148 results on '"Sanchez, Margaux"'
Search Results
2. Chemical exposome and children health: Identification of dose-response relationships from meta-analyses and epidemiological studies
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Rocabois, Audrey, Sanchez, Margaux, Philippat, Claire, Crépet, Amélie, Wies, Blanche, Vrijheid, Martine, Nieuwenhuijsen, Mark, and Slama, Rémy
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- 2024
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3. Structural Elucidation of Complex Polyesters Polyols from Bio-Lubricant Using Off-Line Liquid Chromatography X Supercritical Fluid Chromatography Coupled with Orbitrap Mass Spectrometry
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Sanchez, Margaux, primary, Lacroix-Andrivet, Oscar, additional, Crozet, Delphine, additional, Crepier, Julien, additional, and Faure, Karine, additional
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- 2024
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4. Low socioeconomic position and neighborhood deprivation are associated with uncontrolled asthma in elderly
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Temam, Sofia, Chanoine, Sébastien, Bédard, Annabelle, Dumas, Orianne, Sanchez, Margaux, Boutron-Ruault, Marie-Christine, Siroux, Valérie, Rican, Stéphane, Varraso, Raphaëlle, and Le Moual, Nicole
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- 2019
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5. Personal exposure to particulate matter in peri-urban India: predictors and association with ambient concentration at residence
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Sanchez, Margaux, Milà, Carles, Sreekanth, V., Balakrishnan, Kalpana, Sambandam, Sankar, Nieuwenhuijsen, Mark, Kinra, Sanjay, Marshall, Julian D., and Tonne, Cathryn
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- 2020
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6. Asthma Medication Ratio Phenotypes in Elderly Women
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Chanoine, Sébastien, Pin, Isabelle, Sanchez, Margaux, Temam, Sofia, Pison, Christophe, Le Moual, Nicole, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Bousquet, Jean, Bedouch, Pierrick, Varraso, Raphaëlle, and Siroux, Valérie
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- 2018
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7. Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study
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Havet, Anaïs, Li, Zhen, Zerimech, Farid, Sanchez, Margaux, Siroux, Valérie, Le Moual, Nicole, Brunekreef, Bert, Künzli, Nino, Jacquemin, Bénédicte, Varraso, Raphaëlle, Matran, Régis, and Nadif, Rachel
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- 2019
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8. Ambient Particulate Air Pollution and Blood Pressure in Peri-urban India
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Curto, Ariadna, Wellenius, Gregory A., Milà, Carles, Sanchez, Margaux, Ranzani, Otavio, Marshall, Julian D., Kulkarni, Bharati, Bhogadi, Santhi, Kinra, Sanjay, and Tonne, Cathryn
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- 2019
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9. Perceived 10-year change in respiratory health: Reliability and predictive ability
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Sanchez, Margaux, Varraso, Raphaëlle, Bousquet, Jean, Clavel-Chapelon, Françoise, Pison, Christophe, Kauffmann, Francine, Humbert, Marc, and Siroux, Valérie
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- 2015
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10. Land-Use Change and Cardiometabolic Risk Factors in an Urbanizing Area of South India: A Population-Based Cohort Study
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Mila, Carles, Ranzani, Otavio, Sanchez, Margaux, Ambros, Albert, Bhogadi, Santhi, Kinra, Sanjay, Kogevinas, Manolis, Dadvand, Payam, and Tonne, Cathryn
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Blood cholesterol ,Land use controls ,Mediation ,Urban health ,Physical fitness ,Glucose ,Urbanization ,Air pollution ,Medical research ,Exercise ,Land use -- Spain -- India ,Housing ,Health ,Pollution ,Setting (Literature) ,Remote sensing ,Fasting ,Urban planning ,Retirement benefits ,Triglycerides ,Children ,Environmental issues ,Health - Abstract
Background: Land-use changes in city fringes due to urbanization can lead to a reduction of greenspace that may reduce its associated health benefits. Objectives: We evaluated the association between changes in residential surrounding built-up land use and cardiometabolic risk factors in an urbanizing peri-urban area of south India and explored the mediating roles of air pollution, physical activity, and stress in these associations. Methods: We analyzed data on 6,039 adults from the third follow-up of the Andhra Pradesh Children and Parent Study (APCAPS) cohort (20102012). We generated trajectories of change in residential surrounding built-up land use (buffer areas) from 1995-2009 (stable, slow increase, fast increase) using remote sensing data and image classification methods. We estimated associations between built-up land use trajectories and natural log-transformed blood pressure, waist circumference, triglycerides, fasting glucose, and non-high-density lipoprotein (non-HDL) cholesterol using linear mixed models. We accounted for multiple mediators and the multilevel structure of the data in mediation analyses. Results: We observed positive associations between a fast increase in built-up land use within 300 m of the home and all cardiometabolic risk factors. Compared with participants with stable trajectories, those with the largest increase in built-up land use had 1.5% (95% CI: 0.1, 2.9) higher systolic blood pressure, 2.4% (95% CI: 0.6,4.3) higher diastolic blood pressure, 2.1% (95% CI: 0.5, 3.8) higher waist circumference, and 1.6% (95% CI: -0.6,3.8) higher fasting glucose in fully adjusted models. Associations were positive, but not statistically significant, for triglycerides, fasting glucose, and non-HDL cholesterol. Physical activity and ambient particulate matter [less than or equal to]2.5 [micro]m in aerodynamic diameter ([PM.sub.2.5]) partially mediated the estimated associations. Associations between fast build-up and all cardiometabolic risk factors except non-HDL cholesterol were stronger in women than men. Discussion: Increases in built-up land use surrounding residences were consistently associated with higher levels of cardiometabolic risk factors. Our findings support the need for better integration of health considerations in urban planning in rapidly urbanizing settings. https://doi.org/10.1289/EHP5445, Introduction India is undergoing an epidemiologic transition: The contribution of noncommunicable diseases to the total burden of disease in India (measured in disability-adjusted life years) increased from 31% in 1990 [...]
