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3. Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Author

Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Cluster B, Immuno/reuma patientenzorg, Child Health, Haematologie patientenzorg, Poli Van Creveldkliniek Medisch, SCT patientenzorg, Regenerative Medicine and Stem Cells, MS Oogheelkunde, Onderzoek, MMB Medische Staf, Immuno/reuma ERN, Ohm, Milou, van Straalen, Joeri W, de Joode-Smink, Gerrie, van Montfrans, Joris, Bartels, Marije, van Wildenbeest, Joanne G, Lindemans, Caroline A, Wennink, Roos Aw, de Boer, Joke H, Sanders, Elisabeth Am, Verduyn-Lunel, Frans M, Berbers, Guy Am, Wulffraat, Nico M, Jansen, Marc H A, Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Cluster B, Immuno/reuma patientenzorg, Child Health, Haematologie patientenzorg, Poli Van Creveldkliniek Medisch, SCT patientenzorg, Regenerative Medicine and Stem Cells, MS Oogheelkunde, Onderzoek, MMB Medische Staf, Immuno/reuma ERN, Ohm, Milou, van Straalen, Joeri W, de Joode-Smink, Gerrie, van Montfrans, Joris, Bartels, Marije, van Wildenbeest, Joanne G, Lindemans, Caroline A, Wennink, Roos Aw, de Boer, Joke H, Sanders, Elisabeth Am, Verduyn-Lunel, Frans M, Berbers, Guy Am, Wulffraat, Nico M, and Jansen, Marc H A

Published
2023

4. Additional file 1 of Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Author

Ohm, Milou, van Straalen, Joeri W, de Joode-Smink, Gerrie, van Montfrans, Joris, Bartels, Marije, van Wildenbeest, Joanne G, Lindemans, Caroline A, Wennink, Roos AW, de Boer, Joke H, Sanders, Elisabeth AM, Verduyn-Lunel, Frans M, Berbers, Guy AM, Wulffraat, Nico M, and Jansen, Marc H.A.

Abstract

Supplementary Material 1

Published
2023
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5. Additional file 2 of Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Author

Ohm, Milou, van Straalen, Joeri W, de Joode-Smink, Gerrie, van Montfrans, Joris, Bartels, Marije, van Wildenbeest, Joanne G, Lindemans, Caroline A, Wennink, Roos AW, de Boer, Joke H, Sanders, Elisabeth AM, Verduyn-Lunel, Frans M, Berbers, Guy AM, Wulffraat, Nico M, and Jansen, Marc H.A.

Abstract

Supplementary Material 2

Published
2023
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6. Pneumococcal genetic variability in age-dependent bacterial carriage

Author

Kremer, Philip HC, primary, Ferwerda, Bart, additional, Bootsma, Hester J, additional, Rots, Nienke Y, additional, Wijmenga-Monsuur, Alienke J, additional, Sanders, Elisabeth AM, additional, Trzciński, Krzysztof, additional, Wyllie, Anne L, additional, Turner, Paul, additional, van der Ende, Arie, additional, Brouwer, Matthijs C, additional, Bentley, Stephen D, additional, van de Beek, Diederik, additional, and Lees, John A, additional

Published
2022
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7. Author response: Pneumococcal genetic variability in age-dependent bacterial carriage

Author

Kremer, Philip HC, primary, Ferwerda, Bart, additional, Bootsma, Hester J, additional, Rots, Nienke Y, additional, Wijmenga-Monsuur, Alienke J, additional, Sanders, Elisabeth AM, additional, Trzciński, Krzysztof, additional, Wyllie, Anne L, additional, Turner, Paul, additional, van der Ende, Arie, additional, Brouwer, Matthijs C, additional, Bentley, Stephen D, additional, van de Beek, Diederik, additional, and Lees, John A, additional

Published
2022
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8. Pneumococcal conjugate vaccines for preventing acute otitis media in children

Author

HAG Infectieziekten, Huisartsopleiding, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, de Sévaux, Joline Lh, Venekamp, Roderick P, Lutje, Vittoria, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, Damoiseaux, Roger Amj, HAG Infectieziekten, Huisartsopleiding, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, de Sévaux, Joline Lh, Venekamp, Roderick P, Lutje, Vittoria, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, and Damoiseaux, Roger Amj

