bosnjak, Mihaela Marinovic Glavic, Viktor Domislovic, Ana Jelaković, and Stjepan Frkanec

Subjects
Croatian, Distribution (number theory), Physiology, business.industry, Foundation (engineering), Geodesy, language.human_language, Internal Medicine, language, Medicine, Cardiology and Cardiovascular Medicine, business, Pulse wave velocity, Cohort study
Published
2021
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19. SP091BLOOD PRESSURE AND RENAL FUNCTION IN YOUNG ADULT MEN BORN AFTER INTRAUTERINE GROWTH RESTRICTION – 8 YEAR FOLLOW UP STUDY

Author

M. Fistrek, Mario Laganović, J. Kos, Bojan Jelaković, Vedran Premuzic, Zivka Dika, Andrea Rupcic, Sandra Karanović, and Ivana Vuković Brinar

Subjects
Transplantation, Pediatrics, medicine.medical_specialty, Blood pressure, Nephrology, business.industry, medicine, Follow up studies, Intrauterine growth restriction, Renal function, Young adult, medicine.disease, business
Published
2019
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20. ADJUSTING EQUATIONS FOR GLOMERULAR FILTRATION RATE FOR BODY SURFACE AREA USING DUBOIS AND MOSTELLER FORMULAS

Author

Zivka Dika, Mirjana Fuček, J. Josipovic, I.V. Brinar, Sandra Karanović, Bojan Jelaković, V. Domislovic, Marija Matasin, B. Milicic, Ana Jelaković, K. Dapic, Vanja Ivković, Livija Šimičević, and Heagerty, Anthony M

Subjects
Body surface area, Physiology, business.industry, Mathematical analysis, Internal Medicine, Medicine, Renal function, GLOMERULAR FILTRATION RATE, eGFR, ADJUSTING EQUATIONS FOR GFR, Cardiology and Cardiovascular Medicine, business
Abstract

doi: 10.1097/01.hjh.0000571716.53390.4b

Published
2019

21. SODIUM AND POTASSIUM INTAKE IN RURAL POPULATION

Author

J. Kos, J. Josipovic, Bojan Jelaković, Ana Jelaković, Vanja Ivković, B. Milicic, V. Premuzic, T. Knezevic, K. Dapic, Sandra Karanović, Marija Matasin, L. Gellineo, Mirjana Fuček, B. Krtalic, Zivka Dika, and Heagerty, Anthony M

Subjects
Potassium intake, sodium intake, potassium intake, rural, epidemioogy, Physiology, business.industry, Sodium, chemistry.chemical_element, Sample (statistics), chemistry, Environmental health, Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business, Rural population
Abstract

Objective:Our aim was to determine trends in salt and potassium intake in general rural population during the 7.5 years of follow-up and to analyze differences in results obtained using various equations.Design and method:Out of 1582 subjects (random rural sample) enrolled in ENAH study conducted in

Published
2019

22. HIGH SODIUM, LOW POTASSIUM INTAKE AND CHANGES OF BLOOD PRESSURE CATEGORY DURING 7.5 YEARS FOLLOW-UP PERIOD

Author

B. Krtalic, L. Gellineo, Marija Matasin, J. Kos, J. Josipovic, B. Milicic, Sandra Karanović, K. Dapic, Bojan Jelaković, T. Knezevic, V. Premuzic, Zivka Dika, Ana Jelaković, Mirjana Fuček, and Heagerty, Anthony M

Subjects
Potassium intake, medicine.medical_specialty, education.field_of_study, Physiology, business.industry, Sodium, Population, sodium intake, potassium intake, blood pressure, Clinical course, High sodium, chemistry.chemical_element, Blood pressure, chemistry, Internal medicine, Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business, education
Abstract

Objective:Our aim was to analyze association of sodium and potassium intake on clinical course i.e. changes of blood pressure (BP) category in general population during the 7.5 years of follow up.Design and method:Out of 1582 subjects (random rural sample) enrolled in ENAH study conducted in 2008–20

Published
2019

23. NEW ONSET CHRONIC KIDNEY DISEASE IS ASSOCIATED WITH HIGH SODIUM INTAKE IN POPULATION WITH LOW POTASSIUM CONSUMPTION

Author

B. Krtalic, Mirjana Fuček, B. Milicic, T. Knezevic, K. Dapic, J. Kos, Sandra Karanović, Vanja Ivković, V. Premuzic, L. Gellineo, J. Josipovic, Marija Matasin, Bojan Jelaković, Zivka Dika, Ana Jelaković, and Heagerty, Anthony M

Subjects
education.field_of_study, Potassium intake, medicine.medical_specialty, Physiology, business.industry, Sodium, Potassium, Population, High sodium, chemistry.chemical_element, medicine.disease, New onset, chemistry, Internal medicine, Internal Medicine, medicine, chronic kidney disease, sodium intake, epidemiology, Cardiology and Cardiovascular Medicine, education, business, Kidney disease
Abstract

Objective:Our aim was to analyze association of sodium and potassium intake with new onset chronic kidney disease (CKD) in general population during the 7.5 years of follow up.Design and method:Out of 1582 subjects (random rural sample) enrolled in ENAH study conducted in 2008–2010, 739 were invited

Published
2019

24. ESTIMATED PULSE WAVE VELOCITY (EPWV) AND MORTALITY IN SUBJECTS WITH HEALTHY VASCULAR AGEING (HVA) AND EARLY VASCULAR AGEING (EVA) IN GENERAL POPULATION. EH-UH STUDY

Author

Stjepan Frkanec, Luka Katic, K. Capak, Sandra Karanović, Bojan Jelaković, Vedran Premuzic, Tajana Zeljkovic Vrkic, Mihaela Marinovic Glavic, Ivan Pećin, Ana Jelaković, Marija Matasin, Viktor Domislovic, Jelena Kos, Luka Blagus, Ranko Stevanović, Valentina Kriksic, Zivka Dika, and Vito Bosnjak

Subjects
medicine.medical_specialty, education.field_of_study, Physiology, business.industry, Population, Vascular ageing, Internal medicine, Internal Medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, education, business, Pulse wave velocity
Published
2021
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25. CHRONIC KIDNEY DISEASE AND SURVIVAL AFTER FIRST ISCHEMIC STROKE. CROATIAN COHORT OF THE ESH STROKE SURVEY

Author

Branko Malojčić, Sandra Karanović, Vedran Premuzic, Peter Wohlfahrt, Renata Cifkova, Alena Krajčoviechová, Zivka Dika, Bojan Jelaković, Ana Jelaković, Ranko Stevanović, Tajana Zeljkovic Vrkic, and Jelena Kos

Subjects
Croatian, medicine.medical_specialty, Physiology, business.industry, medicine.disease, language.human_language, Internal medicine, Cohort, Ischemic stroke, Internal Medicine, medicine, language, Cardiology and Cardiovascular Medicine, business, Stroke, Kidney disease
Published
2021
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26. Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy

Author

Vanja Ivković, Vedran Premužić, Sandra Karanović, Živka Dika, Ninoslav Leko, Želimir Stipančić, Ivana Vuković Brinar, Bojan Jelaković, and Ana Jelaković

