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2. (-)-α-Bisabolol attenuates visceral nociception and inflammation in mice.

Author

Leite Gde O, Leite LH, Sampaio Rde S, Araruna MK, de Menezes IR, da Costa JG, and Campos AR

Subjects
Abdominal Pain chemically induced, Acute Disease, Analgesics pharmacology, Animals, Anti-Inflammatory Agents pharmacology, Colon drug effects, Cyclophosphamide, Disease Models, Animal, Ear, Male, Mice, Monocyclic Sesquiterpenes, Mustard Plant, Oils, Volatile chemistry, Peritoneum drug effects, Plant Extracts pharmacology, Plant Oils, Sesquiterpenes pharmacology, Skin drug effects, Abdominal Pain drug therapy, Analgesics therapeutic use, Anti-Inflammatory Agents therapeutic use, Behavior, Animal drug effects, Dermatitis drug therapy, Plant Extracts therapeutic use, Sesquiterpenes therapeutic use
Abstract

The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (-)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2011
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