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Your search keyword '"Sammour, Omaima A."' showing total 189 results
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189 results on '"Sammour, Omaima A."'

24. Simultaneous pulmonary administration of celecoxib and naringin using a nebulization-friendly nanoemulsion: A device-targeted delivery for treatment of lung cancer

Author

Said-Elbahr, Ramy, Nasr, Maha, Alhnan, Mohamed A, Taha, Ismail, Sammour, Omaima, Said-Elbahr, Ramy, Nasr, Maha, Alhnan, Mohamed A, Taha, Ismail, and Sammour, Omaima

Abstract

Lung cancer is a principal cause of death worldwide, and its treatment is very challenging. Nebulization offers a promising means of targeting drugs to their site of action in the lung. In the present study, nebulizable oil in water nanoemulsion formulations was co-loaded with naringin/celecoxib and tested for pulmonary administration by different nebulizer types. The translucent appearance of nanoemulsion formulations was revealed, with particle size (75-106 nm), zeta potential (-3.42 to -4.86 mV), and controlled release profiles for both drugs. The nanoemulsions showed favorable stability profiles and superior cytotoxicity on A549 lung cancer cells. Aerosolization studies on the selected nanoemulsion formulation revealed its high stability during nebulization, with the generation of an aerosol of small volume median diameter and mass median aerodynamic diameter lower than 5 µm. Moreover, it demonstrated considerable safety and bioaccumulation in lung tissues, in addition to accumulation in the brain, liver, and bones, which are the main organs to which lung cancer metastasizes. Nanoemulsion proved to be a promising nebulizable system, which paves the way for treatment of pulmonary diseases other than lung cancer.

Published
2022

43. Recent advances in topical formulation carriers of antifungal agents

Author

Bseiso, Eman, Nasr, Maha, Sammour, Omaima, and Gawad, Nabaweya Abd El

Subjects
Mycoses -- Drug therapy -- Research -- Forecasts and trends -- Health aspects, Antifungal agents -- Forecasts and trends -- Health aspects -- Research, Market trend/market analysis, Health
Abstract

Byline: Eman. Bseiso, Maha. Nasr, Omaima. Sammour, Nabaweya. Abd El Gawad Fungal infections are amongst the most commonly encountered diseases affecting the skin. Treatment approaches include both topical and oral [...]

Published
2015

50. Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation

Author

Shaaban, Mai, Nasr, Maha, Tawfik, Abeer A., Fadel, Maha, and Sammour, Omaima

Abstract

ABSTRACTBackground: Bergamot oil (BO) is a photosensitizer that can be used for photodynamic therapy (PDT) of dermatological diseases such as vitiligo. Being an oil, it can be integrated within the lipidic matrix of nanostructured lipid carriers (NLCs) as the liquid lipid constituent, hence exhibiting a dual role.Research design and methods: NLCs were prepared with different emulsifiers and coemulsifiers, and the effect of the preparation method and formulation variables on the NLCs’ size was elucidated. The prepared NLCs were further characterized for their in vitro release, viscosity, thermal behavior, and in vitro photostability. Furthermore, a preclinical photodynamic study on animal skin was conducted, followed by clinical experimentation on patients with vitiligo.Results: Results showed that BO was successfully incorporated within the NLCs. The selected NLCs formulation was in the nanometer range with a gel consistency, and it provided sustained release of BO for 24 h. NLCs improved the photostability and photodynamic properties of BO, and displayed promising preclinical and clinical results for the topical PDT of vitiligo.Expert Opinion: BO containing NLCs was proven to be promising means for PDT of vitiligo, and can be further explored in other dermatological diseases.

Published
2021
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