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13. Glycemic index, glycemic load and invasive breast cancer incidence in postmenopausal women : The PREDIMED study

Author

Castro-Quezada, Itandehui, Sánchez-Villegas, Almudena, Martínez-González, Miguel Á., Salas-Salvadó, Jordi, Corella, Dolores, Estruch, Ramón, Schröder, Helmut, Álvarez-Pérez, Jacqueline, Ruiz-López, María D., Artacho, Reyes, Ros, Emilio, Bulló, Mónica, Sorli, Jose V., Fitó, Montserrat, Ruiz-Gutiérrez, Valentina, Toledo, Estefanía, Buil-Cosiales, Pilar, Rodríguez, Antonio García, Lapetra, José, Pintó, Xavier, Salaverría, Itziar, Tur, Josep A., Romaguera, Dora, Tresserra-Rimbau, Anna, and Serra-Majem, Lluís

Published
2016

23. 'Effectiveness of a remote nutritional intervention to increase the adherence to the Mediterranean diet among recovered depression patients'.

Author

Cabrera-Suárez, Beatriz, Pla, Jorge, González-Pinto, Ana, Hernández, José, Chiclana-Actis, Carlos, Ortuño, Felipe, Florido-Rodriguez, Monica, Sanchez-Villegas, Almudena, and investigators, PREDI-DEP

Subjects
MEDITERRANEAN diet, MENTAL depression, OLIVE oil, DEPRESSED persons, FOOD habits, SECONDARY prevention, TRANSCRANIAL magnetic stimulation
Abstract

There is substantial evidence supporting that remote interventions are useful to change dietary habits. However, the effect of a remote intervention based on Mediterranean diet (MD) in depressive patients has been less explored. This study aims to assess the effectiveness of a remotely provided Mediterranean diet-based nutritional intervention in the context of a secondary prevention trial of depression. The PREDIDEP study was a 2-year multicenter, randomized, single-blinded trial designed to assess the effect of the MD enriched with extra virgin olive oil (EVOO) on the prevention of depression recurrence. The intervention group received usual care for depressed patients and remote nutritional intervention every three months which included phone contacts and web-based interventions; and the control group, usual care. At baseline and at 1-year and 2-year follow-up, the 14-item MD Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire (FFQ) were collected by a dietitian. Mixed effects linear models were used to assess changes in nutritional variables according to the group of intervention. The trial was registered at ClinicalTrials.gov NCT03081065. Compared with control group, the MD intervention group showed more adherence to MD (between-group difference: 2.76; 95% CI 2.13–3.39; p < 0.001); and a healthier diet pattern with a significant increase in the consumption of olive oil (p < 0.001), and a significant reduction in refined cereals (p = 0.031) after 2 years of intervention. The remote nutritional intervention increases adherence to the MD among recovered depression patients. Trial registration: ClinicalTrials.gov identifier: NCT03081065. [ABSTRACT FROM AUTHOR]

Published
2023
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24. ‘Effectiveness of a remote nutritional intervention to increase the adherence to the Mediterranean diet among recovered depression patients’

Author

Cabrera-Suárez, Beatriz, primary, Pla, Jorge, additional, González-Pinto, Ana, additional, Hernández, José, additional, Chiclana-Actis, Carlos, additional, Ortuño, Felipe, additional, Florido-Rodriguez, Monica, additional, Sanchez-Villegas, Almudena, additional, and investigators, PREDI-DEP, additional

Published
2022
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32. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author

Universitat Rovira i Virgili, Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi;PREDIMED-Plus Investigators, Universitat Rovira i Virgili, and Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi;PREDIMED-Plus Investigators

Abstract

Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m(2)) and micro- to macroalbuminuria (UACR >= 30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m(2)) to mildly impaired GFR (60 to <90 mL/min/1.73 m(2)) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m(2) in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m(2); 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PRE

