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Previous research shows that manipulations (e.g. levels-of-processing) that facilitate true memory often increase susceptibility to false memory. An exception is the generation effect. Using the Deese/Roediger-McDermott (DRM) paradigm, Soraci et al. found that generating rather than reading list items led to an increase in true but not false memories. They argued that generation led to enhanced item-distinctiveness that drove down false memory production. In the current study, we investigated the effects of generative processing on valenced stimuli and after a delayed retention interval to examine factors that may lead to a generation effect that increases false memories. At the immediate test, false recognition rates for both negative and neutral valanced critical lures were similar across read and generate conditions. However, after a one-week delay, we saw a valence differentiation, with a generation effect for false recognition but only for negative stimuli. The roles of item-specific and relational processing during encoding and their interaction with long-term retention are discussed.

Background Significant improvements in mortality among patients with non-small cell lung cancer (NSCLC) in the USA over the past two decades have been reported based on Surveillance, Epidemiology, and End Results (SEER) data. The timing of these improvements led to suggestions that they result from the introduction of new treatments; however, few studies have directly investigated this. The aim of this study was to investigate the extent to which population level improvements in survival of advanced and/or metastatic NSCLC (admNSCLC) patients were associated with changes in treatment patterns. Methods We utilized a de-identified database to select three cohorts of patients with admNSCLC: (1) patients with non-oncogene (EGFR/ALK/ROS1/BRAF) positive tumors, (2) patients with ALK-positive (ALK+) tumors, and (3) patients with EGFR-positive (EGFR+) tumors. All patients were diagnosed with admNSCLC between 2012 and 2019. Multivariable Cox models adjusting for baseline characteristics and receipt of targeted and immunotherapy were utilized to explore the relationship between these variables and changes in the hazard of death by calendar year in each cohort. Results We included 28,154 admNSCLC patients with non-oncogene positive tumors, 598 with ALK+ tumors, and 2464 with EGFR+ tumors eligible for analysis. After adjustment for differences in baseline characteristics, the hazard of death in patients who had non-oncogene positive tumors diagnosed in 2015, 2016, 2017, 2018 ,and 2019 was observed to be 12%, 11%, 17%, 20%, and 21% lower respectively than that for those diagnosed in 2012. Upon additionally adjusting for receipt of first line or second line immunotherapy, the decrease in the hazard of death by calendar year was no longer observed, suggesting improvements in survival observed over time may be explained by the introduction of these treatments. Similarly, decreases in the hazard of death were only observed in patients with ALK+ tumors diagnosed between 2017 and 2019 relative to 2012 but were no longer observed following adjustment for the use of 1st and later generation ALK inhibitors. Among patients with EGFR+ tumors, the hazard of death did not improve significantly over time. Conclusion Our findings expand on the SEER data and provide additional evidence suggesting improvements in survival of patients with advanced and metastatic NSCLC over the past decade could be explained by the change in treatment patterns over this period.

Assessing the risk of tick-borne disease in areas with high visitor numbers is important from a public health perspective. Evidence suggests that tick presence, density, infection prevalence and the density of infected ticks can vary between habitats within urban green space, suggesting that the risk of Lyme borreliosis transmission can also vary. This study assessed nymph density, Borrelia prevalence and the density of infected nymphs across a range of habitat types in nine parks in London which receive millions of visitors each year. Ixodes ricinus were found in only two of the nine locations sampled, and here they were found in all types of habitat surveyed. Established I. ricinus populations were identified in the two largest parks, both of which had resident free-roaming deer populations. Highest densities of nymphs (15.68 per 100 m2) and infected nymphs (1.22 per 100 m2) were associated with woodland and under canopy habitats in Richmond Park, but ticks infected with Borrelia were found across all habitat types surveyed. Nymphs infected with Borrelia (7.9%) were only reported from Richmond Park, where Borrelia burgdorferi sensu stricto and Borrelia afzelii were identified as the dominant genospecies. Areas with short grass appeared to be less suitable for ticks and maintaining short grass in high footfall areas could be a good strategy for reducing the risk of Lyme borreliosis transmission to humans in such settings. In areas where this would create conflict with existing practices which aim to improve and/or meet historic landscape, biodiversity and public access goals, promoting public health awareness of tick-borne disease risks could also be utilised.