Subjects
medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_treatment, pulse wave velocity, 030232 urology & nephrology, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, Balkan endemic nephropathy, 0302 clinical medicine, chronic hemodialysis, Internal medicine, Mean Survival Time, medicine, Pulse wave velocity, Dialysis, Original Research, business.industry, Aristolochic acid nephropathy, medicine.disease, Blood pressure, arterial stiffness, lcsh:RC666-701, aristolochic acid nephropathy, Arterial stiffness, Vascular aging, business, Cardiology and Cardiovascular Medicine, chronic kidney disease
Abstract

Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in lower CV mortality. A total of 186 hemodialysed (HD) patients (90 BEN, 96 non-BEN; 67.3 + 13.0 years) were enrolled and followed-up for 25 months. Brachial blood pressure (BP) and pulse wave velocity (PWV) were determined before mid-week dialysis. BEN patients were older (72.1 ± 37.1 vs. 62.8 ± 15.1; p < 0.001), had shorter duration of HT prior commencement of HD than non-BEN patients (36 vs. 84 months; p < 0.001). There were no differences in BP, but BEN patients were treated with less antihypertensive drugs (p < 0.01). BEN patients had lower PWV values at baseline and at the end of follow-up period despite being chronologically older (p < 0.001). Baseline PWV > 10 m/s was associated with higher risk for CV mortality (aHR 1.8 [1.4, 2.4]). In multivariate analyses BEN was predictor of lower PWV. During the follow-up period significantly less CV deaths were observed in BEN vs. on-BEN patients (12 vs. 31; p = 0.001). CV mortality adjusted for other risk factors was significantly lower in BEN group (aHR 0.2 [0.1, 0.5]). Overall BEN patients had longer mean survival time on HD (22.3 vs. 18.2 months; p < 0.001). Observed slower vascular aging (i.e., lower PWV) in BEN patients compared to other ESRD patients is related to the later onset of HT and milder stages of HT during predialytic clinical course and better control of BP and phosphate during HD.

Published
2018
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27. SODIUM AND POTASSIUM INTAKE IN OVERWEIGHT AND OBESE NORMOTENSIVE AND HYPERTENSIVE SUBJECTS

Author

L. Gellineo, Martina Matovinović, J. Josipovic, T. Knezevic, M. Abramovic, Rea Levicki, Sandra Karanović, Bojan Jelaković, Mirjana Fuček, Zivka Dika, V. Premuzic, B. Krtalic, B. Milicic, J. Kos, Ana Jelaković, and Heagerty, Anthony M

Subjects
sodium intake, potassium intake, overweight, obese, hypertension, medicine.medical_specialty, Potassium intake, Physiology, business.industry, Sodium, chemistry.chemical_element, Overweight, chemistry, Internal medicine, Internal Medicine, Medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Objective: Our aim was to analyze sodium and potassium intake in obese normotensive and hypertensive subjects from rural area. Design and method: Out of 1582 subjects (random rural sample) enrolled in ENAH study conducted in 2008–2010, 739 were invited for the second visit in 2015 and 377 subjects with reliable both urine samples (urine creatinine in normal ranges) were included in further analyses s (80m 297w ; average age 52 ± 13.5). Blood pressure was measured three times (Omron M6) and mean values were calculated. Fasting blood and first morning (spot) urine samples were collected. Sodium and potassium were determined using Tanaka, Kawasaki and Intersalt equations. Potassium intake was further adjusted for intestinal intake (77%) and renal excretion (92%). Optimal, normal, high normal BP, untreated and treated hypertension (HT) were diagnosed in 20.9%, 15.3%, 12.9%, 19.1% and 31.5%, respectively. There were 21.2%, 35.3% and 42.8% subjects in the BMI 1 (30) group, respectively. Results: Significant differences in HT prevalence were observed among the BMI groups (46.9%, 63.6%, 80 %, respectively ; p = 0.001). Sodium excretion were significantly lower in BMI1 vs BMI3 groups (BMI < 0.0001). More than 10 g/day of salt intake was most seldom present in BMI1 and more frequently in BMI3 group (41.9%, 54.5%, 63.1%, respectively ; p < 0.05). Compared to normotensive in hypertensive subjects salt intake >10 g/day was significantly more frequently presented in overweight (X2 = 12.68 ; p = 0.0003) but not in obese subjects. Potassium intake was significantly higher in BMI3 than in BMI1 group (p < 0.001). No differences in Na/K ratio were observed among BMI groups. Conclusions: Higher salt intake contributes to high prevalence of hypertension and according to our results is more closely associated with hypertension in overweight than in obese subjects. No difference in Na/K ratio among BMI groups reflects high sodium and poor potassium intake in all subjects.

Published
2019
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28. Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area

Author

Mirjana Fuček, Živka Dika, Sandra Karanović, Ivana Vuković Brinar, Vedran Premužić, Jelena Kos, Ante Cvitković, Maja Mišić, Josip Samardžić, Dunja Rogić, Bojan Jelaković, Mirjana Fuček, Živka Dika, Sandra Karanović, Ivana Vuković Brinar, Vedran Premužić, Jelena Kos, Ante Cvitković, Maja Mišić, Josip Samardžić, Dunja Rogić, and Bojan Jelaković

Abstract

Introduction: Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. Materials and methods: A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). Results: The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. Conclusions: eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.

Published
2018

29. Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area

Author

Maja Mišić, Ivana Vuković Brinar, Jelena Kos, Vedran Premužić, Živka Dika, Sandra Karanović, Ante Cvitković, Bojan Jelaković, Dunja Rogić, Mirjana Fuček, and Josip Samardžić

Subjects
Male, estimated glomerular filtration rate, Clinical Biochemistry, 030232 urology & nephrology, 030204 cardiovascular system & hematology, urologic and male genital diseases, 0302 clinical medicine, Epidemiology, Prevalence, Aged, 80 and over, Endemic Nephropathy, Middle Aged, Original Papers, female genital diseases and pregnancy complications, Creatinine, language, Female, medicine.symptom, Algorithms, Glomerular Filtration Rate, Adult, medicine.medical_specialty, Adolescent, Croatia, Renal function, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Intensive care medicine, Aged, Croatian, business.industry, Public health, Biochemistry (medical), Reproducibility of Results, medicine.disease, language.human_language, Cross-Sectional Studies, chronic kidney disease, endemic nephropathy, predictive equation, Albuminuria, Rural area, business, Kidney disease
Abstract

Introduction: Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. Materials and methods: A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). Results: The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. Conclusions: eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.

