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4. Impact of the “Zero Resistance” program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study

Author

Álvarez-Lerma, Francisco, Catalán-González, Mercedes, Álvarez, Joaquín, Sánchez-García, Miguel, Palomar-Martínez, Mercedes, Fernández-Moreno, Inmaculada, Garnacho-Montero, José, Barcenilla-Gaite, Fernando, García, Rosa, Aranaz-Andrés, Jesús, Lozano-García, Francisco J., Ramírez-Galleymore, Paula, and Martínez-Alonso, Montserrat

Published
2023
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5. Barley Genomic Research and Breeding Strategies

Author

Visioni, Andrea, Sanchez-Garcia, Miguel, Kashyap, Prem Lal, editor, Gupta, Vikas, editor, Prakash Gupta, Om, editor, Sendhil, R., editor, Gopalareddy, K., editor, Jasrotia, Poonam, editor, and Singh, Gyanendra Pratap, editor

Published
2022
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7. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial

Author

Chochrad, Didier, Dive, Alain, Foret, Frédéric, Simon, Marc, Spapen, Herbert, Creteur, Jacques, Bouckaert, Yves, Biston, Patrick, Bourgeois, Marc, Novacek, Martin, Vymazal, Tomas, Svoboda, Petr, Pachl, Jan, Sramek, Vladimir, Hanauer, Michal, Hruby, Tomas, Balik, Martin, Suchy, Tomas, Lepape, Alain, Argaud, Laurent, Dailler, Frédéric, Desachy, Arnaud, Guitton, Christophe, Mercat, Alain, Meziani, Ferhat, Navellou, Jean-Christophe, Robert, Rene, Souweine, Bertrand, Tadie, Jean-Marc, Maamar, Adel, Annane, Djillali, Tamion, Fabienne, Gros, Antoine, Nseir, Saad, Schwebel, Carole, Francony, Gilles, Lefrant, Jean-Yves, Schneider, Francis, Gründling, Matthias, Motsch, Johann, Reill, Lorenz, Rolfes, Caroline, Welte, Tobias, Cornely, Oliver, Bloos, Frank, Deja, Maria, Schmidt, Katrin, Wappler, Frank, Meier-Hellmann, Andreas, Komnos, Apostolos, Bekos, Vasileios, Koulouras, Vasilios, Soultati, Ioanna, Baltopoulos, Georgios, Filntisis, Georgios, Zakynthinos, Epaminondas, Zakynthinos, Spyros, Pnevmatikos, Ioannis, Krémer, Ildikó, Szentkereszty, Zoltán, Sarkany, Agnes, Marjanek, Zsuzsa, Moura, Pedro, Pintado Delgado, Maria Consuelo, Montejo González, Juan Carlos, Ramirez, Paula, Torres Marti, Antonio, Valia, Juan Carlos, Lorente, Jose, Loza Vazquez, Ana, De Pablo Sanchez, Raúl, Escudero, Dolores, Ferrer Roca, Ricard, Pagani, Jean-Luc, Maggiorini, Marco, François, Bruno, Jafri, Hasan S, Chastre, Jean, Sánchez-García, Miguel, Eggimann, Philippe, Dequin, Pierre-François, Huberlant, Vincent, Viña Soria, Lucia, Boulain, Thierry, Bretonnière, Cédric, Pugin, Jérôme, Trenado, Josep, Hernandez Padilla, Ana Catalina, Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Coenjaerts, Frank E, Ruzin, Alexey, Barraud, Olivier, Timbermont, Leen, Lammens, Christine, Pierre, Vadryn, Wu, Yuling, Vignaud, Julie, Colbert, Susan, Bellamy, Terramika, Esser, Mark T, Dubovsky, Filip, Bonten, Marc J, Goossens, Herman, and Laterre, Pierre-François

Published
2021
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8. Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study