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- 2020
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11. Cleaning sprays, household help and asthma among elderly women
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Bédard, Annabelle, Varraso, Raphaëlle, Sanchez, Margaux, Clavel-Chapelon, Françoise, Zock, Jan-Paul, Kauffmann, Francine, and Le Moual, Nicole
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- 2014
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12. Le danger lié à l’ingestion d’amiante: revue systématique et évaluation du poids des preuves
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Arpin-Pont, Lauren, Sanchez, Margaux, Durand, Emmanuelle, Brochard, Patrick, Clin-Godard, Benedicte, Delva, Fleur, Dublineau, Isabelle, Jaurand, Marie-Claude, Joubert, Olivier, Levallois, Patrick, Manfredi, Sylvain, Tournigand, Christophe, Pairon, Jean-Claude, and Druesne, Christine
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[SDV] Life Sciences [q-bio] - Published
- 2022
13. The French 2016-2020 National Occupational Health Plan: a better understanding of multiple exposures
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Fourneau, Clémence, additional, Sanchez, Margaux, additional, Perouel, Guillaume, additional, Frery, Nadine, additional, Coutrot, Thomas, additional, Boulanger, Guillaume, additional, Courrier, Benoit, additional, Pernelet-Joly, Valérie, additional, and Bastos, Henri, additional
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- 2021
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14. Confirmatory Factor Analysis Compared with Principal Component Analysis to Derive Dietary Patterns: A Longitudinal Study in Adult Women1-3
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Bédard, Annabelle, Garcia-Aymerich, Judith, Sanchez, Margaux, Le Moual, Nicole, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Maccario, Jean, and Varraso, Raphaëlle
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- 2015
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15. Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts
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Cai, Yutong, Schikowski, Tamara, Adam, Martin, Buschka, Anna, Carsin, Anne-Elie, Jacquemin, Benedicte, Marcon, Alessandro, Sanchez, Margaux, Vierkötter, Andrea, Al-Kanaani, Zaina, Beelen, Rob, Birk, Matthias, Brunekreef, Bert, Cirach, Marta, Clavel-Chapelon, Françoise, Declercq, Christophe, de Hoogh, Kees, de Nazelle, Audrey, Ducret-Stich, Regina E, Ferretti, Virginia Valeria, Forsberg, Bertil, Gerbase, Margaret W, Hardy, Rebecca, Heinrich, Joachim, Hoek, Gerard, Jarvis, Debbie, Keidel, Dirk, Kuh, Diana, Nieuwenhuijsen, Mark J, Ragettli, Martina S, Ranzi, Andrea, Rochat, Thierry, Schindler, Christian, Sugiri, Dorothea, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Kauffmann, Francine, Krämer, Ursula, Sunyer, Jordi, Künzli, Nino, Probst-Hensch, Nicole, and Hansell, Anna L
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- 2014
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16. Avis et rapport de l'Anses relatif à l'impact sanitaire et coûts associés de l'ambroisie à feuilles d'armoise en France
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Charpin, Denis, Desneux, Nicolas, Escobar-Gutiérrez, Abraham, Fumanal, Boris, Polomé, Philippe, Poncet, Pascal, Sanchez, Olivier, Thibaudon, Michel, Bayeux, Thomas, Sanchez, Margaux, Assistance Publique - Hôpitaux de Marseille (APHM), Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères (P3F), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Centre d'Innovation et Recherche Technologique / Center for Innovation and Technological Research, Institut Pasteur [Paris], AIRPARIF - Surveillance de la qualité de l'air en Île-de-France, Mission Sciences sociales Expertise et Société (MiSSES), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Direction de l'Evaluation des Risques (DER), ANSES, Université Nice Sophia Antipolis (1965 - 2019) (UNS), Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), and Anses
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Prévention ,Allergy ,Coût social ,Modelling ,Allergic rhinitis ,Allergie ,Coûts ,Heath Impact ,Control ,Rhinite allergique ,Ambroisie ,Impact économique ,[SDV.EE]Life Sciences [q-bio]/Ecology, environment ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,social cost ,Cartographie ,Prevention ,Lutte ,MESH: Ambrosia ,Costs ,Management ,Pollinosis ,Impact sanitaire ,Pollinose ,Modélisation ,Maps ,[SDE]Environmental Sciences ,Economic Impact ,Ambrosia - Abstract
Rapport d'expertise collective du Comité d’experts spécialisé « Évaluation des risques liés aux milieux aériens ». Groupe de Travail « Ambroisie ». ENG: 'Opinon of the French Agency for Food, Environmental and Occupational Health & Safety on the health impact and related costs of common ragweed in France'; As underlined in a previous ANSES publication (ANSES 2014), common ragweed1releases a highly allergenic pollen that can easily travel long distances and is thus a major public health challenge. Widespread in Hungaryand in northern Italy, ragweed is also found in the Rhône Valley in France. Recent maps have shown wider spread of the plantin France over the past few years.The health impact of ragweed is regularly assessed in Auvergne-Rhône-Alpes, the most affected region of France, by the Regional Health Agency (ARS) and the Regional Health Observatory (ORS). According to a telephone survey of the general public, the prevalence of ragweed allergy was estimated at 12.5% to 14.1% in this region and has been increasing since 2004 (Anzivino, Marant-Micallef, andSonko 2014). High spatial disparities have been observed. Expenditure associated with this allergy (including use of medication, consultations and sick leave) was estimated at €8.9 to €13.2 million in 2014 in the Rhône-Alpes region (Gelas 2015). However, the health and economic impact of ragweed still needs to be assessed inthe rest of France (outside of Auvergne-Rhône-Alpes).The Third National Environmental Health Action Plan (2015-2019) provides for measures for the monitoring and assessment of ragweed in France, but with no legal framework. Decree no. 2017-645 of 26 April 2017 defines measures intended to prevent the appearance of ragweed or limit its spread; their implementation is placed under the responsibility of prefects after opinions issued by the ARS and the Departmental Council for the Environment and Health and Technological Risks (CODERST).In this context, the Directorate General for Health submitted a formal request to ANSES on 5 April 2018 to:- Document the prevalence of common ragweed allergy and its changes in recent years in France and abroad based onthe level of exposure to ragweed pollen and the level of infestation.- Identify potential mechanisms and factors associated with differentiated changes in this prevalence. These may include intrinsic factors related to the plant (local spread) and extrinsic factors related to human activity and climate change possibly favouring the spread of ragweed.- Estimate the prevalence of ragweed allergy across France and how it may develop based on proposed scenarios of changes in the state of infestation. A distribution by département will be investigated.