1. Temporary Balloon Occlusion for Hepatic Arterial Flow Redistribution during Yttrium-90 Radioembolization
- Author
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Savannah Fletcher, James Meek, Mary E. Meek, Samuel L. Bezold, Daniel Borja-Cacho, and C. Heath Gauss
- Subjects
Adult ,Male ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Balloon ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Hepatic Artery ,0302 clinical medicine ,Risk Factors ,medicine ,Carcinoma ,Humans ,Yttrium Radioisotopes ,Radiology, Nuclear Medicine and imaging ,Embolization ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Liver Neoplasms ,Multimodal therapy ,Retrospective cohort study ,Balloon Occlusion ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Treatment Outcome ,Response Evaluation Criteria in Solid Tumors ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Female ,Radiology ,Radiopharmaceuticals ,Cardiology and Cardiovascular Medicine ,business ,Liver Circulation - Abstract
This case series describes an approach for radiation segmentectomy-style treatment of hepatic tumors fed by arteries unsuitable for catheterization. The 15-patient cohort (17 cases from 2015 to 2018) included those diagnosed with liver tumors (14 hepatocellular carcinoma, 1 cholangiocarcinoma, 1 renal-cell carcinoma, and 1 metastatic colorectal carcinoma) and chosen for radioembolization via a multimodal approach. In each case, a balloon microcatheter was used to temporarily redistribute intrahepatic flow during infusion for enhanced radioembolic agent delivery to the tumor. A median of 199 Gy was delivered to a median of 3% of total liver volume. Based on modified Response Evaluation Criteria In Solid Tumors, 11 cases had complete responses and 6 had partial responses.
- Published
- 2019
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