Published
2017

30. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid

Author

Xavier Castells, Sandra Karanović, Karla Tomić, Maude Ardin, Jiri Zavadil, and Bojan Jelaković

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Aristolochic acid, Context (language use), Biology, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, Renal cell carcinoma, medicine, Carcinogen, Exome sequencing, Balkan Nephropathy, Kidney disease, Upper urinary tract
Abstract

Aristolochic acid (AA) is a potent dietary cytotoxin and carcinogen, and an established etiological agent underlying severe human nephropathies and associated upper urinary tract urothelial cancers, collectively designated aristolochic acid nephropathy (AAN). Its genome-wide mutational signature, marked by predominant A:T > T:A transversions occurring in the 5'-CpApG-3' trinucleotide context and enriched on the nontranscribed gene strand, has been identified in human upper urinary tract urothelial carcinomas from East Asian patients and in experimental systems. Here we report a whole-exome sequencing screen performed on DNA from formalin-fixed, paraffin-embedded renal cell carcinomas (RCC) arising in chronic renal disease patients from a Balkan endemic nephropathy (EN) region. In the EN regions, the disease results from the consumption of bread made from wheat contaminated by seeds of Aristolochia clematitis, an AA-containing plant. In five of eight (62.5%) tested RCC tumor specimens, we observed the characteristic global mutational signature consistent with the mutagenic effects of AA. This signature was absent in the control RCC samples obtained from patients from a nonendemic, metropolitan region. By identifying a new tumor type associated with the AA-driven genome-wide mutagenic process in the context of renal disease, our results suggest new epidemiological and public health implications for the RCC incidence worldwide, particularly for the high-risk regions with unregulated use of AA-containing traditional herbal medicines.

Published
2014
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31. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 1

Author

Masayuki Iyoda, Taihei Suzuki, Jung Eun Lee, Margherita Conrieri, Angel Sevillano, Katsuyuki Nagatoya, Shankar Prasad Nagaraju, Nicoletta Mezzina, Augusta Praça, A. Malesci, Bjørn Egil Vikse, Tajana Zeljkovic Vrkic, Fumihiko Sasai, Giuseppe Paolo Segoloni, Maki Shinzawa, Terumasa Hayashi, Yutaka Yamaguchi, Maria Elena Donadio, Inês Ferreira, Ioanna Labropoulou, Luca Vergano, Yoshikuni Nagayama, Manuel A Podestà, Guida Meneses, Takayuki Kuragano, Gisele V. Fernandes, Manohar Bairy, Yasuyuki Nagasawa, Ayse Serra Artan, Vedran Premuzic, Barbara Trezzi, Carla Guidi, Manuel Pestana, Makoto Watanabe, Donatella Vizza, Francisco Remédio, Rune Bjørneklett, Niranjan Ambekar, Evangelina Mérida, Narayan Prasad, Ana Cristina Matos, George Toulkeridis, In Mi Han, Enrique Morales, Mohit Kumar Rai, Federica Chiale, Kenichi Sumida, Ann Merethe Vågane, E. Mariz, Adrian Zugravu, Andreas Kronbichler, Michael A. Rudnicki, Praga Manuel, Maria Skoularopoulou, Maria Paola Puccinelli, Mustafa Güllülü, Helena Viana, Loredana Colla, Vasudeva Guddattu, Sung-Bae Park, Sung Jin Moon, Eduardo Gutiérrez, Hirokatsu Atsumi, Junichi Hoshino, Rajeevalochana Parthasarathy, Nimet Aktas, Renzo Bonofilgio, Carla Henriques, Ana Huerta, Jelena Kos, David Cucchiari, Gener Ismail, Renato Alberto Sinico, Anna Varberg Reisæter, Hideki Yamaya, Iuliana Andreiana, Atsushi Yamauchi, Bernardo Faria, Francesca Maria Bosetti, Noriko Hayami, Vincenzo Cantaluppi, Yoshitaka Isaka, Swapnil Karnik, Aydin Turkmen, Alexei Smirnov, Ljiljana Fodor, Jinhyuk Paek, Alberto Boido, Shinichi Uchida, Abdulmecit Yildiz, Takanori Shibata, Sei Sasaki, Xiao-Yan Wei, Ravindra Prabhu, Tiziana Stellato, Roser Torra, Eunah Hwang, Kazuyuki Tasaki, Luigi Biancone, Gutierrez-Solis Elena, Clarissa J. B. Carvalho, Gabriel Mircescu, Ana Teresa Nunes, Elisabet Ars, Tomokazu Okado, Hui Wang, Vanja Ivković, Tushar Anil Dighe, Katsuhito Ihara, Norifumi Hayashi, Roxana Jurubita, Aysegul Oruc, Yasar Caliskan, Mehmet Sukru Sever, Atul Sajgure, Aikaterini Papagianni, Katarzyna Koscielska-Kasprzak, Francesca Leone, Mario Laganović, Archana Buch, Daisuke Komukai, Carina Ferreira, Olga Galkina, Marian Klinger, Sandra Karanović, Manuela Bianciotto, Srinivas Kosuru, Maria Céu Santos, Maurizio Gallieni, Manuel Praga, Yuan-Qing Tian, Ken Iseri, Peter Påhlsson, Kenmei Takaichi, Vikas Agarwal, Manuel Burdese, Aritoshi Kida, Giulio Mengozzi, Giovanni Camussi, Yasutaka Yamamoto, Tomohiro Saito, Seiichi Matsuo, Enyu Imai, Yuki Shindo-Hirai, Edite Pereira, Nida Oztop, Gert Mayer, Tatemitsu Rai, Rosanna Coppo, Hiroshi Okuyama, Dong Ho Shin, Soichiro Iimori, Danilo Lofaro, Hiroki Adachi, Yasemin Ozluk, Maria Alina Gomes de Mattos Cavalcante, Michael C. Carlsson, Bulent Gul, Abhay Sadre, Shunsuke Goto, Vasilii Sipovskii, Kei Fukami, Hiroki Nishiwaki, Tatsuya Suwabe, Daniela Finocchietti, Yuki Matsui, Takshi Nakanishi, Ashwini Sharma, Teresa Papalia, Marijana Cˇorić, Marco D'Amico, Caro-Espada Paula Jara, Francesco Mollica, Licia Peruzzi, Yukihiro Wada, Roberta Camilla, Agata Mollica, E. O. Bogdanova, Raluca Bobeica, Cai-Li Wang, Eugen Mandache, Francesco Reggiani, Joaquim Calado, Li Lv, Elena Saganova, Fernanda Carvalho, Halil Yazici, Yan-Hui Zhang, Elisa Loiacono, Christos Bantis, Teresa Cavero, Salvatore Badalamenti, Hakon Leffler, Sigrid Lundberg, Tarun Jeloka, Ligia Petrescu, Luca Besso, Alline S. A. Oliveira, Stratis Kasimatis, Thomas Knoop, Davide Medica, Germana Daidola, E. Hernandez, Mana Yahiro, Rojas-Rivera Jorge Enrique, João M. Frazão, Kouki Mise, Toshiaki Suzuki, Yoshihiro Kuno, Atul Mulay, Jun Ito, Katarzyna Gniewek, George Efstratiadis, Marijana Ćorić, Jara Caro, Maria Stangou, Aysun Aksoy, Fernando Nolasco, Katarzyna Jakuszko, Paolo Gigliotti, Tae Hyun Yoo, Takeshi Hasegawa, Hideki Fujii, Ricardo Neto, Simona Stancu, Susana Sampaio, Camila Barbosa L Oliveira, Sindhura Lakshmi Koulmane Laxminarayana, Alaattin Yildiz, Shigeo Hara, Kei Matsumoto, Ludmila Taran, Nikoleta Maria Kouri, Shinichi Nishi, Andreea Avram, Zivka Dika, Nobuharu Kaneshima, Charan Bhadrappa Bale, Gian Marco Ghiggeri, Ashio Yoshimura, Lei Nan, Rachele Gallo, Keiji Fujimoto, Alessandro Amore, Mårten Segelmark, Luís H. B. C. Sette, Francesca Brunini, Bojan Jelaković, Lucila Maria Valente, Ryohei Yamamoto, Andreea Andronesi, Julia Kerschbaum, Inna Lastauka, Mohamed R. Daha, Akhilesh Jaiswal, Ni-Ya Jia, Jayraj Korpe, Shinichi Akiyama, Domenico Santoro, Marc A. Seelen, Ebru Acikgoz, Shoichi Maruyama, Anna Perri, Hitoshi Yokoyama, Magdalena Krajewska, Brijesh Yadav, Hyungjong Kim, Irina Zubina, Tatsuya Shoji, Yoshifumi Ubara, Claudio Angelini, Margareta Fištrek Prlić, Ian Proletov, Kentaro Nakai, Isin Kilicaslan, Antonella Radice, Prachi Kate, Sayuri Hamahata, Jose Antonio Moreno, and Marijana Zivko

