87 results on '"Sanders, J.S."'
Search Results
2. The galaxy group merger origin of the Cloverleaf odd radio circle system
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Bulbul, E., primary, Zhang, X., additional, Kluge, M., additional, Bruggen, M., additional, Koribalski, B., additional, Liu, A., additional, Artis, E., additional, Bahar, Y.E., additional, Balzer, F., additional, Garrel, C., additional, Ghirardini, V., additional, Malavasi, N., additional, Merloni, A., additional, Nandra, K., additional, Ramos-Ceja, M.E., additional, Sanders, J.S., additional, and Zelmer, S., additional
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- 2024
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3. The role of interleukin-21 in COVID-19 vaccine-induced B cell-mediated immune responses in patients with kidney disease and kidney transplant recipients.
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Malahe, S.R.K., Hartog, Y.D., Rietdijk, W.J.R., Baarle, D. van, Kuiper, R. de, Reijerkerk, D., Ras, A.M., Geers, D., Diavatopoulos, D.A., Messchendorp, A.L., Molen, R.G. van der, Remmerswaal, E.B.M., Bemelman, F.J., Gansevoort, R.T., Hilbrands, L.B., Sanders, J.S., GeurtsvanKessel, C.H., Kho, M.M.L., Vries, R.D. de, Reinders, M.E.J., Baan, C.C., Malahe, S.R.K., Hartog, Y.D., Rietdijk, W.J.R., Baarle, D. van, Kuiper, R. de, Reijerkerk, D., Ras, A.M., Geers, D., Diavatopoulos, D.A., Messchendorp, A.L., Molen, R.G. van der, Remmerswaal, E.B.M., Bemelman, F.J., Gansevoort, R.T., Hilbrands, L.B., Sanders, J.S., GeurtsvanKessel, C.H., Kho, M.M.L., Vries, R.D. de, Reinders, M.E.J., and Baan, C.C.
- Abstract
01 september 2023, Contains fulltext : 296138.pdf (Publisher’s version ) (Open Access), T-cell-mediated help to B cells is required for the development of humoral responses, in which the cytokine interleukin (IL)-21 is key. Here, we studied the mRNA-1273 vaccine-induced SARS-CoV-2-specific memory T-cell IL-21 response, memory B cell response, and immunoglobulin (Ig)G antibody levels in peripheral blood at 28 days after the second vaccination by ELISpot and the fluorescent bead-based multiplex immunoassay, respectively. We included 40 patients with chronic kidney disease (CKD), 34 patients on dialysis, 63 kidney transplant recipients (KTR), and 47 controls. We found that KTR, but not patients with CKD and those receiving dialysis, showed a significantly lower number of SARS-CoV-2-specific IL-21 producing T cells than controls (P < .001). KTR and patients with CKD showed lower numbers of SARS-CoV-2-specific IgG-producing memory B cells when compared with controls (P < .001 and P = .01, respectively). The T-cell IL-21 response was positively associated with the SARS-CoV-2-specific B cell response and the SARS-CoV-2 spike S1-specific IgG antibody levels (both Pearson r = 0.5; P < .001). In addition, SARS-CoV-2-specific B cell responses were shown to be IL-21 dependent. Taken together, we show that IL-21 signaling is important in eliciting robust B cell-mediated immune responses in patients with kidney disease and KTR.
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- 2023
4. Hard X-ray emission from the core of the Perseus cluster and the thermal content of the radio bubbles
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Sanders, J.S., Fabian, A.C., Leibundgut, Bruno, editor, Böhringer, H., editor, Pratt, G.W., editor, Finoguenov, A., editor, and Schuecker, P., editor
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- 2007
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5. Heating and Cooling in the Perseus Cluster Core
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Fabian, A.C., Sanders, J.S., Leibundgut, Bruno, editor, Böhringer, H., editor, Pratt, G.W., editor, Finoguenov, A., editor, and Schuecker, P., editor
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- 2007
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6. Combining transplant professional's psychosocial donor evaluation and donor self-report measures to optimise the prediction of HRQoL after kidney donation: an observational prospective multicentre study
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Wirken, G.A.A., Middendorp, H. van, Hooghof, C.W., Sanders, J.S., Dam, R., Pant, K. van der, Wierdsma, J., Wellink, H., Ulrichts, P., Hoitsma, A.J., Hilbrands, L.B., Evers, A.W.M., VU University medical center, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), MUMC+: MA Nefrologie (9), RS: FHML non-thematic output, and Nephrology
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Male ,IMPACT ,nephrology ,LIVING KIDNEY ,Kidney ,FATIGUE ,risk management ,quality in health care ,QUALITY-OF-LIFE ,DIALYSIS ,Living Donors ,Humans ,Prospective Studies ,transplant medicine ,COMPLICATIONS ,General Medicine ,ASSOCIATION ,renal transplantation ,Kidney Transplantation ,SURVIVAL ,Quality of Life ,Female ,Self Report ,Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] ,FOLLOW-UP ,MENTAL-HEALTH ,mental health - Abstract
ObjectivesLiving donor kidney transplantation is currently the preferred treatment for patients with end-stage renal disease. The psychosocial evaluation of kidney donor candidates relies mostly on the clinical viewpoint of transplant professionals because evidence-based guidelines for psychosocial donor eligibility are currently lacking. However, the accuracy of these clinical risk judgements and the potential added value of a systematic self-reported screening procedure are as yet unknown. The current study examined the effectiveness of the psychosocial evaluation by transplant professionals and the potential value of donor self-report measures in optimising the donor evaluation. Based on the stress-vulnerability model, the predictive value of predonation, intradonation and postdonation factors to impaired longer term health-related quality of life (HRQoL) of kidney donors was studied.DesignAn observational prospective multicentre study.SettingSeven Dutch transplantation centres.Participants588 potential donors participated, of whom 361 donated. Complete prospective data of 230 donors were available. Also, 1048 risk estimation questionnaires were completed by healthcare professionals.MethodsTransplant professionals (nephrologists, coordinating nurses, social workers and psychologists) filled in risk estimation questionnaires on kidney donor candidates. Furthermore, 230 kidney donors completed questionnaires (eg, on HRQoL) before and 6 and 12 months after donation.Primary and secondary outcome measuresHRQoL, demographic and preoperative, intraoperative and postoperative health characteristics, perceived support, donor cognitions, recipient functioning and professionals risk estimation questionnaires.ResultsOn top of other predictors, such as the transplant professionals’ risk assessments, donor self-report measures significantly predicted impaired longer term HRQoL after donation, particularly by poorer predonation physical (17%–28% explained variance) and psychological functioning (23%).ConclusionsThe current study endorses the effectiveness of the psychosocial donor evaluation by professionals and the additional value of donor self-report measures in optimising the psychosocial evaluation. Consequently, systematic screening of donors based on the most prominent risk factors provide ground for tailored interventions for donors at risk.
