33 results on '"San Feliciano, L."'
Search Results
2. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities
- Author
-
Shah, PS, Lui, K, Reichman, B, Norman, M, Kusuda, S, Lehtonen, L, Adams, M, Vento, M, Darlow, BA, Modi, N, Rusconi, F, Hakansson, S, San Feliciano, L, Helenius, KK, Bassler, D, Hirano, S, Lee, SK, Marshall, P, Schmidt, P, Dhawan, A, Craven, P, De Waal, K, Simmer, K, Gill, A, Pillow, J, Stack, J, Birch, P, Cooke, L, Casalaz, D, Holberton, J, Stewart, A, Downe, L, Stewart, M, Bajuk, B, Berry, A, Hunt, R, Kilburn, C, De Paoli, T, Bolisetty, S, Paradisis, M, Rieger, I, Koorts, P, Kuschel, C, Numa, A, Carlisle, H, Badawi, N, Loughran-Fowlds, A, Koh, G, Davis, J, Luig, M, Andersen, C, Chambers, G, Austin, N, Lynn, A, Darlow, B, Edmonds, L, Mildenhall, L, Buksh, M, Battin, M, Van den Boom, J, Bourchier, D, Richardson, V, Dineen, F, Rajadurai, VS, Fung, G, Harrison, A, Synnes, A, Ting, J, Cieslak, Z, Sherlock, R, Yee, W, Aziz, K, Toye, J, Fajardo, C, Kalapesi, Z, Sankaran, K, Daspal, S, Seshia, M, Alvaro, R, Mukerji, A, Da Silva, O, Nwaesei, C, Lee, K-S, Dunn, M, Lemyre, B, Dow, K, Pelausa, E, Barrington, K, Drolet, C, Piedboeuf, B, Claveau, M, Beltempo, M, Bertelle, V, Masse, E, Canning, R, Mabry, H, Ojah, C, Monterrosa, L, Deshpandey, A, Afifi, J, Kajetanowicz, A, Andersson, S, Tammela, O, Sankilampi, U, Saarela, T, Prazad, P, Noguchi, A, McWan, K, Button, B, Stratton, W, Hamvus, A, Raghaven, A, Derrick, M, Hadley, R, Covert, R, Lablanc, O, Weiss, M, Bell, A, Shareef, M, Silvestri, J, Heymann, E, Zangen, S, Smolkin, T, Mimouni, F, Bader, D, Rothschild, A, Strauss, Z, Felszer, C, Oman, H, Toy-Friedman, SE, Bar-Oz, B, Feldman, M, Saad, N, Flidel-Rimon, O, Weisbrod, M, Lubin, D, Litmanovitz, I, Kngelman, A, Shinwell, E, Klinger, G, Nijim, Y, Bin-Nun, A, Golan, A, Mandel, D, Fleisher-Sheffer, V, Kohelet, D, Bakhrakh, L, Hattori, S, Shirai, M, Ishioka, T, Mori, T, Amiznka, T, Huchimukai, T, Yoshida, H, Sasaki, A, Shimizu, J, Nakamura, T, Maruyama, M, Matsumoto, H, Hosokawa, S, Taki, A, Nakagawa, M, Ko, K, Uozumi, A, Nakata, S, Shimazaki, A, Yoda, T, Numata, O, Imamura, H, Kobayashi, A, Tokuriki, S, Uchida, Y, Arai, T, Ito, M, Ieda, K, Ono, T, Hayashi, M, Maki, K, Yamakawa, M, Kawai, M, Fujii, N, Shiomi, K, Nozaki, K, Wada, H, Kim, T, Tokunaga, Y, Takatera, A, Oshima, T, Sumida, H, Michinomae, Y, Knsumoto, Y, Yoshimoto, S, Morisawa, T, Ohashi, T, Takahashi, Y, Sugimoto, M, Ono, N, Miyagawa, S, Saijo, T, Yamagami, T, Koyano, K, Kobayashi, S, Kanda, T, Sakemi, Y, Aoki, M, Iida, K, Goshi, M, Maruyama, Y, Avila-Alvarez, A, Luis Fernandez-Trisac, J, Couce Pico, ML, Fernandez Seara, MJ, Martinez Gutierrez, A, Vizcaino, C, Salvador Iglesias, M, Sanchez Zaplana, H, Fernandez Colomer, B, Garcia Lopez, JE, Garcia Mozo, R, Gonzalez Martinez, MT, Muro Sebastian, MD, Balart Carbonell, M, Badia Bamnsell, J, Domingo Puiggros, M, Figueras Aloy, J, Botet Mussons, F, Anquela Sanz, I, Ginovart Galiana, G, Coroleu, W, Iriondo, M, Vilella, LC, Porta, R, Demestre, X, Martinez Nadal, S, De Frutos Martinez, C, Lopez Cuesta, MJ, Esquivel Mora, D, Ortiz Tardio, J, Benavente, I, Alonso, A, Aguilera Olmos, R, Garcia Cabezas, MA, Martinez Jimenez, MD, Jaraba Caballero, MF, Ordofiez Diaz, MD, Fagundo, AT, Canals, LM, Garcia-Munoz Rodrigo, F, Urquia Marti, L, Moreno Galdo, MF, Hurtado Suazo, JA, Narbona Lopez, E, Uberos Fernandez, J, Cortajarena Altana, MA, Mora Navarro, D, Teresa Dominguez, M, Ruiz del Prado, MY, Esteban Diez, I, Palau Benavides, MT, Lapena, S, Prada, T, Soler Mir, E, Corredera Sanchez, A, Criado Vega, E, Del Prado, N, Fernandez, C, Cabanillas Vilaplana, L, Cuadrado Perez, I, Lopez Gomez, L, Domingo Comeche, L, Llana Martin, I, Gonzalez Armengod, C, Munoz Labian, C, Santos Munoz, MJ, Blanco Bravo, D, Perez, V, Elorza Fernandez, MD, Diaz Gonzalez, C, Ares Segura, S, Lopez Azorin, M, Belen Jimenez, A, Sanchez-Tamayo, T, Tapia Moreno, E, Gonzalez, M, Sanchez Martinez, JE, Lloreda Garcia, JM, Goni Orayen, C, Vilas Gonzalez, J, Suarez Albo, M, Gonzalez Colmenero, E, Gutierrez Gonzalez, EP, Vacas del Arco, B, Marquez Fernandez, J, Acosta Gordillo, L, Granero Asensio, M, Macias Diaz, C, Albujar, M, Fuster Jorge, P, Romero, S, Rivero Falero, M, Escobar Izquierdo, AB, Estan Capell, J, Izquierdo Macian, MI, Montejo Vicente, MM, Izquierdo Caballero, R, Mercedes Martinez, M, Euba, A, Rodriguez Serna, A, De Heredia Goya, JML, Perez Legorburu, A, Gutierrez Amoros, A, Marugan Isabel, VM, Hernandez Gonzalez, N, Rite Gracia, S, Ventura Faci, MP, Samper Villagrasa, MP, Kofron, J, Brodd, KS, Odlind, A, Alberg, L, Arwehed, S, Hafstrom, O, Kasemo, A, Nederman, K, Ahman, L, Ingemarsson, F, Petersson, H, Thum, P, Albinsson, E, Selander, B, Abrahamsson, T, Heimdahl, I, Sveinsdottir, K, Wejryd, E, Hedlund, A, Soderberg, MK, Hallberg, B, Brune, T, Backstrom, J, Robinson, J, Farooqi, A, Normann, E, Fredriksson, M, Palm, A, Rosenqvist, U, Hagman, C, Ohlin, A, Floral, R, Smedsaas-Lofvenberg, A, Meyer, P, Anderegg, C, Schulzke, S, Nelle, M, Wagner, B, Riedel, T, Kaczala, G, Walde, B, Pfister, RE, Tolsa, J-F, Roth, M, Stocker, M, Laubscher, B, Malzacher, A, Micallef, JP, Hegi, L, Arlettaz, R, Bernet, V, Dani, C, Fiorini, P, Boldrini, A, Tomasini, B, Mittal, A, Kefas, J, Kamalanathan, A, Jayachandran, Yoxall, B, McBride, T, Webb, D, Garr, R, Hassan, A, Ambadkar, P, Dyke, M, McDevitt, K, Rewitzky, G, D'Amore, A, Panasa, N, Settle, P, Maddock, N, Edi-Osagie, N, Zipitis, C, Heal, C, Birch, J, Hasib, A, Soe, A, Kumar, N, Kisat, H, Vasu, V, Lama, M, Gupta, R, Rawlingson, C, Wickham, T, Theron, M, Kendall, G, Gupta, A, Aladangady, N, Ali, I, Alsford, L, Lopez, W, Murthy, V, Sullivan, C, Thomas, M, Bate, T, Godambe, S, Watts, T, Kuna, J, Chang, J, Pai, V, Huddy, C, Yasin, S, Nicholl, R, Pandey, P, Kairamkonda, V, Muogbo, D, Harry, L, Simmons, P, Nycyk, J, Gallagher, A, Pillay, T, Deshpande, S, Mahadevan, Moore, A, Clark, S, Garbash, M, Lal, M, Abu-Harb, M, Allwood, A, Selter, M, Munyard, P, Bartle, D, Paul, S, Whincup, G, Mallik, A, Amess, P, Godden, C, Reynolds, P, Misra, I, De