- Assess the cost of ragweed allergy across France and how it may change taking the same change scenarios into account. A distribution of these costs by départementwill be investigated. The impacts of ragweed vary in nature. In light of the objectives set, this appraisal focused on the health impact and ultimately the costs associated with this impact. However, data are also given for informational purposes to drive reflections concerning the agri-environmental impacts.; Comme l’ont souligné de précédents travaux Anses (Anses 2014), l’ambroisie à feuille d’armoise1émet un pollen fortement allergisant qui est facilement transportable sur de longues distances, constituant ainsi un enjeu de santé publique important. Très présente en Hongrie et au nord de l’Italie, l’ambroisie est également recensée dans la Vallée du Rhône en France. Des cartographies récentes ont mis en évidence une extension de la présence de la plante en France au cours des dernières années.L’impact sanitaire de l’ambroisie est régulièrement évalué en Auvergne-Rhône-Alpes, région française la plus touchée, par l’Agence Régionale de Santé (ARS) et l’Observatoire Régional de Santé (ORS). Selon une enquête téléphonique en population générale, la prévalence de l’allergie à l’ambroisie a été estimée entre 12,5% et 14,1% dans cette région, en augmentation depuis 2004 (Anzivino, Marant-Micallef, et Sonko 2014). De fortes disparités spatiales sont constatées. Les dépenses liées à cette allergie (incluant utilisation de médicaments, consultations, et arrêts de travail) ont quant à elles été estimées entre 8,9 et 13,2 millions d’euros en 2014 en Rhône-Alpes(Gelas 2015). Cependant, l’impact sanitaire et économique lié à l’ambroisie reste à estimer dans le reste du territoire français (hors Auvergne-Rhône-Alpes). Le 3ème Plan national santé-environnement (2015-2019) prévoit des mesures pour la surveillance et l’évaluation de l’ambroisie en France, mais sans cadre juridique. Le décret n°2017-645 du 26 avril 2017 définit les mesures destinées à prévenir l’apparition de l’ambroisie ou lutter contre sa prolifération et dont l’application est placée sous la responsabilité des préfets après avis de l’ARS et du Conseil départemental de l’environnement et des risques sanitaires et technologiques(CODERST).Dans ce cadre, la direction générale de la santé a saisi l’Anses le 05 avril 2018 afin de : •Documenter la prévalence de l’allergie à l’ambroisie à feuilles d’armoise et son évolution au cours des dernières années en France et à l’étranger en fonction notamment du niveau d’exposition au pollen et du niveau d’infestation par la plante.•Identifier les éventuels mécanismes et facteurs associés à l’évolution différenciée de cette prévalence. Il pourra être question des facteurs intrinsèques liés à la plante (propagation sur le territoire) ou des facteurs extrinsèques liés à l’activité humaine et au changement climatique pouvant favoriser la propagation de l’ambroisie.•Estimer la prévalence de l’allergie à l’ambroisie pour l’ensemble du territoire national et son évolution possible sur la base de scénarios d’évolution de l’état d’infestation qui seront proposés. Une distribution par département sera recherchée.•Évaluer le coût de l’allergie à l’ambroisie sur l’ensemble du territoire national et son évolution possible tenant compte des mêmes scénarios d’évolution. Une distribution par département de ces coûts sera recherchée.Les impacts générés par l’ambroisie sont de nature variée. Au regard des objectifs visés, les présents travaux se sont concentrés sur l’impact sanitaire et, in fine, les coûts associés à cet impact. Toutefois, des données pouvant alimenter les réflexions concernant les impacts agro-environnementaux sont citées à titre informatif.
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- 2020
17. Personal exposure to particulate air pollution and vascular damage in peri-urban South India
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Ranzani, Otavio T., primary, Milà, Carles, additional, Sanchez, Margaux, additional, Bhogadi, Santhi, additional, Kulkarni, Bharati, additional, Balakrishnan, Kalpana, additional, Sambandam, Sankar, additional, Sunyer, Jordi, additional, Marshall, Julian D, additional, Kinra, Sanjay, additional, and Tonne, Cathryn, additional
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- 2020
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18. Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project
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Ranzani, Otavio T, primary, Milà, Carles, primary, Sanchez, Margaux, primary, Bhogadi, Santhi, primary, Kulkarni, Bharati, primary, Balakrishnan, Kalpana, primary, Sambandam, Sankar, primary, Sunyer, Jordi, primary, Marshall, Julian D, primary, Kinra, Sanjay, primary, and Tonne, Cathryn, primary
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- 2019
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19. Lack of association between particulate air pollution and blood glucose levels and diabetic status in peri-urban India
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Curto, Ariadna, primary, Ranzani, Otavio, additional, Milà, Carles, additional, Sanchez, Margaux, additional, Marshall, Julian D., additional, Kulkarni, Bharati, additional, Bhogadi, Santhi, additional, Kinra, Sanjay, additional, Wellenius, Gregory A., additional, and Tonne, Cathryn, additional
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- 2019
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20. Plan santé au travail 2016-2020 : mieux connaître la polyexposition.
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Fourneau, Clémence, Sanchez, Margaux, Perouel, Guillaume, Frery, Nadine, Coutrot, Thomas, Boulanger, Guillaume, Courrier, Benoit, Pernelet-Joly, Valérie, and Bastos, Henri
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INDUSTRIAL hygiene ,EMPLOYEE surveillance ,TITERS ,RISK exposure - Abstract
Résumé: Tout au long de leur carrière professionnelle, les travailleurs sont susceptibles d'être exposés simultanément à de multiples facteurs de risque sanitaires. Dans le cadre du Plan santé au travail (PST) 2016-2020, une action spécifique visait l'amélioration de la prise en compte de la polyexposition, un défi majeur pour l'ensemble des acteurs de la sécurité sanitaire et de la prévention. À ce titre, un premier état des lieux a recensé les principales actions conduites sur la question de la polyexposition au niveau institutionnel en France et dans d'autres pays en Europe et en Amérique du Nord. Une seconde phase d'analyse, fondée sur l'exploitation des résultats de l'enquête Sumer 2016-2017 (Surveillance médicale des expositions des salariés aux risques professionnels), a permis l'identification de profils homogènes de travailleurs polyexposés. Ces profils objectivent des situations de polyexpositions qui concernent la quasi-totalité des salariés français. Throughout their professional careers, workers can potentially be exposed to multiple health risk factors simultaneously. As part of the French 2016-2020 National Occupational Health Plan, specific initiatives aimed to improve consideration of multiple exposures and how to avoid them, a major challenge in the field of occupational health, safety, and prevention. To this end, an initial review listed the measures taken to address the question of multiple exposures at institutional level in France and in other countries in Europe and North America. A subsequent analysis phase, based on the exploitation of the 2017 Sumer survey results (Medical surveillance of employees' exposure to occupational risks), identified a range of homogeneous profiles of workers with multiple exposures into which almost all French employees fall. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Poly-expositions au travail : 12 profils pour orienter la prévention et la recherche
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Fourneau, Clémence, Sanchez, Margaux, Coutrot, Thomas, and Frery, Nadine
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Tout au long de leur carrière professionnelle, les travailleurs sont susceptibles d’être exposés simultanément à de multiples facteurs de risques sanitaires.