Published
2021

36. Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED-Plus Study

Author

Universitat Rovira i Virgili, Fernandez-Garcia, Jose Carlos; Munoz-Garach, Araceli; Martinez-Gonzalez, Miguel angel; Salas-Salvado, Jordi; Corella, Dolores; Hernaez, Alvaro; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Garcia-Rios, Antonio; Garcia Molina, Laura; Gaforio, Jose Juan; Matia-Martin, Pilar; Daimiel, Lidia; Martin Sanchez, Vicente; Vidal, Josep; Prieto, Lucia; Ros, Emilio; Goni, Nuria; Babio, Nancy; Ortega-Azorin, Carolina; Castaner, Olga; Konieczna, Jadwiga; Notario Barandiaran, Leyre; Vaquero-Luna, Jessica; Benavente-Marin, Juan Carlos; Zulet, M. Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Gomez Huelgas, Ricardo; Miro-Moriano, Leticia; Gimenez-Gracia, Mariano; Julibert, Alicia; Razquin, Cristina; Basora, Josep; Portoles, Olga; Goday, Albert; Galmes-Panades, Aina M.; Lopez-Garcia, Carmen M.; Moreno-Rodriguez, Anai; Toledo, Estefania; Diaz-Lopez, Andres; Fito, Montserrat; Tinahones, Francisco J.; Bernal-Lopez, M. Rosa;PREDIMED-Plus Investigators, Universitat Rovira i Virgili, and Fernandez-Garcia, Jose Carlos; Munoz-Garach, Araceli; Martinez-Gonzalez, Miguel angel; Salas-Salvado, Jordi; Corella, Dolores; Hernaez, Alvaro; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Garcia-Rios, Antonio; Garcia Molina, Laura; Gaforio, Jose Juan; Matia-Martin, Pilar; Daimiel, Lidia; Martin Sanchez, Vicente; Vidal, Josep; Prieto, Lucia; Ros, Emilio; Goni, Nuria; Babio, Nancy; Ortega-Azorin, Carolina; Castaner, Olga; Konieczna, Jadwiga; Notario Barandiaran, Leyre; Vaquero-Luna, Jessica; Benavente-Marin, Juan Carlos; Zulet, M. Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Gomez Huelgas, Ricardo; Miro-Moriano, Leticia; Gimenez-Gracia, Mariano; Julibert, Alicia; Razquin, Cristina; Basora, Josep; Portoles, Olga; Goday, Albert; Galmes-Panades, Aina M.; Lopez-Garcia, Carmen M.; Moreno-Rodriguez, Anai; Toledo, Estefania; Diaz-Lopez, Andres; Fito, Montserrat; Tinahones, Francisco J.; Bernal-Lopez, M. Rosa;PREDIMED-Plus Investigators

Abstract

Objective The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined. Methods A total of 6,874 individuals aged 55 to 75 with BMI >= 27 and < 40 kg/m(2) were included and classified by presence (HTGW(+)) or absence (HTGW(-)) of HTGW (waist circumference: men >= 102 cm, women >= 88 cm; fasting plasma triglycerides >= 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed. Results A total of 38.2% of the sample met HTGW(+) criteria. HTGW(+) individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low-density lipoprotein cholesterol levels; had lower high-density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW(-) patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW(+). Conclusions HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW(-) individuals were more physically active with greater total physical activity, and fewer had hypertension.

Published
2020

37. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu [[beta].sub.2]-adrenoceptor polymorphism

Author

Martinez, J. Alfredo, Corbalan, Maria S., Sanchez-Villegas, Almudena, Forga, Luis, Marti, Amelia, and Martinez-Gonzalez, Miguel A.

Subjects
Carbohydrates -- Research, Obesity -- Research, Food/cooking/nutrition
Abstract

Interindividual differences in the response to dietary intake are, in some cases, genotype dependent. Moreover, genotype-environment interactions may appear when the impact of lifestyle factors (e.g., diet) on a phenotype (e.g., BMI > 30 kg/[m.sup.2]) differs by genotype. A case-control study (obese subjects vs. normal weight controls) was conducted to assess a possible effect modification on obesity risk of the Gln27Glu polymorphism for the [[beta].sub.2]-adrenoceptor gene depending on dietary intake. The sample included 159 subjects with BMI > 30 kg/[m.sup.2] and 154 controls with BMI < 25 kg/[m.sup.2]. The allele frequency for the Glu27 polymorphism, as assessed by the polymerase chain reaction-restriction fragment length polymorphism methodology, was 0.40 in cases (obese) and 0.37 in controls (lean), which was similar to that of other Caucasian populations. The dietary intake was estimated by using a previously validated food frequency questionnaire. Obesity incidence was not directly affected by the polymorphism [odds ratio (OR) = 1.40; P = 0.246]. However, a significant interaction (effect modification) between carbohydrate (CHO) intake and the presence of the Glu27 variant in the probability of obesity was apparent. Thus, females with the polymorphism and a higher CHO intake [>49% energy (E)] had a higher obesity risk (OR = 2.56, P = 0.051). The product-term introduced in the logistic model to assess effect modification revealed a marginally significant interaction (P = 0.058) between both factors. Furthermore, a high intake of CHO (E > 49%) was associated with higher insulin levels among women carrying the Gln27Glu polymorphism (P < 0.01). This gene-nutrient interaction emphasizes the importance of examining the outcome of some obesity-related mutations depending on lifestyle (including diet) and may explain the heterogeneity of findings from previous studies. KEY WORDS: * [[beta].sub.2]-adrenoceptorgene * Gln27Glu polymorphism * carbohydrate * obesity * gene-nutrient interactions