Halpert, P, Salgia, S, Sanghavi, R, Wigfield, R, Deketelaere, A, Khashu, M, Hall, M, Groves, C, Brown, N, Brennan, N, Vamvakiti, K, McIntyre, J, Pirie, S, Jones, S, Mannix, P, Cairns, P, Eaton, M, Schwarz, K, Gibson, D, Miall, L, Krishnamurthy, University of Zurich, Shah, Prakesh S, Canadian Institutes of Health Research (CIHR), and Neonid NPO
- Subjects
medicine.medical_specialty ,NEW-ZEALAND ,Population ,610 Medicine & health ,RETINOPATHY ,Review Article ,Audit ,Pediatrics ,outcomes research ,MORBIDITY ,Nursing ,neonatal intensive care ,Health care ,medicine ,LOW-BIRTH-WEIGHT ,2735 Pediatrics, Perinatology and Child Health ,education ,education.field_of_study ,Science & Technology ,EXTREMELY PRETERM INFANTS ,business.industry ,MORTALITY ,Public health ,Health services research ,Preterm infants ,Capacity building ,BRONCHOPULMONARY DYSPLASIA ,Benchmarking ,10027 Clinic for Neonatology ,INTENSIVE-CARE UNITS ,TRENDS ,CANADA ,Pediatrics, Perinatology and Child Health ,Outcomes research ,business ,Life Sciences & Biomedicine - Abstract
Neonates born very preterm (before 32 weeks’ gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.
- Published
- 2019
3. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities
- Author
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Shah P, Lui K, Reichman B, Norman M, Kusuda S, Lehtonen L, Adams M, Vento M, Darlow B, Modi N, Rusconi F, Hakansson S, San Feliciano L, Helenius K, Bassler D, Hirano S, Lee S, Marshall P, Schmidt P, Dhawan A, Craven P, de Waal K, Simmer K, Gill A, Pillow J, Stack J, Birch P, Cooke L, Casalaz D, Holberton J, Stewart A, Downe L, Stewart M, Bajuk B, Berry A, Hunt R, Kilburn C, De Paoli T, Bolisetty S, Paradisis M, Rieger I, Koorts P, Kuschel C, Numa A, Carlisle H, Badawi N, Loughran-Fowlds A, Koh G, Davis J, Luig M, Andersen C, Chambers G, Austin N, Lynn A, Edmonds L, Mildenhall L, Buksh M, Battin M, van den Boom J, Bourchier D, Richardson V, Dineen F, Rajadurai V, Fung G, Harrison A, Synnes A, Ting J, Cieslak Z, Sherlock R, Yee W, Aziz K, Toye J, Fajardo C, Kalapesi Z, Sankaran K, Daspal S, Seshia M, Alvaro R, Mukerji A, Da Silva O, Nwaesei C, Lee K, Dunn M, Lemyre B, Dow K, Pelausa E, Barrington K, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Mabry H, Ojah C, Monterrosa L, Deshpandey A, Afifi J, Kajetanowicz A, Andersson S, Tammela O, Sankilampi U, Saarela T, Prazad P, Noguchi A, McWan K, Button B, Stratton W, Hamvus A, Raghaven A, Derrick M, Hadley R, Covert R, Lablanc O, Weiss M, Bell A, Shareef M, Silvestri J, Heymann E, Zangen S, Smolkin T, Mimouni F, Bader D, Rothschild A, Strauss Z, Felszer C, Oman H, Toy-Friedman S, Bar-Oz B, Feldman M, Saad N, Flidel-Rimon O, Weisbrod M, Lubin D, Litmanovitz I, Kngelman A, Shinwell E, Klinger G, Nijim Y, Bin-Nun A, Golan A, Mandel D, Fleisher-Sheffer V, Kohelet D, Bakhrakh L, Hattori S, Shirai M, Ishioka T, Mori T, Amiznka T, Huchimukai T, Yoshida H, Sasaki A, Shimizu J, Nakamura T, Maruyama M, Matsumoto H, Hosokawa S, Taki A, Nakagawa M, Ko K, Uozumi A, Nakata S, Shimazaki A, Yoda T, Numata O, Imamura H, Kobayashi A, Tokuriki S, Uchida Y, Arai T, Ito M, Ieda K, Ono T, Hayashi M, Maki K, Yamakawa M, Kawai M, Fujii N, Shiomi K, Nozaki K, Wada H, Kim T, Tokunaga Y, Takatera A, Oshima T, Sumida H, Michinomae Y, Knsumoto Y, Yoshimoto S, Morisawa T, Ohashi T, Takahashi Y, Sugimoto M, Ono N, Miyagawa S, Saijo T, Yamagami T, Koyano K, Kobayashi S, Kanda T, Sakemi Y, Aoki M, Iida K, Goshi M, Maruyama Y, Avila-Alvarez A, Fernandez-Trisac J, Pico M, Seara M, Gutierrez A, Vizcaino C, Iglesias M, Zaplana H, Colomer B, Lopez J, Mozo R, Martinez M, Sebastian M, Carbonell M, Bamnsell J, Puiggros M, Aloy J, Mussons F, Sanz I, Galiana G, Coroleu W, Iriondo M, Vilella L, Porta R, Demestre X, Nadal S, Martinez C, Cuesta M, Mora D, Tardio J, Benavente I, Alonso A, Olmos R, Cabezas M, Jimenez M, Caballero M, Diaz M, Fagundo A, Canals L, Rodrigo F, Marti L, Galdo M, Suazo J, Lopez E, Fernandez J, Altana M, Navarro D, Dominguez M, del Prado M, Diez I, Benavides M, Lapena S, Prada T, Mir E, Sanchez A, Vega E, del Prado N, Fernandez C, Vilaplana L, Perez I, Gomez L, Comeche L, Martin I, Armengod C, Labian C, Munoz M, Bravo D, Perez V, Fernandez M, Gonzalez C, Segura S, Azorin M, Jimenez A, Sanchez-Tamayo T, Moreno E, Gonzalez M, Martinez J, Garcia J, Orayen C, Gonzalez J, Albo M, Colmenero E, Gonzalez E, del Arco B, Gordillo L, Asensio M, Diaz C, Albujar M, Jorge P, Romero S, Falero M, Izquierdo A, Capell J, Macian M, Vicente M, Caballero R, Euba A, Serna A, Goya J, Legorburu A, Amoros A, Isabel V, Gonzalez N, Gracia S, Faci M, Villagrasa M, Kofron J, Brodd K, Odlind A, Alberg L, Arwehed S, Hafstrom O, Kasemo A, Nederman K, Ahman L, Ingemarsson F, Petersson H, Thum P, Albinsson E, Selander B, Abrahamsson T, Heimdahl I, Sveinsdottir K, Wejryd E, Hedlund A, Soderberg M, Hallberg B, Brune T, Backstrom J, Robinson J, Farooqi A, Normann E, Fredriksson M, Palm A, Rosenqvist U, Hagman C, Ohlin A, Floral R, Smedsaas-Lofvenberg A, Meyer P, Anderegg C, Schulzke S, Nelle M, Wagner B, Riedel