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Breast cancer is one of the most frequent cancers affecting women. Non-coding micro RNAs (miRNAs) seem to play an important role in the regulation of pathways involved in tumor occurrence and progression. Extending on the research in Haakensen et al., where significant miRNAs were selected as being associated with the progression from normal breast tissue to breast cancer, in this work we put forward 112 sets of miRNA combinations, each including at most 5 expressions with high accuracy in discriminating healthy breast tissue from breast carcinoma. Our results are based on a recently developed machine learning technique which, instead of selecting a single model (or combination of features), delivers a set of models with equivalent predictive capabilities that allow to interpret and visualize the interaction of these features. These results shed new light on the biological action of the selected miRNAs which can behave in different ways according to the miRNA network with which they interact.Indeed, these revealed connections may contribute to explain why, in some cases, different studies attribute opposite functions to the same miRNA. It is therefore possible to understand how the role of a genomic variable may change when considered in interaction with other sets of variables, as opposed to only considering its effect when it is evaluated within a unique combination of features. The approach proposed in this work provides a statistical basis for the notion of chameleon miRNAs and is inspired by the emerging field of systems biology.Author SummaryThe notion of a single predictive genomic (statistical) model is replaced by that of a set of models that can be considered as exchangeable due to their indistinguishable (optimal) predictive abilities;Our results indicate that the role of miRNAs cannot be interpreted independently from the combination of features with which they interact and can therefore vary considerably when considered in a network of different combinations. Some miRNAs may act as chameleons and behave in opposite manners thereby showing some kind of antagonistic duality;Some miRNAs are exchangeable inside models with equivalent predictive ability and seem to point to latent biological functions.

The task of inertial sensor calibration has required the development of various techniques to take into account the sources of measurement error coming from such devices. The calibration of the stochastic errors of these sensors has been the focus of increasing amount of research in which the method of reference has been the so-called “Allan variance (AV) slope method” which, in addition to not having appropriate statistical properties, requires a subjective input which makes it prone to mistakes. To overcome this, recent research has started proposing “automatic” approaches where the parameters of the probabilistic models underlying the error signals are estimated by matching functions of the AV or wavelet variance with their model-implied counterparts. However, given the increased use of such techniques, there has been no study or clear direction for practitioners on which approach is optimal for the purpose of sensor calibration. This article, for the first time, formally defines the class of estimators based on this technique and puts forward theoretical and applied results that, comparing with estimators in this class, suggest the use of the Generalized method of Wavelet moments (GMWM) as an optimal choice. In addition to analytical proofs, experiment-driven Monte Carlo simulations demonstrated the superior performance of this estimator. Further analysis of the error signal from a gyroscope was also provided to further motivate performing such analyses, as real-world observed error signals may show significant deviation from manufacturer-provided error models.

In this paper, we study the finite sample accuracy of confidence intervals for index functional built via parametric bootstrap, in the case of inequality indices. To estimate the parameters of the assumed parametric data generating distribution, we propose a Generalized Method of Moment estimator that targets the quantity of interest, namely the considered inequality index. Its primary advantage is that the scale parameter does not need to be estimated to perform parametric bootstrap, since inequality measures are scale invariant. The very good finite sample coverages that are found in a simulation study suggest that this feature provides an advantage over the parametric bootstrap using the maximum likelihood estimator. We also find that overall, a parametric bootstrap provides more accurate inference than its non or semi-parametric counterparts, especially for heavy tailed income distributions.

Cutaneous melanoma is a highly aggressive skin cancer whose treatment and prognosis are critically affected by the presence of metastasis. In this study, we address the following issue: which gene transcripts and what kind of interactions between them can allow to predict nonmetastatic from metastatic melanomas with a high level of accuracy? We carry out a meta-analysis on the first gene expression set of the Leeds melanoma cohort, as made available online on 11 May 2016 through the ArrayExpress platform with MicroArray Gene Expression number 4725. According to the authors, primary melanoma mRNA expression was measured in 204 tumours using an illumina DASL HT12 4 whole-genome array. The tumour transcripts were selected through a recently proposed predictive-based regression algorithm for gene-network selection. A set of 64 equivalent models, each including only two gene transcripts, were each sufficient to accurately classify primary tumours into metastatic and nonmetastatic melanomas. The sensitivity and specificity of the genomic-based models were, respectively, 4% (95% confidence interval: 0.11-21.95%) and 99% (95% confidence interval: 96.96-99.99%). The very high specificity coupled with a significantly large positive likelihood ratio leads to a conclusive increase in the likelihood of disease when these biomarkers are present in the primary tumour. In conjunction with other highly sensitive methods, this approach can aspire to be part of the future standard diagnosis methods for the screening of metastatic cutaneous melanoma. The small dimension of the selected transcripts models enables easy handling of large-scale genomic testing procedures. Moreover, some of the selected transcripts have an understandable link with what is known about cutaneous melanoma oncogenesis, opening a window on the molecular pathways underlying the metastatic process of this disease.

Gene selection has become a common task in most gene expression studies. The objective of such research is often to identify the smallest possible set of genes that can still achieve good predictive performance. To do so, many of the recently proposed classification methods require some form of dimension-reduction of the problem which finally provide a single model as an output and, in most cases, rely on the likelihood function in order to achieve variable selection. We propose a new prediction-based objective function that can be tailored to the requirements of practitioners and can be used to assess and interpret a given problem. Based on cross-validation techniques and the idea of importance sampling, our proposal scans low-dimensional models under the assumption of sparsity and, for each of them, estimates their objective function to assess their predictive power in order to select. Two applications on cancer data sets and a simulation study show that the proposal compares favorably with competing alternatives such as, for example, Elastic Net and Support Vector Machine. Indeed, the proposed method not only selects smaller models for better, or at least comparable, classification errors but also provides a set of selected models instead of a single one, allowing to construct a network of possible models for a target prediction accuracy level.

Stochastic behavior of an instrument is often analyzed by constructing the Allan (or wavelet) variance signatures from an error signal. For inertial sensors, such a signature is conveniently obtained by recording data at rest. The analysis of this signal will result in noise-parameters adequate to such situation. Nonetheless, the value of the noise parameters may change under dynamics or other kind of external influences like for instance the temperature. In this research we study first the influence of the rotational dynamics on the signal of MEMS gyroscopes and then we show how to link this property to the noise-parameter estimation in a rigorous way by a modified version of the Generalized Method of Wavelet Moments (GMWM) estimator. The results of such analysis can then for instance be used in a Kalman filter, where the noise parameters are adapted according to such predetermined functional relationship between sensor noise and the encountered dynamics of the platform/sensor.

This paper presents a novel science indicator to identify, analyze, and capture technology trends based on Wikipedia page views and OpenAlex presented at STI2022. Our webometric methodology is grounded in open science practices and applied to crowd-sourced, open, and free data. We explore the relationships between 36 data protection and encryption technologies, by measuring and classifying their time-varying attention. These highly research-intensive technologies are particularly suitable to illustrate our approach. We first find that Blockchain, Hash Function, and Asymmetric Encryption are the technologies that generate significant public interest. Conversely, niche or longstanding technologies such as Disk Encryption and Email Encryption are considered low-interest technologies with no growth. Our findings suggest that monitoring public attention on Wikipedia can serve as a scientific indicator to provide valuable information on technology trends and inform decision-making related to investment, assessment, and technology road-mapping.