Search

Your search keyword '"Samson, Rebecca"' showing total 358 results
Start Over Author "Samson, Rebecca"
358 results on '"Samson, Rebecca"'

16. Coping with Caregiver Fatigue: How to Manage the Stress and Demands of Caring for a Loved One

Author

Samson, Rebecca

Subjects
Stress management, Caregivers, Burn out (Psychology), Health, Philosophy and religion, Psychology and mental health
Abstract

One in five Americans takes care of an aging family member, spending approximately 25 hours a week on care tasks. The rewarding, but exhausting, responsibility can lead to burnout, unless [...]

Published
2022

17. Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

Author

Brown, J William L, Cunniffe, Nick G, Prados, Ferran, Kanber, Baris, Jones, Joanne L, Needham, Edward, Georgieva, Zoya, Rog, David, Pearson, Owen R, Overell, James, MacManus, David, Samson, Rebecca S, Stutters, Jonathan, ffrench-Constant, Charles, Gandini Wheeler-Kingshott, Claudia A M, Moran, Carla, Flynn, Paul D, Michell, Andrew W, Franklin, Robin J M, Chandran, Siddharthan, Altmann, Daniel R, Chard, Declan T, Connick, Peter, and Coles, Alasdair J

Published
2021
Full Text
View/download PDF

18. Generic acquisition protocol for quantitative MRI of the spinal cord

Author

Cohen-Adad, Julien, Alonso-Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia A. M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen, Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Yuichi, Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber, II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Published
2021
Full Text
View/download PDF

19. Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Author

Cohen-Adad, Julien, Alonso-Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Gandini Wheeler-Kingshott, Claudia A. M., Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Published
2021
Full Text
View/download PDF

20. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Author

Cohen-Adad, Julien, Alonso-Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Gandini Wheeler-Kingshott, Claudia A. M., Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Published
2021
Full Text
View/download PDF

21. Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein–associated disease.

Author

Bianchi, Alessia, Cortese, Rosa, Prados, Ferran, Tur, Carmen, Kanber, Baris, Yiannakas, Marios C, Samson, Rebecca, De Angelis, Floriana, Magnollay, Lise, Jacob, Anu, Brownlee, Wallace, Trip, Anand, Nicholas, Richard, Hacohen, Yael, Barkhof, Frederik, Ciccarelli, Olga, and Toosy, Ahmed T

Subjects
NEUROMYELITIS optica, MULTIPLE sclerosis, MYELIN oligodendrocyte glycoprotein, AQUAPORINS, MAGNETIZATION transfer, OPTIC neuritis
Abstract

Background: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated. Aims: To examine OC differences in non-acute IDD patients with (ON+) and without ON (ON−) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers. Methods: Twenty-eight relapsing-remitting multiple sclerosis (RRMS), 24 AQP4 + NMOSD, 28 MOGAD patients and 32 healthy controls (HCs) underwent clinical evaluation, MRI and optical coherence tomography (OCT) scan. Multivariable linear regression models were applied. Results: ON + IDD patients showed lower OC MTR than HCs (28.87 ± 4.58 vs 31.65 ± 4.93; p = 0.004). When compared with HCs, lower OC MTR was found in ON + AQP4 + NMOSD (28.55 ± 4.18 vs 31.65 ± 4.93; p = 0.020) and MOGAD (28.73 ± 4.99 vs 31.65 ± 4.93; p = 0.007) and in ON− AQP4 + NMOSD (28.37 ± 7.27 vs 31.65 ± 4.93; p = 0.035). ON+ RRMS had lower MTR than ON− RRMS (28.87 ± 4.58 vs 30.99 ± 4.76; p = 0.038). Lower OC MTR was associated with higher number of ON (regression coefficient (RC) = −1.15, 95% confidence interval (CI) = −1.819 to −0.490, p = 0.001), worse visual acuity (RC = −0.026, 95% CI = −0.041 to −0.011, p = 0.001) and lower peripapillary retinal nerve fibre layer (pRNFL) thickness (RC = 1.129, 95% CI = 0.199 to 2.059, p = 0.018) when considering the whole IDD group. Conclusion: OC microstructural damage indicates prior ON in IDD and is linked to reduced vision and thinner pRNFL. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