T, Kaczala G, Walde B, Pfister R, Tolsa J, Roth M, Stocker M, Laubscher B, Malzacher A, Micallef J, Hegi L, Arlettaz R, Bernet V, Dani C, Fiorini P, Boldrini A, Tomasini B, Mittal A, Kefas J, Kamalanathan A, Jayachandran, Yoxall B, McBride T, Webb D, Garr R, Hassan A, Ambadkar P, Dyke M, McDevitt K, Rewitzky G, D'Amore A, Panasa N, Settle P, Maddock N, Edi-Osagie N, Zipitis C, Heal C, Birch J, Hasib A, Soe A, Kumar N, Kisat H, Vasu V, Lama M, Gupta R, Rawlingson C, Wickham T, Theron M, Kendall G, Gupta A, Aladangady N, Ali I, Alsford L, Lopez W, Murthy V, Sullivan C, Thomas M, Bate T, Godambe S, Watts T, Kuna J, Chang J, Pai V, Huddy C, Yasin S, Nicholl R, Pandey P, Kairamkonda V, Muogbo D, Harry L, Simmons P, Nycyk J, Gallagher A, Pillay T, Deshpande S, Mahadevan, Moore A, Clark S, Garbash M, Lal M, Abu-Harb M, Allwood A, Selter M, Munyard P, Bartle D, Paul S, Whincup G, Mallik A, Amess P, Godden C, Reynolds P, Misra I, De Halpert P, Salgia S, Sanghavi R, Wigfield R, Deketelaere A, Khashu M, Hall M, Groves C, Brown N, Brennan N, Vamvakiti K, McIntyre J, Pirie S, Jones S, Mannix P, Cairns P, Eaton M, Schwarz K, Gibson D, Miall L, Krishnamurthy, and Int Network Evaluating Outcomes iN
- Subjects
outcomes research ,neonatal intensive care ,Preterm infants - Abstract
Neonates born very preterm (before 32 weeks' gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.
- Published
- 2019
4. Preventive strategies and factors associated with surgically treated necrotising enterocolitis in extremely preterm infants: an international unit survey linked with retrospective cohort data analysis
- Author
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Adams M, Bassler D, Darlow BA, Lui K, Reichman B, Hakansson S, Norman M, Lee SK, Helenius KK, Lehtonen L, San Feliciano L, Vento M, Moroni M, Beltempo M, Yang J, Shah PS, and International Network for EvaluatingOutcomes (iNeo) of Neonates
- Subjects
neonatology, paediatric gastroenterology, paediatrics, perinatology ,digestive system diseases - Abstract
To compare necrotising enterocolitis (NEC) prevention practices and NEC associated factors between units from eight countries of the International Network for Evaluation of Outcomes of Neonates, and to assess their association with surgical NEC rates.
- Published
- 2019
5. Variations in Oxygen Saturation Targeting, and Retinopathy of Prematurity Screening and Treatment Criteria in Neonatal Intensive Care Units: An International Survey
- Author
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Darlow, BA, Vento, M, Beltempo, M, Lehtonen, L, Hakansson, S, Reichman, B, Helenius, K, Sjors, G, Sigali, E, Lee, S, Noguchi, A, Morisaki, N, Kusuda, S, Bassler, D, San Feliciano, L, Adams, M, Isayama, T, Shah, PS, Lui, K, and Int Network Evaluating Outcomes iN
- Subjects
Very preterm infants ,Neonatal networks ,health care facilities, manpower, and services ,Comparative analysis ,Neonatal intensive care ,Oxygen saturation targeting ,Erythropoietin ,Retinopathy of prematurity - Abstract
Background: Rates of retinopathy of prematurity (ROP) and ROP treatment vary between neonatal intensive care units (NICUs). Neonatal care practices, including oxygen saturation (SpO(2)) targets and criteria for the screening and treatment of ROP, are potential contributing factors to the variations. Objectives: To survey variations in SpO(2) targets in 2015 (and whether there had been recent changes) and criteria for ROP screening and treatment across the networks of the International Network for Evaluating Outcomes in Neonates (iNeo). Methods: Online prepiloted questionnaires on treatment practices for preterm infants were sent to the directors of 390 NICUs in 10 collaborating iNeo networks. Nine questions were asked and the results were summarized and compared. Results: Overall, 329/390 (84%) NICUs responded, and a majority (60%) recently made changes in upper and lower SpO(2) target limits, with the median set higher than previously by 2-3% in 8 of 10 networks. After the changes, fewer NICUs (15 vs. 28%) set an upper SpO(2) target limit >95% and fewer (3 vs. 5%) a lower limit
- Published
- 2018
6. Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus
- Author
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Hines, D, Modi, N, Lee, SK, Isayama, T, Sjors, G, Gagliardi, L, Lehtonen, L, Vento, M, Kusuda, S, Bassler, D, Mori, R, Reichman, B, Hakansson, S, Darlow, BA, Adams, M, Rusconi, F, San Feliciano, L, Lui, K, Morisaki, N, Musrap, N, Shah, PS, Int Network Evaluating Outcomes iN, University of Zurich, and Shah, Prakesh S
- Subjects
National Institute of Child Health and Human Development ,Chronic lung disease ,Pulmonary insufficiency ,mental disorders ,610 Medicine & health ,2735 Pediatrics, Perinatology and Child Health ,Quality improvement ,10027 Clinic for Neonatology ,behavioral disciplines and activities ,Bronchopulmonary dysplasia - Abstract
The use of different definitions for bronchopulmonary dysplasia (BPD) has been an ongoing challenge. We searched papers published in English from 2010 and 2015 reporting BPD as an outcome, together with studies that compared BPD definitions between 1978 and 2015. We found that the incidence of BPD ranged from 6% to 57%, depending on the definition chosen, and that studies that investigated correlations with long-term pulmonary and/or neurosensory outcomes reported moderate-to-low predictive values regardless of the BPD criteria. Conclusion: A comprehensive and evidence-based definition for BPD needs to be developed for benchmarking and prognostic use.