Author

Durá Navarro, Raquel, Ruano Suarez, María Carmen, Alonso Araujo, Inmaculada, Arenzana Seisdedos, Ángel, Córdoba López, Alberto, Camino Redondo, Nuria, Barbadillo Ansorregui, Sandra, Mouriz Fernández, Lorena, Vilas Otero, Maria Elena, Márquez Alonso, José Antonio, Bueno Blázquez, Adoración Gema, Abella Alvarez, Ana, Lobo Palanco, Joaquín, Cofiño Castañeda, Luis, Montejo González, J.C., García García, Miguel Ángel, Sandar Núñez, María Dolores, Tebar Soto, María Teresa, Cabadas Avión, Rafael, Gimeno Costa, Ricardo, Berezo García, José Ángel, García López, Fernando, López Matamala, Blanca, Colomar Ferrá, Asunción, Rey García, María Sopetrán, Cidoncha Calderón, Belén, Alcántara Carmona, Sara, Manteiga Riestra, Eva, Gil Rueda, Bernardo, Gallego González, Carlos, Jiménez Sánchez, Roberto, de Toro Martín-Consuegra, Ismael López, Souto Higueras, Jessica, Lander Azcona, Arantxa, Fuster Lozano, José María, Vera Artázcoz, Paula, Castro Orjales, María José, Arquitecto Marcide, H., Asensio Martín, María José, Estecha Foncea, María Antonia, Reig Valero, Roberto, Priego Sanz, Jesús, Vallés Daunis, Jordi, Ezpeleta Galindo, Ana Isabel, Álvarez Martínez, Braulio, Bobillo de Lamo, Felipe, Margarit Ribas, Antoni, Olaechea Astigarraga, Pedro M., Ballesteros Herráez, Juan Carlos, Saldaña Fernández, María Teresa, Sánchez Miralles, Ángel, Amaya Villar, Rosario, López-Cuervo, Juan Fajardo, Socias, Antonia, Bonet Saris, Alfons, Díaz Lamas, Ana María, Iruretagoyena Amiano, José Ramón, Acosta Rivera, Ingrid, Cerón García, María, Moradillo González, Susana, Rodríguez Pedreira, Paula, Palencia Herrejón, Eduardo, López Núñez, Carlos, Mas Lodo, Margarita, Pardo Talavera, Juan Carlos, Luisa Mora, María, Ferrer Roca, Ricard, de La Fuente Óconnor, Eugenia, Sánchez García, Miguel, Blanco Huelga, Carmen, Garijo Catalina, María Ángeles, Alcalá López, Adoración, Ugalde Gutierrez, Marta, Navarro Ruiz, María Rosa, Román Millan, María José, Lara Aguayo, Pedro, Herreros Gonzalo, María, Claverias Cabrera, Laura, Martos López, José, Valdovinos Mahave, María Concepción, Fontaneda López, Daniel, Matachana Martínez, María, García Sánchez, Esther, Santarrufina Lluch, Carmen, Garcés González, Rafael, Gallego Lara, Sonia, Martinez Trivez, Pilar, Vilanova Pàmies, Cecília, Llanos Jorge, Celina, Montejo Gonzalez, Juan Carlos, Alemparte Pardavila, Enrique, Olaechea Astigarraga, P.M., Álvarez Lerma, F., Beato Zambrano, C., Gimeno Costa, R., Gordo Vidal, F., Durá Navarro, R., Ruano Suarez, C., Aldabó Pallás, T., and Garnacho Montero, J.

Published
2021
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17. Genomic regions of durum wheat involved in water productivity.

Author

Zaïm, Meryem, Sanchez-Garcia, Miguel, Belkadi, Bouchra, Filali-Maltouf, Abdelkarim, Abdallat, Ayed Al, Kehel, Zakaria, and Bassi, Filippo M

Subjects
*DURUM wheat, *GENOME-wide association studies, *CLIMATE change
Abstract

