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14 results on '"Samaszko-Fiertek, Justyna"'

1. Crystal Structures of d-Lyxono-1,4-lactone and Its O -Tosyl Derivative.

Author

Sosnowska, Anna, Chojnacki, Jarosław, Samaszko-Fiertek, Justyna, Madaj, Janusz, and Dmochowska, Barbara

Abstract

γ- and δ-lactones were formed by bromine oxidation of commercially available D-lyxose, as confirmed by IR analysis. The former was isolated, and its structure was confirmed by NMR spectra and X-ray analysis. In this structure, the presence of both intermolecular and intramolecular hydrogen bonds was found. Intermolecular interactions in the crystal were illustrated using the Hirshfeld surfaces. Due to steric reasons, 3,5-O-isopropylidene-d-lyxono-1,4-lactone was formed, which in a further step led to the formation of a 2-O-tosyl derivative. Its structure was confirmed by X-ray diffraction analysis. The additional ring of the O-isopropylidene derivative caused the lactone ring to change conformation to 3E. In the crystal structure of this compound, only C-H⸱⸱⸱O intermolecular interactions were present, as confirmed by the Hirshfeld surface analysis. [ABSTRACT FROM AUTHOR]

Published
2025
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10. Efficient synthesis and antifungal investigation of nucleosides' quaternary ammonium salt derivatives

Author

DMOCHOWSKA, Barbara, PELLOWSKA-JANUSZEK, Lucyna, SAMASZKO-FIERTEK, Justyna, SLUSARZ, Rafal, WAKIEC, Roland, and MADAJ, Janusz

Subjects
Quaternary ammonium salts,uridine-5\textquotesingle-ammonium derivatives,thymidine-5\textquotesingle-ammonium derivatives
Abstract

Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-$O$-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-($N$,$N$-dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.

Published
2019

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