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David Lucio agradece al Ministerio de Ciencia, Innovación y Universidades su apoyo económico a través del programa para la formación de personal investigador (FPI PRE2018-086142). Este trabajo ha sido parcialmente financiado a través del Programa Estatal de PROYECTOS DE I+D+i orientada a los Retos de la sociedad (PID2020-118285RB-I00) del Ministerio de Ciencia, Innovación y Universidades. Los autores agradecen el apoyo recibido del Ministerio de Transición Ecológica y Reto Demográfico a través del proyecto “Contrato de servicios para la elaboración de la metodología y bases de datos para la proyección de impactos del Cambio Climático a lo largo de la costa española”. Los autores agradecen el apoyo recibido de Puertos del Estado a través del proyecto “Aplicación metodológica del análisis de rentabilidad económica-financiera del proyecto de construcción e inversión de una obra marítima mediante el uso dual ROM - MEIPOR”, así como a la empresa McValnera por su participación en dicho proyecto. Finalmente, los autores agradecen el apoyo recibido de la empresa SENER Ingeniería y Sistemas S.A. a través de los distintos proyectos de colaboración realizados en el marco de la “Ingeniería de optimización e ingeniería de detalle de obra de abrigo, dragado y obras complementarias del Puerto de Gran Escala en el Puerto de San Antonio (Chile)”.

RESUMEN: A lo largo de los últimos 10 años, IHCantabria ha venido desarrollando productos para el apoyo operacional, destinados a gestionar actividades costeras y portuarias. Estos sistemas han ido evolucionando en función de los requerimientos y sofisticación de cada estudio/proyecto y, por lo tanto, el método general se ha ido enriqueciendo con nuevas experiencias de uso, manejo de datos, asimilación de información y adopción de nuevas herramientas de análisis. Llegando de esta forma a establecer una arquitectura innovadora y generalista para el montaje de este tipo de sistemas. El objetivo de esta comunicación es mostrar, en primer lugar, la historia de evolución en la metodología para el diseño de sistemas operacionales de ayuda a la gestión costera y portuaria, mostrando el flujo de tareas generales que se recomienda seguir y la filosofía general del concepto de “sistema de alerta temprana” modular, adaptable, relocalizable, eficiente, fiable y realista. En segundo lugar, se presenta una discusión sobre el tipo de pre y post-proceso que requiere cada sistema, en relación directa con las fuentes de datos disponibles y las herramientas matemáticas, numéricas y estadísticas que se han ido desarrollando, heredando, validando y adaptando. Y en tercer lugar se muestran algunas de las historias de éxito que se han desarrollado desde el Grupo de Hidrodinámica e Infraestructuras Costeras de IHCantabria. ABSTRACT: Over the last 10 years, IHCantabria has been developing products for operational support, coastal management and port activities. These systems have evolved according to the requirements and sophistication of each study/project and, therefore, the general method has been enriched with new experiences of use, data handling, information assimilation and adoption of new analysis tools. In this way, an innovative and generalist architecture for the assembly of this type of systems has been established. The objective of this communication is to show, firstly, the evolutionary history of the methodology for the design of operational systems to support coastal and port management, showing the general recommended workflow of tasks to be followed and the general philosophy of the concept of a modular, adaptable, relocatable, efficient, reliable and realistic "early warning system". Secondly, a discussion is presented on the type of pre- and post-processing that each system requires, in direct relation to the available data sources and the mathematical, numerical and statistical tools that have been developed, inherited, validated and adapted. And thirdly, some of the success stories that have been developed by the Hydrodynamics and Coastal Infrastructures Group of IHCantabria are shown.

A través da presente investigación, conformada como Tese de Doutoramento, pretendemos analizar aqueles procesos de educación social e popular e de desenvolvemento comunitario, que foron encabezados por certos sectores da Igrexa galega dende a fin do concilio Vaticano II ata principio dos anos oitenta do século XX. Estes procesos pretendían espertar una conciencia crítica nas propias comunidades onde tiveron lugar. Estas experiencias educativas aconteceron ao longo de toda a xeografía galega, tanto en contextos rurais coma vilegos, mariñeiros ou urbanos.

