183 results on '"Sampson, Kevin J."'
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2. Author response: Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex
3. Cardiac Delayed Rectifier Potassium Channels in Health and Disease
4. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex.
5. Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels
6. K+ Channelopathies (IKs, IKr, and Ito)
7. Adrenergic Regulation and Heritable Arrhythmias: Key Roles of the Slowly Activating Heart I Ks Potassium Channel
8. Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension
9. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex
10. Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers
11. Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements
12. Abstract 14753: Loss of Function ABCC8 Mutations Are Associated With Pulmonary Arterial Hypertension
13. An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval
14. Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels
15. Differential regulation of IKs by targeted recruitment of protein kinase A to distinct sites on the KCNQ1/KCNE1 channel complex
16. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate
17. The cardiac I Ks channel, complex indeed
18. Mutation of an A-Kinase-Anchoring Protein Causes Long-QT Syndrome
19. Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs
20. Molecular mechanisms of adrenergic stimulation in the heart
21. Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.
22. Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes
23. Location, location, regulation: a novel role for β-spectrin in the heart
24. Electrotonic influences on action potential duration dispersion in small hearts: a simulation study
25. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
26. Ion Channels as Targets for Drugs
27. Contributors
28. Simulation and prediction of functional block in the presence of structural and ionic heterogeneity
29. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry
30. Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an IKs transgenic mouse
31. A Novel LQT-3 Mutation Disrupts an Inactivation Gate Complex with Distinct Rate-Dependent Phenotypic Consequences
32. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action
33. Determining Functional KCNQ1/KCNE1 Subunit Interactions in the KCNQ1/KCNE1 Channel
34. Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension
35. The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
36. Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations
37. Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation
38. Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3
39. Data science identifies novel drug interactions that prolong the QT interval
40. Novel Mechanism of Transient Outward Potassium Channel Current Regulation in the Heart
41. KCNE3 Stabilizes the Voltage Sensor S4 of KCNQ1 Channel, KCNE1 Uncouples S4 and the Gate
42. Single-Channel Analysis of the Molecular Pharmacology of the Long QT Syndrome Variant 3
43. Two KCNQ1 Mutations Associated with Familial Atrial Fibrillation, S140G and V141M, Demonstrate Distinct Voltage Sensor Phenotypes
44. Modeling Tissue- and Mutation- Specific Electrophysiological Effects in the Long QT Syndrome: Role of the Purkinje Fiber
45. KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
46. Unique Cardiac Purkinje Fiber Transient Outward Current β-Subunit Composition
47. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
48. Long QT Mutations and KCNE1 β-Subunit Modulate S4 Movement in KCNQ1 Channel
49. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
50. Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation
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