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Your search keyword '"Samara Ben B. B. Bahia"' showing total 2 results
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2 results on '"Samara Ben B. B. Bahia"'

1. Efficient Catalysis of Phosphate Ester Hydrolysis by Bare Silica

Author

Carlos A. Amaya Vargas, Adolfo H. Moraes, Ângelo M. L. Denadai, Samara Ben B. B. Bahia, Tiago A. S. Brandão, and Maria Helena Araujo

Subjects
chemistry.chemical_compound, General Energy, chemistry, Silica gel, Polymer chemistry, Ester hydrolysis, Physical and Theoretical Chemistry, Phosphate, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Catalysis
Abstract

This work reports the catalysis of bare silica materials (MCM-41, SBA-15, and silica gel) for the complete hydrolyses of bis(2,4-nitrophenyl)phosphate (BDNPP) and bis(4-nitrophenyl)phosphate (BNPP)...

Published
2020
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2. Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles

Author

Carlos A. de Simone, Maria Helena Araujo, Samara Ben B. B. Bahia, Cláudia Pessoa, Rubem F. S. Menna-Barreto, Bruno C. Cavalcanti, Wallace J. Reis, Solange L. de Castro, Eufrânio N. da Silva Júnior, Claudia C. Gatto, Francielly T. Souto, and Guilherme A. M. Jardim

Subjects
Drug, Chagas disease, Stereochemistry, media_common.quotation_subject, Pharmaceutical Science, Biology, 010402 general chemistry, 01 natural sciences, Biochemistry, Peripheral blood mononuclear cell, chemistry.chemical_compound, Drug Discovery, medicine, Cytotoxic T cell, IC50, media_common, Pharmacology, 010405 organic chemistry, Organic Chemistry, medicine.disease, Naphthoquinone, 0104 chemical sciences, Molecular hybridization, chemistry, Benznidazole, Molecular Medicine, medicine.drug
Abstract

Quinonoid compounds based on 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles were synthesized using simple methodologies and evaluated against T. cruzi, the etiological agent of Chagas disease, and cancer cell lines PC3, HCT-116, HL-60, MDA-MB-435 and SF-295. The cytotoxic potential of the lapachones was also assayed against peripheral blood mononuclear cells (PBMC). Two compounds 6 and 12 were identified as potential hits against T. cruzi. β-Lapachone-based 1,5-disubstituted-1,2,3-triazole (12) displayed an IC50/24 h = 125.1 μM, similar to benznidazole, the standard drug. Compound 12 was also more active than the precursor β-lapachone against the cancer cell lines. These compounds acting as multitarget quinoidal systems could provide promising new leads for the development of trypanocidal and/or anticancer drugs.

Published
2016
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