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- 2024
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22. Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study
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Havet, Anaïs, Zerimech, Farid, Sanchez, Margaux, Siroux, Valérie, Le Moual, Nicole, Brunekreef, Bert, Stempfelet, Morgane, Künzli, Nino, Jacquemin, Bénédicte, Matran, Régis, Nadif, Rachel, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biochimie et Biologie Moléculaire [CHRU Lille] (Pôle de Biologie Pathologie Génétique), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Epidemiology & Pulmonology [Barcelona, Spain] (ISGlobal), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Universitat Pompeu Fabra [Barcelona] (UPF), Equipe d’Epidémiologie Environnementale - INSERM U1209/CNRS UMR5309 (Site Santé), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Division of Occupational and Environmental Health [Utrecht, the Netherlands] (Institute for Risk Assessment - IRAS), Utrecht University [Utrecht], Julius Center for Health Sciences and Primary Care [Utrecht, the Netherlands], University Medical Center [Utrecht], Institut de Veille Sanitaire (INVS), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Université de Lille, Research was funded in part by the National Hospital program of clinical research (PHRC448 national 2012, EvAdA), ANR-CES-2009, Region Nord Pas-de-Calais, Merck Sharp & Dohme (MSD), the GA2LEN project, Global Allergy and Asthma European Network, and the Fonds AGIR pour les maladies chroniques. ESCAPE (FP7/2007-2011, Grant Nr.211250). Anaïs Havet is financed by the university hospital center of Lille., European Project: 211250,EC:FP7:ENV,FP7-ENV-2007-1,ESCAPE(2008), Universitat Pompeu Fabra [Barcelona] (UPF)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), and Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
International audience; Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m-3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL-1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m-3), and decreased with O3 and O3-summer exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m-3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.
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- 2018
23. Personal exposure to particulate matter in peri-urban India: predictors and association with ambient concentration at residence
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Sanchez, Margaux, primary, Milà, Carles, additional, Sreekanth, V., additional, Balakrishnan, Kalpana, additional, Sambandam, Sankar, additional, Nieuwenhuijsen, Mark, additional, Kinra, Sanjay, additional, Marshall, Julian D., additional, and Tonne, Cathryn, additional
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- 2019
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24. Risk of asthma onset after natural and surgical menopause: Results from the French E3N cohort
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Matulonga-Diakiese, Bobette, primary, Courbon, Dominique, additional, Fournier, Agnès, additional, Sanchez, Margaux, additional, Bédard, Annabelle, additional, Mesrine, Sylvie, additional, Taillé, Camille, additional, Severi, Gianluca, additional, Thabut, Gabriel, additional, Varraso, Raphaëlle, additional, and Leynaert, Bénédicte, additional
- Published
- 2018
- Full Text
- View/download PDF
25. When, Where, and What? Characterizing Personal PM2.5 Exposure in Periurban India by Integrating GPS, Wearable Camera, and Ambient and Personal Monitoring Data
- Author
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Milà, Carles, primary, Salmon, Maëlle, additional, Sanchez, Margaux, additional, Ambrós, Albert, additional, Bhogadi, Santhi, additional, Sreekanth, V., additional, Nieuwenhuijsen, Mark, additional, Kinra, Sanjay, additional, Marshall, Julian D., additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
26. Additional file 1: Table S1. of Ability of ecological deprivation indices to measure social inequalities in a French cohort
- Author
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Temam, Sofia, Varraso, Raphaëlle, Pornet, Carole, Sanchez, Margaux, Affret, Aurélie, Jacquemin, Bénédicte, Clavel-Chapelon, Françoise, Rey, Grégoire, Rican, Stéphane, and Moual, Nicole Le
- Abstract
Variables included in each area-based deprivation index (n=44,709 IRIS). Table S2. Associations between individual- and area-level SEP with smoking initiation and overweight among women who did not move between 1991 and 2005 (n=39,130). Figure S1. Flow-chart: selection of the study population (n=63,888). Figure S2. Distribution of the E3N population in the whole France deprivation indices quintiles. Figure S3. Associations between individual-level and three area-based deprivation indices with smoking status stratified by age. Figure S4. Comparison of the associations between three area-based deprivations indices with smoking status according to weighted and unweighted quintiles. Figure S5. Comparison of associations between three area-based deprivation indices with overweight status according to weighted and unweighted quintiles. Figure S6. Geographical distribution of the three deprivation indices at IRIS level in France. (DOCX 922 kb)
- Published
- 2017
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- View/download PDF
27. Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project.
- Author
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Ranzani, Otavio T, Milà, Carles, Sanchez, Margaux, Bhogadi, Santhi, Kulkarni, Bharati, Balakrishnan, Kalpana, Sambandam, Sankar, Sunyer, Jordi, Marshall, Julian D, Kinra, Sanjay, and Tonne, Cathryn
- Subjects
INDOOR air pollution ,CAROTID intima-media thickness ,AIR pollutants ,AIR pollution ,PARTICULATE matter ,MIDDLE-income countries ,HIV-positive children ,CAROTID artery ,RESEARCH ,ENVIRONMENTAL monitoring ,SUBURBANITES ,CROSS-sectional method ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,ATHEROSCLEROSIS ,COMPARATIVE studies ,RESIDENTIAL patterns ,HOUSING ,ENVIRONMENTAL exposure ,LONGITUDINAL method - Abstract
Background: Evidence linking ambient air pollution with atherosclerosis is lacking from low- and middle-income countries. Additionally, evidence regarding the association between household air pollution and atherosclerosis is limited. We evaluated the association between ambient fine particulate matter [particulate matter with an aerodynamic diameter of ≤2.5 µm (PM2.5)] and biomass fuel use on carotid intima-media thickness (CIMT), a surrogate of atherosclerosis, in India.Methods: We analysed the third follow-up of the Andhra Pradesh Children and Parent Study cohort (2010-2012), which recruited participants from 28 peri-urban villages. Our primary outcome was mean CIMT, measured using a standardized protocol. We estimated annual average PM2.5 outdoors at residence using land-use regression. Biomass cooking fuel was self-reported. We fitted a within-between linear-mixed model adjusting for potential confounders.Results: Among 3278 participants (48% women, mean age 38 years), mean PM2.5 was 32.7 [range 24.4-38.2] µg/m3, and 60% used biomass. After confounder adjustment, we observed positive associations between within-village variation in PM2.5 and CIMT in all participants [1.79%, 95% confidence interval (CI), -0.31 to 3.90 per 1 µg/m3 of PM2.5] and in men (2.98%, 95% CI, 0.23-5.72, per 1 µg/m3 of PM2.5). Use of biomass cooking fuel was associated with CIMT in all participants (1.60%, 95% CI, -0.46 to 3.65), especially in women with an unvented stove (6.14%, 95% CI, 1.40-10.89). The point-estimate for the PM2.5 association was larger in sub-groups with higher cardiometabolic risk profile.Conclusions: Ambient and household air pollution were positively associated with CIMT in a peri-urban population of India, although with limited precision for some estimates. We observed differences in the association between ambient and household air pollution and CIMT by gender. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