Published
2003

42. Healthy dietary indices and risk of depressive outcomes : a systematic review and meta-analysis of observational studies

Author

Lassale, Camille, Batty, G. David, Baghdadli, Amaria, Jacka, Felice, Sanchez-Villegas, Almudena, Kivimäki, Mika, Akbaraly, Tasnime, Clinicum, Faculty of Medicine, and University of Helsinki

Subjects
MEDITERRANEAN DIET, ADHERENCE, SYMPTOMS, AGED WOMEN, COMMON MENTAL-DISORDERS, INFLAMMATORY INDEX, SEGUIMIENTO-UNIVERSIDAD, 3112 Neurosciences, QUALITY, 1182 Biochemistry, cell and molecular biology, DASH DIET, NERVOUS-SYSTEM, 3124 Neurology and psychiatry
Abstract

With depression being the psychiatric disorder incurring the largest societal costs in developed countries, there is a need to gather evidence on the role of nutrition in depression, to help develop recommendations and guide future psychiatric health care. The aim of this systematic review was to synthesize the link between diet quality, measured using a range of predefined indices, and depressive outcomes. Medline, Embase and PsychInfo were searched up to 31st May 2018 for studies that examined adherence to a healthy diet in relation to depressive symptoms or clinical depression. Where possible, estimates were pooled using random effect meta-analysis with stratification by observational study design and dietary score. A total of 20 longitudinal and 21 cross-sectional studies were included. These studies utilized an array of dietary measures, including: different measures of adherence to the Mediterranean diet, the Healthy Eating Index (HEI) and Alternative HEI (AHEI), the Dietary Approaches to Stop Hypertension, and the Dietary Inflammatory Index. The most compelling evidence was found for the Mediterranean diet and incident depression, with a combined relative risk estimate of highest vs. lowest adherence category from four longitudinal studies of 0.67 (95% CI 0.55-0.82). A lower Dietary Inflammatory Index was also associated with lower depression incidence in four longitudinal studies (relative risk 0.76; 95% CI: 0.63-0.92). There were fewer longitudinal studies using other indices, but they and cross-sectional evidence also suggest an inverse association between healthy diet and depression (e.g., relative risk 0.65; 95% CI 0.50-0.84 for HEI/AHEI). To conclude, adhering to a healthy diet, in particular a traditional Mediterranean diet, or avoiding a pro-inflammatory diet appears to confer some protection against depression in observational studies. This provides a reasonable evidence base to assess the role of dietary interventions to prevent depression.

Published
2019

45. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic SyndromeInterim Analysis of the PREDIMED-Plus Randomized Clinical Trial

Author

European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, and Martínez-González, Miguel Ángel

Abstract

[Importance] High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes., [Objective] To assess the effect of a nutritional and physical activity education program on dietary quality., [Design, Setting, and Participants] Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019., [Interventions] Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free., [Main Outcomes and Measures] The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point)., [Results] Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between-group difference, 2.2 [95% CI, 2.1-2.4]; P < .001)., [Conclusions and Relevance] In this preliminary analysis of an ongoing trial, an intervention that encouraged an energy-reduced Mediterranean diet and physical activity, compared with advice to follow an energy-unrestricted Mediterranean diet, resulted in a significantly greater increase in diet adherence after 12 months. Further evaluation of long-term cardiovascular effects is needed., [Trial Registration] isrctn.com Identifier: ISRCTN89898870.

Published
2019

46. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author

Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, and Salas-Salvadó, Jordi

Abstract

[Purpose]: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. [Methods]:A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., [Results]: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., [Conclusions]: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.

Published
2019

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