Subjects
Transplantation, medicine.medical_specialty, Pediatrics, Primary (chemistry), Nephrology, business.industry, Alternative medicine, medicine, business, Intensive care medicine
Published
2014
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32. BLOOD PRESSURE VARIABILITY AND MORTALITY - RESULTS FROM THE EPIDEMIOLOGY OF HYPERTENSION IN CROATIA (EHUH STUDY) - MORTALITY DATA AFTER 17 YEARS OF FOLLOW-UP

Author

Vedran Premuzic, Ana Jelaković, Ranko Stevanović, Sandra Karanović, T. Knezevic, Juraj Jug, J. Kos, I. Golubic, M. Lovric Bencic, T. Zeljkovic Vrkic, B. Krtalic, V. Kriskic, and Bojan Jelaković

Subjects
Croatian, medicine.medical_specialty, education.field_of_study, Physiology, business.industry, Population, medicine.disease, Comorbidity, language.human_language, Blood pressure, Mortality data, Epidemiology, Cohort, Internal Medicine, language, medicine, mortality, arterial hypertension, 17 year follow up, Cardiology and Cardiovascular Medicine, education, business, Demography
Abstract

Objective:Our aim was to analyze association of visit-to-visit blood pressure variability (BPV) with comorbidity and mortality in random sample of Croatian population, an original cohort from the EHUH study.Design and method:EHUH study is nation-wide survey on prevalence, treatment and control of hy

Published
2019
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33. SODIUM-TO-POTASSIUM RATIO AND NEW ONSET HYPERTENSION

Author

Vanja Ivković, Mirjana Fuček, B. Krtalic, T. Knezevic, Bojan Jelaković, J. Kos, J. Josipovic, V. Premuzic, B. Milicic, V. Domislovic, L. Gellineo, Ana Jelaković, M. Abramovic, Zivka Dika, Sandra Karanović, and Heagerty, Anthony M

Subjects
Potassium intake, Physiology, business.industry, Sodium, Potassium, chemistry.chemical_element, New onset, chemistry, Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business, sodium-to-potassium ratio, hypertension
Abstract

Objective:Our aim was to analyze characteristics of subjects with new onset hypertension (NOHT) and impact of sodium and potassium intake on development of NOHT.Design and method:Out of 1582 subjects (random rural sample) enrolled in ENAH study conducted in 2008–2010, 739 were invited for the second

Published
2019
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34. Hypertension - human studies

Author

Fatih Dede, Ling Qiu, Jose Maria Mora, Charles D. Pusey, Rocío Bautista, Caroline Williams, Marlies Antlanger, Nuria Garcia-Fernandez, Len A. Usvyat, Taku Fujimoto, Lanping Jiang, Marcus D. Säemann, Hayet Kaaroud, Vesna Matijević, Zilong Li, Milan Bitunjac, Yang Li, Fernando Margulis, Cesar Flores-Gama, Veronica Golglid, Patrícia Branco, Salim Caliskan, Ioana Elena Bancu, Mizuki Iwanaga, Xiaoli Yuan, Ruben Schiavelli, Vedran Premuzic, Magdalena Bartmańska, Dominka Maciorkowska, Edilia Tapia, Alexandru Ciocalteu, Edyta Zbroch, Zehra Yilmaz, Xuemei Li, Christopher C. Kaltenecker, Neill Duncan, Tuncay Kucukozkan, Ewa Koc-Zorawska, Manuel Alfredo Podestà, Tatsuhumi Oka, Aysun Aybal-Kutlugun, Tolga Yildirim, Bhavna K Pandya, Ligia Petrica, Eriko Iwahashi, Mirjana Fuček, Limeng Chen, Hiroaki Hara, Cristina Marelli, Adrian Enache, Manfred Hecking, Mutlu Hayran, Cassandra Cartagena, Jose Bonet, Kenji Yokoyama, Dolores López, Peng Xia, Sandra Karanović, Premuzic Vedran, Florin Jurca-Simina, Silvia Ramallo, Mary Carter, Olga Prikhodko, Ramón Romero, Jin Suk Han, Yunus Erdem, Koichi Sasaki, Seung Min Lee, Angela Mendes, Keita Uehara, Xuewang Li, Ninoslav Leko, Nihal Ozkayar, Alexandru-Ionel Checherita, Yosuke Tayama, Flaviu Bob, Min Kyung Kim, Augusta C. Gaspar, Takashi Yasuda, Mario Laganović, Kenjiro Kimura, Xiaoxiao Shi, Guangjin Zhu, Mustafa Arici, Gulseren Pehlivan, Aleksandar Sikole, Nathan W. Levin, Nam Ju Heo, Henrique S. Sousa, Johannes J. Kovarik, Yani He, Weiwei Zhang, Paloma Leticia Martín, Vivek Bansal, Ursino Pacheco, Mirta Abramović Barić, Takanori Otowa, Miriam Martinez, Yasmir Quiroz, Leonard J. van Schelven, Tomonari Ogawa, Johannes Werzowa, Hajime Hasegawa, Tota Kiba, Manuel Almeida, Jose Santamaría, Mehmet Taşdemir, Michal Mysliwiec, Michiel Voslkuil, Cristiana David, Adalbert Schiller, Magdalena Szotowska, Yugo Shibagaki, Marit M. Suttorp, Tomoyuki Mitani, Jolanta Malyszko, Sohan Shah, Peter Kotanko, Tiny Hoekstra, Bojan Jelaković, Tomonori Kimura, Lirong Lin, Kwon Wook Joo, Assumpta Serra, Marcin Adamczak, Vesna Gerasimovska, Friedo W. Dekker, Lining Wang, Laima Siddiqi, Gheorghe Bozdog, Mircea Munteanu, Su Yeon Choi, Tuncay Aki, Eva E. Vink, Martha Franco, Fansan Zhu, Samer R. Abbss, Francisco Javier Lavilla, Lourdes Carolina Vazquez Jimenez, Adel Kheder, Bernardo Rodriguez-Iturbe, Jelena Kos, Ana Lucić Vrdoljak, Shinsuke Sakai, Michael Haidinger, Nur Canpolat, Katarzyna Wyskida, Maciej Tarski, Juan Wang, Miguel Mendes, Pedro Errasti, Shinpei Okazaki, Josep Bonet Sol, Daniele Marcelli, Kaori Takayanagi, Stevka Bogdanovska, Hyo Eun Park, Romulus Timar, Nadiia Demikhova, Bulent Altun, Ante Cvitković, Andrei Niculae, Karima Boubaker, Silvia Velciov, Satoshi Minami, Pedro A. Gonçalves, Margareta Fištrek Prlić, P. Liam Oey, Richard J. Johnson, Willemien L. Verloop, Peter J. Blankestijn, Chantal Kopecky, Albert Power, Claudia Castro, Jurong Yang, Biljana Gerasimovska Kitanovska, Marko Poglitsch, Hiroo Kawarazaki, Jose Barata, Milosz Bąba, Harald Heinzl, Jacek S. Malyszko, Yubing Wen, Maria Isabel Troya Saborido, Carmen Vicente Calderon, Lale Sever, Akihiko Matsuda, Koichi Kanozawa, Helder Dores, Ana Rita Martins, Galina Severova Andreevska, Maru Navarro Diaz, Wilko Spiering, Ivan Pećin, Diana Mociar, Andrzej Wiecek, Diana Lopez, Pedro Gonçalves, Tetsuya Mitarai, Oliver Domenig, Juko Asakura, Jiaojiao Wang, Rahmi Yilmaz, Hang Li, Evert-Jan Vonken, Neus Sala, and Katica Zafirovska