This chapter analyses young people’s drinking practices and experiences in suburban and rural England to explore how young people located beyond global cities creatively navigate shifting conditions of possibility and constraint shaping their opportunities to socialize. The chapter investigates young people’s drinking practices in the suburbs of Manchester, and in rural village pubs in Lincolnshire. It pays particular attention to how young people craft and experience ‘drinkscapes’, and the role of classed and other socio-spatial processes of exclusion in the creation and experience of drinkscapes. Suburban and rural drinkscapes offer distinct drinking experiences. The material cultures and sensual atmospheres of suburban and rural drinkscapes have the ability to both allure and repel young people.

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This analysis is part of the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) study. EAVE II is funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE – The Health Data Research Hub for Respiratory Health (MC_PC_19004), which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through the Scottish Government DG Health and Social Care. SAS and AS are also supported by the COVID-19 Longitudinal Health and Wellbeing National Core Study, funded by the Medical Research Council (MC_PC_20030). SVK acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). JM is partly funded by the National Institute for Health Research Applied Research Collaboration West (NIHR ARC West). Objectives COVID-19 has resulted in the greatest disruption to National Health Service (NHS) care in its over 70-year history. Building on our previous work, we assessed the ongoing impact of pandemic-related disruption on provision of emergency and elective hospital-based care across Scotland over the first year of the pandemic. Design We undertook interrupted time-series analyses to evaluate the impact of ongoing pandemic-related disruption on hospital NHS care provision at national level and across demographics and clinical specialties spanning the period 29 March 2020?28 March 2021. Setting Scotland, UK. Participants Patients receiving hospital care from NHS Scotland. Main outcome measures We used the percentage change of accident and emergency attendances, and emergency and planned hospital admissions during the pandemic compared to the average admission rate for equivalent weeks in 2018-2019. Results As restrictions were gradually lifted in Scotland after the first lockdown, hospital-based admissions increased approaching pre-pandemic levels. Subsequent tightening of restrictions in September 2020 were associated with a change in slope of relative weekly admissions rate: -1.98% (-2.38, -1.58) in accident and emergency attendance, -1.36% (-1.68, -1.04) in emergency admissions and -2.31% (-2.95, -1.66) in planned admissions. A similar pattern was seen across sex, socioeconomic status and most age groups, except children (0-14 years) where accident and emergency attendance, and emergency admissions were persistently low over the study period. Conclusions We found substantial disruption to urgent and planned inpatient healthcare provision in hospitals across NHS Scotland. There is the need for urgent policy responses to address continuing unmet health needs and to ensure resilience in the context of future pandemics. Publisher PDF

Grounded theory remains a popular qualitative methodology even after haf-a-century of existence. Recent years have seen a renaissance in the use of the methodology and it is increasingly being utilised in innovative ways. These have included the application of ‘grounded theory to ‘nontraditional’ data such as those derived from the performing arts, literature and visual media. Most published grounded theory analyses using these data appear experimental and/or tentative when drawing their conclusions, and little guidance is published on how to conduct grounded theory on visual and textual media. With this article, we go some way towards redressing this issue and further explore the adaptability and utility of grounded theory as a qualitative methodology. Further, we offer a methodological approach derived from the ‘classical’ school, to be used by psychologists and other social science researchers who wish to explore psychological phenomena in the context of the performing arts, literature and visual media.

The balance between including participants in research, representing them in academic writing, and maintaining their anonymity can be in constant flux. Greater representation may mean compromising participants’ anonymity, while research that is more inclusive may lead to academic representations of data being challenged as inaccurate according to the participants whose data is presented. The situation for the academic in these scenarios becomes akin to walking a tightrope between advocating on behalf of the participants and speaking as an authority on the analysis and interpretation of participants’ data. To deconstruct these methodological and ethical issues, this chapter critically considers the genuine inclusion of research participants in published health and social sciences research, and argues how poor academic practices may lead to tokenism or distinct power imbalances where academic researchers’ voices become elevated compared to the participants’ voices. This is done by introducing the concept of “academic ventriloquism,” whereby researchers may “throw” their voices. This is a term used in ventriloquism to explore how ventriloquists create the illusion their voice is coming from elsewhere (the puppet). Noting how often readers are left unable to “hear” participant’s voices through published research, or where participants’ voices compete for line space, the three sometimes competing concepts of inclusion, representation, and anonymity are discussed. Despite advances in researching “with” rather than conducting research “on” participants, the writing-up of academic research remains primarily the responsibility of the researcher who must develop the ability to “throw” his/her voice, so that participants appear to be heard. The chapter presents several ways in which this can be problematic and propose recommendations for facilitating the inclusion and accurate representation of participants in written academic research, to not only promote participant voices and make them audible, but also document them faithfully so they are a genuine reflection of the participant from whom they came.