Published
2020

9. A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections

Author

Koenen, Mischa H, primary, Bosma, Madeleen, additional, Roorda, Udo A, additional, Wopereis, Fabiënne MY, additional, Roos, Anja, additional, der Vries, Erhard, additional, Bogaert, Debby, additional, Sanders, Elisabeth AM, additional, Boes, Marianne, additional, Heidema, Jojanneke, additional, Montfrans, Joris M, additional, Balemans, Walter AF, additional, Holten, Thijs C, additional, and Verhagen, Lilly M, additional

Published
2021
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11. Pneumococcal conjugate vaccines for preventing acute otitis media in children

Author

Fortanier, Alexandre C, Venekamp, Roderick P, Boonacker, Chantal Wb, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, Damoiseaux, Roger Amj, Fortanier, Alexandre C, Venekamp, Roderick P, Boonacker, Chantal Wb, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, and Damoiseaux, Roger Amj

Published
2019

12. Pneumococcal conjugate vaccines for preventing acute otitis media in children

Author

Infection & Immunity, Epi Infectieziekten Team 1, Huisartsopleiding, Child Health, JC onderzoeksprogramma Infectieziekten, Epi Curriculair Onderwijs, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, Fortanier, Alexandre C, Venekamp, Roderick P, Boonacker, Chantal Wb, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, Damoiseaux, Roger Amj, Infection & Immunity, Epi Infectieziekten Team 1, Huisartsopleiding, Child Health, JC onderzoeksprogramma Infectieziekten, Epi Curriculair Onderwijs, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, Fortanier, Alexandre C, Venekamp, Roderick P, Boonacker, Chantal Wb, Hak, Eelko, Schilder, Anne Gm, Sanders, Elisabeth Am, and Damoiseaux, Roger Amj

Published
2019

14. Hospitalization due to varicella in the Netherlands

Author

Sanders Elisabeth AM, Rodenburg Gerwin D, van der Maas Nicoline AT, van Lier Alies, and de Melker Hester E

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In the Netherlands, incidence of physician's consultations and hospitalizations for varicella is low compared to other countries. Better knowledge about the severity of varicella among Dutch hospitalized patients is needed. Therefore, a medical record research was conducted among hospitalized patients with diagnosis varicella. Methods Hospital admissions due to varicella in 2003-2006 were obtained from the National Medical Register. Retrospectively, additional data were retrieved from the medical record of patients hospitalized with varicella in 23 Dutch hospitals using a standardized form. Analyses were performed using descriptive statistics. Results The study population (N = 296) was representative for all varicella admissions in the Netherlands (N = 1,658) regarding age, sex, duration of admission and type of diagnosis. Complications were recorded in 76% of the patients (37% had at least one relatively severe complication). Bacterial super infections of skin lesions (28%), (imminent) dehydration (19%), febrile convulsions (7%), pneumonia (7%) and gastroenteritis (7%) were most frequently reported. No varicella-related death occurred within the study population and 3% of the patients had serious rest symptoms. Conclusions It is not likely that the severity of varicella among hospitalized patients in the Netherlands differs from other countries. A considerable part of the varicella complications among hospitalized patients was rather moderate and can be treated effectively, although in a third of the hospitalized cases with complications, severe complications occurred. These data are relevant in the decision-making process regarding whether or not to introduce routine varicella vaccination in the Netherlands.

Published
2011
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15. Effectiveness of the DTPa-HBV-IPV/Hib vaccine against invasive Haemophilus influenzae type b disease in the Netherlands (2003–16): a case-control study

Author

Immuno/reuma onderzoek 7 (Montfrans), Child Health, Infection & Immunity, Immuno/reuma patientenzorg, Monge, Susana, Hahné, Susan JM, de Melker, Hester E., Sanders, Elisabeth AM, van der Ende, Arie, Knol, Mirjam J., Immuno/reuma onderzoek 7 (Montfrans), Child Health, Infection & Immunity, Immuno/reuma patientenzorg, Monge, Susana, Hahné, Susan JM, de Melker, Hester E., Sanders, Elisabeth AM, van der Ende, Arie, and Knol, Mirjam J.

