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16 results on '"Sanchez-Pareja, I."'

1. Splicing machinery is profoundly altered in systemic lupus erythematosus and antiphospholipid syndrome and directly linked to key clinical features

Author

Lopez-Pedrera, Ch, Patiño-Trives, A.M., Cerdó, T., Ortega-Castro, R., Sanchez-Pareja, I., Ibañez-Costa, A., Muñoz-Barrera, L., Ábalos-Aguilera, M.C., Ruiz-Vilchez, D., Seguí Azpilcueta, P., Espinosa, M., Barbarroja, N., Escudero-Contreras, A., Castaño, J.P., Luque, R.M., Ortega, R., Aguirre, M.A., and Perez-Sanchez, C.

Published
2023
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2. POS0130 THE USE OF HIGH-THROUGHPUT TECHNOLOGIES FOR MOLECULAR PROFILING IN RHEUMATOID ARTHRITIS ENABLES THE IDENTIFICATION OF PATIENT SUBGROUPS WITH DISTINCTIVE DISEASE ACTIVITY AND THERAPEUTIC RESPONSE

Author

Lopez-Pedrera, C., primary, Sanchez-Pareja, I., additional, Perez-Sanchez, C., additional, Toro-Domínguez, D., additional, Muñoz-Barrera, L., additional, Cerdó, T., additional, Ortega-Castro, R., additional, Calvo-Gutiérrez, J., additional, Rojas-Giménez, M., additional, Ladehesa-Pineda, M. L., additional, Aranda-Valera, C., additional, Ábalos-Aguilera, M. C., additional, Ruíz-Vilchez, D., additional, Merlo-Ruiz, C., additional, Arias-de la Rosa, I., additional, Aguirre-Zamorano, M. Á., additional, López-Medina, C., additional, Barbarroja, N., additional, Alarcon-Riquelme, M., additional, and Escudero-Contreras, A., additional

Published
2024
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3. POS0154 EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS EXHIBIT DISTINCTIVE CIRCULATING INFLAMMATORY SIGNATURES ASSOCIATED WITH RELEVANT BIOLOGIC PATHWAYS

Author

Perez-Sanchez, C., primary, Vellón-García, B., additional, Llamas-Urbano, A., additional, Sanchez-Pareja, I., additional, Muñoz-Barrera, L., additional, Hanaee, Y., additional, Cerdó, T., additional, Merlo-Ruiz, C., additional, Arias-de la Rosa, I., additional, Ruiz-Vilchez, D., additional, Abalos-Aguilera, M. D. C., additional, Ladehesa-Pineda, M. L., additional, Aranda-Valera, C., additional, Rojas-Giménez, M., additional, Calvo-Gutiérrez, J., additional, Collantes-Estevez, E., additional, Barbarroja, N., additional, López-Medina, C., additional, Ortega-Castro, R., additional, Escudero-Contreras, A., additional, and Lopez-Pedrera, C., additional

Published
2024
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4. POS1401 INTEGRATION OF PROTEOMIC AND METABOLOMIC ANALYSES FOR STRATIFYING SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: UNVEILING SIGNATURES ASSOCIATED WITH CARDIOVASCULAR RISK AND RENAL COMPLICATIONS

Author

Lopez-Pedrera, C., primary, Cerdó, T., additional, Woodridge, L., additional, Perez-Sanchez, C., additional, Aguirre-Zamorano, M. Á., additional, Rahman, A., additional, Farinha, F., additional, Ortega-Castro, R., additional, Seguí Azpilcueta, P., additional, Sanchez-Pareja, I., additional, Muñoz-Barrera, L., additional, Corrales-Díaz Flores, S., additional, Merlo-Ruiz, C., additional, Ruiz-Vilchez, D., additional, Ábalos-Aguilera, M. C., additional, Pilar, F. U., additional, Barbarroja, N., additional, López-Medina, C., additional, Escudero-Contreras, A., additional, and Jury, E., additional

Published
2024
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5. POS0293 METABOLOMIC IN ANTIPHOSPHOLIPID SYNDROME STRATIFIED PATIENTS ACCORDING TO THEIR THROMBOTIC RISK

Author

Lopez-Pedrera, C., primary, Aguirre, M. A., additional, Sanchez-Pareja, I., additional, Cerdó, T., additional, Muñoz-Barrera, L., additional, Seguí Azpilcueta, P., additional, Merlo, C., additional, Ortiz Buitrago, P., additional, Ruiz, D., additional, Ábalos-Aguilera, M. C., additional, Barbarroja Puerto, N., additional, Ortega Castro, R., additional, and Perez-Sanchez, C., additional