Universities are as a means of leaving for the city for young people living increasingly precarious and mobile lives. This article explores how male university students (aged 18–25) talk about, and belong to, the places they inhabit in Greater Manchester, England. Drawing on mixed-methods data collection from survey responses and in-depth semi-structured interviews, this article finds that while young men embrace liquid understandings of place, they express tensions between “insiders” and “outsiders.” While universities appear to be significant places for male university students, only half the participants reported feelings of belonging to university communities. Consequently, this article proposes recommendations for universities, in order to ensure male university students feel they can open up to staff, thereby enabling them to feel part of a “learning community”—a key theme of the National Student Survey.

IntroductionFor people with type 2 diabetes mellitus (T2DM) who require an antidiabetic drug as an add-on to metformin, there is controversy about whether newer drug classes such as dipeptidyl peptidase-4 inhibitors (DPP4i) or sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce the risk of long-term complications compared with sulfonylureas (SU). There is widespread variation across National Health Service Clinical Commissioning Groups (CCGs) in drug choice for second-line treatment in part because National Institute for Health and Care Excellence guidelines do not specify a single preferred drug class, either overall or within specific patient subgroups. This study will evaluate the relative effectiveness of the three most common second-line treatments in the UK (SU, DPP4i and SGLT2i as add-ons to metformin) and help target treatments according to individual risk profiles.Methods and analysisThe study includes people with T2DM prescribed one of the second-line treatments-of-interest between 2014 and 2020 within the UK Clinical Practice Research Datalink linked with Hospital Episode Statistics and Office of National Statistics. We will use an instrumental variable (IV) method to estimate short-term and long-term relative effectiveness of second-line treatments according to individuals’ risk profiles. This method minimises bias from unmeasured confounders by exploiting the natural variation in second-line prescribing across CCGs as an IV for the choice of prescribed treatment. The primary outcome to assess short-term effectiveness will be change in haemoglobin A1c (%) 12 months after treatment initiation. Outcome measures to assess longer-term effectiveness (maximum ~6 years) will include microvascular and macrovascular complications, all-cause mortality and hospital admissions during follow-up.Ethics and disseminationThis study was approved by the Independent Scientific Advisory Committee (20-064) and the London School of Hygiene & Tropical Medicine Research Ethics Committee (21395). Results, codelists and other analysis code will be made available to patients, clinicians, policy-makers and researchers.

Importance Quantitative assessment of bias from unmeasured confounding and missing data can help evaluate uncertainty in findings from indirect comparisons using real-world data (RWD). Objective To compare the effectiveness of alectinib vs ceritinib in terms of overall survival (OS) in patients with ALK-positive, crizotinib-refractory, non-small cell lung cancer (NSCLC) and to assess the sensitivity of these findings to unmeasured confounding and missing data assumptions. Design, Setting, and Participants This comparative effectiveness research study compared patients from 2 phase 2 alectinib trials and real-world patients. Patients were monitored from June 2013 to March 2020. Comparisons of interest were between alectinib trial data vs ceritinib RWD and alectinib RWD vs ceritinib RWD. RWD treatment groups were selected from nationally representative cancer data from US cancer clinics, the majority from community centers. Participants were ALK-positive patients aged 18 years or older with advanced NSCLC, prior exposure to crizotinib, and Eastern Cooperative Oncology Group Performance Status (PS) of 0 to 2. Data analysis was performed from October 2020 to March 2021. Exposures Initiation of alectinib or ceritinib therapy. Main Outcomes and Measures The main outcome was OS. Results In total, there were 355 patients: 183 (85 men [46.4%]) in the alectinib trial, 91 (43 men [47.3%]) in the ceritinib RWD group, and 81 (38 men [46.9%]) in the alectinib RWD group. Patients in the alectinib trial were younger (mean [SD] age, 52.53 [11.18] vs 57.97 [11.71] years), more heavily pretreated (mean [SD] number of prior therapy lines, 1.95 [0.72] vs 1.47 [0.81]), and had more favorable baseline ECOG PS (ECOG PS of 0 or 1, 165 patients [90.2%] vs 37 patients [77.1%]) than those in the ceritinib RWD group. The alectinib RWD group (mean [SD] age, 58.69 [11.26] years) had more patients with favorable ECOG PS (ECOG PS of 0 or 1, 49 patients [92.4%] vs 37 patients [77.1%]) and more White patients (56 patients [72.7%] vs 53 patients [62.4%]) compared with the ceritinib group. Compared with ceritinib RWD, alectinib-exposed patients had significantly longer OS in alectinib trials (adjusted hazard ratio [HR], 0.59; 95% CI, 0.44-0.75; P

