16 results on '"Sambugaro R."'
Search Results
2. sThe efficacy of sublingual immunotherapy for respiratory allergy is not affected by different dosage regimens in the induction phase
- Author
-
Sambugaro, R., Puccinelli, P., Burastero, S.E., and Di Rienzo, V.
- Published
- 2003
- Full Text
- View/download PDF
3. Adherence issues related to sublingual immunotherapy as perceived by allergists
- Author
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Scurati, S., Frati, F., Passalacqua, G., Puccinelli, P., Hilaire, C., Incorvaia, C., D Avino, G., Comi, R., Lo Schiavo, M., Pezzuto, F., Montera, C., Pio, A., Teresa Ielpo, M., Cellini, F., Vicentini, L., Pecorari, R., Aresu, T., Capra, L., Benedictis, E., Bombi, C., Zauli, D., Vanzi, A., Alberto Paltrinieri, C., Bondioli, A., Paletta, I., Ventura, D., Mei, F., Paolini, F., Colangelo, C., Cavallucci, E., Cucinelli, F., Tinari, R., Ermini, G., Beltrami, V., Novembre, E., Begliomini, C., Marchese, E., Solito, E., Ammannati, V., Molino, G., Galli, E., Baldassini, M., Di Michele, L., Calvani, M., Gidaro, M., Venuti, A., Li Bianchi, E., Benassi, F., Pocobelli, D., Zangari, P., Rocco, M. 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- Subjects
medicine.medical_specialty ,Pathology ,genetic structures ,efficacy ,Alternative medicine ,Medicine (miscellaneous) ,Adherence, Cost, Efficacy, Side effects, Sublingual immunotherapy ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,sublingual immunotherapy ,ALLERGEN ,cost ,medicine ,Subcutaneous immunotherapy ,Sublingual immunotherapy ,adherence ,Clinical efficacy ,Intensive care medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,sublingual immunoterapy ,Original Research ,Asthma ,AEROALLERGENS ,side effects ,business.industry ,Health Policy ,medicine.disease ,Slit ,eye diseases ,Clinical trial ,Patient Preference and Adherence ,immunotherapy ,sense organs ,Allergists ,ADHERENCE TO TREATMENT ,business ,Social Sciences (miscellaneous) - Abstract
Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence.Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10.Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists.Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.Keywords: adherence, sublingual immunotherapy, efficacy, cost, side effects
- Published
- 2010
4. Applicability of extracellular electrical impedance tomography in monitoring respiratory tract inflammation.
- Author
-
Di Rienzo, V, Minelli, M, Sambugaro, R, Agostinis, F, Nucera, Eleonora, Schiavino, Domenico, Patriarca, Giampiero, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Schiavino, Domenico (ORCID:0000-0003-3824-0619), Di Rienzo, V, Minelli, M, Sambugaro, R, Agostinis, F, Nucera, Eleonora, Schiavino, Domenico, Patriarca, Giampiero, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Schiavino, Domenico (ORCID:0000-0003-3824-0619)
- Abstract
BACKGROUND: The presence of persistent mild inflammation is widely considered to provide the immunopathogenic basis for bronchial, nasal, or sinusal inflammation between critical phases and in asymptomatic periods. Exhaled nitric oxide (NO) is currently the most reliable marker of rhinobronchial inflammation, but its routine assessment is difficult as the test is available only in highly specialized centers. OBJECTIVE: The aim of this study was to evaluate the agreement between a new diagnostic method (extracellular electrical impedance tomography) and immunological and clinical symptom scores, anterior rhinomanometry, peak expiratory flow rate (PEFR), serum eosinophil cationic protein (ECP) level, and blood eosinophil count in the clinical monitoring of respiratory tract inflammation before and after treatment of asthma or rhinitis. PATIENTS AND METHODS: Eighty-seven patients were studied; 73 had mild persistent asthma (PEFR > or = 20% below predicted) and 14 had rhinitis. At baseline (TO), the patients underwent a medical examination to record symptom scores, PEFR, anterior rhinomanometry, an extracellular electrolytic conductivity test (bioimpedance tomography), serum ECP level and blood eosinophil count. Appropriate treatment was prescribed, following the guidelines of the Global Initiative for Asthma and the Allergic Rhinitis and Its Impact on Asthma. After 21 days of therapy (T1), the patients were re-evaluated for the same parameters. RESULTS AND CONCLUSIONS: This study demonstrates the good agreement (Cohen's kappa = 0.689) between the symptom scores of patients with rhinitis and the findings of extracellular tomography and very good agreement (kappa = 0.846) between symptom scores of asthma patients and extracellular tomography. These findings validate the use of this new technique for the real-time monitoring and adjustment of treatment in these clinical settings.
