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Background: Few European groups have published data on series of patients with idiopathic anaphylaxis., Objective: Our aim was to report on our experience with this entity in Spain., Methods: We conducted a two-part investigation. The first part was a descriptive cross-sectional study of 81 patients with idiopathic anaphylaxis, diagnosed between January 1990 and December 1995 in the allergy unit of the General Hospital of Albacete in Albacete, Spain. The second prong was a prospective, longitudinal study that evaluated the activity of the condition., Results: Female patients constituted 68% of the study group with idiopathic anaphylaxis; the mean age of the 81 patients was 30.0 +/- 17.3 years. The number of episodes of idiopathic anaphylaxis during the year of greatest frequency varied widely (median, 2; range, 1 to 130). The duration also varied considerably, with a range of 0.03 to 300 months (median, 2 years). Most patients entered the study in remission, and 93% of these patients remained in remission throughout the followup period. Only 9% of the patients had vascular involvement. Our series of patients with idiopathic anaphylaxis had a notable prevalence of atopic diseases (48%), food allergy (20%), and episodes of anaphylaxis with an identifiable cause (15%). In addition, a high frequency (58%) of idiopathic urticaria was noted; the urticaria was acute in 62% of the affected patients., Conclusions: Our series of patients with idiopathic anaphylaxis is similar to previously published series.

Cutaneous malignant melanoma has an increasing importance all over the world. However very few epidemiological studies have been published from Spain, and Spanish people have not become aware of the problem. This study was designed to examine sun exposure patterns and other related items among 116 consecutive patients with melanoma and 235 controls. Each subject answered a questionnaire covering the place of residence, sun exposure details and other risk factors, and underwent a skin examination. Continuous sun exposure due to residence or occupation was associated with an odds ratio (OR) of 2.0 (95% confidence interval [CI] = 1.2-3.3). People who lived in the city but spent 50% of their time in rural areas for holidays had an OR of 2.2 (95% CI = 1.3-3.8) when compared with those living in urban and rural areas. The OR for people who sunbathed more than 30 times a year was 1.8 (95% CI = 1.2-2.8), and outdoor leisure time was also associated with melanoma appearance when exposure was greater than 60 units in the last 2 years, with an OR of 3.0 (95% CI = 1.6-5.5); 1 unit is equivalent to total body sun exposure for at least 2 h. These OR estimates were adjusted for age, skin type and the number of naevi. Construction workers (OR = 1.6; 95% CI = 0.5-5.6) had increased risk after adjustment for skin type, age and freckle count (OR = 4.3; 95% CI = 1.8 9.9) or mole count (OR = 2.8; 95% CI = 1.4-5.8). Working as a farmer was a protective factor after adjustment (OR = 0.5; 95% CI = 0.3-0.8). The use of sunscreens was a protective factor against melanoma (OR = 2.6; 95% CI = 1.6-3.6 for non-users). Campaigns should focus on advising people to avoid sun exposure in sunny places and to use sunscreens every time they are exposed to the sun.