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- 2022
7. Long-term efficacy and safety of SARS-CoV-2 vaccination in patients with chronic kidney disease, on dialysis or after kidney transplantation: a national prospective observational cohort study
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Bouwmans, P., Messchendorp, A.L., Sanders, J.S., Hilbrands, L.B., Reinders, M.E., Vart, P., Gansevoort, R.T., Hemmelder, M.H., Bouwmans, P., Messchendorp, A.L., Sanders, J.S., Hilbrands, L.B., Reinders, M.E., Vart, P., Gansevoort, R.T., and Hemmelder, M.H.
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Item does not contain fulltext
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- 2022
8. Combining transplant professional's psychosocial donor evaluation and donor self-report measures to optimise the prediction of HRQoL after kidney donation: an observational prospective multicentre study
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Wirken, L., Middendorp, H. van, Hooghof, C.W., Sanders, J.S., Dam, R. van, Pant, K. van der, Wierdsma, J., Wellink, H., Ulrichts, P., Hoitsma, A.J., Hilbrands, L.B., Evers, A.W., Wirken, L., Middendorp, H. van, Hooghof, C.W., Sanders, J.S., Dam, R. van, Pant, K. van der, Wierdsma, J., Wellink, H., Ulrichts, P., Hoitsma, A.J., Hilbrands, L.B., and Evers, A.W.
- Abstract
Item does not contain fulltext, OBJECTIVES: Living donor kidney transplantation is currently the preferred treatment for patients with end-stage renal disease. The psychosocial evaluation of kidney donor candidates relies mostly on the clinical viewpoint of transplant professionals because evidence-based guidelines for psychosocial donor eligibility are currently lacking. However, the accuracy of these clinical risk judgements and the potential added value of a systematic self-reported screening procedure are as yet unknown. The current study examined the effectiveness of the psychosocial evaluation by transplant professionals and the potential value of donor self-report measures in optimising the donor evaluation. Based on the stress-vulnerability model, the predictive value of predonation, intradonation and postdonation factors to impaired longer term health-related quality of life (HRQoL) of kidney donors was studied. DESIGN: An observational prospective multicentre study. SETTING: Seven Dutch transplantation centres. PARTICIPANTS: 588 potential donors participated, of whom 361 donated. Complete prospective data of 230 donors were available. Also, 1048 risk estimation questionnaires were completed by healthcare professionals. METHODS: Transplant professionals (nephrologists, coordinating nurses, social workers and psychologists) filled in risk estimation questionnaires on kidney donor candidates. Furthermore, 230 kidney donors completed questionnaires (eg, on HRQoL) before and 6 and 12 months after donation. PRIMARY AND SECONDARY OUTCOME MEASURES: HRQoL, demographic and preoperative, intraoperative and postoperative health characteristics, perceived support, donor cognitions, recipient functioning and professionals risk estimation questionnaires. RESULTS: On top of other predictors, such as the transplant professionals' risk assessments, donor self-report measures significantly predicted impaired longer term HRQoL after donation, particularly by poorer predonation physical (17%-28% explained va
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- 2022
9. SARS-CoV-2 Spike-specific IFN-gamma T-cell Response After COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant
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Imhof, C., Lianne Messchendorp, A., Heiden, Marieke van der, Baan, Carla C., Molen, R.G. van der, Remmerswaal, E.B.M., Diavatopoulos, D.A., Hilbrands, L.B., Sanders, J.S., Baarle, Debbie van, Imhof, C., Lianne Messchendorp, A., Heiden, Marieke van der, Baan, Carla C., Molen, R.G. van der, Remmerswaal, E.B.M., Diavatopoulos, D.A., Hilbrands, L.B., Sanders, J.S., and Baarle, Debbie van
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Item does not contain fulltext
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- 2022
10. Turbulent heating in galaxy clusters brightest in X-rays
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Zhuravleva, I., Churazov, E., Schekochihin, A.A., Allen, S.W., Arevalo, P., Fabian, A.C., Forman, W.R., Sanders, J.S., Simionescu, A., Sunyaev, R., Vikhlinin, A., and Werner, N.
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X-rays -- Analysis -- Properties -- Research ,Galaxies -- Clusters ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
The hot ([10.sup.7] to [10.sup.8] kelvin), X-ray-emitting intracluster medium (ICM) is the dominant baryonic constituent of clusters of galaxies. In the cores of many clusters, radiative energy losses from the ICM occur on timescales much shorter than the age of the system (1-3).Unchecked, this cooling would lead to massive accumulations of cold gas and vigorous star formation (4), in contradiction to observations (5). Various sources of energy capable of compensating for these cooling losses have been proposed, the most promising being heating by the super-massive black holes in the central galaxies, through inflation of bubbles of relativistic plasma (6-9). Regardless of the original source of energy, the question of how this energy is transferred to the ICM remains open. Here we present a plausible solution to this question based on deep X-ray data and a new data analysis method that enable us to evaluate directly the ICM heating rate from the dissipation of turbulence. We find that turbulent heating is sufficient to offset radiative cooling and indeed appears to balance it locally at each radius--it may therefore be the key element in resolving the gas cooling problem in cluster cores and, more universally, in the atmospheres of X-ray-emitting, gas-rich systems on scales from galaxy clusters to groups and elliptical galaxies., Perseus and Virgo (also known as M87) are well-studied, nearby, cool-core clusters of galaxies in which the central cooling times, owing to the emission of X-rays, are an order of [...]
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- 2014
11. Tracing Gas Motions in the Centaurus Cluster
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Graham, J., Fabian, A.C., Sanders, J.S., Morris, R.G., Leibundgut, Bruno, editor, Aschenbach, B., editor, Burwitz, V., editor, Hasinger, G., editor, and Leibundgut, B., editor
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- 2007
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12. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation
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Peereboom, E.T.M., Matern, B.M., Tomosugi, T., Niemann, M., Drylewicz, J., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Reekum, F.E. van, Verhaar, M.C., Kamburova, E.G., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, A., Lardy, N.M., Swelsen, W., Pant, Karlijn A.M.I. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Vries, A.P.J de, Fijter, J.W. de, Betjes, M. G. H., Roelen, D.L., Claas, F.H.J., Otten, H.G., Heidt, S., Zuilen, A.D. van, Kobayashi, T., Geneugelijk, K., Spierings, E, Peereboom, E.T.M., Matern, B.M., Tomosugi, T., Niemann, M., Drylewicz, J., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Reekum, F.E. van, Verhaar, M.C., Kamburova, E.G., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, A., Lardy, N.M., Swelsen, W., Pant, Karlijn A.M.I. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Vries, A.P.J de, Fijter, J.W. de, Betjes, M. G. H., Roelen, D.L., Claas, F.H.J., Otten, H.G., Heidt, S., Zuilen, A.D. van, Kobayashi, T., Geneugelijk, K., and Spierings, E
- Abstract
Contains fulltext : 241482.pdf (Publisher’s version ) (Open Access), CD4(+) T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft. CD4(+) memory T-helper cells from a previous immunizing event can potentially be reactivated by exposure to HLA mismatches that share T-cell epitopes with the initial immunizing HLA. Consequently, reactivity of CD4(+) memory T-helper cells toward T-cell epitopes that are shared between immunizing HLA and donor HLA could increase the risk of alloimmunity following transplantation, thus affecting transplant outcome. In this study, the amount of T-cell epitopes shared between immunizing and donor HLA was used as a surrogate marker to evaluate the effect of donor-reactive CD4(+) memory T-helper cells on the 10-year risk of death-censored kidney graft failure in 190 donor/recipient combinations using the PIRCHE-II algorithm. The T-cell epitopes of the initial theoretical immunizing HLA and the donor HLA were estimated and the number of shared PIRCHE-II epitopes was calculated. We show that the natural logarithm-transformed PIRCHE-II overlap score, or Shared T-cell EPitopes (STEP) score, significantly associates with the 10-year risk of death-censored kidney graft failure, suggesting that the presence of pre-transplant donor-reactive CD4(+) memory T-helper cells might be a strong indicator for the risk of graft failure following kidney transplantation.