- Published
- 2007
5. Inflammation in Respiratory Allergy Treated by Sublingual Immunotherapy
- Author
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Frati, F., primary, Scurati, S., additional, Puccinelli, P., additional, Morviducci, C., additional, Di Cara, G., additional, Boccardo, R., additional, Piergentili, E., additional, Milioni, M., additional, Bernardini, R., additional, Sambugaro, R., additional, Castellano, F., additional, Varricchio, A., additional, Manfredi, G., additional, Cordero, L., additional, Russello, M., additional, Guercio, E., additional, Mauro, M., additional, and Incorvaia, C., additional
- Published
- 2009
- Full Text
- View/download PDF
6. Intermittent and Persistent Allergic Rhinitis and Association with Asthma in Children
- Author
-
Ciprandi, G., primary, Cadario, G., additional, Di Gioacchino, M., additional, Tosca, M.A., additional, Bernardini, R., additional, Marseglia, G.L., additional, Gangemi, S., additional, Isola, S., additional, Marengo, F., additional, Minelli, M., additional, Ricciardi, L., additional, Ridolo, E., additional, Valle, C., additional, Verini, M., additional, Borrelli, P., additional, Varin, E., additional, Sambugaro, R., additional, Puccinelli, P., additional, Incorvaia, C., additional, Russello, M., additional, Milioni, M., additional, Boccardo, R., additional, Piergentili, E., additional, Di Rienzo, A., additional, and Frati, F., additional
- Published
- 2008
- Full Text
- View/download PDF
7. Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years
- Author
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Rienzo, V. Di, primary, Minelli, M., additional, Musarra, A., additional, Sambugaro, R., additional, Pecora, S., additional, Canonica, W. G., additional, and Passalacqua, G., additional
- Published
- 2005
- Full Text
- View/download PDF
8. Post marketing survey on the safety of sublingual immunotherapy in children below the age of 5
- Author
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Passalacqua, G., primary, Di Rienzo, V., additional, Minelli, M., additional, Musarra, A., additional, Sambugaro, R., additional, Pecora, S., additional, and Canonica, G.W., additional
- Published
- 2005
- Full Text
- View/download PDF
9. The efficacy of sublingual immunotherapy for respiratory allergy is not affected by different dosage regimens in the induction phase
- Author
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Sambugaro, R, primary, Puccinelli, P, additional, Burastero, SE, additional, and Di Rienzo, V, additional
- Published
- 2003
- Full Text
- View/download PDF
10. La gastropatia ipertrofica proteino-disperdente transitoria del bambino. Descrizione di due casi clinici e revisione della letteratura
- Author
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Ravelli, Angelo, Sambugaro, R., Viola, S., Monafo, V., Fiori, P., Beluffi, G., and Martini, Alberto
- Published
- 1987
11. Calcinosis as the presenting sign of juvenile dermatomyositis in a 14-month-old boy
- Author
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Martini, A., Ravelli, A., Viola, S., Sambugaro, R., and fabrizio De Benedetti
- Subjects
Male ,Calcinosis ,etiology/radionuclide imaging, Dermatomyositis ,complications/radionuclide imaging, Humans, Infant, Male, Technetium ,Humans ,Infant ,Technetium ,etiology/radionuclide imaging ,Radionuclide Imaging ,Dermatomyositis ,complications/radionuclide imaging - Abstract
We describe a 14-month-old child with dermatomyositis in whom calcinosis was the first sign of the disease. This case shows that calcinosis, usually a late complication of dermatomyositis, may be the presenting sign of the disease even in young children and when Gottron's sign is still absent and muscular weakness not prominent.
12. Behaviour of rust in new and in old inner leaves in conilon coffee
- Author
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Silva, M. B., Fábio Luiz Partelli, Sambugaro, R., and Oliari, L. S.
13. Efficacy of sublingual specific immunotherapy in intermittent and persistent allergic rhinitis in children: an observational case-control study on 171 patients. The EFESO-children multicenter trial.