Published
2018

16. Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study

Author

Martinón-Torres, Federico, primary, Salas, Antonio, additional, Rivero-Calle, Irene, additional, Cebey-López, Miriam, additional, Pardo-Seco, Jacobo, additional, Herberg, Jethro A, additional, Boeddha, Navin P, additional, Klobassa, Daniela S, additional, Secka, Fatou, additional, Paulus, Stephane, additional, de Groot, Ronald, additional, Schlapbach, Luregn J, additional, Driessen, Gertjan J, additional, Anderson, Suzanne T, additional, Emonts, Marieke, additional, Zenz, Werner, additional, Carrol, Enitan D, additional, Van der Flier, Michiel, additional, Levin, Michael, additional, Coin, Lachlan, additional, Gormley, Stuart, additional, Hamilton, Shea, additional, Herberg, Jethro, additional, Hourmat, Bernardo, additional, Hoggart, Clive, additional, Kaforou, Myrsini, additional, Sancho-Shimizu, Vanessa, additional, Wright, Victoria, additional, Abdulla, Amina, additional, Agapow, Paul, additional, Bartlett, Maeve, additional, Bellos, Evangelos, additional, Eleftherohorinou, Hariklia, additional, Galassini, Rachel, additional, Inwald, David, additional, Mashbat, Meg, additional, Menikou, Stefanie, additional, Mustafa, Sobia, additional, Nadel, Simon, additional, Rahman, Rahmeen, additional, Thakker, Clare, additional, Bokhandi, Sumit, additional, Power, Sue, additional, Barham, Heather, additional, Pathan, Nazima, additional, Ridout, Jenna, additional, White, Deborah, additional, Thurston, Sarah, additional, Faust, Saul, additional, Patel, Sanjay, additional, McCorkell, Jenni, additional, Davies, Patrick, additional, Crate, Lindsey, additional, Navarra, Helen, additional, Carter, Stephanie, additional, Ramaiah, Raghu, additional, Patel, Rekha, additional, Tuffrey, Catherine, additional, Gribbin, Andrew, additional, McCready, Sharon, additional, Peters, Mark, additional, Hardy, Katie, additional, Standing, Fran, additional, O'Neill, Lauren, additional, Abelake, Eugenia, additional, Deep, Akash, additional, Nsirim, Eniola, additional, Pollard, Andrew, additional, Willis, Louise, additional, Young, Zoe, additional, Royad, C, additional, White, Sonia, additional, Fortune, Peter Marc, additional, Hudnott, Phil, additional, Martinón-Torres, Federico, additional, Salas Ellacuriaga, Antonio, additional, Álvez González, Fernando, additional, Barral-Arca, Ruth, additional, Curras-Tuala, María José, additional, García, Natalia, additional, García Vicente, Luisa, additional, Gómez-Carballa, Alberto, additional, Gómez Rial, Jose, additional, Grela Beiroa, Andrea, additional, Justicia Grande, Antonio, additional, Leboráns Iglesias, Pilar, additional, Martínez Santos, Alba Elena, additional, Martinón-Torres, Nazareth, additional, Martinón Sánchez, José María, additional, Morillo Gutiérrez, Beatriz, additional, Mosquera Pérez, Belén, additional, Obando Pacheco, Pablo, additional, Pischedda, Sara, additional, Rodríguez-Tenreiro, Carmen, additional, Redondo-Collazo, Lorenzo, additional, Serén Fernández, Sonia, additional, Porto Silva, María del Sol, additional, Vega, Ana, additional, Vilanova Trillo, Lucía, additional, Reyes, Susana Beatriz, additional, León León, María Cruz, additional, Navarro Mingorance, Álvaro, additional, Gabaldó Barrios, Xavier, additional, Oñate Vergara, Eider, additional, Concha Torre, Andrés, additional, Vivanco, Ana, additional, Fernández, Reyes, additional, Giménez Sánchez, Francisco, additional, Sánchez Forte, Miguel, additional, Rojo, Pablo, additional, Ruiz Contreras, Jesús, additional, Palacios, Alba, additional, Epalza Ibarrondo, Cristina, additional, Fernández Cooke, Elizabeth, additional, Navarro, Marisa, additional, Álvarez Álvarez, Cristina, additional, Lozano, María José, additional, Carreras, Eduardo, additional, Brió Sanagustín, Sonia, additional, Neth, Olaf, additional, Martínez Padilla, María del Carmen, additional, Prieto Tato, Luis Manuel, additional, Guillén, Sara, additional, Fernández Silveira, Laura, additional, Moreno, David, additional, van Furth, A. Marceline, additional, van der Flier, Michiel, additional, Boeddha, Navin Prekash, additional, Driessen, Gertjan JA, additional, Hazelzet, Jan A, additional, Kuijpers, Taco