Search

Your search keyword '"Samanta, Ipsita"' showing total 6 results
Start Over Author "Samanta, Ipsita"
6 results on '"Samanta, Ipsita"'

6. Thyroid dysfunction modulates glucoregulatory mechanism in rat.

Author

Chakrabarti S, Guria S, Samanta I, and Das M

Subjects
Alanine Transaminase blood, Animals, Blood Glucose analysis, Body Weight, Glucose Tolerance Test, Hyperthyroidism blood, Hyperthyroidism metabolism, Hyperthyroidism pathology, Hypothyroidism blood, Hypothyroidism metabolism, Hypothyroidism pathology, Liver Glycogen analysis, Metabolic Networks and Pathways physiology, Rats, Thyroid Diseases blood, Thyroxine blood, Triiodothyronine blood, Glucose metabolism, Thyroid Diseases metabolism, Thyroid Diseases pathology
Abstract

The role of the thyroid gland in glucose homeostasis remains incompletely understood. To get a better insight hypo-and hyperthyroid conditions were experimentally induced in rat and found severe defects in glucose homeostasis. While blood glucose level returned to normal level after 2.5 hr of oral glucose challenge in control rats the blood glucose level remained high even after 24 hr of glucose load in both hypo- and hyperthyroid rats. These experimentally manipulated rats displayed higher levels of liver glycogen (10.45-22.8-fold) and serum glutamic pyruvic transaminase (1.48-9.8-fold). Liver histology of hyperthyroid treated rats revealed hepatotoxicity. From the results it can be concluded that thyroid gland plays an important role in glucose homeostasis.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results