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15 results on '"Samson, Andrew J."'

5. Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

Author

Du, Ting, Mestre, Humberto, Kress, Benjamin T, Liu, Guojun, Sweeney, Amanda M, Samson, Andrew J, Rasmussen, Martin Kaag, Mortensen, Kristian Nygaard, Bork, Peter A R, Peng, Weiguo, Olveda, Genaro E, Bashford, Logan, Toro, Edna R, Tithof, Jeffrey, Kelley, Douglas H, Thomas, John H, Hjorth, Poul G, Martens, Erik A, Mehta, Rupal I, Hirase, Hajime, Mori, Yuki, Nedergaard, Maiken, Du, Ting, Mestre, Humberto, Kress, Benjamin T, Liu, Guojun, Sweeney, Amanda M, Samson, Andrew J, Rasmussen, Martin Kaag, Mortensen, Kristian Nygaard, Bork, Peter A R, Peng, Weiguo, Olveda, Genaro E, Bashford, Logan, Toro, Edna R, Tithof, Jeffrey, Kelley, Douglas H, Thomas, John H, Hjorth, Poul G, Martens, Erik A, Mehta, Rupal I, Hirase, Hajime, Mori, Yuki, and Nedergaard, Maiken

Abstract

Cerebral edema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that edema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of cerebrospinal fluid (CSF). Edema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of edema. Edema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of edema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral edema formation after cardiac arrest.

Published
2022

6. Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

Author

Du, Ting, primary, Mestre, Humberto, additional, Kress, Benjamin T, additional, Liu, Guojun, additional, Sweeney, Amanda M, additional, Samson, Andrew J, additional, Rasmussen, Martin Kaag, additional, Mortensen, Kristian Nygaard, additional, Bork, Peter A R, additional, Peng, Weiguo, additional, Olveda, Genaro E, additional, Bashford, Logan, additional, Toro, Edna R, additional, Tithof, Jeffrey, additional, Kelley, Douglas H, additional, Thomas, John H, additional, Hjorth, Poul G, additional, Martens, Erik A, additional, Mehta, Rupal I, additional, Hirase, Hajime, additional, Mori, Yuki, additional, and Nedergaard, Maiken, additional

Published
2021
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7. Cerebrospinal fluid influx drives acute ischemic tissue swelling

Author

Mestre, Humberto, primary, Du, Ting, additional, Sweeney, Amanda M., additional, Liu, Guojun, additional, Samson, Andrew J., additional, Peng, Weiguo, additional, Mortensen, Kristian Nygaard, additional, Stæger, Frederik Filip, additional, Bork, Peter A. R., additional, Bashford, Logan, additional, Toro, Edna R., additional, Tithof, Jeffrey, additional, Kelley, Douglas H., additional, Thomas, John H., additional, Hjorth, Poul G., additional, Martens, Erik A., additional, Mehta, Rupal I., additional, Solis, Orestes, additional, Blinder, Pablo, additional, Kleinfeld, David, additional, Hirase, Hajime, additional, Mori, Yuki, additional, and Nedergaard, Maiken, additional

Published
2020
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8. Cerebrospinal fluid influx drives acute ischemic tissue swelling

Author

Mestre, Humberto, Du, Ting, Sweeney, Amanda M., Liu, Guojun, Samson, Andrew J., Peng, Weiguo, Mortensen, Kristian Nygaard, Stæger, Frederik Filip, Bork, Peter A.R., Bashford, Logan, Toro, Edna R., Tithof, Jeffrey, Kelley, Douglas H., Thomas, John H., Hjorth, Poul G., Martens, Erik A., Mehta, Rupal I., Solis, Orestes, Blinder, Pablo, Kleinfeld, David, Hirase, Hajime, Mori, Yuki, Nedergaard, Maiken, Mestre, Humberto, Du, Ting, Sweeney, Amanda M., Liu, Guojun, Samson, Andrew J., Peng, Weiguo, Mortensen, Kristian Nygaard, Stæger, Frederik Filip, Bork, Peter A.R., Bashford, Logan, Toro, Edna R., Tithof, Jeffrey, Kelley, Douglas H., Thomas, John H., Hjorth, Poul G., Martens, Erik A., Mehta, Rupal I., Solis, Orestes, Blinder, Pablo, Kleinfeld, David, Hirase, Hajime, Mori, Yuki, and Nedergaard, Maiken

Abstract

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.

Published
2020

9. Astrocytes:Tailored to Support the Demand of Neural Circuits?

Author

Rasmussen, Rune, Samson, Andrew J., Rasmussen, Rune, and Samson, Andrew J.

Abstract

Anatomy, physiology, proteomics, and genomics reveal the prospect of distinct highly specialized astrocyte subtypes within neural circuits.

Published
2017

15. Light-Stable Silver N-Heterocyclic Carbene Catalysts for the Alkynylation of Ketones in Air.

Author

Lazreg, Faïma, Lesieur, Mathieu, Samson, Andrew J., and Cazin, Catherine S. J.

Subjects
CARBENES, KETONES, CATALYSTS, ACETYLIDES, LIGANDS (Chemistry), SILVER compounds
Abstract

N-Heterocyclic carbene (NHC) silver(I) complexes were employed efficiently in the alkynylation of ketones. These cationic complexes were highly active and efficient under mild conditions and in air without the need for an additive. The mechanism of this transformation was investigated. Experiments suggest that the formation of a silver acetylide key intermediate and the release of one ligand from the silver centre enable the transformation. [ABSTRACT FROM AUTHOR]

Published
2016
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