This article reports on the use of an innovative reflective diary method with paid home care workers caring for people with dementia. It examines the key features of the diary design, recruitment and training of participants, diarists’ approaches and responses to diary-keeping, and evaluates the use of diaries in this context. Following training, 11 volunteers (all female) employed by a U.K.-based home care organization kept diaries of their experiences of caring for those with dementia. Using specially designed diaries, they wrote about their visits to clients for a period of approximately 4 months and were remunerated for up to 16 extra hours at their usual hourly rate of pay. Overall, home care workers engaged well with the process, keeping regular, lengthy, timely, and reflective diary entries. Diary-keeping provided a means for these workers to express their emotions about their work, while enhancing their self-insight and care practices. We demonstrate the feasibility of diaries for research with this occupational group and conclude that the written reflexivity employed in diaries can document, enrich, and improve the work of these caregivers.

Previous research has shown that with reduced attention at encoding, false recognition of critical lures for negative arousing DRM lists were higher than positive arousing lists. The current study extends this research to examine the role of attention for both arousing and nonarousing valenced false memory formation. Further, due to contradictory findings in past research, we examined attention at encoding using both within- (Experiment 1) and between-(Experiment 2) participants design. Participants were exposed to high and low arousing, valenced DRM lists under full and reduced attention conditions. Experiment 1 revealed that only negative arousing false memories were not affected by reduced attention at study, all other false memories decreased. In Experiment 2, although recognition of negative high arousing critical lures was higher, false memories increased in the reduced attention condition for all list types. Differences in attention during encoding affect the retrieval of emotional stimuli dependent on arousal and valence, however, our decision strategies can override the impact of this when it comes to retrieval.

This paper emerges from a multidisciplinary research project called “Brews and Brows: Shaping Stories from Eyebrows to Scousebrows” that entailed gathering stories about eyebrow grooming from women and men from the city of Liverpool, UK, and creating a new taxonomy of the eyebrow where none currently exists. The point of departure for this paper is to challenge the negative commentary on the Scousebrow in the press and social media by engaging people in discussions surrounding the personal significance of eyebrow shaping and styling. In challenging this denigration, this paper uses data from in-depth interviews with eyebrow artists and clients and ethnographic interviews at a four-day event held in Liverpool. This paper argues that the everyday (little c) creative practice of eyebrow grooming is not only an important part of crafting and performing identity, particularly for Scouse women, but also an example of bottom-up placemaking in the city of Liverpool.

In this Viewpoints piece, we reflect on the process of applying for National Health Service (NHS) ethical approval and governance for research with children in England. We present a case study of our experiences of navigating the Integrated Research Application System (IRAS) for one study, The Hair Study. We argue that, for children’s geographers, getting to grips with the complex processes of applying for NHS ethical approval and governance is important when considering the move towards interdisciplinary working, and engagement with children in underexplored spaces and places, such as: doctors surgeries; hospitals; dentists; and other services commissioned by the NHS.

9047 Background: Whilst the impact of certain mutations on aNSCLC survival outcomes has been evaluated, real-world (rw) evidence on its predictive and prognostic value remains limited. We aimed to identify the predictive and prognostic value of non-driver mutations that are deemed to be clinically relevant in aNSCLC. Methods: This retrospective cohort study analysed de-identified electronic medical records from the Flatiron Clinico-Genomic (FCGD) and FoundationCORE™ databases of aNSCLC patients who have initiated 1L cancer immunotherapy (CIT, alone or in combination) or chemotherapy (chemo) under routine care between 2016 and 2021. Propensity-based multivariable models were used to determine associations between mutational status and progression-free survival (rwPFS), overall survival (rwOS) and overall response (rwR). Results: Of 10,795 patients identified, 2,999 met inclusion criteria (1,042 chemo, 1,957 CIT). Among these, 53% were men and 65% were ≥65 years old. Patients mostly had non-squamous histology (68%), a previous history of smoking (95%) and ECOG ≤1 (61%). 58% of patients were diagnosed as de novo. A total of 185 different mutations were identified in this population, and variants of the same mutation were grouped, identifying 58 mutation families. STK11, KEAP1 and CDKN2A/B mutations were significantly associated with all effectiveness outcomes (Table), indicating lower response (rwR OR1) in patients harbouring mutated vs. wild type genes. APC and KRAS mutations were only significantly associated with lower rwR, while FGRF and HRAS mutations were related to worse rwPFS and rwOS, respectively. In contrast, a significantly higher likelihood of response or PFS was associated with ATM/R/RX and GATA3 mutations, respectively. Moreover, our results suggest that KRAS mutations potentially have predictive value for PFS in CIT-treated patients. Mutations with prognostic value on clinical outcomes (overall population). HR, hazard ratio; PFS, progression-free survival; OR, odds ratio; OS, overall survival; rw, real-world. Conclusions: STK11, KEAP1 and CDKN2A/B mutations were significantly associated with poor prognosis in all effectiveness outcomes. In addition, KRAS mutations resulted in clinically significant differences in terms of PFS. Further analyses should be conducted to confirm this clinical significance and to evaluate the relevance of these mutations in future clinical trials design.[Table: see text]