Anal squamous cell carcinoma is the most frequent virus-related non-AIDS-defining neoplasia among HIV-infected individuals, especially MSM. The objectives of this study were to analyze the effectiveness of the quadrivalent HPV (qHPV) vaccine to prevent anal &ge, high-grade squamous intraepithelial lesions (&ge, HSILs), external ano-genital lesions (EAGLs), and infection by qHPV vaccine genotypes in HIV+ MSM, and to study the immunogenicity of the vaccine and risk factors for &ge, HSILs. This study is nested within a randomized, double-blind, placebo-controlled trial of the qHPV vaccine, which enrolled participants between May 2012 and May 2014, with a 48-month follow-up. A vaccine or placebo was administered at 0, 2, and 6 months, and vaccine antibody titers were evaluated at 7, 12, 24, 36, and 48 months. Data were gathered at 12, 24, 36, and 48 months on sexual habits, CD4/CD8 cell/counts, HIV viral load, and the results of cytology (Thin Prep&reg, Pap Test), HPV PCR genotyping (Linear Array HPV Genotyping Test), and high-resolution anoscopy (Zeiss 150 fc&copy, colposcope). The study included 129 patients (mean age of 38.8 years, 40 [31%] with a history of AIDS, 119 [92.2%] receiving ART, and 4 [3.3%] with virological failure), 66 (51.2%) in vaccine arm and 63 (48.4%) in placebo arm. The vaccine and placebo groups did not differ in &ge, HSILs (14.1 vs. 13.1%, respectively, p = 0.98) or EAGL (11.1 vs. 6.8%, p = 0.4) rates during follow-up, however, a protective effect against HPV 6 was observed during the first year of follow-up in the vaccine versus placebo group (7.5% vs. 23.4%, p = 0.047). A between-arm difference (p = 0.0001) in antibodies against qHPV vaccine genotypes was observed at 7 months (76.9% in vaccine arm vs. 30.2% in placebo arm), 12 months (68.1% vs. 26.5%), 24 months (75% vs. 32.5%), 36 months (90% vs. 24.4%), and 48 months (87.2% vs. 30%). Finally, the factor associated with the risk of anal &ge, HSIL onset during the four-year follow-up was the receipt of the last dose of the vaccine less than 6 months earlier in comparison to those vaccinated for a longer period (82.4% vs. 17.6% (OR 0.869 [95% CI, 0.825&ndash, 0.917]). Vaccine and placebo arms did not significantly differ in &ge, HSIL or EAGL rates or in protection against infection by HPV genotype vaccine except for HPV6 at 12 months after the first dose. A long-lasting immune response was observed in almost all the vaccinated men. The main protective factor against &ge, HSIL was to have completed the vaccination regimen more than 6 months earlier.

The clinical and microbiological characteristics of pleuro-pulmonary infection (PPI) caused by Streptococcus intermedius is described, including 6 cases in the literature and 9 cases handled at the present centre. Out of the 15 patients, 12 were male; mean age at diagnosis was 62.06 ± 15 years. Twelve had risk factors for S. intermedius infection such as alcoholism in 5 (35.7%) patients, periodontal disease in 3 (24.6%) cases, chronic obstructive pulmonary disease in 3 (24.6%), and diabetes mellitus in 2 (14.2%). Cough was present in 12 (80%) patients and chest pain and dyspnea in 9 (60%). The mean diagnosis interval was 34 days. The diagnosis was obtained from pleural fluid aspirate in 13 (86.6%) cases and from biopsy/tissue samples in 2. The most frequently antimicrobials used for treatment were ceftriaxone + levofloxacin. Ten patients cured with a combination of medical and surgical treatment and 2 patients died as a consequence of infection. The incidence of PPI caused by S. intermedius is increasing in our health area; drainage along with antibiotic therapy is recommended for treatment.

Los autores agradecen el apoyo del Ministerio de Ciencia, Innovación y Universidades por la financiación recibida para llevar a cabo este proyecto (BIA2017-87213-R).

Se agradece a DRAGADOS, FCC, Ministerio de Defensa, Instituto HIdrográfico de la Marina y Puertos del Estado por el apoyo recibido en la realización de los proyectos a ser mostrados.