Durum wheat is a staple food in the Mediterranean Basin, mostly cultivated under rainfed conditions. As such, the crop is often exposed to moisture stress. Therefore, the identification of genetic factors controlling the capacity of genotypes to convert moisture into grain yield (i.e. water productivity) is quintessential to stabilize production despite climatic variations. A global panel of 384 accessions was tested across 18 Mediterranean environments (in Morocco, Lebanon, and Jordan) representing a vast range of moisture levels. The accessions were assigned to water responsiveness classes, with genotypes 'Responsive to Low Moisture' reaching an average +1.5 kg ha–1 mm–1 yield advantage. Genome wide association studies revealed that six loci explained most of this variation. A second validation panel tested under moisture stress confirmed that carrying the positive allele at three loci on chromosomes 1B, 2A, and 7B generated an average water productivity gain of +2.2 kg ha–1 mm–1. These three loci were tagged by kompetitive allele specific PCR (KASP) markers, and these were used to screen a third independent validation panel composed of elites tested across moisture stressed sites. The three KASP combined predicted up to 10% of the variation for grain yield at 60% accuracy. These loci are now ready for molecular pyramiding and transfer across cultivars to improve the moisture conversion of durum wheat. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Contributors

Author

Bauer, Eva, primary, Bentley, Alison R., additional, Braun, Hans-Joachim, additional, Dreisigacker, Susanne, additional, Fahima, Tzion, additional, Fatiukha, Andrii, additional, Frisch, Matthias, additional, Ganal, Martin W., additional, Gardiner, Laura-Jayne, additional, Habekuss, Antje, additional, Hall, Anthony, additional, Hatta, M. Asyraf Md., additional, Hayes, Ben, additional, Herzog, Eva, additional, Hickey, Lee T., additional, Hiei, Yukoh, additional, Hohmeyer, Anja, additional, Huang, Lin, additional, Ishida, Yuji, additional, Joynson, Ryan, additional, Kis-Papo, Tamar, additional, Klymiuk, Valentina, additional, Komari, Toshihiko, additional, Kopahnke, Doris, additional, Korzun, Viktor, additional, Krugman, Tamar, additional, Kumlehn, Jochen, additional, Miedaner, Thomas, additional, Ordon, Frank, additional, Perovic, Dragan, additional, Plieske, Jörg, additional, Polley, Andreas, additional, Rabanus-Wallace, M. Timothy, additional, Röder, Marion S., additional, Sanchez-Garcia, Miguel, additional, Sansaloni, Carolina, additional, Saranga, Yehoshua, additional, Schweizer, Patrick, additional, Sehgal, Deepmala, additional, Serfling, Albrecht, additional, Singh, Ravi P., additional, Sorrells, Mark E., additional, Stein, Nils, additional, Steuernagel, Burkhard, additional, Sukumaran, Sivakumar, additional, Sun, Jin, additional, Sweeney, Daniel W., additional, Taagen, Ella, additional, Voss-Fels, Kai P., additional, Watson, Amy, additional, Wei, Zhen-zhen, additional, Wulff, Brande B.H., additional, and Würschum, Tobias, additional

Published
2019
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24. Convergently selected NPF2.12 coordinates root growth and nitrogen use efficiency in wheat and barley.

Author

Siddiqui, Md. Nurealam, Pandey, Kailash, Bhadhury, Suzan Kumer, Sadeqi, Bahman, Schneider, Michael, Sanchez‐Garcia, Miguel, Stich, Benjamin, Schaaf, Gabriel, Léon, Jens, and Ballvora, Agim

Subjects
ROOT growth, NITRATE reductase, WHEAT, HAPLOTYPES, BARLEY, GENE expression, NITRIC oxide, FIELD research
Abstract

Summary: Understanding the genetic and molecular function of nitrate sensing and acquisition across crop species will accelerate breeding of cultivars with improved nitrogen use efficiency (NUE).Here, we performed a genome‐wide scan using wheat and barley accessions characterized under low and high N inputs that uncovered the NPF2.12 gene, encoding a homolog of the Arabidopsis nitrate transceptor NRT1.6 and other low‐affinity nitrate transporters that belong to the MAJOR FACILITATOR SUPERFAMILY.Next, it is shown that variations in the NPF2.12 promoter correlated with altered NPF2.12 transcript levels where decreased gene expression was measured under low nitrate availability. Multiple field trials revealed a significantly enhanced N content in leaves and grains and NUE in the presence of the elite allele TaNPF2.12TT grown under low N conditions. Furthermore, the nitrate reductase encoding gene NIA1 was up‐regulated in npf2.12 mutant upon low nitrate concentrations, thereby resulting in elevated levels of nitric oxide (NO) production. This increase in NO correlated with the higher root growth, nitrate uptake, and N translocation observed in the mutant when compared to wild‐type.The presented data indicate that the elite haplotype alleles of NPF2.12 are convergently selected in wheat and barley that by inactivation indirectly contribute to root growth and NUE by activating NO signaling under low nitrate conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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30. List of contributors