28. Particle Exposure Assessment in Peri-Urban India: Lessons Learned from the CHAI Project
- Author
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Tonne, Cathryn, primary, Sanchez, Margaux, additional, Mila, Carles, additional, Sreekanth, V, additional, Sambandam, Sankar, additional, Balakrishnan, Kalpana, additional, and Marshall, Julian, additional
- Published
- 2018
- Full Text
- View/download PDF
29. Residential Ambient Particulate Air Pollution and Blood Pressure in Peri-Urban India
- Author
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Curto Tirado, Ariadna, primary, Wellenius, Gregory A, additional, Mila, Carles, additional, Sanchez, Margaux, additional, Ranzani, Otavio, additional, Marshall, Julian, additional, Kulkarni, Bharati, additional, Bhogadi, Santhi, additional, Kinra, Sanjay, additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
30. Residential Built-Up Area in Relation to Markers of Cardiovascular Health in Peri-Urban South India
- Author
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Sanchez, Margaux, primary, Mila, Carles, additional, Ambros, Albert, additional, Ranzani, Otavio, additional, Kinra, Sanjay, additional, Dadvand, Payam, additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
31. Outdoor Air Pollution, Fluorescent Oxidation Products and Persistent Asthma: The EGEA Study
- Author
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Havet, Anaïs, primary, Li, Zhen, additional, Zerimech, Farid, additional, Sanchez, Margaux, additional, Siroux, Valérie, additional, Le Moual, Nicole, additional, Brunekreef, Bert, additional, Küenzli, Nino, additional, Jacquemin, Bénédicte, additional, Varraso, Raphaëlle, additional, Matran, Régis, additional, and Nadif, Rachel, additional
- Published
- 2018
- Full Text
- View/download PDF
32. Air Pollution and Subclinical Atherosclerosis in a Peri-Urban Area in South India (CHAI-Project)
- Author
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Ranzani, Otavio, primary, Mila, Carles, additional, Sanchez, Margaux, additional, Marshall, Julian, additional, Kinra, Sanjay, additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
33. Development of land-use regression models for fine particles and black carbon in peri-urban South India
- Author
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Sanchez, Margaux, primary, Ambros, Albert, additional, Milà, Carles, additional, Salmon, Maëlle, additional, Balakrishnan, Kalpana, additional, Sambandam, Sankar, additional, Sreekanth, V., additional, Marshall, Julian D., additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
34. Wearable camera-derived microenvironments in relation to personal exposure to PM2.5
- Author
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Salmon, Maëlle, primary, Milà, Carles, additional, Bhogadi, Santhi, additional, Addanki, Srivalli, additional, Madhira, Pavitra, additional, Muddepaka, Niharika, additional, Mora, Amaravathi, additional, Sanchez, Margaux, additional, Kinra, Sanjay, additional, Sreekanth, V., additional, Doherty, Aiden, additional, Marshall, Julian D., additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
35. Multimorbidity medications and poor asthma prognosis
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Chanoine, Sébastien, primary, Sanchez, Margaux, additional, Pin, Isabelle, additional, Temam, Sofia, additional, Le Moual, Nicole, additional, Fournier, Agnès, additional, Pison, Christophe, additional, Bousquet, Jean, additional, Bedouch, Pierrick, additional, Boutron-Ruault, Marie-Christine, additional, Varraso, Raphaëlle, additional, and Siroux, Valérie, additional
- Published
- 2018
- Full Text
- View/download PDF
36. Development of Land Use Regression Model for Fine Particles in Peri-Urban South India
- Author
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Sanchez, Margaux, primary, Ambros, Albert, additional, Salmon, Maëlle, additional, Mila, Carles, additional, Sreekanth, Vakacherla, additional, Marshall, Julian D., additional, and Tonne, Cathryn, additional
- Published
- 2018
- Full Text
- View/download PDF
37. Ability of ecological deprivation indices to measure social inequalities in a French cohort
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Temam, Sofia, primary, Varraso, Raphaëlle, additional, Pornet, Carole, additional, Sanchez, Margaux, additional, Affret, Aurélie, additional, Jacquemin, Bénédicte, additional, Clavel-Chapelon, Françoise, additional, Rey, Grégoire, additional, Rican, Stéphane, additional, and Le Moual, Nicole, additional
- Published
- 2017
- Full Text
- View/download PDF
38. Outdoor air pollution, 8-isoprostanes and asthma in adults of the EGEA study
- Author
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Havet, Anaïs, primary, Zerimech, Farid, additional, Sanchez, Margaux, additional, Huyvaert, Hélène, additional, Le Moual, Nicole, additional, Siroux, Valérie, additional, Jacquemin, Bénédicte, additional, Matran, Régis, additional, and Nadif, Rachel, additional
- Published
- 2017
- Full Text
- View/download PDF
39. Integrated assessment of exposure to PM2.5 in South India and its relation with cardiovascular risk: Design of the CHAI observational cohort study
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Tonne, Cathryn, primary, Salmon, Maëlle, additional, Sanchez, Margaux, additional, Sreekanth, V., additional, Bhogadi, Santhi, additional, Sambandam, Sankar, additional, Balakrishnan, Kalpana, additional, Kinra, Sanjay, additional, and Marshall, Julian D., additional
- Published
- 2017
- Full Text
- View/download PDF
40. Predictors of Daily Mobility of Adults in Peri-Urban South India
- Author
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Sanchez, Margaux, primary, Ambros, Albert, additional, Salmon, Maëlle, additional, Bhogadi, Santhi, additional, Wilson, Robin, additional, Kinra, Sanjay, additional, Marshall, Julian, additional, and Tonne, Cathryn, additional
- Published
- 2017
- Full Text
- View/download PDF
41. Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis
- Author
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Bédard, Annabelle, primary, Serra, Ignasi, additional, Dumas, Orianne, additional, Basagaña, Xavier, additional, Clavel-Chapelon, Françoise, additional, Le Moual, Nicole, additional, Sanchez, Margaux, additional, Siroux, Valérie, additional, Varraso, Raphaëlle, additional, and Garcia-Aymerich, Judith, additional
- Published
- 2017
- Full Text
- View/download PDF
42. Socioeconomic position and outdoor nitrogen dioxide (NO2) exposure in Western Europe: A multi-city analysis
- Author
