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2. Time-varying exposure history and subsequent health outcomes: a two-stage approach to identify critical windows

Author

Wagner, Maude, Grodstein, Francine, Leffondre, Karen, Samieri, Cécilia, and Proust-Lima, Cécile

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

Long-term behavioral and health risk factors constitute a primary focus of research on the etiology of chronic diseases. Yet, identifying critical time-windows during which risk factors have the strongest impact on disease risk is challenging. To assess the trajectory of association of an exposure history with an outcome, the weighted cumulative exposure index (WCIE) has been proposed, with weights reflecting the relative importance of exposures at different times. However, WCIE is restricted to a complete observed error-free exposure whereas exposures are often measured with intermittent missingness and error. Moreover, it rarely explores exposure history that is very distant from the outcome as usually sought in life-course epidemiology. We extend the WCIE methodology to (i) exposures that are intermittently measured with error, and (ii) contexts where the exposure time-window precedes the outcome time-window using a landmark approach. First, the individual exposure history up to the landmark time is estimated using a mixed model that handles missing data and error in exposure measurement, and the predicted complete error-free exposure history is derived. Then the WCIE methodology is applied to assess the trajectory of association between the predicted exposure history and the health outcome collected after the landmark time. In our context, the health outcome is a longitudinal marker analyzed using a mixed model. A simulation study first demonstrates the correct inference obtained with this approach. Then, applied to the Nurses' Health Study (19,415 women) to investigate the association between BMI history (collected from midlife) and subsequent cognitive decline after age 70. In conclusion, this approach, easy to implement, provides a flexible tool for studying complex dynamic relationships and identifying critical time windows while accounting for exposure measurement errors., Comment: Pages 35, Main Figures 5, Web Figures 13, Work presented at the Alzheimers Association International eConference (2020), eMELODEM conference, MEthods for LOngitudinal studies in DEMentia (2020), and ISCB, International Society for Clinical Biostatistics (2019)

Published
2020
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4. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O’Keefe, James H., Tintle, Nathan L., Harris, William S., O’Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu (Amelia), Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W.M. Monique, Boer, Jolanda M.A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2024
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7. Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

Author

Yassine, Hussein N, Samieri, Cécilia, Livingston, Gill, Glass, Kimberly, Wagner, Maude, Tangney, Christy, Plassman, Brenda L, Ikram, M Arfan, Voigt, Robin M, Gu, Yian, O'Bryant, Sid, Minihane, Anne Marie, Craft, Suzanne, Fink, Howard A, Judd, Suzanne, Andrieu, Sandrine, Bowman, Gene L, Richard, Edo, Albensi, Benedict, Meyers, Emily, Khosravian, Serly, Solis, Michele, Carrillo, Maria, Snyder, Heather, Grodstein, Francine, Scarmeas, Nikolaos, and Schneider, Lon S

Published
2022
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10. Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Author

Lefèvre-Arbogast, Sophie, Hejblum, Boris P, Helmer, Catherine, Klose, Christian, Manach, Claudine, Low, Dorrain Y, Urpi-Sarda, Mireia, Andres-Lacueva, Cristina, González-Domínguez, Raúl, Aigner, Ludwig, Altendorfer, Barbara, Lucassen, Paul J, Ruigrok, Silvie R, De Lucia, Chiara, Du Preez, Andrea, Proust-Lima, Cécile, Thuret, Sandrine, Korosi, Aniko, and Samieri, Cécilia

Published
2021
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11. Nutrition and the ageing brain: Moving towards clinical applications

Author

Flanagan, Emma, Lamport, Daniel, Brennan, Lorraine, Burnet, Philip, Calabrese, Vittorio, Cunnane, Stephen C., de Wilde, Martijn C., Dye, Louise, Farrimond, Jonathan A., Emerson Lombardo, Nancy, Hartmann, Tobias, Hartung, Thomas, Kalliomäki, Marko, Kuhnle, Gunther G., La Fata, Giorgio, Sala-Vila, Aleix, Samieri, Cécilia, Smith, A. David, Spencer, Jeremy P.E., Thuret, Sandrine, Tuohy, Kieran, Turroni, Silvia, Vanden Berghe, Wim, Verkuijl, Martin, Verzijden, Karin, Yannakoulia, Mary, Geurts, Lucie, and Vauzour, David

Published
2020
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12. Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., Mozaffarian, Dariush, O'Keefe, James H., Tintle, Nathan L., Harris, William S., O'Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Sørensen Bork, Christian, Berg Schmidt, Erik, Krogh Venø, Stine, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Rudholm Feldreich, Tobias, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W. M. Monique, Boer, Jolanda M. A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Abstract

BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

Published
2024
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13. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, Mozaffarian, Dariush, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, O'Keefe, James H, Tintle, Nathan L, Harris, William S, O'Keefe, Evan L, Sala-Vila, Aleix, Attia, John, Garg, G Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Lemaitre, Rozenn N, and Mozaffarian, Dariush

Published
2024

15. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H Y, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, and Lemaitre, Rozenn N

Published
2019
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16. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Ajana, Soufiane, Arango-Gonzalez, Blanca, Armento, Angela, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Vasiliev, Vassil, de Koning-Backus, Alexandra P.M., Delyfer, Marie-Noëlle, Kiefte-de Jong, Jessica C., Féart, Catherine, Samieri, Cécilia, Franco, Oscar H., and Korobelnik, Jean-François

Published
2019
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17. A universal approximate cross-validation criterion and its asymptotic distribution

Author

Commenges, Daniel, Proust-Lima, Cécile, Samieri, Cécilia, and Liquet, Benoit

Subjects
Mathematics - Statistics Theory, 62F99
Abstract

A general framework is that the estimators of a distribution are obtained by minimizing a function (the estimating function) and they are assessed through another function (the assessment function). The estimating and assessment functions generally estimate risks. A classical case is that both functions estimate an information risk (specifically cross entropy); in that case Akaike information criterion (AIC) is relevant. In more general cases, the assessment risk can be estimated by leave-one-out crossvalidation. Since leave-one-out crossvalidation is computationally very demanding, an approximation formula can be very useful. A universal approximate crossvalidation criterion (UACV) for the leave-one-out crossvalidation is given. This criterion can be adapted to different types of estimators, including penalized likelihood and maximum a posteriori estimators, and of assessment risk functions, including information risk functions and continuous rank probability score (CRPS). This formula reduces to Takeuchi information criterion (TIC) when cross entropy is the risk for both estimation and assessment. The asymptotic distribution of UACV and of a difference of UACV is given. UACV can be used for comparing estimators of the distributions of ordered categorical data derived from threshold models and models based on continuous approximations. A simulation study and an analysis of real psychometric data are presented., Comment: 23 pages, 2 figures

Published
2012
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18. The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk

Author

Cavaillès, Clémence, primary, Letellier, Noémie, additional, Berr, Claudine, additional, Samieri, Cecilia, additional, Empana, Jean‐Philippe, additional, Tzourio, Christophe, additional, Dartigues, Jean‐François, additional, Benmarhnia, Tarik, additional, Dauvilliers, Yves, additional, and Jaussent, Isabelle, additional

Published
2023
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19. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Author

Wu, Jason H Y, Marklund, Matti, Imamura, Fumiaki, Tintle, Nathan, Ardisson Korat, Andres V, de Goede, Janette, Zhou, Xia, Yang, Wei-Sin, de Oliveira Otto, Marcia C, Kröger, Janine, Qureshi, Waqas, Virtanen, Jyrki K, Bassett, Julie K, Frazier-Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Rajaobelina, Kalina, Del Gobbo, Liana C, Forouhi, Nita G, Luben, Robert, Khaw, Kay-Tee, Wareham, Nick, Kalsbeek, Anya, Veenstra, Jenna, Luo, Juhua, Hu, Frank B, Lin, Hung-Ju, Siscovick, David S, Boeing, Heiner, Chen, Tzu-An, Steffen, Brian, Steffen, Lyn M, Hodge, Allison, Eriksdottir, Gudny, Smith, Albert V, Gudnason, Vilmunder, Harris, Tamara B, Brouwer, Ingeborg A, Berr, Claudine, Helmer, Catherine, Samieri, Cecilia, Laakso, Markku, Tsai, Michael Y, Giles, Graham G, Nurmi, Tarja, Wagenknecht, Lynne, Schulze, Matthias B, Lemaitre, Rozenn N, Chien, Kuo-Liong, Soedamah-Muthu, Sabita S, Geleijnse, Johanna M, Sun, Qi, Harris, William S, Lind, Lars, Ärnlöv, Johan, Riserus, Ulf, Micha, Renata, and Mozaffarian, Dariush

Published
2017
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22. The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk.