- Published
- 2017
7. Country-Specific vs. Common Birthweight-for-Gestational Age References to Identify Small for Gestational Age Infants Born at 24-28 weeks: An International Study
- Author
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Martin, LJ, Sjors, G, Reichman, B, Darlow, BA, Morisaki, N, Modi, N, Bassler, D, Mirea, L, Adams, M, Kusuda, S, Lui, K, San Feliciano, L, Hakansson, S, Isayama, T, Mori, R, Vento, M, Lee, SK, Shah, PS, and Int Network Evaluating Outcomes IN
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Neonatal outcomes ,Infant, Extremely Premature ,Infant, Small for Gestational Age ,reproductive and urinary physiology - Abstract
Background: Controversy exists as to whether birthweight-for-gestational age references used to classify infants as small for gestational age (SGA) should be country specific or based on an international (common) standard. We examined whether different birthweight-for-gestational age references affected the association of SGA with adverse outcomes among very preterm neonates. Methods: Singleton infants (n = 23 788) of 24(0)-28(6) weeks' gestational age in nine high-resource countries were classified as SGA (
- Published
- 2016
8. 98: The Organization of Health Services for VLBW/VPT Neonates: Between-Country Comparisons
- Author
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Martin, L, primary, Modi, N, additional, Reichman, B, additional, Sjors, G, additional, Hakansson, S, additional, Darlow, B, additional, Lui, K, additional, Adams, M, additional, San Feliciano, L, additional, Kusuda, S, additional, Lee, S, additional, and Shah, P, additional
- Published
- 2015
- Full Text
- View/download PDF
9. 97: Variations in Patent Ductus Arteriosus Treatment of Very Preterm Neonates from 7 Countries: The iNeo Experience
- Author
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Isayama, T, primary, Mirea, L, additional, Reichman, B, additional, Sjors, G, additional, Modi, N, additional, Adams, M, additional, San Feliciano, L, additional, Kusuda, S, additional, Hakansson, S, additional, Lee, S, additional, and Shah, P, additional
- Published
- 2015
- Full Text
- View/download PDF
10. 94: Variations in Mortality of Very Preterm Neonates Between Eight National Neonatal Databases: The iNeo Experience
- Author
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Shah, P, primary, Sjors, G, additional, Reichman, B, additional, Morisaki, N, additional, Modi, N, additional, Mirea, L, additional, Lui, K, additional, Adams, M, additional, Bassler, D, additional, San Feliciano, L, additional, Santhakumaran, S, additional, and Lee, S, additional
- Published
- 2015
- Full Text
- View/download PDF
11. 96: Comparison of Mortality and Major Morbidity of Very Preterm Neonates Using Data from Eight National Neonatal Databases: The iNeo Experience
- Author
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Shah, P, primary, Mirea, L, additional, Yang, J, additional, Lui, K, additional, Darlow, B, additional, Sjors, G, additional, Hakansson, S, additional, Reichman, B, additional, Kusuda, S, additional, Mori, R, additional, Adams, M, additional, San Feliciano, L, additional, Modi, N, additional, Bassler, D, additional, Santhakumaran, S, additional, and Lee, S, additional
- Published
- 2015
- Full Text
- View/download PDF
12. 93: Birth Weight for Gestational Age: Impact of Using Different Growth References on the Comparison of Neonatal Outcomes Between the Countries in iNeo
- Author
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Martin, L, primary, Mirea, L, additional, Modi, N, additional, Lui, K, additional, Adams, M, additional, Shah, P, additional, Reichman, B, additional, Mori, R, additional, San Feliciano, L, additional, Sjors, G, additional, and Hakansson, S, additional
- Published
- 2015
- Full Text
- View/download PDF
13. Evolución a los 2 años de edad corregida de una cohorte de recién nacidos con peso inferior o igual a 1.500 g de los hospitales pertenecientes a la red neonatal SEN1500
- Author
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García, P., primary, San Feliciano, L., additional, Benito, F., additional, García, R., additional, Guzmán, J., additional, Salas, S., additional, Fernández, C., additional, del Prado, N., additional, Ciprián, D., additional, and Figueras, J., additional
- Published
- 2013
- Full Text
- View/download PDF
14. 489 Inhaled Nitric Oxide After Oxidative Stress in Newborn Rats. Effects on Vegf Expression and Alveolarization
- Author
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Hernández-Bejarano, M J, primary, San Feliciano, L, additional, Remesal, A, additional, and Ludeña, M D, additional
- Published
- 2010
- Full Text
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15. 322 Prenatal Glucocorticoids: Effects on Lung of Newborn Rats Exposed to Hypoxia and Recovered in Hyperoxia or Air.
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San Feliciano, L, primary, Pedraz, C, additional, Ludeña, D, additional, Remesal, A, additional, Revestido, R, additional, and Hernández, M J, additional
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- 2005
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16. Respuesta inmune respiratoria al año de vida en el niño prematuro.
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Matías, V., Iglesias, V., San Feliciano, L., Fernández, J. E., Lapeña, S., Ardura, J., Soga, M. J., Aragón, M. P., Remesal, A., Benito, F., Andrés, J., Eiros, J. M., Varillas, D., Centeno, F., Marugán, V., Hernández, N., Bachiller, R., Almansa, R., Ortiz de Lejarazu, R., and Ramilo, O.
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RESPIRATORY infections ,PREMATURE infants ,IMMUNE response ,INFLAMMATION ,CELLS - Abstract
Copyright of Acta Pediátrica Española is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2012
17. Respiratory immune response in first year of a preterm infant,Respuesta inmune respiratoria al año de vida en el niño prematuro
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Matías, V., Iglesias, V., San Feliciano, L., Fernández, J. E., Lapeña, S., Ardura, J., Soga, M. J., Aragón, M. P., Remesal, A., Benito, F., Andrés, J., Eiros, J. M., Varillas, D., Centeno, F., Marugán, V., Hernández, N., Bachiller, R., Raquel Almansa, Ortiz Lejarazu, R., Ramilo, O., and Bermejo-Martín, J. F.
18. INHALED NITRIC OXIDE AFTER OXIDATIVE STRESS IN NEWBORN RATS. EFFECTS ON VEGF EXPRESSION AND ALVEOLARIZATION
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HernándezBejarano, M. J., San Feliciano, L., Remesal, A., and Ludeña, M. D.