W, additional, Pajkrt, Dasja, additional, Sanders, Elisabeth AM, additional, van de Beek, Diederik, additional, van der Ende, Arie, additional, Philipsen, Ria LA, additional, Adeel, Abdul OA, additional, Breukels, Meike A, additional, Brinkman, Danielle MC, additional, de Korte, Carla CMM, additional, de Vries, Esther, additional, de Waal, Wouter J, additional, Dekkers, Roel, additional, Dings-Lammertink, Anouk, additional, Doedens, Rienus A, additional, Donker, Albertine E, additional, Dousma, Mieke, additional, Faber, Tina E, additional, Gerrits, G Peter JM, additional, Gerver, Jan AM, additional, Heidema, Jojanneke, additional, Homan-van der Veen, Jenneke, additional, Jacobs, Monique AM, additional, Jansen, Nicolaas JG, additional, Kawczynski, Pawel, additional, Klucovska, Kristine, additional, Kneyber, Martin CJ, additional, Koopman-Keemink, Yvonne, additional, Langenhorst, Veerle J, additional, Leusink, José, additional, Loza, Bettina F, additional, Merth, Istvan T, additional, Miedema, Carien J, additional, Neeleman, Chris, additional, Noordzij, Jeroen G, additional, Obihara, Charles C, additional, van Overbeek - van Gils, A Lidy T, additional, Poortman, Geriska H, additional, Potgieter, Steph T, additional, Potjewijd, Joke, additional, Rosias, Philippe PR, additional, Sprong, Tom, additional, ten Tussher, Gavin W, additional, Thio, Boony J, additional, Tramper-Stranders, Gerdien A, additional, van Deuren, Marcel, additional, van der Meer, Henny, additional, van Kuppevelt, Andre JM, additional, van Wermeskerken, Anne-Marie, additional, Verwijs, Wim A, additional, Wolfs, Tom FW, additional, Schlapbach, Luregn Jan, additional, Agyeman, Philipp, additional, Aebi, Christoph, additional, Berger, Christoph, additional, Giannoni, Eric, additional, Stocker, Martin, additional, Posfay-Barbe, Klara M, additional, Heininger, Ulrich, additional, Bernhard-Stirnemann, Sara, additional, Niederer-Loher, Anita, additional, Kahlert, Christian, additional, Hasters, Paul, additional, Relly, Christa, additional, Baer, Walter, additional, Carrol, Enitan, additional, Paulus, Stéphane, additional, Frederick, Hannah, additional, Jennings, Rebecca, additional, Johnston, Joanne, additional, Kenwright, Rhian, additional, Fink, Colin G, additional, Pinnock, Elli, additional, Agbeko, Rachel Sarah, additional, Bojang, Kalifa A, additional, Sarr, Isatou, additional, Kebbeh, Ngange, additional, Sey, Gibbi, additional, Saidykhan, Momodou, additional, Cole, Fatoumata, additional, Thomas, Gilleh, additional, Antonio, Martin, additional, Klobassa, Daniela Sabine, additional, Binder, Alexander, additional, Schweintzger, Nina Alexandra, additional, Sagmeister, Manfred, additional, Baumgart, Hinrich, additional, Baumgartner, Markus, additional, Behrends, Uta, additional, Biebl, Ariane, additional, Birnbacher, Robert, additional, Blanke, Jan-Gerd, additional, Boelke, Carsten, additional, Breuling, Kai, additional, Brunner, Jürgen, additional, Buller, Maria, additional, Dahlem, Peter, additional, Dietrich, Beate, additional, Eber, Ernst, additional, Elias, Johannes, additional, Emhofer, Josef, additional, Etschmaier, Rosa, additional, Farr, Sebastian, additional, Girtler, Ylenia, additional, Grigorow, Irina, additional, Heimann, Konrad, additional, Ihm, Ulrike, additional, Jaros, Zdenek, additional, Kalhoff, Hermann, additional, Kaulfersch, Wilhelm, additional, Kemen, Christoph, additional, Klocker, Nina, additional, Köster, Bernhard, additional, Kohlmaier, Benno, additional, Komini, Eleni, additional, Kramer, Lydia, additional, Neubert, Antje, additional, Ortner, Daniel, additional, Pescollderungg, Lydia, additional, Pfurtscheller, Klaus, additional, Reiter, Karl, additional, Ristic, Goran, additional, Rödl, Siegfried, additional, Sellner, Andrea, additional, Sonnleitner, Astrid, additional, Sperl, Matthias, additional, Stelzl, Wolfgang, additional, Till, Holger, additional, Trobisch, Andreas, additional, Vierzig, Anne, additional, Vogel, Ulrich, additional, Weingarten, Christina, additional, Welke, Stefanie, additional, Wimmer, Andreas, additional, Wintergerst, Uwe, additional, Wüller, Daniel, additional, Zaunschirm, Andrew, additional, Ziuraite, Ieva, additional, and Žukovskaja, Veslava, additional