Published
2023
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6. POS1038 NAD+ BOOSTERS AS A NOVEL ANTI-INFLAMMATORY TOOL IN RHEUMATOID ARTHRITIS PATIENTS

Author

Perez-Sanchez, C., primary, Escudero Contreras, A., additional, Cerdó, T., additional, Muñoz-Barrera, L., additional, Arias de la Rosa, I., additional, Sanchez-Pareja, I., additional, Marina Mendoza, L., additional, Barbarroja Puerto, N., additional, Ábalos-Aguilera, M. C., additional, Ruiz, D., additional, Moreno, J., additional, Burón, M. I., additional, González-Reyes, J. A., additional, Pilar, F. U., additional, Rojas-Giménez, M., additional, Calvo, J., additional, Collantes Estevez, E., additional, Villalba, J. M., additional, and Lopez-Pedrera, C., additional

Published
2023
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7. POS0623 INTEGRATED SERUM PROTEOMIC AND METABOLOMIC PROFILES IN SYSTEMIC SCLEROSIS PATIENTS CHARACTERIZE NEW BIOMARKERS ASSOCIATED TO RELEVANT PATHOLOGICAL FEATURES

Author

Sanchez-Pareja, I., primary, Ortega Castro, R., additional, Pilar, F. U., additional, Cerdó, T., additional, Muñoz-Barrera, L., additional, Ábalos-Aguilera, M. C., additional, Merlo, C., additional, Ortiz Buitrago, P., additional, Barbarroja Puerto, N., additional, Collantes Estevez, E., additional, Aguirre, M. A., additional, Perez-Sanchez, C., additional, and Lopez-Pedrera, C., additional

Published
2023
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8. POS0058 IDENTIFICATION OF NOVEL BIOMARKERS OF DISEASE ACTIVITY IN SYSTEMIC AUTOIMMUNE DISEASES THROUGH NEXT GENERATION PROTEOMICS

Author

Lopez-Pedrera, C., primary, Muñoz-Barrera, L., additional, Escudero Contreras, A., additional, Aguirre-Zamorano, M. Á., additional, Ortiz Buitrago, P., additional, López-Medina, C., additional, Calvo Gutierrez, J., additional, Ortega Castro, R., additional, Pilar, F. U., additional, Sanchez-Pareja, I., additional, Ábalos-Aguilera, M. C., additional, Barbarroja Puerto, N., additional, Collantes Estevez, E., additional, and Perez-Sanchez, C., additional

Published
2022
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9. POS0465 UNSUPERVISED CLUSTERING ANALYSIS OF THE SERUM PROTEOME IDENTIFIES SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH DISTINCTIVE DISEASE SEVERITY AND LUPUS NEPHROPATHY

Author

Lopez-Pedrera, C., primary, Aguirre-Zamorano, M. Á., additional, Muñoz-Barrera, L., additional, Sanchez-Pareja, I., additional, Pilar, F. U., additional, Ábalos-Aguilera, M. C., additional, Barbarroja Puerto, N., additional, Collantes Estevez, E., additional, Ortega Castro, R., additional, and Perez-Sanchez, C., additional

Published
2022
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10. POS0440 THE ANALYSIS OF THE INFLAMMATORY PROTEOME IN RHEUMATOID ARTHRITIS IDENTIFIES COMMON SIGNATURES ASSOCIATED WITH THE CLINICAL RESPONSE TO DMARDs AND TNFi THERAPIES

Author

Muñoz-Barrera, L., primary, Perez-Sanchez, C., additional, Escudero Contreras, A., additional, Aguirre-Zamorano, M. Á., additional, Calvo Gutierrez, J., additional, Ortega Castro, R., additional, Romero-Gómez, M., additional, Sanchez-Pareja, I., additional, Ábalos-Aguilera, M. C., additional, Barbarroja Puerto, N., additional, Pérez Venegas, J. J., additional, Ruiz-Montesinos, D., additional, Rodríguez-Escalera, C., additional, Romero-Barco, C. M., additional, Mena-Vázquez, N., additional, Fernandez-Nebro, A., additional, Uceda, J., additional, Marenco, J. L., additional, Collantes Estevez, E., additional, and Lopez-Pedrera, C., additional

Published
2022
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11. POS0488 IDENTIFICATION OF NOVEL DISEASE BIOMARKERS IN SYSTEMIC SCLEROSIS THROUGH HIGH-THROUGHPUT PROTEOMICS

Author

Ortega Castro, R., primary, Pilar, F. U., additional, Martinez-Monllor, M., additional, Muñoz-Barrera, L., additional, Sanchez-Pareja, I., additional, Ábalos-Aguilera, M. C., additional, Barbarroja Puerto, N., additional, Collantes Estevez, E., additional, Aguirre-Zamorano, M. Á., additional, Perez-Sanchez, C., additional, and Lopez-Pedrera, C., additional

Published
2022
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12. INTEGRATED METABOLOMICS AND PROTEOMICS NETWORK ANALYSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS HIGHLIGHTS METABOLIC AND IMMUNITY PATHWAYS ASSOCIATED WITH DISTINCTIVE CLINICAL PROFILES.