Subjects
Transplantation, Human studies, Nephrology, business.industry, Medicine, business, Bioinformatics
Published
2013
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35. Epidemiology - renal outcomes

Author

Neil R. Powe, Bolesław Rutkowski, Serpil Muge Deger, Mitsuru Yanai, Arun Ashok, Chie Saito, Noha A. Osman, Merike Luman, Masahiro Hagiwara, Giulia Ubaldi, Natalie Ebert, Keita Kamei, Marian Klinger, Ingi Elsayed, Rajiv Saran, Rene Clavero, Vasil Cholakov, Dragana Juric, Annie Rein-Weston, Merel van Diepen, Paloma Gallar, Margareta Fištrek, Olivier Moranne, Vesna Gerasimovska, Moniek C.M. de Goeij, Tanushree Banerjee, Hillary Morgan, Sebastjan Bevc, Turgay Arinsoy, Akira Hiwatashi, Anca Tilea, Ewa Król, Richard J. Silverwood, Keigyo Yoh, Zbigniew Gaciong, Amanda B. Greer, Shahed Ahmed, Marcora Mandreoli, Cristina Di Giogia, Shouichi Fujimoto, Yukiko Hasuike, Laurence Lutteri, Dino Gibertoni, Kyrill S. Rogacev, Bojan Jelaković, Gunnar H. Heine, Ahad A. Abdalla, Alan G. Jardine, Joichi Usui, Ailish Hannigan, Biljana Gerasimovska Kitanovska, Rachel Hilton, Mariusz Kusztal, Ronald D. Perrone, Dunja Rogic, Hideaki Yoshida, Isao Kubota, Austin G. Stack, Olimpia Ortega, Rebecca Cheng, Sandra Karanović, Nieves Vasquez, Zbigniew Heleniak, Toshiki Moriyama, Joanna Rymaszewska, Jason C. Cole, Dario Tedesco, Ahmet B. Ozbay, Syuichi Tsuruoka, Ivana Vuković Lela, Yasuo Ohashi, Hanna Wiatr, A. Tilea, Peter Rutherford, Etienne Cavalier, Leszek Tylicki, Mohamed M. NasrAllah, Ana Lucić Vrdoljak, Ami Nagasawa, Marcin Rutkowski, Manuel Macía, Hala S El-Wakil, Tomasz Szychliński, Beatriz Tapia, Lukasz Zdrojewski, Mohalab Adam, Mary Pierce, Abdelhafeez Fadl, Sreelatha Melemadathil, Yuji Sato, Takahiro Kuragano, Sue Siddall, Ana Jarque, Antonios Douros, Kazuhiro Matsuyama, Kunihiro Yamagata, Elizabeth Hedgeman, Sususmu Takahashi, Kazuyoshi Okada, Antonio Santoro, Kürşad Öneç, Julie Hinostroza, Jean-Marie Krzesinski, Hirayasu Kai, Joachim Jankowski, Hanna Augustyniak-Bartosik, Mattia Monti, Sunny Sallam, Stevka Bogdanovska, Naveed Sattar, Aniana Oliet, Liam F. Casserly, Arif Khwaja, Noeleen Ryan, Mirjana Fuček, Yasuyuki Nagasawa, Giovanni Tripepi, Fabio Olmeda, D Steffick, Adam M. Zawada, Magdalena Pryczkowska, P. Kotanko, Vedran Premuzic, Orod Osanlou, Kazuhisa Takeuchi, N. Levin, Tomasz Gołębiowski, Ewa Bartosińska, Gavin Taylor-Stokes, S.W. Han, Jennifer Sayers, Tomasz Zdrojewski, Mario Hair, Paola Rucci, Viatcheslav Rakov, Ewa Trafidlo, Anna Schulz, Mark S. MacGregor, Fredrik Uhlin, Lea Katalinić, Judith Van Den Bosch, Katarzyna Madziarska, Tawfik Ghabrah, Frances Mortimer, Tadeusz Jȩdrzejczyk, Ana Vigil, Pierre Delanaye, David Goldsmith, Samar Abd ElHafeez, Hiroko Sato, Moustafa Nawar, Charles J. Ferro, Issei Kurahashi, Arlene B. Chapman, F. Finkelstein, Lisa Burnapp, Carlos Bermudez, Ante Cvitkovic, Magdalena Cieplińska, Antonio Lupo, Kazuko Suzuki, Vera Jankowski, G. Eisele, Nilka Rios-Burrows, Margaret Kiser, Ivana Vuković-Lela, Mona M. Abdel-Gawad, Ulver Derici, Caroline O. S. Savage, Holly B. Krasa, Desmond Williams, Elke Schaeffner, Mario Laganović, Mehmet Akif Ozturk, Galina Severova Andreevska, Anders Fernström, Maki Shinzawa, Danilo Fliser, Michihiro Hosojima, Suk-Hee Yu, Gabriela Cobo, Enrique Tevar, Magdalena Krajewska, Hakan Nacak, Jung-ho Shin, Glenn Blake, Christopher Sibley-Allen, Noha Awad, Dorothea Nitsch, Hanna Kotlowska, Nina Hojs, Masaki Hara, Bogdan Wyrzykowski, Eman El Bassuoni, Thomas Archer, Vera Krane, Reneta Koycheva, Hiromi Rakugi, R. Sands, A. Stack, Atif A Khalil, Olga Jakob, Friedo W. Dekker, Rosen Iliev, Radovan Hojs, Simone Warren, Samir H. Asaad, Shona Methven, Patrizia Bernich, Takeshi Nakanishi, Olivier Bruyère, Diana Kuh, Jose Antonio Martin, Su Hyun Kim, J. Carlos Herrero, Gianluigi Zaza, Naoki Morito, Kosuke Kudo, Robert Ekart, Ahmed G. Adam, Ken Tsuchiya, Minoru Ando, Kazunobu Ichikawa, Kosaku Nitta, Isabel Rodríguez, Margarit Penev, Aleksandar Sikole, Hala ElWakil, Beng So, B. Gillespie, Ron D. Hays, Yoshitaka Isaka, R. Saran, Wacław Weyde, Ivo Fridolin, Marcus Richards, Jivko Andreev, Piotr Bandosz, Ryouhei Yamamoto, Dorothee Oberdhan, Frank Schiepe, Koichi Asahi, Kazuhiko Tsuruya, Rebecca Hardy, Nieves del Castillo, Osama El Minshawy, Akihiko Saito, Zahira M. Gad, Tatiana Aldunate, Zivka Dika, Carmen Mon, Elena Sestigiani, Reinhold Kreutz, Kunitoshi Iseki, Milagros Ortiz, Jelena Kos, Tetyana Chernenko, Tsuneo Konta, Tsuyoshi Watanabe, Bogdan Solnica, Jana Holmar, Carmine Zoccali, Sukru Sindel, Kei Nagai, Steven E. Marx, Walter Zidek, Thakshyanee Bhuvanakrishna, Galip Guz, Maria Luisa Mendez, Sarah Seiler, Abdelmageed Hamza, and Hoang T. Nguyen