22. What contributes to disability in progressive MS? A brain and cervical cord–matched quantitative MRI study.

Author

Tur, Carmen, Battiston, Marco, Yiannakas, Marios C, Collorone, Sara, Calvi, Alberto, Prados, Ferran, Kanber, Baris, Grussu, Francesco, Ricciardi, Antonio, Pajak, Patrizia, Martinelli, Daniele, Schneider, Torben, Ciccarelli, Olga, Samson, Rebecca S, and Wheeler-Kingshott, Claudia AM Gandini

Abstract

Background: We assessed the ability of a brain-and-cord-matched quantitative magnetic resonance imaging (qMRI) protocol to differentiate patients with progressive multiple sclerosis (PMS) from controls, in terms of normal-appearing (NA) tissue abnormalities, and explain disability. Methods: A total of 27 patients and 16 controls were assessed on the Expanded Disability Status Scale (EDSS), 25-foot timed walk (TWT), 9-hole peg (9HPT) and symbol digit modalities (SDMT) tests. All underwent 3T brain and (C2-C3) cord structural imaging and qMRI (relaxometry, quantitative magnetisation transfer, multi-shell diffusion-weighted imaging), using a fast brain-and-cord–matched protocol with brain-and-cord–unified imaging readouts. Lesion and NA-tissue volumes and qMRI metrics reflecting demyelination and axonal loss were obtained. Random forest analyses identified the most relevant volumetric/qMRI measures to clinical outcomes. Confounder-adjusted linear regression estimated the actual MRI-clinical associations. Results: Several qMRI/volumetric differences between patients and controls were observed (p < 0.01). Higher NA-deep grey matter quantitative-T1 (EDSS: beta = 7.96, p = 0.006; 9HPT: beta = −0.09, p = 0.004), higher NA-white matter orientation dispersion index (TWT: beta = −3.21, p = 0.005; SDMT: beta = −847.10, p < 0.001), lower whole-cord bound pool fraction (9HPT: beta = 0.79, p = 0.001) and higher NA-cortical grey matter quantitative-T1 (SDMT = −94.31, p < 0.001) emerged as particularly relevant predictors of greater disability. Conclusion: Fast brain-and-cord–matched qMRI protocols are feasible and identify demyelination – combined with other mechanisms – as key for disability accumulation in PMS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Optimisation of quantitative magnetisation transfer (QMT) MRI to study restricted protons in the living human brain

Author

Samson, Rebecca Sara

Subjects
616.07548
Abstract

Magnetisation Transfer (MT) imaging exploits magnetisation exchange between 'free' protons and 'restricted' protons attached to macromolecules in biological tissue, to indirectly provide access to the restricted protons, which are invisible using conventional MR imaging techniques. The Magnetisation Transfer Ratio (MTR) is calculated from a pair of images with different MT "weightings", however it reflects a complex combination of biological and acquisition dependent factors. Quantitative MT (qMT) imaging allows the examination of fundamental parameters underlying the MT exchange process independently of sequence details. The effect of B errors on MTR measurements was investigated, both theoretically and experimentally, and a method for correcting for B errors was proposed, based on the collection of a B map in addition to MTR data. The temperature dependence of many quantitative MR properties may cause systematic errors in phantom Quality Assurance (QA) measurements, which could have an impact on the interpretation of quantitative changes observed in long-term clinical studies. Many traditional thermometry methods are unsuitable for use in an MRI scanner. Using localised 1H-MRS acquisition sequences routinely available on clinical MRI scanners, and commonly available analysis packages, internal thermometry in phantoms using DSS (sodium 3-(trimethylsilyl)propane-1-sulphonate)) as a chemical shift reference was shown to be realistic, with a minimum detectable temperature difference of 100 ( 20) mK. The qMT acquisition parameters (combinations of MT pulse amplitude and offset frequency) were optimised, via the minimisation of the Cramer-Rao Minimum Variance Bound (CRMVB). Compared to a conventional acquisition, the optimisation enables less data to be acquired, reducing acquisition time without compromising uncertainties in estimated parameters. Alternatively, for the same number of MT-weighted data points, the parameter map noise could be reduced. This analytical approach was verified numerically, using Monte Carlo simulations, and experimentally, and optimised acquisition schemes were shown to be applicable to a range of brain tissues.