Author

Cavaillès, Clémence, Letellier, Noémie, Berr, Claudine, Samieri, Cecilia, Empana, Jean‐Philippe, Tzourio, Christophe, Dartigues, Jean‐François, Benmarhnia, Tarik, Dauvilliers, Yves, and Jaussent, Isabelle

Subjects
DROWSINESS, DISEASE risk factors, ALZHEIMER'S disease, VASCULAR dementia, OLDER people, DEMENTIA
Abstract

Summary: Many studies suggest a relationship between excessive daytime sleepiness (EDS) and dementia incidence, but the underlying mechanisms remain uncertain. The study aimed to investigate the role of cardiovascular burden in the relationship between EDS and dementia incidence over a 12‐year follow‐up in community‐dwelling older adults. We performed analyses on 6171 subjects (aged ≥65 years) free of dementia and vascular disease at baseline. Participants self‐reported EDS at baseline and an expert committee validated both prevalent and incident dementia. We defined cardiovascular burden by a low Cardiovascular Health score, constructed using the American Heart Association metrics, and incident vascular events. To explore the potential role of the cardiovascular burden in the relationship between EDS and dementia, we conducted mediation analyses with inverse odds ratio‐weighted estimation, using multivariable‐adjusted proportional hazard Cox and logistic regression models. Subjects with EDS had a higher risk of all‐cause dementia (hazard ratio [HR] 1.39, 95% confidence interval [CI] 1.13–1.69) and dementia with vascular component (DVC) (HR 2.14, 95% CI 1.30–3.51), but not Alzheimer's disease (HR 1.18, 95% CI 0.93–1.51). Cardiovascular burden explained 5% (95% CI 4.1–5.2) and 11% (95% CI 9.7–11.3) of the relationship between EDS and all‐cause dementia and DVC, respectively. These findings confirm that EDS may be implicated in the development of dementia and indicate a weaker than expected role of cardiovascular burden in the relationship between EDS and DVC. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

Author

Ma, Yiyi, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Manichaikul, Ani W, Chu, Audrey Y, Samieri, Cecilia, Zhou, Xia, Guan, Weihua, Wang, Lu, Biggs, Mary L, Chen, Yii-Der I, Hernandez, Dena G, Borecki, Ingrid, Chasman, Daniel I, Rich, Stephen S, Ferrucci, Luigi, Irvin, Marguerite Ryan, Aslibekyan, Stella, Zhi, Degui, Tiwari, Hemant K, Claas, Steven A, Sha, Jin, Kabagambe, Edmond K, Lai, Chao-Qiang, Parnell, Laurence D, Lee, Yu-Chi, Amouyel, Philippe, Lambert, Jean-Charles, Psaty, Bruce M, King, Irena B, Mozaffarian, Dariush, McKnight, Barbara, Bandinelli, Stefania, Tsai, Michael Y, Ridker, Paul M, Ding, Jingzhong, Mstat, Kurt Lohmant, Liu, Yongmei, Sotoodehnia, Nona, Barberger-Gateau, Pascale, Steffen, Lyn M, Siscovick, David S, Absher, Devin, Arnett, Donna K, Ordovás, José M, and Lemaitre, Rozenn N

Published
2016
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25. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease : pooled analysis of 19 cohorts

Author

Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, Wu, Jason H. Y., Ong, Kwok Leung, Marklund, Matti, Huang, Liping, Rye, Kerry-Anne, Hui, Nicholas, Pan, Xiong-Fei, Rebholz, Casey M., Kim, Hyunju, Steffen, Lyn M., Westing, Anniek C. van, Geleijnse, Johanna M., Hoogeveen, Ellen K., Chen, Yun-Yu, Chien, Kuo-Liong, Fretts, Amanda M., Lemaitre, Rozenn N., Imamura, Fumiaki, Forouhi, Nita G., Wareham, Nicholas J., Birukov, Anna, Jaeger, Susanne, Kuxhaus, Olga, Schulze, Matthias B., Mello, Vanessa Derenji de, Tuomilehto, Jaakko, Uusitupa, Matti, Lindstroem, Jaana, Tintle, Nathan, Harris, William S., Yamasaki, Keisuke, Hirakawa, Yoichiro, Ninomiya, Toshiharu, Tanaka, Toshiko, Ferrucci, Luigi, Bandinelli, Stefania, KVirtanen, Jyrki, Voutilainen, Ari, Jayasena, Tharusha, Thalamuthu, Anbupalam, Poljak, Anne, Bustamante, Sonia, Sachdev, Perminder S., Senn II, Mackenzie K, Rich, Stephen S., Tsai, Michael Y., Wood, Alexis C., Laakso, Markku, Lankinen, Maria, Yang, Xiaowei, Sun, Liang, Li, Huaixing, Lin, Xu, Nowak, Christoph, Ärnlöv, Johan, Risérus, Ulf, Lind, Lars, Le Goff, Melanie, Samieri, Cecilia, Helmer, Catherine, Qian, Frank, Micha, Renata, Tin, Adrienne, Koettgen, Anna, Boer, Ian H. de, Siscovick, David S., Mozaffarian, Dariush, and Wu, Jason H. Y.