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine
Published
2013
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36. Could Disappearance of Endemic (Balkan) Nephropathy Be Expected in Forthcoming Decades?

Author

Mirjana Fuček, Dragana Jurić, Sandra Karanović, Ante Cvitković, Bojan Jelaković, Ivana Vuković-Lela, Dubravka Čvorišćec, and Karen L. Edwards

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Adolescent, Endemic Diseases, Croatia, Balkan Nephropathy, Young Adult, Epidemiology, medicine, Humans, Aged, Aged, 80 and over, Original Paper, business.industry, Endemic Nephropathy, General Medicine, Middle Aged, Health Surveys, Nephrology, eEndemic nephropathy, prevalence, epidemiology, Female, Who criteria, Endemic diseases, Cardiology and Cardiovascular Medicine, business, Forecasting, Demography
Abstract

Background/Aims: An epidemiological survey of endemic nephropathy (EN) was performed in endemic Croatian areas and the current prevalence was compared to that reported for the same villages several decades ago. Methods: A total of 2,487 adult farmers from 6 endemic villages and 3 non-endemic villages were enrolled. An extensive epidemiological questionnaire, clinical examination and laboratory analyses of blood and urine were performed. According to the modified WHO criteria, participants were classified into diseased, suspected of having EN, and those at risk of developing EN. Results: The overall prevalence of EN in the Croatian areas was 1.0%, ranging between 0.3 and 2.3% in different villages. Those suspected of having EN amounted to 3.9%. In the endemic villages a decreasing trend in the prevalence of EN was observed comparable to the results obtained in previous surveys. It is interesting to note that no EN patients were recorded in the endemic village of Dubočac. Conclusion: The prevalence of EN in the endemic Croatian areas appears to be decreasing. For the first time, we failed to detect any EN patients in a village that was previously considered endemic, which might indicate that EN is diminishing.

Published
2011
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37. Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency

Author

Margareta Fistrek Prlic, Marijana Coric, Laura Calabresi, Chiara Pavanello, Lorena Mosca, Ugo Cavallari, Ivana Vukovic Brinar, Sandra Karanovic, Mario Laganovic, and Bojan Jelakovic

Subjects
LCAT deficiency, Nephrotic syndrome, Gene variants, LCAT gene, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background and aims: We report the first two cases of familial lecithin:cholesterol acyltransferase (LCAT) deficiency in Croatia with classical clinical and biochemical features. Patients and methods: A 30-year-old man with nephrotic syndrome, corneal opacities, hepatosplenomegaly, anemia, low high-density lipoprotein (HDL)-cholesterol levels and arterial hypertension (blood pressure >200/100 mmHg) was admitted to our department. At admission, he had an elevated creatinine serum level (233 μmol/L), proteinuria of 12 g in 24-h urine (g/24 h), 3–7 erythrocytes in urine sediment and notable anemia (hemoglobin level 90 g/l). His HDL-cholesterol was significantly low (0.42 mmol/L). Besides chronic kidney disease (CKD), other secondary causes of hypertension were ruled out. The patient was previously diagnosed with membranous nephropathy and treated unsuccessfully with immunosuppressive agents (steroids, cyclosporine, cyclophosphamide). Re-evaluation of histopathological findings of kidney biopsy revealed massive deposition of lipid material in the glomerular basal membrane and in the mesangial region. His 4-year younger brother was also evaluated due to corneal opacities and new-onset arterial hypertension. Nephrotic range proteinuria with preserved global renal function was determined. He also had very low HDL-cholesterol levels. Results: Kidney biopsies from both patients were consistent with LCAT deficiency. The disease was confirmed by measurement of LCAT enzyme activity, plasma cholesterol esterification rate, and genetic testing. Two novel missense variants in the LCAT gene (c.496G > A and c.1138T > C) were found. Conclusions: To our knowledge, the presented cases are the first reported cases of genetic LCAT deficiency in Croatia. Given the clinical presentation, the complete lack of LCAT activity and cholesterol esterification rate, diagnosis of familial LCAT deficiency was made.

Published
2022
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38. FIXED DOSE COMBINATION THERAPY IS ASSOCIATED WITH BETTER BLOOD PRESSURE CONTROL AND LOWER ALBUMINURIA IN REAL-LIFE COHORT DURING 7 YEARS OF FOLLOW UP. ENAH – CROATIAN RURAL STUDY

Author

I. Vukovic Brinar, J. Josipovic, Ana Jelaković, V. Premuzic, K. Djapic, J. Kos, Mirjana Fuček, Bojan Jelaković, V. Domislovic, Ninoslav Leko, Vesna Matijević, L. Gelineo, Sandra Karanović, Zivka Dika, and M. Abramovic

Subjects
Croatian, Blood pressure control, medicine.medical_specialty, Physiology, business.industry, Fixed-dose combination, language.human_language, Internal medicine, Cohort, Internal Medicine, Albuminuria, medicine, language, In real life, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published
2018
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39. HYPERTENSION IN PRIMARY GLOMERULONEPHRITIS - REPORT FROM THE CROATIAN REFERRAL CENTRE FOR GLOMERULAR DISEASES

Author

Ana Jelaković, Sandra Karanović, Vedran Premužić, T. Željković Vrkić, I. Vukovic Brinar, L. Gellineo, Stela Bulimbasic, Mario Laganović, Lea Katalinic, Marijana Ćorić, Tamara Knežević, Bojan Jelaković, and Živka Dika

Subjects
Croatian, medicine.medical_specialty, Physiology, business.industry, Glomerulonephritis, medicine.disease, language.human_language, Internal medicine, Referral centre, Internal Medicine, medicine, language, Cardiology and Cardiovascular Medicine, business, Glomerular diseases
Published
2018
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40. Chronic dietary exposure to aristolochic Acid and kidney function in native farmers from a croatian endemic area and bosnian immigrants