Homecare workers provide essential physical, social and emotional support to growing numbers of older people with dementia in the UK. Although it is acknowledged that the work can sometimes be demanding, some homecare workers regularly ‘go the extra mile’ for service users, working above and beyond the usual remit of the job. This form of voluntarism has been interpreted as an expression of an essentially caring nature, but also as the product of a work environment structured to tacitly endorse the provision of unpaid labour. This paper draws on a qualitative study of what constitutes ‘good’ homecare for older people with dementia. Using homecare workers’ reflexive diaries ( n = 11) and interviews with homecare workers ( n = 14) and managers ( n = 6), we explore manifestations of, and motivations for, homecare workers going the extra mile in their everyday work. We describe three modes of voluntary labour based on these accounts which we characterise as affective, performative and pragmatic. Our study highlights the complex relationships between job satisfaction, social benefit and commercial gain in the homecare work sector. Further research is needed to define the full range of affective and technical skills necessary to deliver good homecare, and to ensure that homecare work is appropriately credited.

This paper draws on two favourite characters from British reality television show, Love Island 2018: Jack Fincham, a former stationery sales manager, and Alex George, an Accident & Emergency [A&E] doctor, to explore how heterosexual norms are constructed and challenged. We study the romantic on-screen relationships these characters have with the female contestants, and between the two male characters themselves through the notion of ‘bromance’. Through a textual analysis of the spoken words and physical interactions between characters in episodes forming the fourth series of Love Island and analysis of social media posts and articles in popular press outlets, we use the notion of gender performativity to explore how these characters perform both hegemonic and, what we argue is, ‘threatened’ masculinity. We use the ‘Male Gaze’ to methodologically lens the performances by characters and their romantic interactions on the television show. In particular, we focus on Jack and Alex’s budding relationship and the condemning of this relationship by the public amid Alex’s termination of his romantic relationship. The decision by Alex to end this relationship led to many viewers questioning his sexuality, with specific reference to his adoration for Jack. Whilst broadly, this paper contributes to debates on the sociological potential of reality television shows, such as Love Island, its specific contribution is to a small, but growing body of international scholarship on homosocial relationships and male love stories in television and film. With this paper, we also contribute towards redressing the marginalization of women within the study of bromance.

Assessing the risk of tick-borne disease in areas with high visitor numbers is important from a public health perspective. Evidence suggests that tick presence, density, infection prevalence and the density of infected ticks can vary between habitats within urban green space, suggesting that the risk of Lyme borreliosis transmission can also vary. This study assessed nymph density, Borrelia prevalence and the density of infected nymphs across a range of habitat types in nine parks in London which receive millions of visitors each year. Ixodes ricinus were found in only two of the nine locations sampled, and here they were found in all types of habitat surveyed. Established I. ricinus populations were identified in the two largest parks, both of which had resident free-roaming deer populations. Highest densities of nymphs (15.68 per 100 m

Women and girls have long been confronted with unrealistic, unattainable body image norms. Additionally, the ‘ideal feminine’ body has been subject to constant change over the last centuries and decades. With the proliferation of the Internet, women and girls are continuously exposed to advice from heteronormative discourses of womanhood. Demand for cosmetic surgery has dramatically increased and is still expanding. Recently, women’s and girls’ awareness has shifted towards how they should ‘improve’ the aesthetic appeal of their labia, ‘optimise’ their vaginas, and generally make their vulva ‘healthier’, leading to a growing popularity of female genital cosmetic surgery. Proponents of surgical interventions (falsely) claim them as agentic methods of self-expression and promise ‘improvement’ beyond the individual’s control. The marketing of these procedures is predicated on shame and has been described as aggressive. Our postmodern era brings new visions of desired body image, and a rise of Internet-based digital connections between people. This means new body image ‘norms’ are instantly circulated and changed, and body image is continuously scrutinised and shamed. Coupled with increased accessibility of Internet-based nudity and pornographic material, and prevailing associations of shame and taboo about female genitalia, consequences particularly for young women’s perceptions of body image are drastic. This chapter discusses the Internet’s role in the recent desire by young women and girls to seek genital cosmetic surgery..