Published
2007

27. Remyelination varies between and within lesions in multiple sclerosis following bexarotene

Author

Brown, J. William L., primary, Prados, Ferran, additional, Altmann, Daniel R., additional, Kanber, Baris, additional, Stutters, Jonathan, additional, Cunniffe, Nick G., additional, Jones, Joanne L., additional, Georgieva, Zoya G., additional, Needham, Edward J., additional, Daruwalla, Cyrus, additional, Wheeler‐Kingshott, Claudia Gandini, additional, Connick, Peter, additional, Chandran, Siddharthan, additional, Franklin, Robin, additional, MacManus, David, additional, Samson, Rebecca, additional, Coles, Alasdair, additional, and Chard, Declan, additional

Published
2022
Full Text
View/download PDF

29. Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis

Author

Calvi, Alberto, Carrasco, Ferran Prados, Tur, Carmen, Chard, Declan T., Stutters, Jonathan, de Angelis, Floriana, John, Nevin, Williams, Thomas, Doshi, Anisha, Samson, Rebecca S., MacManus, David, Gandini Wheeler-Kingshott, Claudia A., Ciccarelli, Olga, Chataway, Jeremy, Barkhof, Frederik, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, and Amsterdam Neuroscience - Neuroinfection & -inflammation

Subjects
Multiple Sclerosis, Brain, Humans, Neurology (clinical), Multiple Sclerosis, Chronic Progressive, Magnetic Resonance Imaging, Retrospective Studies
Abstract

Background and ObjectiveTo explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS).MethodsWe retrospectively studied 345 patients with SPMS enrolled in the MS-SMART trial. They underwent brain MRI at baseline and at 24 and 96 weeks. Definite SELs were defined as concentrically expanding T2 lesions, as assessed by nonlinear deformation of volumetric T1-weighted images. Associations of SEL volumes with other MRI metrics and disability were assessed through Pearson correlations and regression analyses.ResultsAveraged across patients, 29% of T2 lesions were classified as being definite SELs. A greater volume of definite SELs correlated with a higher total baseline T2 lesion volume (r = 0.55, p < 0.001) and percentage brain volume reduction (r = −0.26, p < 0.001), a higher number of new persisting T1 black holes (r = 0.19, p < 0.001), and, in a subset of 106 patients, with a greater reduction in magnetization transfer ratio (adjusted difference 0.52, p < 0.001). In regression analyses, a higher definite SEL volume was associated with increasing disability, as assessed by the Expanded Disability Status Scale (β = 0.23, p = 0.020), z scores of the Multiple Sclerosis Functional Composite (β = −0.47, p = 0.048), Timed 25-Foot Walk Test (β = −2.10, p = 0.001), and Paced Auditory Serial Addition Task (β = −0.27, p = 0.006), and increased risk of disability progression (odds ratio 1.92, p = 0.025).DiscussionDefinite SELs represent almost one-third of T2 lesions in SPMS. They are associated with neurodegenerative MRI markers and related to clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.

Published
2022

31. Comparison of multicenter MRI protocols for visualizing the spinal cord gray matter

Author

Cohen‐Adad, Julien, primary, Alonso‐Ortiz, Eva, additional, Alley, Stephanie, additional, Lagana, Maria Marcella, additional, Baglio, Francesca, additional, Vannesjo, Signe Johanna, additional, Karbasforoushan, Haleh, additional, Seif, Maryam, additional, Seifert, Alan C., additional, Xu, Junqian, additional, Kim, Joo‐Won, additional, Labounek, René, additional, Vojtíšek, Lubomír, additional, Dostál, Marek, additional, Valošek, Jan, additional, Samson, Rebecca S., additional, Grussu, Francesco, additional, Battiston, Marco, additional, Gandini Wheeler‐Kingshott, Claudia A. M., additional, Yiannakas, Marios C., additional, Gilbert, Guillaume, additional, Schneider, Torben, additional, Johnson, Brian, additional, and Prados, Ferran, additional

Published
2022
Full Text
View/download PDF

32. Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Author

Leutritz, Tobias, Seif, Maryam, Helms, Gunther, Samson, Rebecca S, Curt, Armin, Freund, Patrick, Weiskopf, Nikolaus, University of Zurich, and Leutritz, Tobias

Subjects
Adult, Male, Brain Mapping, Reproducibility of Results, 610 Medicine & health, clinical trial, 2702 Anatomy, quantitative MRI, Magnetic Resonance Imaging, 2728 Neurology (clinical), multicenter study, 2808 Neurology, Image Processing, Computer-Assisted, 2741 Radiology, Nuclear Medicine and Imaging, Humans, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center, in vivo histology using MRI, Female, reproducibility, 3614 Radiological and Ultrasound Technology, Research Articles, multiparameter mapping, Research Article
Abstract

Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI‐toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter‐site comparability, the intra‐site (i.e., scan‐rescan experiment) coefficient of variation (CoV), inter‐site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra‐ and inter‐site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra‐site CoV (16%) was observed in R2* maps. The inter‐site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials., We developed and optimized a quantitative acquisition technique, which enables the fast high‐resolution mapping of multiple parameters on standard clinical MRI hard‐ and software. A travelling heads study on five healthy volunteers demonstrated its excellent reproducibility and comparability across six different sites with MRI scanners from two different vendors. The low inter‐site bias (

Published
2020

33. Assessing Lumbar Plexus and Sciatic Nerve Damage in Relapsing-Remitting Multiple Sclerosis Using Magnetisation Transfer Ratio

Author

Boonsuth, Ratthaporn, primary, Samson, Rebecca S., additional, Tur, Carmen, additional, Battiston, Marco, additional, Grussu, Francesco, additional, Schneider, Torben, additional, Yoneyama, Masami, additional, Prados, Ferran, additional, Ttofalla, Antrea, additional, Collorone, Sara, additional, Cortese, Rosa, additional, Ciccarelli, Olga, additional, Gandini Wheeler-Kingshott, Claudia A. M., additional, and Yiannakas, Marios C., additional

Published
2021
Full Text
View/download PDF

34. Tracking White and Gray Matter Degeneration along the Spinal Cord Axis in Degenerative Cervical Myelopathy

Author

Vallotton, Kevin, primary, David, Gergely, additional, Hupp, Markus, additional, Pfender, Nikolai, additional, Cohen-Adad, Julien, additional, Fehlings, Michael G., additional, Samson, Rebecca S., additional, Wheeler-Kingshott, Claudia A.M. Gandini, additional, Curt, Armin, additional, Freund, Patrick, additional, and Seif, Maryam, additional

Published
2021
Full Text
View/download PDF

37. Cortical involvement determines impairment 30 years after a clinically isolated syndrome

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Haider, Lukas, Prados, Ferran, Chung, Karen, Goodkin, Olivia, Kanber, Baris, Sudre, Carole, Yiannakas, Marios, Samson, Rebecca S, Mangesius, Stephanie, Thompson, Alan J, Gandini Wheeler-Kingshott, Claudia A M, Ciccarelli, Olga, Chard, Declan T, Barkhof, Frederik, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Haider, Lukas, Prados, Ferran, Chung, Karen, Goodkin, Olivia, Kanber, Baris, Sudre, Carole, Yiannakas, Marios, Samson, Rebecca S, Mangesius, Stephanie, Thompson, Alan J, Gandini Wheeler-Kingshott, Claudia A M, Ciccarelli, Olga, Chard, Declan T, and Barkhof, Frederik

Abstract

Many studies report an overlap of MRI and clinical findings between patients with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), which in part is reflective of inclusion of subjects with variable disease duration and short periods of follow-up. To overcome these limitations, we examined the differences between RRMS and SPMS and the relationship between MRI measures and clinical outcomes 30 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis. Sixty-three patients were studied 30 years after their initial presentation with a clinically isolated syndrome; only 14% received a disease modifying treatment at any time point. Twenty-seven patients developed RRMS, 15 SPMS and 21 experienced no further neurological events; these groups were comparable in terms of age and disease duration. Clinical assessment included the Expanded Disability Status Scale, 9-Hole Peg Test and Timed 25-Foot Walk and the Brief International Cognitive Assessment For Multiple Sclerosis. All subjects underwent a comprehensive MRI protocol at 3 T measuring brain white and grey matter (lesions, volumes and magnetization transfer ratio) and cervical cord involvement. Linear regression models were used to estimate age- and gender-adjusted group differences between clinical phenotypes after 30 years, and stepwise selection to determine associations between a large sets of MRI predictor variables and physical and cognitive outcome measures. At the 30-year follow-up, the greatest differences in MRI measures between SPMS and RRMS were the number of cortical lesions, which were higher in SPMS (the presence of cortical lesions had 100% sensitivity and 88% specificity), and grey matter volume, which was lower in SPMS. Across all subjects, cortical lesions, grey matter volume and cervical cord volume explained 60% of the variance of the Expanded Disability Status Scale; cortical lesions alone explained 43%. Grey ma