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- 2010
19. PRENATAL GLUCOCORTICOIDS EFFECTS ON LUNG OF NEWBORN RATS EXPOSED TO HYPOXIA AND RECOVERED IN HYPEROXIA OR AIR.
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SAN FELICIANO, L, PEDRAZ, C, LUDEÑA, D, REMESAL, A, REVESTIDO, R, and HERNÁNDEZ, M J
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- 2005
20. Effect of prenatal steroidal inhibition of sPLA2 in a rat model of preterm lung
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María Isidoro-García, Ettore Capoluongo, Angelo Minucci, Laura San Feliciano, Dolores Ludena de la Cruz, Gemma Fabriàs, Ana Remesal, Daniele De Luca, Josefina Casas, Krizia Pocino, Remesal, A., De Luca, D., San Feliciano, L., Isidoro-Garcia, M., Minucci, A., Pocino, K., Casas, J., Fabrias, G., Capoluongo, Ettore Domenico, and de la Cruz, D. L.
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Anti-Inflammatory Agents ,Phospholipase ,Secretory phospholipase A2 ,Betamethasone ,Dexamethasone ,chemistry.chemical_compound ,Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,0302 clinical medicine ,Pregnancy ,Surfactant ,Pharmacology (medical) ,Inflammation Mediator ,Lung ,Lysophospholipid ,Anti-Inflammatory Agent ,medicine.anatomical_structure ,Premature Birth ,Steroids ,Female ,Tumor necrosis factor alpha ,Inflammation Mediators ,medicine.drug ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Offspring ,03 medical and health sciences ,030225 pediatrics ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Phospholipases A2, Secretory ,Steroid ,Animal ,Tumor Necrosis Factor-alpha ,business.industry ,Catabolism ,Preterm neonate ,Biochemistry (medical) ,Lysophosphatidylethanolamine ,Pulmonary Surfactants ,Lipid Metabolism ,Rats ,Endocrinology ,Animals, Newborn ,030228 respiratory system ,chemistry ,Rat ,Lysophospholipids ,Pulmonary Surfactant ,business - Abstract
Introduction Secretory phospholipase A2 regulates surfactant catabolism and inflammatory cascade. This enzyme is correlated with compliance, oxygenation and major outcomes in various forms of acute respiratory failure. Steroids inhibit secretory phospholipase A2 in cell culture and are widely used to boost surfactant production before preterm delivery. No data are available about the effect of antenatal steroids on secretory phospholipase A2 in the offspring: we aimed to study this effect in a rat model of preterm lung. Material and methods Fifteen pregnant Wistar rats were randomized to receive betamethasone, dexamethasone or placebo at 20 and 21 days gestation. Newborn rats were supported for 8 h and then sacrificed: lung tissue was analysed for secretory phospholipase A2 expression and activity, inflammatory mediators and protein content. Lipidomics was analysed using liquid chromatography-mass spectrometry. Results Secretory phospholipase A2 expression was significantly reduced by antenatal steroids (p
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- 2016
21. Late-Onset Sepsis among Extremely Preterm Infants of 24-28 Weeks Gestation: An International Comparison in 10 High-Income Countries.
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Klinger G, Reichman B, Norman M, Kusuda S, Battin M, Helenius K, Isayama T, Lui K, Adams M, Vento M, Hakansson S, Beltempo M, Poggi C, San Feliciano L, Lehtonen L, Bassler D, Yang J, and Shah PS
- Abstract
Introduction: Despite advances in neonatal care, late-onset sepsis remains an important cause of preventable morbidity and mortality. Neonatal late-onset sepsis rates have decreased in some countries, while in others they have not. Our objective was to compare trends in late-onset sepsis rates in 9 population-based networks from 10 countries and to assess the associated mortality within 7 days of late-onset sepsis., Methods: We performed a retrospective population-based cohort study. Infants born at 24-28 weeks' gestation between 2007 and 2019 were eligible for inclusion. Late-onset sepsis was defined as a positive blood or cerebrospinal fluid culture. Late-onset sepsis rates were calculated for 3 epochs (2007-11, 2012-15, and 2016-19). Adjusted risk ratios (aRRs) for late-onset sepsis were calculated for each network., Results: Of a total of 82,850 infants, 16,914 (20.4%) had late-onset sepsis, with Japan having the lowest rate (7.1%) and Spain the highest (44.6%). Late-onset sepsis rates decreased in most networks and remained unchanged in a few. Israel, Sweden, and Finland showed the largest decrease in late-onset sepsis rates. The aRRs for late-onset sepsis showed wide variations between networks. The rate of mortality temporally related to late-onset sepsis was 10.9%. The adjusted mean length of stay for infants with late-onset sepsis was increased by 5-18 days compared to infants with no late-onset sepsis., Conclusions: One in 5 neonates of 24-28 weeks' gestation develops late-onset sepsis. Wide variability in late-onset sepsis rates exists between networks with most networks exhibiting improvement. Late-onset sepsis was associated with increased mortality and length of stay., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
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- 2024
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22. Trends, Characteristic, and Outcomes of Preterm Infants Who Received Postnatal Corticosteroid: A Cohort Study from 7 High-Income Countries.
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Parikh S, Reichman B, Kusuda S, Adams M, Lehtonen L, Vento M, Norman M, San Feliciano L, Isayama T, Hakansson S, Helenius K, Bassler D, Yang J, Shah PS, and Gellineo L
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- Infant, Humans, Infant, Newborn, Male, Cohort Studies, Retrospective Studies, Developed Countries, Gestational Age, Adrenal Cortex Hormones therapeutic use, Infant, Premature, Bronchopulmonary Dysplasia etiology
- Abstract
Introduction: Our objective was to evaluate the temporal trend of systemic postnatal steroid (PNS) receipt in infants of 24-28 weeks' gestational age, identify characteristics associated with PNS receipt, and correlate PNS receipt with the incidence of bronchopulmonary dysplasia (BPD) and BPD/death from an international cohort included in the iNeo network., Methods: We conducted a retrospective study using data from 2010 to 2018 from seven international networks participating in iNeo (Canada, Finland, Israel, Japan, Spain, Sweden, and Switzerland). Neonates of 24 and 28 weeks' gestational age who survived 7 days and who received PNS were included. We assessed temporal trend of rates of systemic PNS receipt and BPD/death., Results: A total of 47,401 neonates were included. The mean (SD) gestational age was 26.4 (1.3) weeks and birth weight was 915 (238) g. The PNS receipt rate was 21% (12-28% across networks) and increased over the years (18% in 2010 to 26% in 2018; p < 0.01). The BPD rate was 39% (28-44% across networks) and remained unchanged over the years (35.2% in 2010 to 35.0% in 2018). Lower gestation, male sex, small for gestational age status, and presence of persistent ductus arteriosus (PDA) were associated with higher rates of PNS receipt, BPD, and BPD/death., Conclusion: The use of PNS in extremely preterm neonates increased, but there was no correlation between increased use and the BPD rate. Research is needed to determine the optimal timing, dose, and indication for PNS use in preterm neonates., (© 2023 The Author(s). Published by S. Karger AG, Basel.)