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- 2021
13. Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients
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Boer, S de, Sanders, J.S., Bemelman, F.J., Betjes, M. G. H., Burgerhof, J.G.M., Hilbrands, L.B., Hesselink, D.A., Berger, S.P., Boer, S de, Sanders, J.S., Bemelman, F.J., Betjes, M. G. H., Burgerhof, J.G.M., Hilbrands, L.B., Hesselink, D.A., and Berger, S.P.
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Contains fulltext : 245104.pdf (Publisher’s version ) (Open Access)
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- 2021
14. Probing the non-thermal emission in the Perseus cluster with the JVLA
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Gendron-Marsolais, M., Hlavacek-Larrondo, J., Weeren, R.J. van, Clarke, T., Fabian, A.C., Intema, H.T., Taylor, G.B., Blundell, K.M., Sanders, J.S., Asada, K., de Gouveia Dal Pino, E., Giroletti, M., Nagai, H., and Nemmen, R.
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Very large array ,Physics ,education.field_of_study ,010504 meteorology & atmospheric sciences ,Astrophysics::High Energy Astrophysical Phenomena ,Perseus Cluster ,Population ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Thermal emission ,Astrophysics ,01 natural sciences ,Jansky ,Radio relics ,Space and Planetary Science ,0103 physical sciences ,Cluster (physics) ,Radio frequency ,education ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,0105 earth and related environmental sciences - Abstract
We present deep low radio frequency (230-470 MHz) observations from the Karl G. Jansky Very Large Array of the Perseus cluster, probing the non-thermal emission from the old particle population of the AGN outflows. Our observations of this nearby relaxed cool core cluster have revealed a multitude of new structures associated with the mini-halo, extending to hundreds of kpc in size. Its irregular morphology seems to have been influenced both by the AGN activity and by the sloshing motion of the cluster’ gas. In addition, it has a filamentary structure similar to that seen in radio relics found in merging clusters. These results illustrate the high-quality images that can be obtained with the new JVLA at low radio-frequencies.
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- 2018
15. SUN-300 NON-INVASIVE QUANTIFICATION OF COLLAGEN VI DEPOSITION IN KIDNEY TRANSPLANT RECIPIENTS: A POST-HOC ANALYSES OF THE MECANO TRIAL
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RASMUSSEN, D., primary, Sotomayor G, C., additional, Yepes-Calderón, M., additional, Velde-Keyzer, C.A.T., additional, van Londen, M., additional, van Dijk, M., additional, Berger, S.P., additional, Genovese, F., additional, Karsdal Asser, M., additional, Bakker, S.J.L., additional, Sanders, J.S., additional, and Born van den, J., additional
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- 2020
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16. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients
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Heidt, S., Haasnoot, G.W., Witvliet, M.D., Linden-van Oevelen, M.J.H. van der, Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, K. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Otten, H.G., Roelen, D.L., Claas, F.H., Heidt, S., Haasnoot, G.W., Witvliet, M.D., Linden-van Oevelen, M.J.H. van der, Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, K. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Otten, H.G., Roelen, D.L., and Claas, F.H.
- Abstract
Contains fulltext : 208426.pdf (publisher's version ) (Open Access), Whereas regular allocation avoids unacceptable mismatches on the donor organ, allocation to highly sensitized patients within the Eurotransplant Acceptable Mismatch (AM) program is based on the patient's HLA phenotype plus acceptable antigens. These are HLA antigens to which the patient never made antibodies, as determined by extensive laboratory testing. AM patients have superior long-term graft survival compared with highly sensitized patients in regular allocation. Here, we questioned whether the AM program also results in lower rejection rates. From the PROCARE cohort, consisting of all Dutch kidney transplants in 1995-2005, we selected deceased donor single transplants with a minimum of 1 HLA mismatch and determined the cumulative 6-month rejection incidence for patients in AM or regular allocation. Additionally, we determined the effect of minimal matching criteria of 1 HLA-B plus 1 HLA-DR, or 2 HLA-DR antigens on rejection incidence. AM patients showed significantly lower rejection rates than highly immunized patients in regular allocation, comparable to nonsensitized patients, independent of other risk factors for rejection. In contrast to highly sensitized patients in regular allocation, minimal matching criteria did not affect rejection rates in AM patients. Allocation based on acceptable antigens leads to relatively low-risk transplants for highly sensitized patients with rejection rates similar to those of nonimmunized individuals.
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- 2019
17. Antibodies against ARHGDIB are associated with long-term kidney graft loss
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Kamburova, E.G., Gruijters, M.L., Kardol-Hoefnagel, T., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A., Plaisier, L., Melchers, R.C., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, K. van der, Weerd, N.C. van der, Berge, I.J. Ten, Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., Bemelman, F.J., Otten, H.G., Kamburova, E.G., Gruijters, M.L., Kardol-Hoefnagel, T., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A., Plaisier, L., Melchers, R.C., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, K. van der, Weerd, N.C. van der, Berge, I.J. Ten, Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., Bemelman, F.J., and Otten, H.G.
- Abstract
Contains fulltext : 215571.pdf (publisher's version ) (Open Access), The clinical significance of non-HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large-scale studies incorporating analysis of multiple non-HLA antibodies simultaneously. We developed a multiplex non-HLA antibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non-HLA antibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP-dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased-donor kidney (N = 3276) but not in recipients of a living-donor kidney (N = 1496). At 10 years after deceased-donor transplantation, recipients with anti-ARHGDIB antibodies (94/3276 = 2.9%) had a 13% lower death-censored covariate-adjusted graft survival compared to the anti-ARHGDIB-negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32-2.53; P = .0003). These antibodies occur independently from donor-specific anti-HLA antibodies (DSA) or other non-HLA antibodies investigated. No significant relations with graft loss were found for the other 13 non-HLA antibodies. We suggest that pretransplant risk assessment can be improved by measuring anti-ARHGDIB antibodies in all patients awaiting deceased-donor transplantation.