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Temam, Sofia, primary, Burte, Emilie, additional, Adam, Martin, additional, Antó, Josep M., additional, Basagaña, Xavier, additional, Bousquet, Jean, additional, Carsin, Anne-Elie, additional, Galobardes, Bruna, additional, Keidel, Dirk, additional, Künzli, Nino, additional, Le Moual, Nicole, additional, Sanchez, Margaux, additional, Sunyer, Jordi, additional, Bono, Roberto, additional, Brunekreef, Bert, additional, Heinrich, Joachim, additional, de Hoogh, Kees, additional, Jarvis, Debbie, additional, Marcon, Alessandro, additional, Modig, Lars, additional, Nadif, Rachel, additional, Nieuwenhuijsen, Mark, additional, Pin, Isabelle, additional, Siroux, Valérie, additional, Stempfelet, Morgane, additional, Tsai, Ming-Yi, additional, Probst-Hensch, Nicole, additional, and Jacquemin, Bénédicte, additional
- Published
- 2017
- Full Text
- View/download PDF
43. Évolution de l’asthme au long cours : aspects méthodologiques et lien avec la pollution atmosphérique
- Author
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Sanchez, Margaux, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Sud - Paris XI, Valérie Siroux, and Marc Humbert
- Subjects
Épidémiologie ,Méthodologie ,Pollution atmosphérique ,Epidemiology ,Air pollution ,Methodology ,Long term ,Asthme ,Variability ,Variabilité ,Long terme ,Asthma ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Unlike most chronic diseases, which tend to get progressively worse over time, the expression of asthma is variable over time. Asthma may onset at any age and is known to clinically persist, possibly resolve, or present any combination of remissions and relapses over several years, even decades. Such long-term variability has been difficult to describe in adults as data are scarce. Through an epidemiological approach, the aim of the thesis is to gain a better understanding of the variability of asthma expression over the long term in adults, in two French cohorts: the E3N study (l’Étude Épidémiologique auprès des femmes de la Mutuelle Générale de l’Éducation Nationale) and the EGEA study (the Epidemiological study on the Genetics and Environment of Asthma). The first axis is methodological and relates to the characterization of asthma expression variability over the long term. The second axis is environmental and related to the effect of air pollution on such long-term variability. Regarding the methodological axis, the in-depth analysis of answers to a single question on ever asthma repeated 7 times over 13 years in the E3N study has shown that apparently inconsistent succession of answers (positive and negative) could capture part of the medium-term variability of asthma activity, suggesting the usefulness of such approach to improve the characterization of asthma expression over time. In a context of growing interest for perceived health, a simple retrospective self-assessment of 10-year change in respiratory health has been shown to provide complementary insights to classical epidemiological and clinical tools to describe the long-term trajectory of asthma, and could predict part of the asthma evolution. Following a recent meta-analysis including 6 European cohorts (23000 participants), in which results suggest a deleterious effect of chronic ambient air pollution on asthma incidence in adults, an analysis investigated the evolution of asthma medication dispensations over 4 consecutive years, in relation with air pollution. Among the women with asthma in the E3N study, an increased estimated exposure to outdoor nitrogen dioxide and particles was associated with increased rate of controller dispensations over time, suggesting the long-term effect of air pollution on asthma progression. In conclusion, results of the thesis showed that simple tools such as several repeated answers to a single question on asthma and the self-assessment of long-term change in respiratory health may be useful in order to better characterize the variability of asthma expression over the long term, as a complementary approach alongside with classical tools. Combined with the literature, results of the thesis support the deleterious impact of chronic air pollution on progression of asthma and strengthen the need of public health interventions to reduce air pollutants concentration.; Contrairement à la majorité des maladies chroniques qui s’aggravent progressivement, l’expression de l’asthme est variable au cours du temps. L’asthme peut apparaître, disparaître, s’aggraver ou s’améliorer au cours de plusieurs années, voire une décennie, à tout âge de la vie. Cette variabilité à long terme est particulièrement mal décrite chez l’adulte car les données sont rares. Par une approche épidémiologique, la thèse a pour objectif de mieux comprendre la variabilité de l’expression de l’asthme au long cours chez l’adulte dans deux cohortes françaises : E3N, l’Étude Épidémiologique auprès des femmes de la Mutuelle Générale de l’Éducation Nationale et EGEA, l’étude Épidémiologique des facteurs Génétiques et Environnementaux de l’Asthme. Le premier axe, méthodologique, porte sur la mesure de la variabilité de l’expression de l’asthme au long cours. Le second axe, environnemental, porte sur le rôle de la pollution atmosphérique sur cette variabilité. Concernant l’axe méthodologique, l’étude des réponses à une unique question sur l’asthme répétée 7 fois sur 13 ans dans le cadre de la cohorte E3N a montré qu’une succession incohérente de réponses (positives et négatives) reflétait une partie de la variabilité de l’activité de l’asthme à moyen terme, suggérant l’intérêt de cette approche pour affiner la caractérisation de l’expression de la maladie au cours du temps. Dans le contexte d’un intérêt croissant pour la santé perçue, l’étude d’une question portant sur l’auto-évaluation rétrospective du changement dans la santé respiratoire au cours des 10 dernières années a montré que l’information ainsi obtenue était complémentaire de celle d’outils épidémiologiques et cliniques existants pour décrire la trajectoire à long terme de l’asthme, et permettait de prédire en partie l’évolution de l’asthme.À la suite d’une récente méta-analyse regroupant 6 cohortes européennes (avec 23 000 participants) dont les résultats suggèrent le rôle d’une exposition chronique à la pollution atmosphérique dans l’incidence de l’asthme chez l’adulte, une analyse a porté sur l’évolution des traitements de fond et de secours de l’asthme sur une période de 4 ans en lien avec la pollution atmosphérique. Chez les femmes asthmatiques de la cohorte E3N, plus l’exposition chronique au dioxyde d’azote et aux particules était élevée, plus la consommation de corticoïdes inhalés augmentait au cours du temps, suggérant le rôle à long terme du dioxyde d’azote dans la progression de l’asthme. En conclusion, les résultats de la thèse montrent que des outils simples, tels que l’utilisation de réponses successives à une unique question sur l’asthme et l’auto-évaluation du changement dans la santé respiratoire sur 10 ans, peuvent être utilisés pour mieux caractériser la variabilité de l’expression de l’asthme au long cours, de façon complémentaire aux outils déjà existants. Associés à ceux de la littérature, les résultats de la thèse soutiennent le rôle délétère d’une exposition chronique à la pollution de l’air extérieur sur l’évolution de l’asthme au long cours et renforcent l’intérêt d’interventions de santé publique visant à diminuer la concentration des polluants atmosphériques.