Author

Ninoslav Leko, Dubravka Čvorišćec, Živka Dika, Vedran Premužić, Arthur P. Grollman, Kathleen G. Dickman, Mario Laganović, Mirjana Fuček, Jelena Kos, Maja Šekoranja, Karen L. Edwards, Maja Mišić, Tamara Poljičanin, Ivana Vuković Lela, Sandra Karanović, Ante Cvitković, Mirta Abramović, Bojan Jelaković, Tomislav Teskera, Vesna Matijević, and Marica Miletić Medved

Subjects
Male, Time Factors, Bosnian, Epidemiology, Cross-sectional study, Critical Care and Intensive Care Medicine, Kidney Tubules, Proximal, chemistry.chemical_compound, Residence Characteristics, Risk Factors, Odds Ratio, Prevalence, Aged, 80 and over, Traditional medicine, Agriculture, Middle Aged, Nephrology, Creatinine, language, Aristolochic Acids, Female, medicine.symptom, CKD, albuminuria, interstitial fibrosis, proximal tubule, Glomerular Filtration Rate, Adult, Adolescent, Croatia, Balkan Nephropathy, Aristolochic acid, Emigrants and Immigrants, Food Contamination, Lower risk, Nephropathy, Young Adult, Environmental health, Occupational Exposure, Alpha-Globulins, medicine, Humans, Aged, Bosnia and Herzegovina, Transplantation, business.industry, Editorials, Original Articles, Odds ratio, medicine.disease, language.human_language, Agricultural Workers' Diseases, Diet, Cross-Sectional Studies, Logistic Models, chemistry, Multivariate Analysis, Albuminuria, business, Biomarkers
Abstract

Improvements in agricultural practices in Croatia have reduced exposure to consumption of aristolochic acid- contaminated flour and development of endemic (Balkan) nephropathy. Therefore, it was hypothesized that Bosnian immigrants who settled in an endemic area in Croatia 15-30 years ago would be at lower risk of developing endemic nephropathy because of reduced exposure to aristolochic acid. To test this hypothesis, past and present exposure to aristolochic acid, proximal tubule damage as a hallmark of endemic nephropathy, and prevalence of CKD in Bosnian immigrants were analyzed. In this cross- sectional observational study from 2005 to 2010, 2161 farmers were divided into groups: indigenous inhabitants from endemic nephropathy and nonendemic nephropathy villages and Bosnian immigrants ; α-1 microglobulin-to- creatinine ratio >31.5 mg/g and eGFR

Published
2015
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41. Low-coverage exome sequencing screen in formalin- Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Viktoria S. Sidorenko, Adriana Heguy, James McKay, Geoffroy Durand, Catherine Voegele, Kathleen G. Dickman, Evanguelos Xylinas, Andrea Fernandes, Karla Tomić, Magali Olivier, Krešimir Karlović, Arthur P. Grollman, Sandra Karanović, Florence Le Calvez-Kelm, Jiri Zavadil, Maude Ardin, Stephanie Villar, Nathalie Forey, Shahrokh F. Shariat, Damir Dittrich, Igor Dolgalev, Xavier Castells, Maja Mišić, and Bojan Jelaković

Subjects
Nonsynonymous substitution, Pathology, medicine.medical_specialty, Tissue Fixation, Epidemiology, aristolochic acid, urothelial carcinoma, formalin-fixed paraffin-embedded tumors, whole-exome sequencing, mutational signature, Aristolochic acid, Biology, Article, Nephropathy, chemistry.chemical_compound, Formaldehyde, Neoplasms, medicine, Humans, Exome, Transversion, Exome sequencing, Paraffin Embedding, Bladder cancer, Cancer, Sequence Analysis, DNA, medicine.disease, Oncology, chemistry, Carcinogens, Cancer research, Aristolochic Acids
Abstract

Background: Dietary exposure to cytotoxic and carcinogenic aristolochic acid (AA) causes severe nephropathy typically associated with urologic cancers. Monitoring of AA exposure uses biomarkers such as aristolactam-DNA adducts, detected by mass spectrometry in the kidney cortex, or the somatic A>T transversion pattern characteristic of exposure to AA, as revealed by previous DNA-sequencing studies using fresh-frozen tumors. Methods: Here, we report a low-coverage whole-exome sequencing method (LC-WES) optimized for multisample detection of the AA mutational signature, and demonstrate its utility in 17 formalin-fixed paraffin-embedded urothelial tumors obtained from 15 patients with endemic nephropathy, an environmental form of AA nephropathy. Results: LC-WES identified the AA signature, alongside signatures of age and APOBEC enzyme activity, in 15 samples sequenced at the average per-base coverage of approximately 10×. Analysis at 3 to 9× coverage revealed the signature in 91% of the positive samples. The exome-wide distribution of the predominant A>T transversions exhibited a stochastic pattern, whereas 83 cancer driver genes were enriched for recurrent nonsynonymous A>T mutations. In two patients, pairs of tumors from different parts of the urinary tract, including the bladder, harbored overlapping mutation patterns, suggesting tumor dissemination via cell seeding. Conclusions: LC-WES analysis of archived tumor tissues is a reliable method applicable to investigations of both the exposure to AA and its biologic effects in human carcinomas. Impact: By detecting cancers associated with AA exposure in high-risk populations, LC-WES can support future molecular epidemiology studies and provide evidence-base for relevant preventive measures. Cancer Epidemiol Biomarkers Prev; 24(12); 1873–81. ©2015 AACR.

Published
2015

42. ENDEMSKA NEFROPATIJA U HRVATSKOJ

Author

Bojan, Jelaković, Živka, Dika, Sandra, Karanović, and Ivana Vuković, Lela

Subjects
Endemska nefropatija – epidemiologija, etiologija, genetika, dijagnoza, patologija, Aristolohične kiseline – toksičnost, Karcinogene tvari iz okoliša – toksičnost, Izloženost okolišu – štetni učinci, Ureterni tumori – epidemiologija, etiologija, genetika, dijagnoza, patologija, Bubrežna kora – patologija, Tumor-supresorski protein p53 – genetika, Mutacija – genetika, Kineski biljni lijekovi – toksičnost, Hrvatska – epidemiologija, Croatia, Balkan Nephropathy, Incidence, Mutation, Aristolochic Acids, Humans, Balkan nephropathy – epidemiology, etiology, genetics, diagnosis, pathology, Aristolochic acids – toxicity, Carcinogens, environmental – toxicity, Environmental exposure – adverse effects, Ureteral neoplasms – epidemiology, etiology, genetics, diagnosis, pathology, Kidney cortex – pathology, Tumor suppressor protein p53 – genetics, Mutation – genetics, Drugs, chinese herbal – toxicity, Croatia – epidemiology, Genes, p53
Abstract