Published
2018
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18. Otitis media and its consequences: beyond the earache

Author

Vergison, Anne, Dagan, Ron, Arguedas, Adriano, Bonhoeffer, Jan, Cohen, Robert, DHooge, Ingeborg, Hoberman, Alejandro, Liese, Johannes, Marchisio, Paola, Palmu, Arto A, Ray, G Thomas, Sanders, Elisabeth AM, Simões, Eric AF, Uhari, Matti, van Eldere, Johan, and Pelton, Stephen I

Published
2010
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19. Impact of early daycare on healthcare resource use related to upper respiratory tract infections during childhood: prospective WHISTLER cohort study

Author

de Hoog, Marieke LA, primary, Venekamp, Roderick P, additional, van der Ent, Cornelis K, additional, Schilder, Anne, additional, Sanders, Elisabeth AM, additional, Damoiseaux, Roger AMJ, additional, Bogaert, Debby, additional, Uiterwaal, Cuno SPM, additional, Smit, Henriette A, additional, and Bruijning-Verhagen, Patricia, additional

Published
2014
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21. Pneumococcal population in the era of vaccination: changes in composition and the relation to clinical outcomes.

Author

Elberse, Karin E, Wagenvoort, Gertjan HJ, Pluister, Gerlinde N, de Melker, Hester E, Sanders, Elisabeth AM, der Ende, Arie van, and Knol, Mirjam J

Abstract

Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes. [ABSTRACT FROM AUTHOR]

Published
2016
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27. Pleconaril-Resistant Chronic Parechovirus-Associated Enteropathy in Agammaglobulinaemia

Author

van de Ven, Annick AJM, Douma, Jan Willem, Rademaker, Carin, van Loon, Anton M, Wensing, Annemarie MJ, Boelens, Jaap-Jan, Sanders, Elisabeth AM, and van Montfrans, Joris M

Abstract

A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection- related immune dysregulation in an immuno-compromised host.

Published
2011
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28. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Author

Lees, John A, Ferwerda, Bart, Kremer, Philip HC, Wheeler, Nicole E, Serón, Mercedes Valls, Croucher, Nicholas J, Gladstone, Rebecca A, Bootsma, Hester J, Rots, Nynke Y, Wijmega-Monsuur, Alienke J, Sanders, Elisabeth AM, Trzciński, Krzysztof, Wyllie, Anne L, Zwinderman, Aeilko H, Van Den Berg, Leonard H, Van Rheenen, Wouter, Veldink, Jan H, Harboe, Zitta B, Lundbo, Lene F, De Groot, Lisette CPGM, Van Schoor, Natasja M, Van Der Velde, Nathalie, Ängquist, Lars H, Sørensen, Thorkild IA, Nohr, Ellen A, Mentzer, Alexander J, Mills, Tara C, Knight, Julian C, Du Plessis, Mignon, Nzenze, Susan, Weiser, Jeffrey N, Parkhill, Julian, Madhi, Shabir, Benfield, Thomas, Von Gottberg, Anne, Van Der Ende, Arie, Brouwer, Matthijs C, Barrett, Jeffrey C, Bentley, Stephen D, and Van De Beek, Diederik