- Published
- 2015
44. Long-Term Trajectory of Asthma : Methodological Aspects and Impact of Outdoor Air Pollution
- Author
-
Sanchez, Margaux, STAR, ABES, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Sud - Paris XI, Valérie Siroux, and Marc Humbert
- Subjects
Méthodologie ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Epidemiology ,Methodology ,Air pollution ,Asthme ,Variabilité ,Asthma ,Épidémiologie ,Pollution atmosphérique ,Long term ,Variability ,Long terme ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Unlike most chronic diseases, which tend to get progressively worse over time, the expression of asthma is variable over time. Asthma may onset at any age and is known to clinically persist, possibly resolve, or present any combination of remissions and relapses over several years, even decades. Such long-term variability has been difficult to describe in adults as data are scarce. Through an epidemiological approach, the aim of the thesis is to gain a better understanding of the variability of asthma expression over the long term in adults, in two French cohorts: the E3N study (l’Étude Épidémiologique auprès des femmes de la Mutuelle Générale de l’Éducation Nationale) and the EGEA study (the Epidemiological study on the Genetics and Environment of Asthma). The first axis is methodological and relates to the characterization of asthma expression variability over the long term. The second axis is environmental and related to the effect of air pollution on such long-term variability. Regarding the methodological axis, the in-depth analysis of answers to a single question on ever asthma repeated 7 times over 13 years in the E3N study has shown that apparently inconsistent succession of answers (positive and negative) could capture part of the medium-term variability of asthma activity, suggesting the usefulness of such approach to improve the characterization of asthma expression over time. In a context of growing interest for perceived health, a simple retrospective self-assessment of 10-year change in respiratory health has been shown to provide complementary insights to classical epidemiological and clinical tools to describe the long-term trajectory of asthma, and could predict part of the asthma evolution. Following a recent meta-analysis including 6 European cohorts (23000 participants), in which results suggest a deleterious effect of chronic ambient air pollution on asthma incidence in adults, an analysis investigated the evolution of asthma medication dispensations over 4 consecutive years, in relation with air pollution. Among the women with asthma in the E3N study, an increased estimated exposure to outdoor nitrogen dioxide and particles was associated with increased rate of controller dispensations over time, suggesting the long-term effect of air pollution on asthma progression. In conclusion, results of the thesis showed that simple tools such as several repeated answers to a single question on asthma and the self-assessment of long-term change in respiratory health may be useful in order to better characterize the variability of asthma expression over the long term, as a complementary approach alongside with classical tools. Combined with the literature, results of the thesis support the deleterious impact of chronic air pollution on progression of asthma and strengthen the need of public health interventions to reduce air pollutants concentration., Contrairement à la majorité des maladies chroniques qui s’aggravent progressivement, l’expression de l’asthme est variable au cours du temps. L’asthme peut apparaître, disparaître, s’aggraver ou s’améliorer au cours de plusieurs années, voire une décennie, à tout âge de la vie. Cette variabilité à long terme est particulièrement mal décrite chez l’adulte car les données sont rares. Par une approche épidémiologique, la thèse a pour objectif de mieux comprendre la variabilité de l’expression de l’asthme au long cours chez l’adulte dans deux cohortes françaises : E3N, l’Étude Épidémiologique auprès des femmes de la Mutuelle Générale de l’Éducation Nationale et EGEA, l’étude Épidémiologique des facteurs Génétiques et Environnementaux de l’Asthme. Le premier axe, méthodologique, porte sur la mesure de la variabilité de l’expression de l’asthme au long cours. Le second axe, environnemental, porte sur le rôle de la pollution atmosphérique sur cette variabilité. Concernant l’axe méthodologique, l’étude des réponses à une unique question sur l’asthme répétée 7 fois sur 13 ans dans le cadre de la cohorte E3N a montré qu’une succession incohérente de réponses (positives et négatives) reflétait une partie de la variabilité de l’activité de l’asthme à moyen terme, suggérant l’intérêt de cette approche pour affiner la caractérisation de l’expression de la maladie au cours du temps. Dans le contexte d’un intérêt croissant pour la santé perçue, l’étude d’une question portant sur l’auto-évaluation rétrospective du changement dans la santé respiratoire au cours des 10 dernières années a montré que l’information ainsi obtenue était complémentaire de celle d’outils épidémiologiques et cliniques existants pour décrire la trajectoire à long terme de l’asthme, et permettait de prédire en partie l’évolution de l’asthme.À la suite d’une récente méta-analyse regroupant 6 cohortes européennes (avec 23 000 participants) dont les résultats suggèrent le rôle d’une exposition chronique à la pollution atmosphérique dans l’incidence de l’asthme chez l’adulte, une analyse a porté sur l’évolution des traitements de fond et de secours de l’asthme sur une période de 4 ans en lien avec la pollution atmosphérique. Chez les femmes asthmatiques de la cohorte E3N, plus l’exposition chronique au dioxyde d’azote et aux particules était élevée, plus la consommation de corticoïdes inhalés augmentait au cours du temps, suggérant le rôle à long terme du dioxyde d’azote dans la progression de l’asthme. En conclusion, les résultats de la thèse montrent que des outils simples, tels que l’utilisation de réponses successives à une unique question sur l’asthme et l’auto-évaluation du changement dans la santé respiratoire sur 10 ans, peuvent être utilisés pour mieux caractériser la variabilité de l’expression de l’asthme au long cours, de façon complémentaire aux outils déjà existants. Associés à ceux de la littérature, les résultats de la thèse soutiennent le rôle délétère d’une exposition chronique à la pollution de l’air extérieur sur l’évolution de l’asthme au long cours et renforcent l’intérêt d’interventions de santé publique visant à diminuer la concentration des polluants atmosphériques.
- Published
- 2015
45. When, Where, and What? Characterizing Personal PM2.5 Exposure in Periurban India by Integrating GPS, Wearable Camera, and Ambient and Personal Monitoring Data.