Abstract

OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived a linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). DESIGN: Pooled analysis. DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020. STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. MAIN OUTCOME MEASURES: Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/ min/1.73 m(2). In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m(2) and <75% of baseline rate. RESULTS: 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I-2=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I-2=0.0%). Plant derived a linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I-2=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (=60 v <60 years), estimated glomerular filtration rate (60

Published
2023
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26. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Author

Yassine, Hussein N., Self, Wade, Kerman, Bilal E., Santoni, Giulia, Shanmugam, NandaKumar Navalpur, Abdullah, Laila, Golden, Lesley R., Fonteh, Alfred N., Harrington, Michael G., Graff, Johannes, Gibson, Gary E., Kalaria, Raj, Luchsinger, Jose A., Feldman, Howard H., Swerdlow, Russell H., Johnson, Lance A., Albensi, Benedict C., Zlokovic, Berislav V., Tanzi, Rudolph, Cunnane, Stephen, Samieri, Cecilia, Scarmeas, Nikolaos, Bowman, Gene L., Yassine, Hussein N., Self, Wade, Kerman, Bilal E., Santoni, Giulia, Shanmugam, NandaKumar Navalpur, Abdullah, Laila, Golden, Lesley R., Fonteh, Alfred N., Harrington, Michael G., Graff, Johannes, Gibson, Gary E., Kalaria, Raj, Luchsinger, Jose A., Feldman, Howard H., Swerdlow, Russell H., Johnson, Lance A., Albensi, Benedict C., Zlokovic, Berislav V., Tanzi, Rudolph, Cunnane, Stephen, Samieri, Cecilia, Scarmeas, Nikolaos, and Bowman, Gene L.

Abstract

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions.

Published
2023
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29. Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

Author

Imamura, Fumiaki, Fretts, Amanda M., Marklund, Matti, Ardisson Korat, Andres V., Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Virtanen, Jyrki K., Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Chen, Yun-yu, Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Riserus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Senn, Mackenzie, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Tuomainen, Tomi-Pekka, Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, and Forouhi, Nita G.

Subjects
Analysis, Fatty acids -- Analysis, Type 2 diabetes -- Analysis, Exercise -- Analysis, Triglycerides -- Analysis
Abstract

Author(s): Fumiaki Imamura 1,*, Amanda M. Fretts 2, Matti Marklund 3,4,5, Andres V. Ardisson Korat 6,7, Wei-Sin Yang 8, Maria Lankinen 9, Waqas Qureshi 10, Catherine Helmer 11, Tzu-An Chen [...], Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). Methods and findings Seventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970-1973 to 2006-2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3-75.5 years; % women = 20.4%-62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41-1.66; p < 0.001) for 16:0, 1.40 (1.33-1.48; p < 0.001) for 16:1n-7, 1.14 (1.05-1.22; p = 0.001) for 18:0, and 1.16 (1.07-1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I.sup.2 = 51.1%-73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94-1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors. Conclusions Concentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.

Published
2020
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30. Abstract MP62: Fatty Acid Biomarkers of 15:0, 17:0 and Trans 16:1n-7 and Incident Coronary Heart Disease and Stroke: A Pooling Project of 15 Prospective Cohorts in the Fatty Acids and Outcomes Research Consortium

Author

Ardisson Korat, Andres V, primary, Qian, Frank, additional, Malik, Vasanti, additional, Lehr, Marcus, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Laakso, Markku, additional, van Dam, Rob, additional, Harris, William, additional, Marklund, Matti, additional, Samieri, Cecilia, additional, Senn, MacKenzie, additional, Leander, Karin, additional, Forouhi, Nita, additional, Riserus, Ulf, additional, Chien, Kou-Liong, additional, Chen, Amelia, additional, Wood, Alexis, additional, Guan, Weihua, additional, Tsai, Michael Y, additional, Murphy, Rachel, additional, Siscovick, David S, additional, Lemaitre, Rozenn, additional, Mozaffarian, Dariush, additional, and Sun, Qi, additional

Published
2023
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37. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Author