Endemska nefropatija (EN) kronična je tubulointersticijska nefropatija aristolohične kiseline (AAN) koja se javlja u stanovnika određenih sela u dolinama velikih pritoka Dunava na jugoistoku Europe uključujući i Hrvatsku. Oboljeli od EN-a imaju znatno veću učestalost karcinoma prijelaznog epitela mokraćovoda nego opća populacija. Danas se smatra da je A:T transverzija gena p53 »potpisna« mutacija za aristolohičnu kiselinu koja je uzrok endemske nefropatije. Postojeći kriteriji za EN su zastarjeli, neujednačeni (tri vrste kriterija) te nisu u skladu s novim preporukama za klasifikaciju bubrežnih bolesti. Stoga su na temelju sadašnjih znanja i stručnosti grupe znanstvenika i stručnjaka iz svih zemalja s EN-om, kao i svijeta u kojem je AAN opisan stvoreni novi dijagnostički kriteriji i nova klasifikacija stanovništva endemskih sela na simpoziju o EN-u. EN je velik javnozdravstveni problem pa bi nam sadašnja znanja o ovoj bolesti, kao i novi dijagnostički kriteriji trebali pomoći u njezinu ranom otkrivanju i liječenju, a možda u nekoj bližoj budućnosti i njezinoj eradikaciji., Endemic nephropathy (EN) is a chronic tubulointerstitial aristolochic acid nephropathy (AAN) affecting residents of the certain villages in the valleys of the major tributaries of the Danube river in the south-east Europe including Croatia. Patients with EN have a significantly higher incidence of transitional cell carcinoma of the ureter than the general population. A-T transversion of the p53 gene is now considered to be a mutational »signature« of aristolochic acid, which is a cause of endemic nephropathy. Currently used diagnostic criteria for EN are outdated, uneven (three types of criteria) and are not in agreement with proposed new guidelines for kidney diseases. Therefore, based on current knowledge and expertise of a group of scientists and experts from all countries with EN as well as world where AAN has been reported, new diagnostic criteria and the new classification of the population of endemic villages were created at a symposium on EN. EN presents a major public health problem and current knowledge about this disease as well as new diagnostic criteria should help us in its early detection and treatment and maybe in a near future its eradication.

Published
2015

43. [PP.03.07] PREDICTORS OF INCIDENT HYPERTENSION IN PREHYPERTENSIVES

Author

Mario Laganović, J. Kos, I. Vukovic, Dunja Rogić, Claudio Borghi, M. Abramovic Baric, Sandra Karanović, Ana Lucić Vrdoljak, Vanja Ivković, S. Bachelli, Sergio D'Addato, D Degli Esposti, Elisa Grandi, Martina Rosticci, Marcella Cagnati, Angelo Parini, Mirjana Fuček, Arrigo Fg Cicero, and Bojan Jelaković

Subjects
medicine.medical_specialty, Physiology, business.industry, Internal medicine, Internal Medicine, medicine, Cardiology and Cardiovascular Medicine, business
Published
2016
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44. [PP.03.11] PREHYPERTENSION IS ASSOCIATED WITH CHRONIC KIDNEY DISEASE IN EUROPEAN RURAL POPULATION- DATA FROM BRISGHELA HEART STUDY (ITALY) AND ENAH STUDY (CROATIA)

Author

Sergio D'Addato, Angelo Parini, J. Kos, Sandra Karanović, Mirjana Fuček, M. Abramovic Baric, D Degli Esposti, Martina Rosticci, Marcella Cagnati, Mario Laganović, Claudio Borghi, Arrigo Fg Cicero, E. Ivandic, D. Grandi, Dunja Rogić, Vanja Ivković, Bojan Jelaković, Stefano Bacchelli, and Ana Lucić Vrdoljak

Subjects
Traditional medicine, Physiology, business.industry, Environmental health, Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Rural population, Prehypertension, Kidney disease
Published
2016
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45. [PP.30.29] PREHYPERTENSION AND SINGLE NUCLEOTIDE POLYMORPHISM RS13333226 OF THE UROMODULIN (UMOD) GENE

Author

Mirjana Fuček, T. Zeljkovic Vrkic, J. Kos, Mario Laganović, L. Gellineo, Sandra Karanović, Livija Šimičević, Dunja Rogić, J. Josipovic, V. Domislovic, Zivka Dika, Jadranka Sertić, K. Dapic, I. Vukovic Brinar, Ana Jelaković, and Bojan Jelaković

Subjects
Genetics, Tamm–Horsfall protein, biology, Physiology, business.industry, Internal Medicine, biology.protein, Medicine, Single-nucleotide polymorphism, Cardiology and Cardiovascular Medicine, business, Gene, Prehypertension
Published
2017
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46. [PP.26.03] CLINICAL SIGNIFICANCE OF MISSLEADING OFFICE BLOOD PRESSURE MEASUREMENTS IN TREATMENT OF HYPERTENSION

Author

Ana Jelaković, Mario Laganović, T. Zeljkovic Vrkic, J. Kos, Sandra Karanović, J. Josipovic, Zivka Dika, Robert Likić, V. Premuzic, Darko Počanić, Bojan Jelaković, V. Domislovic, and K. Dapic

Subjects
medicine.medical_specialty, Blood pressure, Physiology, business.industry, Internal Medicine, Medicine, Clinical significance, Cardiology and Cardiovascular Medicine, business, Intensive care medicine
Published
2017
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47. SP093FAMILIAL LECITHIN-CHOLESTEROL ACYLTRANSFERASE DEFICIENCY: REPORT OF A CASE

Author

Margareta Fištrek Prlić, Sandra Karanović, Laura Calabresi, Mario Laganović, Tajana Zeljkovic Vrkic, Chiara Pavanello, Zivka Dika, Bojan Jelaković, and Marijana Ćorić

Subjects
Transplantation, Lecithin cholesterol acyltransferase deficiency, medicine.medical_specialty, Endocrinology, Nephrology, business.industry, Internal medicine, medicine, medicine.disease, business
Published
2017
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48. TO040ARISTOLACTAM-DNA ADDUCTS ARE A BIOMARKER OF ENVIRONMENTAL EXPOSURE TO ARISTOLOCHIC ACID OUT OF ESTABLISHED ENDEMIC NEPHROPATHY RURAL VILLAGES

Author

Sefik Hasukic, Zelimir Stipancic, Sandra Karanović, Karla Tomić, Arthur P. Grollman, Krešimir Karlović, Krunoslav Jakovina, Josip Samardzic, Branko Brdar, and Bojan Jelaković

Subjects
Transplantation, business.industry, Endemic Nephropathy, Aristolochic acid, Environmental exposure, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Biomarker, 0302 clinical medicine, chemistry, Nephrology, Medicine, 030212 general & internal medicine, business, DNA
Published
2017
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50. Salt intake in the Croatian continental rural population – ENAH study

Author

Mario Laganović, Tajana Željković Vrkić, Lana Gellineo, Josipa Josipović, Mirjana Fuček, Ljiljana Fodor, Ema Ivandić, Josip Čulig, Krešimir Đapić, Vanja Ivković, Ana Jelaković, Vesna Matijević, Bojan Jelaković, Viktor Domislovic, Ivana Vuković Brinar, Jelena Kos, Živka Dika, Sandra Karanović, and Ranko Stevanović

Subjects
Croatian, Geography, Environmental protection, Environmental health, language, Salt intake, Cardiology and Cardiovascular Medicine, Rural population, language.human_language
Published
2017
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