Author

Amrapali, Shephalika, primary, Amri, Ahmad, additional, Babu, Banisetti Kalyana, additional, Baum, Michael, additional, Boczkowska, Maja, additional, Dweikat, Ismail, additional, Dwivedi, Sangam Lal, additional, Kant, Lakshmi, additional, Łapiński, Bogusław, additional, Mohapatra, Trilochan, additional, Ngangkham, Umakanta, additional, Ogbonnaya, Francis C., additional, Patra, Bhaskar C., additional, Pattanashetti, Santosh K., additional, Podyma, Wiesław, additional, Ray, Soham, additional, Reddy, Kothapally Narsimha, additional, Sanchez-Garcia, Miguel, additional, Singh, Shailesh Kumar, additional, Singh, Mohar, additional, Sohail, Quahir, additional, Tadesse, Wuletaw, additional, Upadhyaya, Hari D., additional, Vetriventhan, Mani, additional, and Wang, Yi-Hong, additional

Published
2016
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31. Wheat

Author

Tadesse, Wuletaw, primary, Amri, Ahmad, additional, Ogbonnaya, Francis.C., additional, Sanchez-Garcia, Miguel, additional, Sohail, Quahir, additional, and Baum, Michael, additional

Published
2016
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33. New trends in infective endocarditis

Author

Fariñas, M. Carmen, Llinares, Pedro, Almirante, Benito, Barberán, José, de Dios Colmenero, Juan, Garau, Javier, Gudiol, Francisco, Hernández Quero, José, Mensa, José, Montejo, Miguel, Pachón, Jerónimo, Rodríguez-Baño, Jesús, and Sánchez-García, Miguel

Published
2011
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37. Malting Quality of ICARDA Elite Winter Barley (Hordeum vulgare L.) Germplasm Grown in Moroccan Middle Atlas.

Author

Bouhlal, Outmane, Affricot, Jean Raymond, Puglisi, Damiano, El-Baouchi, Adil, El Otmani, Fatima, Kandil, Mostafa, Hafidi, Abdellatif, Keser, Mesut, Sanchez-Garcia, Miguel, and Visioni, Andrea

Subjects
BARLEY, MALTING, PEARSON correlation (Statistics), GERMPLASM, PRINCIPAL components analysis, MALT
Abstract

The use of barley (Hordeum vulgare L.) in Morocco is still limited to food and feed despite the amplified demand by local industries for imported malt. This study aims to evaluate 36 barley elite lines for major grain physicochemical parameters and malt quality traits. Analysis of variance, Pearson correlation, principal component analysis (PCA), and hierarchical cluster analysis (HCA) were performed. The results showed significant genotypic variation among genotypes for individual grain and malt traits. High broad sense heritability was obtained for all traits except for plump grain percentage, malt friability, and germination capacity. Starch, malt extract, Kolbach index, grain area, and test weight correlated significantly and negatively with barley protein. Malt extract correlated positively with Kolbach index and starch, but a negative correlation with soluble protein and malt protein was found. Based on 12 characters, 77% of the total genotypic variation was explained by the three first principal components following PCA and four clusters were depicted based on HCA. Genotypes of high interest with desirable levels of quality standards were identified to be used as a malt quality traits donor while designing crossing programs. Supplemental data for this article is available online at https://doi.org/10.1080/03610470.2021.1978036. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Malting Quality of ICARDA Elite Winter Barley (Hordeum vulgareL.) Germplasm Grown in Moroccan Middle Atlas