- Author
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Acquistapace F, Agostinis F, Castella V, Kantar A, Novembre E, Perrone MR, Pietrasanta M, Sambugaro R, and Milani M
- Subjects
- Adolescent, Adrenal Cortex Hormones therapeutic use, Anti-Allergic Agents therapeutic use, Case-Control Studies, Child, Female, Histamine Antagonists therapeutic use, Humans, Male, Treatment Outcome, Allergens administration & dosage, Asthma prevention & control, Desensitization, Immunologic methods, Rhinitis, Allergic, Perennial drug therapy, Rhinitis, Allergic, Perennial etiology, Rhinitis, Allergic, Perennial therapy, Rhinitis, Allergic, Seasonal drug therapy, Rhinitis, Allergic, Seasonal etiology, Rhinitis, Allergic, Seasonal therapy
- Abstract
Sublingual-specific immunotherapy (SLIT) is considered as a valid treatment of respiratory allergies. However, there are few data on large sample size regarding its clinical role in 'real life' in term of reduction of symptoms, rescue medications and prevention of asthma in patients suffering from allergic rhinitis (AR) especially in children. We performed a multicenter, case-control study to evaluate the effect of SLIT in children (age 6-18 yr) with intermittent or persistent AR. 171 children (27% girls and 73% boys) with AR due to seasonal or perennial allergens were enrolled in a multicenter case-control study. Cases (n = 90) were defined as patients with intermittent (64%) or persistent (36%) AR who were treated for at least two consecutive years with specific SLIT with the related allergen extracts (SLITone ALK-Abellò). Controls (n = 81) were defined as sex-age- and type of allergen matched AR children who were never treated with specific immunotherapy and had no asthmatic symptoms at the beginning of observation period. Main outcomes of the study were the rhinoconjunctivitis symptom score (SS) (sneezing, rhinorrea, nasal itch, congestion, ocular itch and watery eyes) with a ranging scale from 0 (=no symptoms) to 3 (=severe symptoms) and the medication score (MS) evaluating symptomatic drug intake (antihystamine and inhaled corticosteroids). SS and MS were evaluated at the end of the observational period in relation with the period, considering the last 12 months, in which patients suffered the highest symptoms levels (i.e., peak of relevant pollen season (seasonal AR) or during the period of maximum allergen exposure in case of perennial AR). Secondary outcome of the study was the development of asthma symptoms during the observation period. SS (mean +/- SD) was 4.5 +/- 2.5 in cases and 9.0 +/- 3.0 in controls (-50%) (p = 0.0001). MS (mean +/- SD) was 2.5 +/- 1.9 and 3.6 +/- 2.1 in the case and control groups, respectively (-31%) (p = 0.0001). At the end of the observation period asthma symptoms were present in 14 subjects in the case group (15%) and in 20 children (24%) in the control group (p = 0.13). New skin sensitizations appeared in 6% of cases (n = 2) and in 36% (n = 12) of the controls (p = 0.001). The EFESO trial shows that a 2-yr once daily SLIT treatment in children with intermittent or persistent AR is associated with lower symptom and medication scores in comparison with subjects treated with symptomatic drugs only.
- Published
- 2009
- Full Text
- View/download PDF
14. Applicability of extracellular electrical impedance tomography in monitoring respiratory tract inflammation.
- Author
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Di Rienzo V, Minelli M, Sambugaro R, Agostinis F, Nucera E, Schiavino D, and Patriarca G
- Subjects
- Adult, Asthma drug therapy, Electric Impedance, Female, Humans, Male, Neural Networks, Computer, Peak Expiratory Flow Rate, Rhinitis drug therapy, Asthma diagnosis, Rhinitis diagnosis, Tomography methods
- Abstract
Background: The presence of persistent mild inflammation is widely considered to provide the immunopathogenic basis for bronchial, nasal, or sinusal inflammation between critical phases and in asymptomatic periods. Exhaled nitric oxide (NO) is currently the most reliable marker of rhinobronchial inflammation, but its routine assessment is difficult as the test is available only in highly specialized centers., Objective: The aim of this study was to evaluate the agreement between a new diagnostic method (extracellular electrical impedance tomography) and immunological and clinical symptom scores, anterior rhinomanometry, peak expiratory flow rate (PEFR), serum eosinophil cationic protein (ECP) level, and blood eosinophil count in the clinical monitoring of respiratory tract inflammation before and after treatment of asthma or rhinitis., Patients and Methods: Eighty-seven patients were studied; 73 had mild persistent asthma (PEFR > or = 20% below predicted) and 14 had rhinitis. At baseline (TO), the patients underwent a medical examination to record symptom scores, PEFR, anterior rhinomanometry, an extracellular electrolytic conductivity test (bioimpedance tomography), serum ECP level and blood eosinophil count. Appropriate treatment was prescribed, following the guidelines of the Global Initiative for Asthma and the Allergic Rhinitis and Its Impact on Asthma. After 21 days of therapy (T1), the patients were re-evaluated for the same parameters., Results and Conclusions: This study demonstrates the good agreement (Cohen's kappa = 0.689) between the symptom scores of patients with rhinitis and the findings of extracellular tomography and very good agreement (kappa = 0.846) between symptom scores of asthma patients and extracellular tomography. These findings validate the use of this new technique for the real-time monitoring and adjustment of treatment in these clinical settings.
- Published
- 2007
15. [Transient protein-losing hypertrophic gastropathy in children. Description of 2 clinical cases and review of the literature].
- Author
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Ravelli A, Sambugaro R, Viola S, Monafo V, Fiori P, Beluffi G, and Martini A
- Subjects
- Child, Humans, Hypertrophy complications, Infant, Male, Protein-Losing Enteropathies physiopathology, Gastric Mucosa pathology, Protein-Losing Enteropathies etiology
- Published
- 1987
16. Calcinosis as the presenting sign of juvenile dermatomyositis in a 14-month-old boy.
- Author
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Martini A, Ravelli A, Viola S, Sambugaro R, and De Benedetti F
- Subjects
- Calcinosis diagnostic imaging, Dermatomyositis diagnostic imaging, Humans, Infant, Male, Radionuclide Imaging, Technetium, Calcinosis etiology, Dermatomyositis complications
- Abstract
We describe a 14-month-old child with dermatomyositis in whom calcinosis was the first sign of the disease. This case shows that calcinosis, usually a late complication of dermatomyositis, may be the presenting sign of the disease even in young children and when Gottron's sign is still absent and muscular weakness not prominent.
- Published
- 1987
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