Published
2021

38. Tracking White and Gray Matter Degeneration along the Spinal Cord Axis in Degenerative Cervical Myelopathy

Author

Vallotton, Kevin, David, Gergely, Hupp, Markus, Pfender, Nikolai, Cohen-Adad, Julien, Fehlings, Michael G, Samson, Rebecca S, Wheeler-Kingshott, Claudia A M Gandini, Curt, Armin, Freund, Patrick, Seif, Maryam, Vallotton, Kevin, David, Gergely, Hupp, Markus, Pfender, Nikolai, Cohen-Adad, Julien, Fehlings, Michael G, Samson, Rebecca S, Wheeler-Kingshott, Claudia A M Gandini, Curt, Armin, Freund, Patrick, and Seif, Maryam

Abstract

This study aims to determine tissue-specific neurodegeneration across the spinal cord in patients with mild-moderate degenerative cervical myelopathy (DCM). Twenty-four mild-moderate DCM and 24 healthy subjects were recruited. In patients, a T2-weighted scan was acquired at the compression site, whereas in all participants a T2*-weighted and diffusion-weighted scan was acquired at the cervical level (C2-C3) and in the lumbar enlargement (i.e., rostral and caudal to the site of compression). We quantified intramedullary signal changes, maximal canal and cord compression, white (WM) and gray matter (GM) atrophy, and microstructural indices from diffusion-weighted scans. All patients underwent clinical (modified Japanese Orthopaedic Association; mJOA) and electrophysiological assessments. Regression analysis assessed associations between magnetic resonance imaging (MRI) readouts and electrophysiological and clinical outcomes. Twenty patients were classified with mild and 4 with moderate DCM using the mJOA scale. The most frequent site of compression was at the C5-C6 level, with maximum cord compression of 38.73% ± 11.57%. Ten patients showed imaging evidence of cervical myelopathy. In the cervical cord, WM and GM atrophy and WM microstructural changes were evident, whereas in the lumbar cord only WM showed atrophy and microstructural changes. Remote cervical cord WM microstructural changes were pronounced in patients with radiological myelopathy and associated with impaired electrophysiology. Lumbar cord WM atrophy was associated with lower limb sensory impairments. In conclusion, tissue-specific neurodegeneration revealed by quantitative MRI is already apparent across the spinal cord in mild-moderate DCM before the onset of severe clinical impairments. WM microstructural changes are particularly sensitive to remote pathologically and clinically eloquent changes in DCM.

Published
2021

39. Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers (vol 8, 219, 2021)

Author

Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., Xu, Junqian, Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Published
2021

43. Cortical involvement determines impairment 30 years after a clinically isolated syndrome

Author

Haider, Lukas, primary, Prados, Ferran, additional, Chung, Karen, additional, Goodkin, Olivia, additional, Kanber, Baris, additional, Sudre, Carole, additional, Yiannakas, Marios, additional, Samson, Rebecca S, additional, Mangesius, Stephanie, additional, Thompson, Alan J, additional, Gandini Wheeler-Kingshott, Claudia A M, additional, Ciccarelli, Olga, additional, Chard, Declan T, additional, and Barkhof, Frederik, additional

Published
2021
Full Text
View/download PDF

44. Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual-vendor reproducibility and repeatability study

Author

Leutritz, Tobias; https://orcid.org/0000-0002-9871-4073, Seif, Maryam; https://orcid.org/0000-0002-9253-5680, Helms, Gunther; https://orcid.org/0000-0002-1371-5123, Samson, Rebecca S; https://orcid.org/0000-0002-0197-702X, Curt, Armin, Freund, Patrick; https://orcid.org/0000-0002-4851-2246, Weiskopf, Nikolaus; https://orcid.org/0000-0001-5239-1881, Leutritz, Tobias; https://orcid.org/0000-0002-9871-4073, Seif, Maryam; https://orcid.org/0000-0002-9253-5680, Helms, Gunther; https://orcid.org/0000-0002-1371-5123, Samson, Rebecca S; https://orcid.org/0000-0002-0197-702X, Curt, Armin, Freund, Patrick; https://orcid.org/0000-0002-4851-2246, and Weiskopf, Nikolaus; https://orcid.org/0000-0001-5239-1881

Abstract

Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole-brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI-toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter-site comparability, the intra-site (i.e., scan-rescan experiment) coefficient of variation (CoV), inter-site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra- and inter-site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra-site CoV (16%) was observed in R2* maps. The inter-site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results