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- 2023
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23. Survival and Survival without Major Morbidity Seem to Be Consistently Better throughout Gestational Age in 24- to 30-Week Gestational Age Very-Low-Birth-Weight Female Infants Compared to Males.
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García-Muñoz Rodrigo F, Fabres JG, Zozaya Nieto C, San Feliciano L, Figueras-Aloy J, Saenz de Pipaon M, D'Apremont I, Genes de Lovera LE, Bancalari A, Tapia JL, and Vento M
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- Female, Gestational Age, Humans, Infant, Infant Mortality, Infant, Newborn, Male, Morbidity, Pregnancy, Retrospective Studies, Bronchopulmonary Dysplasia epidemiology, Infant, Very Low Birth Weight
- Abstract
Introduction: Several studies showed advantages in outcomes for very-low-birth-weight (VLBW) female infants. It has been suggested that recent advances in perinatal care might have benefited boys relatively more than girls, making differences disappear., Objectives: The aims of the study were (1) to determine if sex differences in survival and survival without morbidity in VLBW infants are still present in the context of more advanced perinatal care and (2) to know whether these differences are consistent throughout gestational age (GA)., Methods: Retrospective cohort study in seven countries participating in the Spanish SEN1500 and the South American NEOCOSUR neonatal networks. We included VLBW infants 24-30 weeks' GA, born alive without major congenital anomalies (2013-2016). Major morbidity, survival, and survival without morbidity were compared between male and female infants overall and stratified by GA., Results: 10,565 patients were included: 5,620 (53.2%) males and 4,945 (46.8%) females. Female infants exhibited a lower incidence rate ratio (95% CI) of respiratory distress syndrome: 0.91 (0.88, 0.94), necrotizing enterocolitis: 0.83 (0.74, 0.93), major brain damage: 0.79 (0.72, 0.86), moderate-severe bronchopulmonary dysplasia (BPD): 0.77 (0.72, 0.83), higher survival: 1.03 (1.01, 1.05), survival without BPD: 1.11 (1.07, 1.16), survival without major brain damage: 1.05 (1.02, 1.08), and survival without major morbidity: 1.14 (1.07, 1.21). Survival and survival without morbidity were almost consistently favourable to females throughout GA., Conclusions: Our findings suggest that perinatal results continue to be favourable for VLBW female infants in the context of current perinatology, and that they are almost consistent throughout GA., (© 2022 S. Karger AG, Basel.)
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- 2022
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24. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities.
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Shah PS, Lui K, Reichman B, Norman M, Kusuda S, Lehtonen L, Adams M, Vento M, Darlow BA, Modi N, Rusconi F, Håkansson S, San Feliciano L, Helenius KK, Bassler D, Hirano S, and Lee SK
- Abstract
Neonates born very preterm (before 32 weeks' gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care., Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
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- 2019
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25. Variations in Oxygen Saturation Targeting, and Retinopathy of Prematurity Screening and Treatment Criteria in Neonatal Intensive Care Units: An International Survey.
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Darlow BA, Vento M, Beltempo M, Lehtonen L, Håkansson S, Reichman B, Helenius K, Sjörs G, Sigali E, Lee S, Noguchi A, Morisaki N, Kusuda S, Bassler D, San Feliciano L, Adams M, Isayama T, Shah PS, and Lui K
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- Gestational Age, Health Care Surveys, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Internationality, Oxygen blood, Practice Guidelines as Topic, Practice Patterns, Physicians', Retina surgery, Intensive Care Units, Neonatal organization & administration, Oxygen administration & dosage, Oxygen Inhalation Therapy adverse effects, Retinopathy of Prematurity diagnosis, Retinopathy of Prematurity etiology
- Abstract
Background: Rates of retinopathy of prematurity (ROP) and ROP treatment vary between neonatal intensive care units (NICUs). Neonatal care practices, including oxygen saturation (SpO2) targets and criteria for the screening and treatment of ROP, are potential contributing factors to the variations., Objectives: To survey variations in SpO2 targets in 2015 (and whether there had been recent changes) and criteria for ROP screening and treatment across the networks of the International Network for Evaluating Outcomes in Neonates (iNeo)., Methods: Online prepiloted questionnaires on treatment practices for preterm infants were sent to the directors of 390 NICUs in 10 collaborating iNeo networks. Nine questions were asked and the results were summarized and compared., Results: Overall, 329/390 (84%) NICUs responded, and a majority (60%) recently made changes in upper and lower SpO2 target limits, with the median set higher than previously by 2-3% in 8 of 10 networks. After the changes, fewer NICUs (15 vs. 28%) set an upper SpO2 target limit > 95% and fewer (3 vs. 5%) a lower limit < 85%. There were variations in ROP screening criteria, and only in the Swedish network did all NICUs follow a single guideline. The initial retinal examination was carried out by an ophthalmologist in all but 6 NICUs, and retinal photography was used in 20% but most commonly as an adjunct to indirect ophthalmoscopy., Conclusions: There is considerable variation in SpO2 targets and ROP screening and treatment criteria, both within networks and between countries., (© 2018 S. Karger AG, Basel.)
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- 2018
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26. Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus.
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Hines D, Modi N, Lee SK, Isayama T, Sjörs G, Gagliardi L, Lehtonen L, Vento M, Kusuda S, Bassler D, Mori R, Reichman B, Håkansson S, Darlow BA, Adams M, Rusconi F, San Feliciano L, Lui K, Morisaki N, Musrap N, and Shah PS
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- Humans, Infant, Newborn, Infant, Premature, Bronchopulmonary Dysplasia, Terminology as Topic
- Abstract
The use of different definitions for bronchopulmonary dysplasia (BPD) has been an ongoing challenge. We searched papers published in English from 2010 and 2015 reporting BPD as an outcome, together with studies that compared BPD definitions between 1978 and 2015. We found that the incidence of BPD ranged from 6% to 57%, depending on the definition chosen, and that studies that investigated correlations with long-term pulmonary and/or neurosensory outcomes reported moderate-to-low predictive values regardless of the BPD criteria., Conclusion: A comprehensive and evidence-based definition for BPD needs to be developed for benchmarking and prognostic use., (©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
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- 2017
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27. Neonatal Outcomes of Very Low Birth Weight and Very Preterm Neonates: An International Comparison.