The addition of cattle health and immunity traits to genomic selection indices holds promise to increase individual animal longevity and productivity, and decrease economic losses from disease. However, highly variable genomic loci that contain multiple immune-related genes were poorly assembled in the first iterations of the cattle reference genome assembly and underrepresented during the development of most commercial genotyping platforms. As a consequence, there is a paucity of genetic markers within these loci that may track haplotypes related to disease susceptibility. By using hierarchical assembly of bacterial artificial chromosome inserts spanning 3 of these immune-related gene regions, we were able to assemble multiple full-length haplotypes of the major histocompatibility complex, the leukocyte receptor complex, and the natural killer cell complex. Using these new assemblies and the recently released ARS-UCD1.2 reference, we aligned whole-genome shotgun reads from 125 sequenced Holstein bulls to discover candidate variants for genetic marker development. We selected 124 SNPs, using heuristic and statistical models to develop a custom genotyping panel. In a proof-of-principle study, we used this custom panel to genotype 1,797 Holstein cows exposed to bovine tuberculosis (bTB) that were the subject of a previous GWAS study using the Illumina BovineHD array. Although we did not identify any significant association of bTB phenotypes with these new genetic markers, 2 markers exhibited substantial effects on bTB phenotypic prediction. The models and parameters trained in this study serve as a guide for future marker discovery surveys particularly in previously unassembled regions of the cattle genome.

Mobility in the context of higher education is often privileged to large(r)-scaled international movements, consequently neglecting the everyday mobilities practiced by students. This is an important neglect since banal mobilities constitute important affective experiences for students (Holton and Finn 2018). In responding to calls for a micro-bodily mobilities approach to student geographies in the UK (Holton and Finn 2018), this paper draws on in-depth semi-structured interviews conducted with university students aged 18-25 studying in Greater Manchester. Through a discussion of the complex and multi-layered everyday walking mobilities of students, this paper illuminates how embodied, emotional and affective walking mobility practices shape students’ experiences and identities. Findings show that, for students in our study, moorings are often as important as mobilities to identity formation, and place attachment. Bringing to the fore the embodied, emotional and affective nature of student micro-mobilities is important because students in this paper make clear that various forms of movement and stillness are of great importance to their wellbeing, enabling them to have space and time to think, reflect, and form attachments and belonging with people and spaces. This paper has important implications for higher education and urban designers, as we contend that it is crucial to draw attention to students’ experiences of walking and sitting in the city, which significantly contribute to constructing sense of place and belonging to the university city.

In the current ecology of care, social, rather than medical, support is critical in enabling frail older people to live at home. This paper reports findings from a qualitative study about how home care workers (HCWs) support persons with dementia living in the community. Semi-structured qualitative interviews were carried out in England with 14 family care-givers (FCGs) recruited from a single private home care provider. A thematic analysis of the data was undertaken using the constant comparative method. In every instance, it was FCGs who initiated domiciliary care for the person with dementia, highlighting ambiguity about who is the ‘client’. Rather than focusing on the HCWs’ work in undertaking practical tasks and personal care, respondents prioritised HCWs as companions, providing emotional and social support for their relatives. From an organisational perspective, respondents valued the capacity of the provider to deliver a consistent, personal, reliable and punctual service. These attributes were important in supporting their relative's agency and dignity. Respondents described HCWs engaging in skilled and sensitive communication with clients but considered ‘character’ and ‘innate’ caring abilities to be more important than those derived from training. The results highlight the need to acknowledge the family, rather than the individual client, as the functioning unit of care, and to recognise the highly skilled communicative and emotional work undertaken by HCWs.