- Author
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Milà, Carles, Salmon, Maëlle, Sanchez, Margaux, Ambrós, Albert, Bhogadi, Santhi, Sreekanth, V., Nieuwenhuijsen, Mark, Kinra, Sanjay, Marshall, Julian D., and Tonne, Cathryn
- Published
- 2018
- Full Text
- View/download PDF
46. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)
- Author
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Jacquemin, Bénédicte, Siroux, Valérie, Sanchez, Margaux, Carsin, Anne-Elie, Schikowski, Tamara, Adam, Martin, Bellisario, Valeria, Buschka, Anna, Bono, Roberto, Brunekreef, Bert, Cai, Yutong, Cirach, Marta, Clavel-Chapelon, Françoise, Declercq, Christophe, de Marco, Roberto, de Nazelle, Audrey, Ducret-Stich, Regina E, Ferretti, Virginia Valeria, Gerbase, Margaret W, Hardy, Rebecca, Heinrich, Joachim, Janson, Christer, Jarvis, Deborah, Al Kanaani, Zaina, Keidel, Dirk, Kuh, Diana, Le Moual, Nicole, Nieuwenhuijsen, Mark J, Marcon, Alessandro, Modig, Lars, Pin, Isabelle, Rochat, Thierry, Schindler, Christian, Sugiri, Dorothea, Stempfelet, Morgane, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Vienneau, Danielle, Vierkötter, Andrea, Hansell, Anna L, Krämer, Ursula, Probst-Hensch, Nicole M, Sunyer, Jordi, Künzli, Nino, Kauffmann, Francine, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), IRAS RATIA2, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), IRAS RATIA2, and Risk Assessment of Toxic and Immunomodulatory Agents
- Subjects
Male ,Pediatrics ,Health, Toxicology and Mutagenesis ,Air pollution ,010501 environmental sciences ,medicine.disease_cause ,NO2 ,01 natural sciences ,0302 clinical medicine ,immune system diseases ,Medicine ,Prospective Studies ,Young adult ,Aged, 80 and over ,Air Pollutants ,Ambient air pollution ,Incidence (epidemiology) ,Incidence ,Public Health, Global Health, Social Medicine and Epidemiology ,Environmental exposure ,Middle Aged ,Adult ,Lung function ,Spirometry ,Europe ,Follow-Up Studies ,Humans ,Nitrogen Oxides ,Particulate Matter ,Environmental Exposure ,PM10 ,3. Good health ,Female ,medicine.medical_specialty ,03 medical and health sciences ,Young Adult ,Environmental health ,Asthma incidence ,Adverse effect ,0105 earth and related environmental sciences ,Asthma ,Aged ,business.industry ,Research ,Òxids de nitrogen -- Aspectes ambientals ,Public Health, Environmental and Occupational Health ,Asma -- Epidemiologia ,medicine.disease ,respiratory tract diseases ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Logistic Models ,030228 respiratory system ,13. Climate action ,business - Abstract
Background Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective We aimed to investigate the association between air pollution and adult onset asthma. Methods Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10–5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. Citation Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613–621; http://dx.doi.org/10.1289/ehp.1408206
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- 2014
47. Cleaning sprays, household help and asthma among elderly women
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Bédard, Annabelle, Varraso, Raphaëlle, Sanchez, Margaux, Clavel-Chapelon, Françoise, Zock, Jan-Paul, Kauffmann, Francine, Le Moual, Nicole, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre for Research in Environmental Epidemiology (CREAL), IMIM-Hospital del Mar, Generalitat de Catalunya, CIBER de Epidemiología y Salud Pública (CIBERESP), and The E3N study is supported by the Mutuelle Générale de l‟Education Nationale (MGEN), the French Leagueagainst Cancer (LNCC), the Gustave Roussy Institute (IGR) and the National Institute for Health and MedicalResearch (Inserm). The respiratory survey is supported by the Fonds de Dotation Respiratoire.
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[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
International audience; There is increasing evidence on the deleterious role in asthma of the use of household cleaning products in spray forms in adults. Household help might induce misclassification errors. The aim of the present analysis was to study associations between household exposure to cleaning sprays and current asthma in elderly women, taking into account household help. A nested case-control survey on respiratory health was undertaken among a random sample of French women from the E3N study. Data were available for 570 women (235 with current asthma and 335 without asthma history; 68 years old on average, 59% never smokers). Three estimates of domestic exposure were used: 1) self-reported, 2) using principal component analysis, 3) a composite score for sprays. Associations between domestic exposures and asthma were assessed by logistic regression, adjusted for age, educational level, BMI and smoking status. Analyses were further stratified on household help in order to evaluate a potential misclassification bias. Among women without household help (n = 325), a significant association was observed between weekly use of at least one spray and current asthma (OR [95% CI]: 1.86[1.04-3.33]). No association was observed among women with household help. Weekly household use of cleaning sprays may have a deleterious effect on asthma. It is important to take into account household help to limit misclassification bias.
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- 2013
48. Implications of daily mobility around residence for air pollution assessment in peri-urban South India
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Sanchez*, Margaux, primary, Ambros, Albert, additional, Salmon, Maëlle, additional, Bhogadi, Santhi, additional, Marshall, Julian D, additional, and Tonne, Cathryn, additional
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- 2016
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49. When, Where, and What? Characterizing Personal PM2.5Exposure in Periurban India by Integrating GPS, Wearable Camera, and Ambient and Personal Monitoring Data
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Milà, Carles, Salmon, Maëlle, Sanchez, Margaux, Ambrós, Albert, Bhogadi, Santhi, Sreekanth, V., Nieuwenhuijsen, Mark, Kinra, Sanjay, Marshall, Julian D., and Tonne, Cathryn
- Abstract
Evidence identifying factors that influence personal exposure to air pollutants in low- and middle-income countries is scarce. Our objective was to identify the relative contribution of the time of the day (when?), location (where?), and individuals’ activities (what?) to PM2.5personal exposure in periurban South India. We conducted a panel study in which 50 participants were monitored in up to six 24-h sessions (n= 227). We integrated data from multiple sources: continuous personal and ambient PM2.5concentrations; questionnaire, GPS, and wearable camera data; and modeled long-term exposure at residence. Mean 24-h personal exposure was 43.8 μg/m3(SD 24.6) for men and 39.7 μg/m3(SD 12.0) for women. Temporal patterns in exposure varied between women (peak exposure in the morning) and men (more exposed throughout the rest of the day). Most exposure occurred at home, 67% for men and 89% for women, which was proportional to the time spent in this location. Ambient daily PM2.5was an important predictor of 24-h personal exposure for both genders. Among men, activities predictive of higher hourly average exposure included presence near food preparation, in the kitchen, in the vicinity of smoking, or in industry. For women, predictors of exposure were largely related to cooking.
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- 2018
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50. Prospective study of menopause and adult-onset asthma: The E3N French cohort
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Matulonga, Bobette, primary, Courbon, Dominique, additional, Forrnier, Agnès, additional, Bédard, Annabelle, additional, Mesrine, Sylvie, additional, Sanchez, Margaux, additional, Thabut, Gabriel, additional, Clavel, Françoise, additional, Varraso, Raphaëlle, additional, and Leynaert, Bénédicte, additional
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- 2015
- Full Text
- View/download PDF
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