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Weed species many times possess allelochemicals as a part of their survival strategy. These metabolites can be potential targets in search of natural phytotoxins. This study aims to evaluate the phytotoxic ability of fatty aldehyde-rich essential oil from spiny coriander (Eryngium foetidum) leaves, also known as fitweed or spiritweed and to further identify the active phytotoxins. This oil dose-dependently inhibited the wheatgrass coleoptile and radicle growth in multiple bioassays with half maximal inhibitory concentration (IC 50 ) 30.6-56.7 μg/mL, while exhibiting a less pronounced effect on the germination (IC 50 181.8 μg/mL). The phytotoxicity assessment of two oil constituents identified eryngial (trans-2-dodecenal), exclusively major fatty aldehydic constituent as the potent growth inhibitor with IC 50 in the range 20.8-36.2 μg/mL during an early phase of wheatgrass emergence. Eryngial-inspired screening of eleven saturated fatty aldehydes and alcohols did not find a significantly higher phytotoxic potency. In an open vessel, eryngial as the supplementation in agar medium, dose-dependently inhibited the growth of pre-germinated seeds of one monocot (bermudagrass) and one dicot (green amaranth) weed species with IC 50 in the range 23.8-65.4 μg/mL. The current study identified eryngial, an α,β-unsaturated fatty aldehyde of coriander origin to be a promising phytotoxic candidate for weed control., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)

Dihydrocarvone, possessing four stereoisomers is an important flavour and chiral building block in chemical synthesis. Ascomycetes are well known for the selective bioreduction of carvone to dihydrocarvone. Often, these fungi produce mycotoxins which may contaminate the biocatalytic product. Herein, Ganoderma sessile , a polypore mushroom, selectively reduced S-(+)-carvone to cis -(-)-dihydrocarvone (DHC) in its submerged culture. In an optimised condition (0.75 g/L, 18 h, pH 3-5, 30 °C and 150 rpm), 82.7% cis -(-)-DHC was obtained in gas chromatography-mass spectrometry profile of the fermented product. The absolute titre of cis -(-)-DHC in fermentation medium was 0.35 ± 0.01 g/L. However, substrate toxicity (IC 50 0.15 g/L) drastically reduced the transformation at higher carvone concentration (≥1.0 g/L). On the other hand, R-(-)-carvone was less selective and efficient in producing the desired isomer i.e. trans -(+)-DHC. G. sessile is the member of a group of non-toxic medicinal mushrooms and may be a safer yet efficient option for producing cis -(-)-DHC biocatalytically.