The Young's modulus, Poisson's ratio and flexural strength of 218 beams of radiolytically oxidised nuclear graphite have been determined by combining electronic speckle pattern interferometry, ESPI, and inverse finite element modelling techniques. The graphite was extracted from three operational advanced gas cooled reactor stations where it had been subjected to fast neutron irradiation and radiolytic oxidation resulting in mass loss. The 6 × 6 × 19 mm beam samples had densities ranging from 1063 – 1840 kg.m−3, equivalent to weight losses up to 46 %, with cumulative neutron doses of up to 161 × 1020 n.cm−2 equivalent Dido nickel dose, or 21.1 displacements per atom, significantly extending the datasets available in the open literature to higher levels of both dose and oxidation. In situ ESPI measurements were collected during three-point bend tests, creating full field displacement maps of the evolving deformation to which simulations were matched by chi-squared minimisation of the elastic properties. Potential loading abnormalities were accounted for in the fitting process to ensure the simulations were representative, with total uncertainties in the determined Young's modulus and Poisson's ratio values of ± 4.5 % and ± 0.08, respectively. Consistent trends were observed in the behaviour of the material from the different stations, with strong positive dependences on density for both the flexural strength and Young's modulus. The strength and Young's modulus remained well correlated even to high levels of oxidation mass loss. Conversely, the Poisson's ratio was practically invariant with oxidation with mean values of 0.21 ± 0.03, 0.24 ± 0.05 and 0.25 ± 0.05 for the three stations. The combined ESPI-finite element measurement approach is demonstrated as robust for irradiated small specimens, making it suitable for monitoring graphite in future reactors. The collected data support the safety assessments of the current reactors, enabling predictions of the responses to progressively higher mean core mass loss.

This paper offers an autoethnographic account of my first academic year as a Human Geography lecturer at a ‘new’ public university in the North West of England. This research is timely and much needed, since teaching at universities in England has recently come under increasing scrutiny. The Teaching Excellence Framework is a new scheme, which aims to recognise and reward excellence in teaching, learning, and outcomes, and helps to inform student choice. This paper is theoretically framed by drawing on notions of theatrical performance, and performativity. This paper offers insight into the coping strategies, in respect of teaching, that I deployed as a new university lecturer. Findings are discussed around the themes of: performing teaching identities, and inauthenticity. With regard to performing teaching identities, this paper discusses the need for identity to be multiple and shifting, and how, as a young female, I undertook identity work, in order to perform competence. I also bring to the fore feelings of inauthenticity; that is, how I did not feel as if I was a genuine academic, and how I fabricated / falsified aspects of my academic identity in order to ‘fit in’ with the expectations of both students and staff. As the voice of a new lecturer in her first year of teaching, this paper makes a useful contribution to the scholarship on early career academics and teaching development. This paper concludes with recommendations for change in practice-based settings, in order to assist new lecturers to settle into the job role, and enhance and enrich teaching practice.

IntroductionThe German health technology assessment (HTA) rejected additional benefit of alectinib for second line (2L) ALK+ NSCLC, citing possible biases from missing ECOG performance status data and unmeasured confounding in real-world evidence (RWE) for 2L ceritinib that was submitted as a comparator to the single arm alectinib trial. Alectinib was approved in the US and therefore US post-launch RWE can be used to evaluate this HTA decision.MethodsWe compared the real-world effectiveness of alectinib with ceritinib in 2L post-crizotinib ALK+ NSCLC using the nationwide Flatiron Health electronic health record (EHR)-derived de-identified database. Using quantitative bias analysis (QBA), we estimated the strength of (i) unmeasured confounding and (ii) deviation from missing-at-random (MAR) assumptions needed to nullify any overall survival (OS) benefit.ResultsAlectinib had significantly longer median OS than ceritinib in complete case analysis. The estimated effect size (Hazard Ratio: 0.55) was robust to risk ratios of unmeasured confounder-outcome and confounder-exposure associations of Based on tipping point analysis, missing baseline ECOG performance status for ceritinib-treated patients (49% missing) would need to be more than 3.4-times worse than expected under MAR to nullify the OS benefit observed for alectinib.ConclusionsOnly implausible levels of bias reversed our conclusions. These methods could provide a framework to explore uncertainty and aid decision-making for HTAs to enable patient access to innovative therapies.

This article adopts a reflexive stance as the authors look back on their doctoral research projects; the first author exploring young people’s relationships with community radio, and the second author studying young people’s alcohol consumption practices and experiences, both in the North West of England, UK. The authors discuss the methods of data collection they employed, which enabled young people the opportunity to participate in meaningful ways. However, drawing on snapshots from their PhD theses, the authors question whether decisions made when writing up related to protecting anonymity, (re)presenting speech characteristics, and editing, independently of participants, potentially undid some of the hard work exerted in creating an equitable space for young people’s contributions, resultantly perpetuating the regulation of young people and keeping them ‘in their place’. The authors propose some recommendations for facilitating the inclusion of young people in the writing up of participatory research.