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- 2019
18. A deep Chandra observation of 3C294
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Crawford, C.S., Fabian, A.C., Sanders, J.S., and Ettori, S.
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- 2003
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19. Magnetic support of the optical emission line filaments in NGC 1275
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Fabian, A.C., Johnstone, R.M., Sanders, J.S., Conselice, C.J., Crawford, C.S., Gallagher, III, J.S., and Zweibel, E.
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Telescope -- Usage ,Galaxies -- Observations -- Usage -- Research ,Acceleration (Mechanics) -- Research -- Usage ,Magnetic fields -- Research -- Usage ,Environmental issues ,Science and technology ,Zoology and wildlife conservation ,Observations ,Usage ,Research - Abstract
The giant elliptical galaxy NGC 1275, at the centre of the Perseus cluster, is surrounded by a well-known giant nebulosity of emission line filaments (1,2), which are plausibly in excess [...]
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- 2008
20. Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure
- Author
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Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A.C., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M.A., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, Karlijn A.M.I. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A.J., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., Otten, H.G., Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Drop, A.C., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M.A., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, S.A., Lardy, N.M., Swelsen, W., Pant, Karlijn A.M.I. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A.J., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., and Otten, H.G.
- Abstract
Item does not contain fulltext
- Published
- 2018
21. Magnetic Fields in the Center of the Perseus Cluster
- Author
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Taylor, G.B., primary, Gugliucci, N.E., additional, Fabian, A.C., additional, Sanders, J.S., additional, Gentile, Gianfranco, additional, and Allen, S.W., additional
- Published
- 2006
- Full Text
- View/download PDF
22. Tracing Gas Motions in the Centaurus Cluster
- Author
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Graham, James, primary, Fabian, A.C., additional, Sanders, J.S., additional, and Morris, R.G., additional
- Published
- 2006
- Full Text
- View/download PDF
23. OP0047 Circulating cd24hicd38hi regulatory b cells influence th17 cell responses in patients with anca-associated vasculitides
- Author
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von Borstel, A., primary, Lintermans, L.L., additional, Heeringa, P., additional, Rutgers, A., additional, Stegeman, C.A., additional, Sanders, J.S., additional, and Abdulahad, W.H., additional
- Published
- 2018
- Full Text
- View/download PDF
24. 7.1 keV sterile neutrino constraints from X-ray observations of 33 clusters of galaxies with Chandra ACIS
- Author
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Hofmann, F., Sanders, J.S., Nandra, K., Clerc, N., Gaspari, M., and Sanders, J.
- Subjects
Sterile neutrino ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,Astrophysics::High Energy Astrophysical Phenomena ,Dark matter ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Spectral line ,0103 physical sciences ,Cluster (physics) ,Emission spectrum ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,biology ,010308 nuclear & particles physics ,X-ray ,Astronomy and Astrophysics ,biology.organism_classification ,Acis ,Galaxy ,Space and Planetary Science ,High Energy Physics::Experiment ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Recently an unidentified emission line at 3.55 keV has been detected in X-ray spectra of clusters of galaxies. The line has been discussed as a possible decay signature of 7.1 keV sterile neutrinos, which have been proposed as a dark matter candidate. We aim at putting constraints on the proposed line emission in a large sample of Chandra-observed clusters and obtain limits on the mixing-angle in a 7.1 keV sterile neutrino dark matter scenario. For a sample of 33 high-mass clusters of galaxies we merge all observations from the Chandra data archive. Each cluster has more than 100 ks of combined exposure. The resulting high signal-to-noise spectra are used to constrain the flux of an unidentified line emission at 3.55 keV in the individual spectra and a merged spectrum of all clusters. We obtained very detailed spectra around the 3.55 keV range and limits on an unidentified emission line. Assuming all dark matter were made of 7.1 keV sterile neutrinos the upper limits on the mixing angle are $\rm{sin^2(2��)}$ $\rm{, 20 pages, 6 figures, accepted for publication in A&A
- Published
- 2016
25. High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey
- Author
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Assfalg, V., Huser, N., Meel, M. van, Haller, B., Rahmel, A., Boer, J. den, Matevossian, E., Novotny, A., Knops, N., Weekers, L., Friess, H., Pratschke, J., Fugger, R., Janko, O., Rasoul-Rockenschaub, S., Bosmans, J.L., Broeders, N., Peeters, P., Mourad, M., Kuypers, D., Slavicek, J., Muehlfeld, A., Sommer, F., Viebahn, R., Pascher, A., Giet, M. van der, Zantvoort, F., Woitas, R.P., Putz, J., Grabitz, K., Kribben, A., Hauser, I., Pisarski, P., Weimer, R., Lorf, T., Fornara, P., Morath, C., Nashan, B., Lehner, F., Kliem, V., Sester, U., Grimm, M.O., Feldkamp, T., Kleinert, R., Arns, W., Monch, C., Schoenberg, M.B., Nitschke, M., Kruger, B., Thorban, S., Arbogast, H.P., Wolters, H.H., Maier, T., Lutz, J., Heller, K., Banas, B., Hakenberg, O., Kalus, M., Nadalin, S., Keller, F., Lopau, K., Bemelman, F.J., Nurmohamed, S., Sanders, J.S., Fijter, J.W. de, Christiaans, M., Hilbrands, L.B., Betjes, M., Zuilen, A. van, Heemann, U., Assfalg, V., Huser, N., Meel, M. van, Haller, B., Rahmel, A., Boer, J. den, Matevossian, E., Novotny, A., Knops, N., Weekers, L., Friess, H., Pratschke, J., Fugger, R., Janko, O., Rasoul-Rockenschaub, S., Bosmans, J.L., Broeders, N., Peeters, P., Mourad, M., Kuypers, D., Slavicek, J., Muehlfeld, A., Sommer, F., Viebahn, R., Pascher, A., Giet, M. van der, Zantvoort, F., Woitas, R.P., Putz, J., Grabitz, K., Kribben, A., Hauser, I., Pisarski, P., Weimer, R., Lorf, T., Fornara, P., Morath, C., Nashan, B., Lehner, F., Kliem, V., Sester, U., Grimm, M.O., Feldkamp, T., Kleinert, R., Arns, W., Monch, C., Schoenberg, M.B., Nitschke, M., Kruger, B., Thorban, S., Arbogast, H.P., Wolters, H.H., Maier, T., Lutz, J., Heller, K., Banas, B., Hakenberg, O., Kalus, M., Nadalin, S., Keller, F., Lopau, K., Bemelman, F.J., Nurmohamed, S., Sanders, J.S., Fijter, J.W. de, Christiaans, M., Hilbrands, L.B., Betjes, M., Zuilen, A. van, and Heemann, U.