Del Gobbo, Liana C., Imamura, Fumiaki, Aslibekyan, Stella, Marklund, Matti, Virtanen, Jyrki K., Wennberg, Maria, Yakoob, Mohammad Y., Chiuve, Stephanie E., dela Cruz, Luicito, Frazier-Wood, Alexis C., Fretts, Amanda M., Guallar, Eliseo, Matsumoto, Chisa, Prem, Kiesha, Tanaka, Tosh, Wu, Jason H. Y., Zhou, Xia, Helmer, Catherine, Ingelsson, Erik, Yuan, Jian-Min, Barberger-Gateau, Pascale, Campos, Hannia, Chaves, Paulo H. M., Djoussé, Luc, Giles, Graham G., Gómez-Aracena, Jose, Hodge, Allison M., Hu, Frank B., Jansson, Jan-Håkan, Johansson, Ingegerd, Khaw, Kay-Tee, Koh, Woon-Puay, Lemaitre, Rozenn N., Lind, Lars, Luben, Robert N., Rimm, Eric B., Risérus, Ulf, Samieri, Cecilia, Franks, Paul W., Siscovick, David S., Stampfer, Meir, Steffen, Lyn M., Steffen, Brian T., Tsai, Michael Y., van Dam, Rob M., Voutilainen, Sari, Willett, Walter C., Woodward, Mark, and Mozaffarian, Dariush

Published
2016
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41. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author

Qian, Frank, Ardisson Korat, Andres V, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K, Zhou, Xia, Bassett, Julie K, Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Samieri, Cecilia, Pertiwi, Kamalita, De Mello, Vanessa D, Guan, Weihua, Forouhi, Nita G, Wareham, Nick, Hu, InterAct Consortium Frank B, Riserus, Ulf, Lind, Lars, Harris, William S, Shadyab, Aladdin H, Robinson, Jennifer G, Steffen, Lyn M, Hodge, Allison, Giles, Graham G, Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindström, Jaana, Laakso, Markku, Siscovick, David S, Helmer, Catherine, Geleijnse, Johanna M, Wu, Jason HY, Fretts, Amanda, Lemaitre, Rozenn N, Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Fatty Acids And Outcomes Research Consortium (FORCE), Qian, Frank [0000-0002-5579-3410], Virtanen, Jyrki K [0000-0002-0648-999X], Hirakawa, Yoichiro [0000-0002-4405-4399], Pertiwi, Kamalita [0000-0003-2861-9051], de Mello, Vanessa D [0000-0003-3414-6983], Forouhi, Nita G [0000-0002-5041-248X], Ninomiya, Toshiharu [0000-0003-1345-9032], Laakso, Markku [0000-0002-3394-7749], Lemaitre, Rozenn N [0000-0002-7038-1844], Sun, Qi [0000-0002-8480-1563], and Apollo - University of Cambridge Repository

Subjects
Cohort Studies, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Humans, Prospective Studies, Biomarkers
Abstract

OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.

Published
2021

42. Diabetes Care

Author

QIAN, Frank, ARDISSON KORAT, Andres V., IMAMURA, Fumiaki, MARKLUND, Matti, TINTLE, Nathan, VIRTANEN, Jyrki K., ZHOU, Xia, BASSETT, Julie K., LAI, Heidi, HIRAKAWA, Yoichiro, CHIEN, Kuo-Liong, WOOD, Alexis C., LANKINEN, Maria, MURPHY, Rachel A., SAMIERI, Cecilia, PERTIWI, Kamalita, DE MELLO, Vanessa D., GUAN, Weihua, FOROUHI, Nita G., WAREHAM, Nick, HU, InterAct Consortium Frank B, RISERUS, Ulf, LIND, Lars, HARRIS, William S., SHADYAB, Aladdin H., ROBINSON, Jennifer G., STEFFEN, Lyn M., HODGE, Allison, GILES, Graham G., NINOMIYA, Toshiharu, UUSITUPA, Matti, TUOMILEHTO, Jaakko, LINDSTROM, Jaana, LAAKSO, Markku, SISCOVICK, David S., HELMER, Catherine, GELEIJNSE, Johanna M., WU, Jason H. Y., FRETTS, Amanda, LEMAITRE, Rozenn N., MICHA, Renata, MOZAFFARIAN, Dariush, SUN, Qi, FATTY, Acids, and OUTCOMES RESEARCH, Consortium

Published
2021

47. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia

Author

Feart, Catherine, Samieri, Cecilia, Rondeau, Virginie, Amieva, Helene, Portet, Florence, Dartigues, Jean-Francois, Scarmeas, Nikolaos, and Barberger-Gateau, Pascale

Subjects
Cognition disorders -- Prevention, Dementia -- Prevention, Aged -- Health aspects
Abstract

The study aims to evaluate the relationship between a Mediterranean diet and cognitive decline and the risk of dementia among elderly individuals. The results indicate that a stricter adherence to the diet led to slower cognitive decline; however, higher adherence was not associated with a risk of dementia.

Published
2009

50. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Author

Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djousse, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Kupers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., Mozaffarian, Dariush, Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djousse, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Kupers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Abstract

Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality. The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

Published
2021
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