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4 results on '"San Lucas-Coque, Segundo Moisés"'

1. Genes codificantes de ATPasas P-Tipo IID como base para el tratamiento antifúngico de Aspergillus fumigatus

Author

San Lucas Coque, Segundo Moisés

Subjects
deleción, Bomba de eflujo, antiportadores, antifúngicos, diana antifúngica
Abstract

Aspergillus fumigatus es el principal hongo filamentoso causante de aspergilosis invasiva en pacientes con un importante déficit de la inmunidad celular. La familia de genes ENA (efflux of Natrium) pertenecientes al grupo de ATPasas P-tipo IID, codifican un sistema de eflujo para la desintoxicación de sodio desde el interior de la célula en la mayoría de las especies en hongos y levaduras. Este artículo tiene como objetivo estudiar una nueva posible diana antifúngica en dos genes del hongo A. fumigatus AFUA_6G03690 y AFUA_4G09440 que codifican proteínas similares a ENA1 S. cerevisiae y la proteína AN6642.2 activa para la desintoxicación de sodio en A. nidulans. Las células mutantes pueden obtenerse usando un casete de reemplazo genético por recombinación homóloga. El impacto de la eliminación de los genes debe analizarse en los cultivos por separado y en combinación. Para los análisis de resistencia celular a la toxicidad iónica se analizan pruebas de incubación multifactoriales a distintos niveles como: la temperatura de incubación, pH del medio y concentración molar de sodio. Los datos obtenidos en un laboratorio experimental empleando este método, de ser positivos, tienen el potencial de dar paso al desarrollo de nuevas terapias antimicóticas para A. fumigatus dirigidas a esta diana.

Published
2023

2. Evolución clínica de Staphylococcus aureus resistente a la meticilina en pacientes en edad pediátrica.

Author

San Lucas Coque, Segundo Moisés, Aguilar Armendariz, Sareli Anahi, and Galarza López, Juan Diego

Abstract

Methicillin-resistant Staphylococcus aureus is a pathogen that has been noted over the years due to the increasing number of cases in pediatric patients, with community infectious origin. The number of clinical cases since 2018 has been increasing progressively to the present, which is worrying due to its consequences in the future. The treatment is mainly based on Vancomycin, Clindamycin and Linezolid, obtaining mostly positive results, however, the bioavailability of the drug in the focus of the infection and the age of the patient makes the use of these antibiotics difficult. This work analyzes 6 relevant studies for presenting a community infectious origin, patient age, treatment and the impact of signs and symptoms in contrast to mortality presented in the last 5 years to obtain an updated view of the course of the disease and the considerations therapeutic. The limitation of the spread of the infection is denoted mainly by hygiene control. Therefore, the implementation of good hygienic habits in hospitals and childcare centers can prevent infectious diseases caused by opportunistic pathogenic microorganisms. [ABSTRACT FROM AUTHOR]

Published
2023

3. Abordaje clínico del delirio secundario a parasitosis.

Author

San Lucas-Coque, Segundo Moisés, Latorre-Barragán, María Fernanda, and Guadalupe Pico-Pérez, Karla

Subjects
THERAPEUTICS, DRUG efficacy, CLINICAL pathology, EVALUATION of medical care, DELUSIONAL parasitosis, CHRONIC diseases, DELIRIUM, HEALTH care teams, OLANZAPINE, INTERPROFESSIONAL relations, ANTIPSYCHOTIC agents, RISPERIDONE
Abstract

Copyright of Revista de Ciencias Médicas de Pinar del Río is the property of Editorial Ciencias Medicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

4. Estudio Neutrosófico de las Implicaciones del Fármaco Miltefosina en el Tratamiento de Leishmaniasis.

Author

Culqui Molina, Washington Paul, Chango Gadvay, Marco Vinicio, and San Lucas Coque, Segundo Moisés

Abstract

Copyright of Neutrosophic Computing & Machine Learning is the property of Multimedia Larga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

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