- Abstract
Item does not contain fulltext, BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on the outcomes of HU transplantation are sparse and the benefit is controversial. METHODS: We systematically analysed data from 898 ET HU kidney transplant recipients from 61 transplant centres between 1996 and 2010 and investigated the 5-year patient and graft outcomes and differences between relevant subgroups. RESULTS: Kidney recipients with an HU status were younger (median 43 versus 55 years) and spent less time on the waiting list compared with non-HU recipients (34 versus 54 months). They received grafts with significantly more mismatches (mean 3.79 versus 2.42; P < 0.001) and the percentage of retransplantations was remarkably higher (37.5 versus 16.7%). Patient survival (P = 0.0053) and death with a functioning graft (DwFG; P < 0.0001) after HU transplantation were significantly worse than in non-HU recipients, whereas graft outcome was comparable (P = 0.094). Analysis according to the different HU indications revealed that recipients listed HU because of an imminent lack of access for dialysis had a significantly worse patient survival (P = 0.0053) and DwFG (P = 0.0462) compared with recipients with psychological problems and suicidality because of dialysis. In addition, retransplantation had a negative impact on patient and graft outcome. CONCLUSIONS: Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis.
- Published
- 2016
26. How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?
- Author
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Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M., Bots, M.L., Drop, A.C., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Vanderlocht, J., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, A., Lardy, N.M., Swelsen, W., Pant, K.A. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., Otten, H.G., Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., Reekum, F.E. van, Zuilen, A.D. van, Verhaar, M., Bots, M.L., Drop, A.C., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Vanderlocht, J., Voorter, C.E.M., Wieten, L., Duijnhoven, E.M. van, Gelens, M., Christiaans, M.H., Ittersum, F.J. van, Nurmohamed, A., Lardy, N.M., Swelsen, W., Pant, K.A. van der, Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A., Boog, P.J. van der, Fijter, J.W. de, Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., and Otten, H.G.
- Abstract
Item does not contain fulltext, Solid-phase multiplex-bead assays are widely used in transplantation to detect anti-human leukocyte antigen (HLA) antibodies. These assays enable high resolution detection of low levels of HLA antibodies. However, multiplex-bead assays are costly and yield variable measurements that limit the comparison of results between laboratories. In the context of a Dutch national Consortium study we aimed to determine the inter-assay and inter-machine variability of multiplex-bead assays, and we assessed how to reduce the assay reagents costs. Fifteen sera containing a variety of HLA antibodies were used yielding in total 7092 median fluorescence intensities (MFI) values. The inter-assay and inter-machine mean absolute relative differences (MARD) of the screening assay were 12% and 13%, respectively. The single antigen bead (SAB) inter-assay MARD was comparable, but showed a higher lot-to-lot variability. Reduction of screening assay reagents to 50% or 40% of manufacturers' recommendations resulted in MFI values comparable to 100% of the reagents, with an MARD of 12% or 14%, respectively. The MARD of the 50% and 40% SAB assay reagent reductions were 11% and 22%, respectively. From this study, we conclude that the reagents can be reliably reduced at least to 50% of manufacturers' recommendations with virtually no differences in HLA antibody assignments.
- Published
- 2016
27. Marine Protected Areas. Country Case Studies on Policy, Governance and Institutional Issues. Japan-Mauritania-Philippines-Samoa
- Author
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Sanders, J.S, Gréboval, D., Hjort, A., comps, Sanders, J.S, Gréboval, D., and Hjort, A., comps
- Subjects
- Marine parks and reserves--Government policy, Marine parks and reserves--Government policy--Japan, Marine parks and reserves--Government policy--Mauritania, Marine parks and reserves--Government policy--Philippines, Marine parks and reserves--Government policy--Samoa
- Abstract
This document presents case studies of the policy, governance and institutional issues of marine protected areas in Japan, Mauritania, the Philippines and Samoa. It is the second of four in a global series of case studies on MPAs. The set of global MPA case studies was designed to close a deficit in information on the governance of MPAs and spatial management tools, within both fisheries management and biodiversity conservation contexts.
- Published
- 2013
28. Chandra observation of two shock fronts in the merging galaxy cluster Abell 2146
- Author
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Russell, H.R., Sanders, J.S., Fabian, A.C., Baum, S.A., Donahue, M., Edge, A.C., McNamara, B.R., and O'Dea, C.P.
- Subjects
Clusters ,X-rays ,Astrophysics::High Energy Astrophysical Phenomena ,Abell 2146 ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Galaxies ,Astrophysics::Galaxy Astrophysics ,Intergalactic medium - Abstract
We present a new Chandra observation of the galaxy cluster Abell 2146 which has revealed a complex merging system with a gas structure that is remarkably similar to the Bullet cluster. The X-ray image and temperature map show a cool 2 –3 keV subcluster with a ram pressure stripped tail of gas just exiting the disrupted 6 − 7 keV primary cluster. From the sharp jump in the temperature and density of the gas, we determine that the subcluster is preceded by a bow shock with a Mach number M= 2.2 ± 0.8, corresponding to a velocity v= 2200+1000−900 km s−1 relative to the main cluster. We estimate that the subcluster passed through the primary core only 0.1 –0.3 Gyr ago. In addition, we observe a slower upstream shock propagating through the outer region of the primary cluster and calculate a Mach number M= 1.7 ± 0.3. Based on the measured shock Mach numbers M∼ 2 and the strength of the upstream shock, we argue that the mass ratio between the two merging clusters is between 3 and 4 to one. By comparing the Chandra observation with an archival Hubble Space Telescope observation, we find that a group of galaxies is located in front of the X-ray subcluster core but the brightest cluster galaxy is located immediately behind the X-ray peak.
- Published
- 2010
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29. Sunyaev-Zel'dovich observation of the Bullet-like cluster Abell 2146 with the Arcminute Microkelvin Imager
- Author
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Rodriguez-Gonzalvez, C., Olamaie, M., Davies, M.L., Fabian, A.C., Feroz, F., Franzen, T.M.O., Grainge, K.J.B., Hobson, M.P., Hurley-Walker, N., Lasenby, A.N., Pooley, G.G., Russell, H.R., Sanders, J.S., Saunders, R.D.E., Scaife, A.M.M., Schammel, M.P., Scott, P.F., Shimwell, T.W., Titterington, D.J., Waldram, E.M., and Zwart, J.T.L.
- Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present 13.9-18.2 GHz observations of the Sunyaev-Zel'dovich (SZ) effect towards Abell 2146 using the Arcminute Microkelvin Imager (AMI). The cluster is detected with a peak SNR ratio of 13 sigma in the radio source subtracted map. Comparison of the SZ and X-ray images suggests that they both have extended regions which lie approximately perpendicular to one another, with their emission peaks significantly displaced. These features indicate non-uniformities in the distributions of the gas temperature and pressure, indicative of a cluster merger. We use a Bayesian cluster analysis to explore the high-dimensional parameter space of the cluster-plus-sources model to obtain cluster parameter estimates in the presence of radio point sources, receiver noise and primordial CMB anisotropy; the probability of SZ + CMB primordial structure + radio sources + receiver noise to CMB + radio sources + receiver noise is 3 x 10^{6}:1. We compare the results from three different cluster models. Our preferred model exploits the observation that the gas fractions do not appear to vary greatly between clusters. Given the relative masses of the two merging systems in Abell 2146, the mean gas temperature can be deduced from the virial theorem (assuming all of the kinetic energy is in the form of internal gas energy) without being affected significantly by the merger event, provided the primary cluster was virialized before the merger. In this model we fit a simple spherical isothermal beta-model, despite the inadequacy of this model for a merging system like Abell 2146, and assume the cluster follows the mass-temperature relation of a virialized, singular, isothermal sphere. We note that this model avoids inferring large-scale cluster parameters internal to r_200 under the widely used assumption of hydrostatic equilibrium. We find that at r_200 M_T= 4.1 \pm 0.5 x 10^{14} h^{-1}M_sun and T=4.5 \pm 0.5 keV., Comment: 14 pages, 15 figures, 7 tables
- Published
- 2010
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30. The PROCARE consortium: Toward an improved allocation strategy for kidney allografts
- Author
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Otten, H.G., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M., Spierings, E., Hack, C.E., Reekum, F. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G.J., Vanderlocht, J., Voorter, C.E.M., Wieten, L., Duijnhoven, E. van, Gelens, M., Christiaans, M., Ittersum, F. van, Nurmohamed, A., Lardy, N.M., Swelsen, W.T., Donselaar-van Pant, K.A., Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A.J., Fijter, J.W. de, Betjes, M.G., Roelen, D.L., Claas, F.H., Otten, H.G., Joosten, I., Allebes, W.A., Meer, A. van der, Hilbrands, L.B., Baas, M., Spierings, E., Hack, C.E., Reekum, F. van, Zuilen, A.D. van, Verhaar, M.C., Bots, M.L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G.J., Vanderlocht, J., Voorter, C.E.M., Wieten, L., Duijnhoven, E. van, Gelens, M., Christiaans, M., Ittersum, F. van, Nurmohamed, A., Lardy, N.M., Swelsen, W.T., Donselaar-van Pant, K.A., Weerd, N.C. van der, Berge, I.J. Ten, Bemelman, F.J., Hoitsma, A.J., Fijter, J.W. de, Betjes, M.G., Roelen, D.L., and Claas, F.H.
- Abstract
Item does not contain fulltext, Kidney transplantation is the best treatment option for patients with end-stage renal failure. At present, approximately 800 Dutch patients are registered on the active waiting list of Eurotransplant. The waiting time in the Netherlands for a kidney from a deceased donor is on average between 3 and 4years. During this period, patients are fully dependent on dialysis, which replaces only partly the renal function, whereas the quality of life is limited. Mortality among patients on the waiting list is high. In order to increase the number of kidney donors, several initiatives have been undertaken by the Dutch Kidney Foundation including national calls for donor registration and providing information on organ donation and kidney transplantation. The aim of the national PROCARE consortium is to develop improved matching algorithms that will lead to a prolonged survival of transplanted donor kidneys and a reduced HLA immunization. The latter will positively affect the waiting time for a retransplantation. The present algorithm for allocation is among others based on matching for HLA antigens, which were originally defined by antibodies using serological typing techniques. However, several studies suggest that this algorithm needs adaptation and that other immune parameters which are currently not included may assist in improving graft survival rates. We will employ a multicenter-based evaluation on 5429 patients transplanted between 1995 and 2005 in the Netherlands. The association between key clinical endpoints and selected laboratory defined parameters will be examined, including Luminex-defined HLA antibody specificities, T and B cell epitopes recognized on the mismatched HLA antigens, non-HLA antibodies, and also polymorphisms in complement and Fc receptors functionally associated with effector functions of anti-graft antibodies. From these data, key parameters determining the success of kidney transplantation will be identified which will lead to the identification
- Published
- 2014
31. Tracing Gas Motions in the Centaurus Cluster
- Author
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Graham, J., primary, Fabian, A.C., additional, Sanders, J.S., additional, and Morris, R.G., additional
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32. The effect of CYP3A4*22, CYP3A5*3 and CYP3A combined genotypes on cyclosporine, everolimus and tacrolimus pharmacokinetics in renal transplant recipients
- Author
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D.J.A.R., Moes, primary, Swen, J.J., additional, den Hartigh, J., additional, van der Straaten, T., additional, Homan van der Heide, J.J., additional, Sanders, J.S., additional, Bemelman, F.J., additional, de Fijter, J.W., additional, and Guchelaar, H.-J., additional
- Published
- 2014
- Full Text
- View/download PDF
33. Effect of a single intraoperative high-dose ATG-Fresenius on delayed graft function in donation after cardiac-death donor renal allograft recipients: a randomized study
- Author
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Hoogen, M.W.F. van den, Kho, M.M., Abrahams, A.C., Zuilen, A.D. van, Sanders, J.S., Dijk, M., Hilbrands, L.B., Weimar, W., Hoitsma, A.J., Hoogen, M.W.F. van den, Kho, M.M., Abrahams, A.C., Zuilen, A.D. van, Sanders, J.S., Dijk, M., Hilbrands, L.B., Weimar, W., and Hoitsma, A.J.
- Abstract
Item does not contain fulltext, OBJECTIVES: Reducing the incidence of delayed graft function after transplant with donation after cardiac death donor renal allografts would facilitate managing recipients during their first weeks after a transplant. To reduce this incidence, in most studies, induction therapy with depleting anti-T-lymphocyte antibodies is coupled with a reduction of the dosage of the calcineurin inhibitor. The separate effect of anti-T-cell therapy on the incidence and duration of delayed graft function is therefore difficult to assess. PATIENTS AND METHODS: We performed a randomized study to evaluate the effect of a single intraoperative high-dose of anti-T-lymphocyte immunoglobulin (ATG)-Fresenius (9 mg/kg body weight) on the incidence of delayed graft function. Eligible adult recipients of a first donation after cardiac death donor renal allograft were randomly assigned to ATG-Fresenius or no induction therapy. Maintenance immunosuppression consisted of tacrolimus, in an unadjusted dose, mycophenolate mofetil, and steroids. RESULTS: The study was prematurely terminated because of a lower-than-anticipated inclusion rate. Baseline characteristics were comparable in the ATG-Fresenius group (n=28) and the control group (n=24). Twenty-two patients in the ATG-Fresenius group (79%) had delayed graft function, compared with 13 in the control group (54%; P = .06). Allograft and patient survival were comparable in both groups. Serious adverse events occurred more frequently in the ATG-Fresenius group than they did in the control group (57% vs 29%; P < .05). CONCLUSIONS: Intraoperative administration of a single high-dose of ATG-Fresenius in donation after cardiac death donor renal allograft recipients, followed by triple immunosuppression with an unadjusted tacrolimus dose, seems ineffective to reduce the incidence of delayed graft function. Moreover, this was associated with a higher rate of serious adverse events (EudraCT-number, 2007-000210-36.).