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Shah PS, Lui K, Sjörs G, Mirea L, Reichman B, Adams M, Modi N, Darlow BA, Kusuda S, San Feliciano L, Yang J, Håkansson S, Mori R, Bassler D, Figueras-Aloy J, and Lee SK
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- Female, Global Health, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Very Low Birth Weight, Male, Retrospective Studies, Infant, Premature, Diseases mortality
- Abstract
Objective: To compare rates of a composite outcome of mortality or major morbidity in very-preterm/very low birth weight infants between 8 members of the International Network for Evaluating Outcomes., Study Design: We included 58 004 infants born weighing <1500 g at 24(0)-31(6) weeks' gestation from databases in Australia/New Zealand, Canada, Israel, Japan, Spain, Sweden, Switzerland, and the United Kingdom. We compared a composite outcome (mortality or any of grade ≥3 peri-intraventricular hemorrhage, periventricular echodensity/echolucency, bronchopulmonary dysplasia, or treated retinopathy of prematurity) between each country and all others by using standardized ratios and pairwise using logistic regression analyses., Results: Despite differences in population coverage, included neonates were similar at baseline. Composite outcome rates varied from 26% to 42%. The overall mortality rate before discharge was 10% (range: 5% [Japan]-17% [Spain]). The standardized ratio (99% CIs) estimates for the composite outcome were significantly greater for Spain 1.09 (1.04-1.14) and the United Kingdom 1.16 (1.11-1.21), lower for Australia/New Zealand 0.93 (0.89-0.97), Japan 0.89 (0.86-0.93), Sweden 0.81 (0.73-0.90), and Switzerland 0.77 (0.69-0.87), and nonsignificant for Canada 1.04 (0.99-1.09) and Israel 1.00 (0.93-1.07). The adjusted odds of the composite outcome varied significantly in pairwise comparisons., Conclusions: We identified marked variations in neonatal outcomes between countries. Further collaboration and exploration is needed to reduce variations in population coverage, data collection, and case definitions. The goal would be to identify care practices and health care organizational factors, which has the potential to improve neonatal outcomes., (Copyright © 2016 Elsevier Inc. All rights reserved.)
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- 2016
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28. Effect of prenatal steroidal inhibition of sPLA2 in a rat model of preterm lung.
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Remesal A, De Luca D, San Feliciano L, Isidoro-Garcia M, Minucci A, Pocino K, Casas J, Fabrias G, Capoluongo ED, and de la Cruz DL
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- Animals, Animals, Newborn, Anti-Inflammatory Agents pharmacology, Betamethasone pharmacology, Dexamethasone pharmacology, Female, Inflammation Mediators metabolism, Lipid Metabolism drug effects, Lung pathology, Lysophospholipids metabolism, Pregnancy, Pulmonary Surfactants metabolism, Rats, Rats, Wistar, Tumor Necrosis Factor-alpha metabolism, Lung enzymology, Phospholipases A2, Secretory antagonists & inhibitors, Premature Birth pathology, Steroids pharmacology
- Abstract
Introduction: Secretory phospholipase A2 regulates surfactant catabolism and inflammatory cascade. This enzyme is correlated with compliance, oxygenation and major outcomes in various forms of acute respiratory failure. Steroids inhibit secretory phospholipase A2 in cell culture and are widely used to boost surfactant production before preterm delivery. No data are available about the effect of antenatal steroids on secretory phospholipase A2 in the offspring: we aimed to study this effect in a rat model of preterm lung., Material and Methods: Fifteen pregnant Wistar rats were randomized to receive betamethasone, dexamethasone or placebo at 20 and 21 days gestation. Newborn rats were supported for 8 h and then sacrificed: lung tissue was analysed for secretory phospholipase A2 expression and activity, inflammatory mediators and protein content. Lipidomics was analysed using liquid chromatography-mass spectrometry., Results: Secretory phospholipase A2 expression was significantly reduced by antenatal steroids (p < 0.001). Secretory phospholipase A2 activity, TNFα and lysophosphatidylethanolamine, a product of phospholipase reaction, were lowest in betamethasone-treated rats (p < 0.001). There was a strong correlation between secretory phospholipase A2 activity and lysophosphatidylethanolamine (r = 0.75; p = 0.001) and this remained significant after adjustment for total proteins or phospholipids., Conclusions: Antenatal steroids decrease secretory phospholipase A2 in rat model of preterm lung., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
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- 2016
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29. [Outcome at two years corrected age of a cohort of very low birth weight infants from hospitals within the neonatal SEN1500 network].
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García P, San Feliciano L, Benito F, García R, Guzmán J, Salas S, Fernández C, Del Prado N, Ciprián D, and Figueras J
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- Age Factors, Cerebral Palsy complications, Child, Preschool, Developmental Disabilities complications, Female, Follow-Up Studies, Hospitals, Humans, Incidence, Infant, Newborn, Male, Retrospective Studies, Developmental Disabilities epidemiology, Developmental Disabilities physiopathology, Infant, Very Low Birth Weight growth & development
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Objective: To describe growth and neurodevelopmental status of 4,944 children who completed a follow-up at two years of corrected age out of the 10,456 newborns with weight ≤1500g born between the years 2002-2007 and discharged from hospitals within the network SEN1500. A total of 522 newborns were excluded as they had some type of malformation. The total number of children assessed represents the 49.76% of children discharged alive and without malformations., Methods: A retrospective review was conducted using prospectively collected data in the SEN1500 database. We compared growth data at two years of corrected age according to birth weight and sex. Motor impairment, incidence of cerebral palsy, visual and hearing disabilities, and abnormal neurodevelopment for gestational age were analysed between groups. We studied the associations between cerebral palsy (CP) and perinatal factors., Results: At 2 years of age 44.2% of children had a weight <2 SD for corrected age. Children with birth weight ≤1000g showed worse outcomes in growth. Some type of motor impairment was observed in 6.96% of the infants, and 4.56% of them were diagnosed with CP. The incidence was higher among males with birth weight ≤1000g. There was an incidence of 5.21% of visual disability, with 0.5% of children being blind in one or both eyes. Cerebral palsy was associated with retinopathy of prematurity, severe intraventricular haemorrhage, and periventricular leukomalacia, in particular cystic periventricular leukomalacia., (Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.)
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- 2013
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30. Host and environmental factors influencing respiratory secretion of pro-wheezing biomarkers in preterm children.
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Matías V, San Feliciano L, Fernández JE, Lapeña S, Garrido E, Ardura J, Soga MJ, Aragón MP, Remesal A, Benito F, Andrés J, Centeno F, Marugán V, Bachiller R, and Bermejo-Martin JF
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- Biomarkers metabolism, Cytokines metabolism, Environmental Exposure adverse effects, Female, Humans, Infant, Infant, Newborn, Intercellular Signaling Peptides and Proteins metabolism, Interleukin 1 Receptor Antagonist Protein metabolism, Male, Respiratory Mucosa immunology, Sex Factors, Smoking adverse effects, Socioeconomic Factors, Spain, Asthma immunology, Infant, Premature immunology, Respiratory Sounds immunology
- Abstract
Cytokines are actively secreted by the respiratory mucosa of preterm children and participate in the pathogenesis of wheezing. This study aimed to identify the factors that could potentially influence respiratory secretion of cytokines in these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm children 1 yr after birth. NPAs from 14 healthy, 1-yr-old term children were collected in parallel. 27 cytokines were measured in the NPAs using a multiplex assay. Multivariate stepwise regression analysis with Bonferroni correction evidenced that the variable [daycare attendance] was associated with higher levels of [monocyte chemoattractant protein-1 (MCP-1), IL-6, vascular endothelial growth factor (VEGF), IL-1β, IL-10, tumor necrosis factor (TNF)-α]; [male sex] with higher levels of (MCP-1, VEGF, and IL-1β); [smokers at home] was associated with higher levels of MCP-1 (p < 0.0013). In turn, [prophylaxis with palivizumab] was associated with lower levels of (IL-6, IL-7) (p < 0.0013). All these mediators participate in the pathogenesis of asthma and recurrent wheezing. Preterm children secreted higher levels of chemokines (interferon-gamma inducible protein-10, macrophage inflammatory protein-1α, Eotaxin, MCP-1), growth factors (platelet-derived growth factor-bb, VEGF, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor), Th1 (IL12, interferon-γ), Th2 (IL-9, IL-13), Th17 (IL-6, IL-17) cytokines, and immunomodulatory mediators (IL1RA and granulocyte colony-stimulating factor) than term children. In conclusion, we have identified for the first time a group of individual and environmental factors influencing respiratory secretion of cytokines in preterm children at the long term after birth. To know these factors could help to prevent the instauration of conditions linked to the appearance of chronic respiratory diseases such as wheezing or asthma., (© 2012 John Wiley & Sons A/S.)