Author

Bouhlal, Outmane, Affricot, Jean Raymond, Puglisi, Damiano, El-Baouchi, Adil, El Otmani, Fatima, Kandil, Mostafa, Hafidi, Abdellatif, Keser, Mesut, Sanchez-Garcia, Miguel, and Visioni, Andrea

Abstract

AbstractThe use of barley (Hordeum vulgareL.) in Morocco is still limited to food and feed despite the amplified demand by local industries for imported malt. This study aims to evaluate 36 barley elite lines for major grain physicochemical parameters and malt quality traits. Analysis of variance, Pearson correlation, principal component analysis (PCA), and hierarchical cluster analysis (HCA) were performed. The results showed significant genotypic variation among genotypes for individual grain and malt traits. High broad sense heritability was obtained for all traits except for plump grain percentage, malt friability, and germination capacity. Starch, malt extract, Kolbach index, grain area, and test weight correlated significantly and negatively with barley protein. Malt extract correlated positively with Kolbach index and starch, but a negative correlation with soluble protein and malt protein was found. Based on 12 characters, 77% of the total genotypic variation was explained by the three first principal components following PCA and four clusters were depicted based on HCA. Genotypes of high interest with desirable levels of quality standards were identified to be used as a malt quality traits donor while designing crossing programs.Supplemental data for this article is available online at https://doi.org/10.1080/03610470.2021.1978036 .

Published
2022
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44. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

Author

Welte, Tobias, Dellinger, R. Phillip, Ebelt, Henning, Ferrer, Miguel, Opal, Steven M., Singer, Mervyn, Vincent, Jean-Louis, Werdan, Karl, Martin-Loeches, Ignacio, Almirall, Jordi, Artigas, Antonio, Ignacio Ayestaran, Jose, Nuding, Sebastian, Ferrer, Ricard, Sirgo Rodriguez, Gonzalo, Shankar-Hari, Manu, Alvarez-Lerma, Francisco, Riessen, Reimer, Sirvent, Josep-Maria, Kluge, Stefan, Zacharowski, Kai, Bonastre Mora, Juan, Lapp, Harald, Woebker, Gabriele, Achtzehn, Ute, Brealey, David, Kempa, Axel, Sanchez Garcia, Miguel, Brederlau, Joerg, Kochanek, Matthias, Reschreiter, Henrik Peer, Wise, Matthew P., Belohradsky, Bernd H., Bobenhausen, Iris, Dalken, Benjamin, Dubovy, Patrick, Langohr, Patrick, Mayer, Monika, Schuettrumpf, Joerg, Wartenberg-Demand, Andrea, Wippermann, Ulrike, Wolf, Daniele, Torres, Antoni, Welte, Tobias, Dellinger, R. Phillip, Ebelt, Henning, Ferrer, Miguel, Opal, Steven M., Singer, Mervyn, Vincent, Jean-Louis, Werdan, Karl, Martin-Loeches, Ignacio, Almirall, Jordi, Artigas, Antonio, Ignacio Ayestaran, Jose, Nuding, Sebastian, Ferrer, Ricard, Sirgo Rodriguez, Gonzalo, Shankar-Hari, Manu, Alvarez-Lerma, Francisco, Riessen, Reimer, Sirvent, Josep-Maria, Kluge, Stefan, Zacharowski, Kai, Bonastre Mora, Juan, Lapp, Harald, Woebker, Gabriele, Achtzehn, Ute, Brealey, David, Kempa, Axel, Sanchez Garcia, Miguel, Brederlau, Joerg, Kochanek, Matthias, Reschreiter, Henrik Peer, Wise, Matthew P., Belohradsky, Bernd H., Bobenhausen, Iris, Dalken, Benjamin, Dubovy, Patrick, Langohr, Patrick, Mayer, Monika, Schuettrumpf, Joerg, Wartenberg-Demand, Andrea, Wippermann, Ulrike, Wolf, Daniele, and Torres, Antoni