- Published
- 2013
34. Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19
- Author
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Bredrup, C., Saunier, S., Oud, M.M., Fiskerstrand, T., Hoischen, A., Brackman, D., Leh, S.M., Midtbo, M., Filhol, E., Bole-Feysot, C., Nitschke, P., Gilissen, C.F.H.A., Haugen, O.H., Sanders, J.S., Stolte-Dijkstra, I., Mans, D.A., Steenbergen, E., Hamel, B.C.J., Matignon, M., Pfundt, R., Jeanpierre, C., Boman, H., Rodahl, E., Veltman, J.A., Knappskog, P.M., Knoers, N.V.A.M., Roepman, R., Arts, H.H., Bredrup, C., Saunier, S., Oud, M.M., Fiskerstrand, T., Hoischen, A., Brackman, D., Leh, S.M., Midtbo, M., Filhol, E., Bole-Feysot, C., Nitschke, P., Gilissen, C.F.H.A., Haugen, O.H., Sanders, J.S., Stolte-Dijkstra, I., Mans, D.A., Steenbergen, E., Hamel, B.C.J., Matignon, M., Pfundt, R., Jeanpierre, C., Boman, H., Rodahl, E., Veltman, J.A., Knappskog, P.M., Knoers, N.V.A.M., Roepman, R., and Arts, H.H.
- Abstract
Item does not contain fulltext, A subset of ciliopathies, including Sensenbrenner, Jeune, and short-rib polydactyly syndromes are characterized by skeletal anomalies accompanied by multiorgan defects such as chronic renal failure and retinitis pigmentosa. Through exome sequencing we identified compound heterozygous mutations in WDR19 in a Norwegian family with Sensenbrenner syndrome. In a Dutch family with the clinically overlapping Jeune syndrome, a homozygous missense mutation in the same gene was found. Both families displayed a nephronophthisis-like nephropathy. Independently, we also identified compound heterozygous WDR19 mutations by exome sequencing in a Moroccan family with isolated nephronophthisis. WDR19 encodes IFT144, a member of the intraflagellar transport (IFT) complex A that drives retrograde ciliary transport. We show that IFT144 is absent from the cilia of fibroblasts from one of the Sensenbrenner patients and that ciliary abundance and morphology is perturbed, demonstrating the ciliary pathogenesis. Our results suggest that isolated nephronophthisis, Jeune, and Sensenbrenner syndromes are clinically overlapping disorders that can result from a similar molecular cause.
- Published
- 2011
35. Randomized clinical trial of extended versus standard azathioprine maintenance therapy in newly diagnosed PR3-ANCA positive vasculitis patients at high-risk for disease relapse
- Author
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De Joode, A.A.E., primary, Sanders, J.S., additional, Cohen Tervaert, J.W., additional, and Stegeman, C.A., additional
- Published
- 2013
- Full Text
- View/download PDF
36. Premature ovarian failure in women with ANCA-associated vasculitis
- Author
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Tuin, J., primary, Sanders, J.S., additional, Hoek, A., additional, and Stegeman, C.A., additional
- Published
- 2013
- Full Text
- View/download PDF
37. Co-trimoxazole monotherapy as induction therapy for localized granulomatosis with polyangiitis
- Author
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Tuin, J., primary, Sanders, J.S., additional, and Stegeman, C.A., additional
- Published
- 2013
- Full Text
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38. Hard X-ray emission from the core of the Perseus cluster and the thermal content of the radio bubbles.
- Author
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Leibundgut, Bruno, Böhringer, H., Pratt, G.W., Finoguenov, A., Schuecker, P., Sanders, J.S., and Fabian, A.C.
- Abstract
We use a very deep 900 ks Chandra X-ray observation of the core of the Perseus cluster to measure and confirm the hard X-ray emission detected from a previous analysis. By fitting a model made up of multiple temperature components plus a powerlaw or hot thermal component, we map the spatial distribution of the hard flux. We confirm there is a strong hard excess within the central regions. The total luminosity in the 2-10 keV band inside 3 arcmin radius is ∼ 5X1043 erg s-1. As a second project we place limits on the thermal gas content of the X-ray cavities in the cluster core. This is done by fitting a model made up of multiple components to spectra from inside and outside of the bubbles, and looking at the the difference in strength of a component at a particular temperature. This approach avoids assumptions about the geometry of the core of the cluster. Only up to 50 per cent of the volume of the cavities can be filled with thermal gas with a temperature of 50 keV. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
39. Heating and Cooling in the Perseus Cluster Core.
- Author
-
Leibundgut, Bruno, Böhringer, H., Pratt, G.W., Finoguenov, A., Schuecker, P., Fabian, A.C., and Sanders, J.S.
- Published
- 2007
- Full Text
- View/download PDF
40. Spatially resolved X-ray spectroscopy of the core of the Centaurus cluster.
- Author
-
Sanders, J.S. and Fabian, A.C.
- Subjects
- *
STAR clusters , *X-ray spectroscopy - Abstract
We present Chandra data from a 31.7-ks observation of the Centaurus cluster, using the ACIS-S detector. Images of the X-ray emission show a plume-like feature at the centre of the cluster, of extent 60 arcsec (20 kpc in projection). The feature has the same metallicity as gas at a similar radius, but is cooler. Using adaptive binning, we generate temperature, abundance and absorption maps of the cluster core. The radial abundance profile shows that the previously known, steep abundance gradient peaks with a metallicity of 1.3–1.8 Z[sub ⊙] at a radius of about 45 arcsec (15 kpc), before falling back to 0.4 Z[sub ⊙] at the centre of the cluster. A radial temperature profile shows that the temperature decreases inwards. We determine the spatial distributions of each of two temperature components, where applicable. The radiative cooling time of the cooler component within the inner 10 arcsec (3 kpc) is less than 2×10[sup 7] yr. X-ray holes in the image coincident with the radio lobes are seen, as well as two outer sharp temperature drops, or cold fronts. The origin of the plume is unclear. The existence of the strong abundance gradient is a strong constraint on extensive convection or gas motion driven by a central radio source. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
41. Adaptive binning of X-ray galaxy cluster images.
- Author
-
Sanders, J.S. and Fabian, A.C.