Author

Cerdó, T., Perez-Sanchez, C., Aguirre, M. A., Seguí Azpilcueta, P., Sanchez-Pareja, I., Muñoz-Barrera, L., Merlo, C., Ortiz Buitrago, P., Ruiz, D., Ábalos-Aguilera, M. C., Pilar, F. U., Barbarroja Puerto, N., Collantes Estevez, E., Ortega Castro, R., and Lopez-Pedrera, C.

Published
2023
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13. NAD+ BOOSTERS AS A NOVEL ANTI-INFLAMMATORY TOOL IN RHEUMATOID ARTHRITIS PATIENTS.

Author

Perez-Sanchez, C., Escudero Contreras, A., Cerdó, T., Muñoz-Barrera, L., Arias de la Rosa, I., Sanchez-Pareja, I., Mendoza, L. Marina, Puerto, N. Barbarroja, Ábalos-Aguilera, M. C., Ruiz, D., Moreno, J., Burón, M. I., González-Reyes, J. A., Pilar, F. U., Rojas-Giménez, M., Calvo, J., Estevez, E. Collantes, Villalba, J. M., and Lopez-Pedrera, C.

Published
2023
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16. Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs.

Author

Muñoz-Barrera L, Perez-Sanchez C, Ortega-Castro R, Corrales S, Luque-Tevar M, Cerdó T, Sanchez-Pareja I, Font P, Lopez-Mejías R, Calvo J, Abalos-Aguilera MC, Ruiz-Vilchez D, Segui P, Merlo C, Perez-Venegas J, Ruiz Montesino MD, Rodriguez-Escalera C, Barco CR, Fernandez-Nebro A, Vazque NM, Marenco JL, Montañes JU, Godoy-Navarrete J, Cabezas-Lucena AM, Estevez EC, Aguirre MA, González-Gay MA, Barbarroja N, Escudero-Contreras A, and Lopez-Pedrera C

Subjects
Humans, Endothelial Cells, Risk Factors, Inflammation drug therapy, Heart Disease Risk Factors, Cardiovascular Diseases drug therapy, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid drug therapy, Antirheumatic Agents therapeutic use, Biological Products therapeutic use
Abstract

Background & Objectives: This study aimed to: 1) analyze the inflammatory profile of Rheumatoid Arthritis (RA) patients, identifying clinical phenotypes associated with cardiovascular (CV) risk; 2) evaluate biologic and targeted-synthetic disease-modifying antirheumatic drugs (b-DMARDs and ts-DMARDs': TNFi, IL6Ri, JAKinibs) effects; and 3) characterize molecular mechanisms in immune-cell activation and endothelial dysfunction., Patients & Methods: A total of 387 RA patients and 45 healthy donors were recruited, forming three cohorts: i) 208 RA patients with established disease but without previous CV events; ii) RA-CVD: 96 RA patients with CV events, and iii) 83 RA patients treated with b-DMARDs/ts-DMARDs for 6 months. Serum inflammatory profiles (cytokines/chemokines/growth factors) and NETosis/oxidative stress-linked biomolecules were evaluated. Mechanistic in vitro studies were performed on monocytes, neutrophils and endothelial cells (EC)., Results: In the first RA-cohort, unsupervised clustering unveiled three distinct groups: cluster 3 (C3) displayed the highest inflammatory profile, significant CV-risk score, and greater atheroma plaques prevalence. In contrast, cluster 1 (C1) exhibited the lowest inflammatory profile and CV risk score, while cluster 2 (C2) displayed an intermediate phenotype. Notably, 2nd cohort RA-CVD patients mirrored C3's inflammation. Treatment with b-DMARDs or ts-DMARDs effectively reduced disease-activity scores (DAS28) and restored normal biomolecules levels, controlling CV risk. In vitro, serum from C3-RA or RA-CVD patients increased neutrophils activity and CV-related protein levels in cultured monocytes and EC, which were partially prevented by pre-incubation with TNFi, IL6Ri, and JAKinibs., Conclusions: Overall, analyzing circulating molecular profiles in RA patients holds potential for personalized clinical management, addressing CV risk and assisting healthcare professionals in tailoring treatment, ultimately improving outcomes., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Published
2024
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