Abstract

Purpose: The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing similar to 23% immunoglobulin (Ig) M, similar to 21% IgA, and similar to 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). Methods: In this double-blind, phase II study (NCT01420744), 160 patients with sCAP requiring invasive mechanical ventilation were randomized (1:1) to trimodulin (42 mg IgM/kg/day) or placebo for five consecutive days. Primary endpoint was ventilator-free days (VFDs). Secondary endpoints included 28-day all-cause and pneumonia-related mortality. Safety and tolerability were monitored. Exploratory post hoc analyses were performed in subsets stratified by baseline C-reactive protein (CRP; >= 70 mg/L) and/or IgM (<= 0.8 g/L). Results: Overall, there was no statistically significant difference in VFDs between trimodulin (mean 11.0, median 11 [n = 81]) and placebo (mean 9.6; median 8 [n = 79]; p = 0.173). Twenty-eight-day all-cause mortality was 22.2% vs. 27.8%, respectively (p = 0.465). Time to discharge from intensive care unit and mean duration of hospitalization were comparable between groups. Adverse-event incidences were comparable. Post hoc subset analyses, which included the majority of patients (58-78%), showed significant reductions in all-cause mortality (trimodulin vs. placebo) in patients with high CRP, low IgM, and high CRP/low IgM at baseline. Conclusions: No significant differences were found in VFDs and mortality between trimodulin and placebo groups. Post hoc analyses supported improved outcome regarding mortality with trimodulin in subsets of patients with elevated CRP, reduced IgM, or both. These findings warrant further investigation.

Published
2018

46. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, II kirurgian klinikka, Department of Surgery, and Clinicum

Subjects
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, INTENSIVE-CARE-UNIT, SPECTRUM-BETA-LACTAMASE, VENTILATOR-ASSOCIATED PNEUMONIA, CLINICAL-PRACTICE GUIDELINES, GRAM-NEGATIVE BACTERIA, CLOSTRIDIUM-DIFFICILE INFECTION, BLOOD-STREAM INFECTIONS, 3126 Surgery, anesthesiology, intensive care, radiology, CRITICALLY-ILL PATIENTS, VANCOMYCIN-RESISTANT ENTEROCOCCI
Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

47. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

48. Antimicrobials

Author

University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

50. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, primary, Weber, Dieter G., additional, Ruppé, Etienne, additional, Bassetti, Matteo, additional, Wright, Brian J., additional, Ansaloni, Luca, additional, Catena, Fausto, additional, Coccolini, Federico, additional, Abu-Zidan, Fikri M., additional, Coimbra, Raul, additional, Moore, Ernest E., additional, Moore, Frederick A., additional, Maier, Ronald V., additional, De Waele, Jan J., additional, Kirkpatrick, Andrew W., additional, Griffiths, Ewen A., additional, Eckmann, Christian, additional, Brink, Adrian J., additional, Mazuski, John E., additional, May, Addison K., additional, Sawyer, Rob G., additional, Mertz, Dominik, additional, Montravers, Philippe, additional, Kumar, Anand, additional, Roberts, Jason A., additional, Vincent, Jean-Louis, additional, Watkins, Richard R., additional, Lowman, Warren, additional, Spellberg, Brad, additional, Abbott, Iain J., additional, Adesunkanmi, Abdulrashid Kayode, additional, Al-Dahir, Sara, additional, Al-Hasan, Majdi N., additional, Agresta, Ferdinando, additional, Althani, Asma A., additional, Ansari, Shamshul, additional, Ansumana, Rashid, additional, Augustin, Goran, additional, Bala, Miklosh, additional, Balogh, Zsolt J., additional, Baraket, Oussama, additional, Bhangu, Aneel, additional, Beltrán, Marcelo A., additional, Bernhard, Michael, additional, Biffl, Walter L., additional, Boermeester, Marja A., additional, Brecher, Stephen M., additional, Cherry-Bukowiec, Jill R., additional, Buyne, Otmar R., additional, Cainzos, Miguel A., additional, Cairns, Kelly A., additional, Camacho-Ortiz, Adrian, additional, Chandy, Sujith J., additional, Che Jusoh, Asri, additional, Chichom-Mefire, Alain, additional, Colijn, Caroline, additional, Corcione, Francesco, additional, Cui, Yunfeng, additional, Curcio, Daniel, additional, Delibegovic, Samir, additional, Demetrashvili, Zaza, additional, De Simone, Belinda, additional, Dhingra, Sameer, additional, Diaz, José J., additional, Di Carlo, Isidoro, additional, Dillip, Angel, additional, Di Saverio, Salomone, additional, Doyle, Michael P., additional, Dorj, Gereltuya, additional, Dogjani, Agron, additional, Dupont, Hervé, additional, Eachempati, Soumitra R., additional, Enani, Mushira Abdulaziz, additional, Egiev, Valery N., additional, Elmangory, Mutasim M., additional, Ferrada, Paula, additional, Fitchett, Joseph R., additional, Fraga, Gustavo P., additional, Guessennd, Nathalie, additional, Giamarellou, Helen, additional, Ghnnam, Wagih, additional, Gkiokas, George, additional, Goldberg, Staphanie R., additional, Gomes, Carlos Augusto, additional, Gomi, Harumi, additional, Guzmán-Blanco, Manuel, additional, Haque, Mainul, additional, Hansen, Sonja, additional, Hecker, Andreas, additional, Heizmann, Wolfgang R., additional, Herzog, Torsten, additional, Hodonou, Adrien Montcho, additional, Hong, Suk-Kyung, additional, Kafka-Ritsch, Reinhold, additional, Kaplan, Lewis J., additional, Kapoor, Garima, additional, Karamarkovic, Aleksandar, additional, Kees, Martin G., additional, Kenig, Jakub, additional, Kiguba, Ronald, additional, Kim, Peter K., additional, Kluger, Yoram, additional, Khokha, Vladimir, additional, Koike, Kaoru, additional, Kok, Kenneth Y. Y., additional, Kong, Victory, additional, Knox, Matthew C., additional, Inaba, Kenji, additional, Isik, Arda, additional, Iskandar, Katia, additional, Ivatury, Rao R., additional, Labbate, Maurizio, additional, Labricciosa, Francesco M., additional, Laterre, Pierre-François, additional, Latifi, Rifat, additional, Lee, Jae Gil, additional, Lee, Young Ran, additional, Leone, Marc, additional, Leppaniemi, Ari, additional, Li, Yousheng, additional, Liang, Stephen Y., additional, Loho, Tonny, additional, Maegele, Marc, additional, Malama, Sydney, additional, Marei, Hany E., additional, Martin-Loeches, Ignacio, additional, Marwah, Sanjay, additional, Massele, Amos, additional, McFarlane, Michael, additional, Melo, Renato Bessa, additional, Negoi, Ionut, additional, Nicolau, David P., additional, Nord, Carl Erik, additional, Ofori-Asenso, Richard, additional, Omari, AbdelKarim H., additional, Ordonez, Carlos A., additional, Ouadii, Mouaqit, additional, Pereira Júnior, Gerson Alves, additional, Piazza, Diego, additional, Pupelis, Guntars, additional, Rawson, Timothy Miles, additional, Rems, Miran, additional, Rizoli, Sandro, additional, Rocha, Claudio, additional, Sakakhushev, Boris, additional, Sanchez-Garcia, Miguel, additional, Sato, Norio, additional, Segovia Lohse, Helmut A., additional, Sganga, Gabriele, additional, Siribumrungwong, Boonying, additional, Shelat, Vishal G., additional, Soreide, Kjetil, additional, Soto, Rodolfo, additional, Talving, Peep, additional, Tilsed, Jonathan V., additional, Timsit, Jean-Francois, additional, Trueba, Gabriel, additional, Trung, Ngo Tat, additional, Ulrych, Jan, additional, van Goor, Harry, additional, Vereczkei, Andras, additional, Vohra, Ravinder S., additional, Wani, Imtiaz, additional, Uhl, Waldemar, additional, Xiao, Yonghong, additional, Yuan, Kuo-Ching, additional, Zachariah, Sanoop K., additional, Zahar, Jean-Ralph, additional, Zakrison, Tanya L., additional, Corcione, Antonio, additional, Melotti, Rita M., additional, Viscoli, Claudio, additional, and Viale, Perluigi, additional

Published
2016
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