Subjects
Adult, Male, Genome, Human, Meningitis, Pneumococcal, Genetic Variation, Proteins, Middle Aged, 3. Good health, Streptococcus pneumoniae, Bacterial Proteins, Host-Pathogen Interactions, Humans, Female, Genetic Predisposition to Disease, Prospective Studies, Genome, Bacterial, Aged, Genome-Wide Association Study
Abstract

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, identifying variants in CCDC33 associated with susceptibility. Pneumococcal genetic variation explains a large amount of invasive potential (70%), but has no effect on severity. Serotype alone is insufficient to explain invasiveness, suggesting other pneumococcal factors are involved in progression to invasive disease. We identify pneumococcal genes involved in invasiveness including pspC and zmpD, and perform a human-bacteria interaction analysis. These genes are potential candidates for the development of more broadly-acting pneumococcal vaccines.

29. Effectiveness of the DTPa-HBV-IPV/Hib vaccine against invasive Haemophilus influenzae type b disease in the Netherlands (2003-16): a case-control study.

Author

Hahné, Susan JM, de Melker, Hester E, Sanders, Elisabeth AM, Knol, Mirjam J, Monge, Susana, and van der Ende, Arie

Subjects
*VACCINE effectiveness, *HAEMOPHILUS influenzae, *JUVENILE diseases, *EPIDEMIOLOGY, *CASE-control method, *THERAPEUTICS, *VACCINATION, *DPT vaccines, *HEPATITIS B vaccines, *POLIOMYELITIS vaccines, *COMBINED vaccines, *COMPARATIVE studies, *DIPHTHERIA, *HAEMOPHILUS diseases, *IMMUNIZATION, *RESEARCH methodology, *MEDICAL cooperation, *MEDICAL protocols, *RESEARCH, *EVALUATION research, *TETANUS, *PREVENTION, *VACCINES
Abstract

Background: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness.Methods: We did a case-control study in the Netherlands. We selected patients with a Hib infection (cases) by use of the surveillance records of the Netherlands Reference Laboratory for Bacterial Meningitis (Amsterdam). Cases with a Hib infection that began from Jan 1, 2003, to Dec 31, 2016, and who were younger than age 5 years were included. Ten controls from the national vaccination register (Praeventis) were selected for each case, matched by date of birth. Vaccination status was ascertained by use of Praeventis, which details the vaccination records of children living in the Netherlands. The last recorded vaccine dose was used to classify the child as having received the hexavalent DTPa-HBV-IPV/Hib vaccine or a pentavalent vaccine (which excludes the hepatitis B virus component) or another vaccine. We estimated the effectiveness of these vaccines by use of conditional logistic regression.Findings: We included 159 (94%) of 170 cases reported and 1590 matched controls, who had a median age of 1·5 years (IQR 0·8-2·9). The remaining 11 cases could not be cross-matched with vaccination records from Praeventis. 91 (57%) of 159 cases had been vaccinated, compared with 1408 (89%) of 1590 controls. The overall vaccine effectiveness was 92·8% (95% CI 88·7-95·4), with no differences between the year of disease onset (p=0·9670). There were no differences conferred by type of vaccine given: vaccine effectiveness of the pentavalent and other vaccines was 91·8% (95% CI 86·1-95·1) versus 94·0% (89·0-96·8) for the hexavalent vaccine (OR 0·72, 95% CI 0·36-1·45; p=0·3591). Vaccine effectiveness was highest in children aged 1-2 years at disease onset (97·1-99·0%) and was lowest in children aged 3-4 years at disease onset (60·7-82·3%; p=0·0008).Interpretation: Our results support the current vaccination programme, since Hib vaccine effectiveness has not decreased over time or by the introduction of the hexavalent DTPa-HBV-IPV/Hib vaccine. Vaccine effectiveness was high but waned with age. Alternative explanations for the increase in Hib disease therefore need to be assessed.Funding: Dutch Ministry of Health, Welfare and Sports. [ABSTRACT FROM AUTHOR]

Published
2018
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