Aim To assess the comparative effects of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors, sulphonylureas (SUs) and dipeptidyl peptidase‐4 (DPP‐4) inhibitors on cardiometabolic risk factors in routine care. Materials and methods Using primary care data on 10 631 new users of SUs, SGLT2 inhibitors or DPP‐4 inhibitors added to metformin, obtained from the UK Clinical Practice Research Datalink, we created propensity‐score matched cohorts and used linear mixed models to describe changes in glycated haemoglobin (HbA1c), estimated glomerular filtration rate (eGFR), systolic blood pressure (BP) and body mass index (BMI) over 96 weeks. Results HbA1c levels fell substantially after treatment intensification for all drugs: mean change at week 12: SGLT2 inhibitors: −15.2 mmol/mol (95% confidence interval [CI] –16.9, −13.5); SUs: −14.3 mmol/mol (95% CI –15.5, −13.2); and DPP‐4 inhibitors: −11.9 mmol/mol (95% CI –13.1, −10.6). Systolic BP fell for SGLT2 inhibitor users throughout follow‐up, but not for DPP‐4 inhibitor or SU users: mean change at week 12: SGLT2 inhibitors: −2.3 mmHg (95% CI –3.8, −0.8); SUs: −0.8 mmHg (95% CI –1.9, +0.4); and DPP‐4 inhibitors: −0.9 mmHg (95% CI –2.1,+0.2). BMI decreased for SGLT2 inhibitor and DPP‐4 inhibitor users, but not SU users: mean change at week 12: SGLT2 inhibitors: −0.7 kg/m2 (95% CI –0.9, −0.5); SUs: 0.0 kg/m2 (95% CI –0.3, +0.2); and DPP‐4 inhibitors: −0.3 kg/m2 (95% CI –0.5, −0.1). eGFR fell at 12 weeks for SGLT2 inhibitor and DPP‐4 inhibitor users. At 60 weeks, the fall in eGFR from baseline was similar for each drug class. Conclusions In routine care, SGLT2 inhibitors had greater effects on cardiometabolic risk factors than SUs. Routine care data closely replicated the effects of diabetes drugs on physiological variables measured in clinical trials.

© 2019 Sage Publications and YOUNG Editorial Group. This article draws on qualitative research conducted with 40 young people, aged 15–24, in the Chorlton and Wythenshawe, Manchester, UK. With a focus on alcohol consumption, this article shows how older siblings transmit embodied knowledge to younger siblings. This article finds that older siblings are an important source of protection for younger siblings when starting their drinking careers. Moreover, they play a fundamental role in facilitating open intragenerational dialogue surrounding alcohol consumption. Through highlighting the important role of older siblings in transmitting embodied knowledge to younger siblings during the transition to adulthood, this article argues that there is a need to encourage greater involvement of siblings in formal educational settings surrounding learning about important issues, such as: alcohol consumption; drug consumption; and relationships and sex education, to help ensure consistent messages.

This chapter considers the relationship between childhood disability and clothing. It reviews literature to discuss the social and symbolic status of clothing – both mainstream clothing and adaptive clothing – for disabled children. The chapter argues that rehabilitation professionals need to take clothing-related issues faced by disabled children seriously, so that opportunities for social participation can be maximised. It explains the stance of the social model of disability. The chapter discusses the social and symbolic status of clothing – both mainstream clothing and adaptive clothing – for disabled children and young people. It presents an overview of literature on children and clothing. The chapter deals with a call for rehabilitation professionals to take clothing-related issues faced by disabled children seriously – as opposed to considering them purely aesthetic – so that opportunities for social participation can be maximised. It considers the extent to which disabled children are othered by dress or, alternatively, use dress to feel less othered.© 2019 selection and editorial matter, Nadia von Benzon and Catherine Wilkinson; individual chapters, the contributors.

The perspective of domiciliary workers is needed to recruit a high-quality workforce and meet growing demand. An English ethnographic study yielded extensive insights. To structure analysis of the study data, we apply a method developed by political theorists Boltanski and Thevenot that identifies key variables in different values systems. This "orders of worth" framework is used to map out the distinctive features of the subjective world of home carers. The results can be drawn on to formulate recruitment and retention policies, to design reward strategies or to ensure that training and education opportunities engage effectively with the workforce.