140 results on '"Samas, Brian"'
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2. Understanding the Dehydration of Levofloxacin Hemihydrate
3. Thermodynamic Stability Considerations for Isostructural Dehydrates
4. Crystal structures of anhydrous and hydrated ceftibuten
5. A Thermodynamic-Based Approach to Analyzing a Highly Solvating Polymorphic System: The Desolvation Window Method
6. Five Degrees of Separation: Characterization and Temperature Stability Profiles for the Polymorphs of PD-0118057 (Molecule XXIII)
7. pH-Dependent Degradation of T3P-Related Byproducts
8. Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib
9. Prediction of the Relative Free Energies of Drug Polymorphs above Zero Kelvin
10. The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors
11. An intravenous formulation decision tree for discovery compound formulation development
12. Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib.
13. Prediction of the Relative Free Energies of Drug Polymorphs above Zero Kelvin.
14. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization
15. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
16. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus
17. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects
18. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
19. Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT4 Partial Agonist
20. The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product
21. ChemInform Abstract: Substituent Effects on the Amination of Racemic Allyl Carbonates Using Commercially Available Chiral Rhodium Catalysts.
22. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1
23. The efficient synthesis of (3 R,4 R,5 R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α 2δ protein
24. Substituent effects on the amination of racemic allyl carbonates using commercially available chiral rhodium catalysts
25. On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin
26. Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT4 Partial Agonist.
27. Long Directional Interactions (LDIs) in Oligomeric Cofacial Silicon Phthalocyanines and Other Oligomeric and Polymeric Cofacial Phthalocyanines
28. Stereoselective Synthesis of (S)-3-(Methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile
29. Discovery and Characterization of Atropisomer PH‐797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate
30. Long, Directional Interactions in Cofacial Silicon Phthalocyanine Oligomers
31. Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors
32. An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-Carboxylate Derivatives
33. 2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1,3-dithiane
34. ChemInform Abstract: Robust Preparation of Novel Imidazo[5,1‐b][1,3,4]oxadiazoles.
35. N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain
36. A Highly Enantioselective Allylic Amination Reaction Using a Commercially Available Chiral Rhodium Catalyst: Resolution of Racemic Allylic Carbonates
37. The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein
38. Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles
39. (1 R,2 S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production
40. Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production
41. Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
42. 2,6-Diisopropylanilinium chloride
43. (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production
44. 1:1 Cocrystal of (S)-3-(ammoniomethyl)-5-methylhexanoate and (S)-mandelic acid
45. 2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan-2-one monohydrate
46. Bis[(2,6-diisopropylphenyl)ammonium] ethane-1,2-disulfonate dihydrate
47. (E,E)-1,8-Dioxacyclotetradeca-3,10-diene-2,9-dione
48. Quininium (S)-2-chloro-n-butyrate
49. Unique 11b-Substituted Indeno[2,1-c]quinolin-6-one Ring System.
50. (1S*,2S*)-(+)-2-Amino-1-[4-(methylsulfanyl)phenyl]propane-1,3-diol
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