- Subjects
- *
IMAGE processing , *GALAXY clusters , *X-ray astronomy - Abstract
We present a simple method for adaptively binning the pixels in an image. The algorithm groups pixels into bins of size such that the fractional error on the photon count in a bin is less than or equal to a threshold value, and the size of the bin is as small as possible. The process is particularly useful for generating surface brightness and colour maps, with clearly defined error maps, from images with a large dynamic range of counts, for example X-ray images of galaxy clusters. We demonstrate the method in application to data from Chandra ACIS-S and ACIS-I observations of the Perseus cluster of galaxies. We use the algorithm to create intensity maps, and colour images that show the relative X-ray intensities in different bands. The colour maps can later be converted, through spectral models, into maps of physical parameters, such as temperature, column density, etc. The adaptive binning algorithm is applicable to a wide range of data, from observations or numerical simulations, and is not limited to two-dimensional data. [ABSTRACT FROM AUTHOR]
- Published
- 2001
- Full Text
- View/download PDF
42. Chandra imaging of the X-ray core of Abell 1795.
- Author
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Fabian, A.C., Sanders, J.S., Ettori, S., Taylor, G.B., Allen, S.W., Crawford, C.S., Iwasawa, K., and Johnstone, R.M.
- Subjects
- *
X-rays , *GALAXY clusters , *SOLAR spectra - Abstract
Focuses on the discovery of a 40arcsec long X-ray filament in the core of the cluster of galaxies Abell 1795. Temperature of the X-ray emitting gas; Presentation of the temperature map of the core; Radiative cooling time of the X-ray emitting gas in the filament.
- Published
- 2001
- Full Text
- View/download PDF
43. Chandra imaging of the complex X-ray core of the Perseus cluster.
- Author
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Fabian, A.C., Sanders, J.S., Ettori, S., Taylor, G.B., Allen, S.W., Crawford, C.S., Iwasawa, K., Johnstone, R.M., and Ogle, P.M.
- Subjects
- *
GALAXY clusters , *GALAXIES , *X-ray spectroscopy - Abstract
Investigates the chandra imaging of the complex X-ray core of the Perseus cluster. Appearance of the X-ray cooler gas and the outer optical parts of NGC 1275 galaxy; Interpretation of the low surface brightness; Determination of the energy content of the radio source.
- Published
- 2000
- Full Text
- View/download PDF
44. X-ray colour maps of the cores of galaxy clusters.
- Author
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Sanders, J.S., Fabian, A.C., and Allen, S.W.
- Subjects
- *
GALAXY clusters , *X-rays - Abstract
We present an analysis of X-ray colour maps of the cores of clusters of galaxies, formed from the ratios of counts in different X-ray bands. Our technique groups pixels lying between contours in an adaptively smoothed image of a cluster. We select the contour levels to minimize the uncertainties in the colour ratios, whilst preserving the structure of the object. We extend the work of Allen & Fabian by investigating the spatial distributions of cooling gas and absorbing material in cluster cores. Their sample is almost doubled: we analyse archive ROSAT Position Sensitive Proportional Counter (PSPC) data for 33 clusters from the sample of the 55 brightest X-ray clusters in the sky. Many of our clusters contain strong cooling flows. We present colour maps of a sample of the clusters, in addition to adaptively smoothed images in different bands. Most of the cooling flow clusters display little substructure, unlike several of the non-cooling-flow clusters. We fitted an isothermal plasma model with galactic absorption and constant metallicity to the mid-over-high energy colours in our clusters. Those clusters with known strong cooling flows have inner contours which fit a significantly lower temperature than the outer contours. Clusters in the sample without strong cooling flows show no significant temperature variation. The inclusion of a metallicity gradient alone was not sufficient to explain the observations. A cooling flow component plus a constant temperature phase did account for the colour profiles in clusters with known strong cooling flow components. We also had to increase the levels of absorbing material to fit the low-over-high colours at the cluster centres. Our results provide more evidence that cooling flows accumulate absorbing material. No evidence for increased absorption was found for the non-cooling-flow clusters. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
45. Tracing Gas Motions in the Centaurus Cluster.
- Author
-
Leibundgut, Bruno, Aschenbach, B., Burwitz, V., Hasinger, G., Leibundgut, B., Graham, J., Fabian, A.C., Sanders, J.S., and Morris, R.G.
- Published
- 2008
- Full Text
- View/download PDF
46. Making the Computer Neuter
- Author
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Sanders, J.S.
- Subjects
Social Issue ,Survey ,Social Responsibility ,Political Issue ,Computer Education ,Scientific Research ,Study ,Women ,Men ,Children ,Adolescents ,Home Computers ,Education ,Methods ,Discrimination ,Issues/Society - Published
- 1985
47. The Computer: Male, Female or Androgynous?
- Author
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Sanders, J.S.
- Subjects
Access Rights ,Discrimination ,Social Issue ,Psychological Issue ,Women ,Men ,Research and Development ,Study ,Analysis - Published
- 1984
48. Table of Contents.
- Author
-
Crawford, C.S., Johnstone, R.M., Morris, R.G., Sanders, J.S., and Schmidt, R.W.
- Subjects
ASTRONOMY ,STARS ,DWARF galaxies - Abstract
Presents the topics of discussion in the May 2002 issue of an astronomical journal. Formation mechanism of brown stars; Rotation of dwarf elliptical galaxies; X-ray luminosity in cluster cooling flows.
- Published
- 2002
49. A novel concept for hyperspectral remote sensing.
- Author
-
Sanders, J.S., Williams, R.E., Driggers, R.G., and Halford, C.E.
- Published
- 1992
- Full Text
- View/download PDF
50. The relationship between the optical Hα filaments and the X-ray emission in the core of the Perseus cluster.
- Author
-
Fabian, A.C., Sanders, J.S., Crawford, C.S., Conselice, C.J., Gallagher III, J.S., and Wyse, R.F.G.
- Subjects
- *
GALAXY clusters , *X-ray spectroscopy - Abstract
ABSTRACT NGC 1275 in the centre of the Perseus cluster of galaxies, Abell 426, is surrounded by a spectacular filamentary Hα nebula. Deep Chandra X-ray imaging has revealed that the brighter outer filaments are also detected in soft X-rays. This can be due to conduction and mixing of the cold gas in the filaments with the hot, dense intracluster medium. We show the correspondence of the filaments in both wavebands and draw attention to the relationship of two prominent curved north-west filaments to an outer, buoyant radio bubble seen as a hole in the X-ray image. There is a strong resemblance in the shape of the hole and the disposition of the filaments to the behaviour of a large air bubble rising in water. If this is a correct analogy, then the flow is laminar and the intracluster gas around this radio source is not turbulent. We obtain a limit on the viscosity of this gas. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
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