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- 2012
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31. Dexamethasone and betamethasone for prenatal lung maturation: differences in vascular endothelial growth factor expression and alveolarization in rats.
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San Feliciano L, Remesal A, Isidoro-García M, and Ludeña D
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- Animals, Animals, Newborn, Betamethasone therapeutic use, Dexamethasone therapeutic use, Female, Fetal Organ Maturity genetics, Gene Expression Regulation, Developmental drug effects, Lung embryology, Lung metabolism, Lung physiology, Pregnancy, Prenatal Care methods, Pulmonary Alveoli embryology, Pulmonary Alveoli growth & development, Pulmonary Alveoli metabolism, Rats, Rats, Wistar, Time Factors, Vascular Endothelial Growth Factor A metabolism, Betamethasone pharmacology, Dexamethasone pharmacology, Fetal Organ Maturity drug effects, Lung drug effects, Pulmonary Alveoli drug effects, Vascular Endothelial Growth Factor A genetics
- Abstract
Background: Fetal and postnatal lung development is regulated by glucocorticoids. The use of antenatal corticosteroids is reported to produce effects on vascular endothelial growth factor (VEGF), which plays a crucial role in pulmonary development., Objectives: The purpose of this study was to compare pulmonary VEGF expression in newborn rats that were exposed to antenatal betamethasone versus dexamethasone and to evaluate its impact on the alveolarization period of rats (0-14 days of life)., Methods: Betamethasone, dexamethasone or equivalent saline solution (control group) was administered to pregnant rats on 20th and 21st days of gestation. Pulmonary VEGF mRNA, VEGF protein expression, and alveolarization changes were evaluated at birth and at 14 days of life., Results: Betamethasone and dexamethasone were observed to have different actions on VEGF expression with a correlation with alveolarization on both days of study. Antenatal dexamethasone decreased VEGF expression, betamethasone tended to produce the induction of the expression of VEGF, and moreover, betamethasone did not produce a decrease in alveolarization as seen in the animals that received dexamethasone., Conclusions: Our results support the notion that betamethasone could be a better choice than dexamethasone for antenatal lung maturation., (Copyright © 2011 S. Karger AG, Basel.)
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- 2011
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32. Effects of antenatal betamethasone and dexamethasone on the lung expression of vascular endothelial growth factor and alveolarization in newborn rats exposed to acute hypoxia and recovered in normoxia or hyperoxia.
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Remesal A, San Feliciano L, Isidoro-García M, and Ludeña D
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- Acute Disease, Animals, Animals, Newborn, Disease Models, Animal, Female, Gene Expression Regulation, Developmental drug effects, Hyperoxia genetics, Hypoxia genetics, Maternal Exposure, Pregnancy, Pulmonary Alveoli growth & development, Pulmonary Alveoli metabolism, RNA, Messenger metabolism, Rats, Rats, Wistar, Tissue Array Analysis, Vascular Endothelial Growth Factor A genetics, Betamethasone pharmacology, Dexamethasone pharmacology, Glucocorticoids pharmacology, Hyperoxia metabolism, Hypoxia metabolism, Pulmonary Alveoli drug effects, Vascular Endothelial Growth Factor A metabolism
- Abstract
The use of antenatal corticosteroids is widespread and it is important to know their effect(s) on vascular endothelial growth factor (VEGF), which plays a crucial role in pulmonary development. The purpose of this study was to compare pulmonary VEGF expression in newborn rats that were exposed to antenatal betamethasone versus dexamethasone under normoxia, hypoxia and oxidative stress, and to evaluate its impact on alveolarization. Betamethasone, dexamethasone or equivalent saline solution (control group) was administered to pregnant rats. Newborn rats were randomized to room air, hypoxia followed by hyperoxia, or hypoxia followed by air. Pulmonary VEGF protein, VEGF mRNA, and alveolarization were evaluated at 4 days of life. Betamethasone and dexamethasone were observed to have different actions on VEGF expression with a correlation with alveolarization. Antenatal dexamethasone decreased VEGF expression, and dexamethasone and hyperoxia had an additive effect on the inhibition of VEGF with a reduction in alveolar development. Betamethasone appeared to have an effect on the induction of the expression of VEGF, and it seemed to inhibit the negative action of hyperoxia on VEGF. Moreover, betamethasone did not produce a decrease in alveolarization. Our results support the notion that betamethasone could be better than dexamethasone for antenatal lung maturation., (Copyright © 2010 S. Karger AG, Basel.)
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- 2010
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33. Pulmonary expression of vascular endothelial growth factor (VEGF) and alveolar septation in a newborn rat model exposed to acute hypoxia and recovered under conditions of air or hyperoxia.
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Remesal A, Pedraz C, San Feliciano L, and Ludeña D
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- Acute Disease, Air, Animals, Animals, Newborn, Fluorescent Antibody Technique, Direct, Hyperoxia genetics, Immunohistochemistry, Lung growth & development, Lung metabolism, Lung Injury, Pulmonary Alveoli cytology, Pulmonary Alveoli drug effects, Pulmonary Alveoli growth & development, Rats, Rats, Wistar, Vascular Endothelial Growth Factor A metabolism, Disease Models, Animal, Fetal Hypoxia metabolism, Hyperoxia metabolism, Pulmonary Alveoli metabolism, Vascular Endothelial Growth Factor A genetics
- Abstract
Vascular endothelial growth factor (VEGF) is an endothelial cell growth factor expressed in normal lung tissue. The aim of the study was to investigate the expression of VEGF and its repercussions as regards alveolarization in the developing rat lung. We studied pulmonary VEGF expression at 0 and 14 days of life in Wistar rats. Rat pups were exposed to hypoxia for two hours during the first hours of life and recovered under conditions of hyperoxia or normoxia for a further two hours, or not recovered. The animals of the control group were only exposed to conditions of normoxia. Our results showed that VEGF was increased in the lungs of the animals that were exposed to hypoxia but we did not find any correlation with the septation. The VEGF was decreased in the lungs of animals exposed to hyperoxia after neonatal hypoxia. We observed this at 0 and 14 days of life, and it was correlated with a lower degree of alveolarization at 14 days of life. Our data suggest that hyperoxia after neonatal hypoxia at birth may give rise to a decrease in the expression of VEGF, possibly permanently, together with a reduction in alveolar development.
- Published
- 2009
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