1. Association of low vitamin D levels with metabolic syndrome in hemodialysis patients
- Author
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Mitra Mahdavi-Mazdeh, Mahboob Lessan-Pezeshki, Farrokhlagha Ahmadi, Effat Razeghi, Sima Maziar, and Samaneh Damghani
- Subjects
education.field_of_study ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Population ,Parathyroid hormone ,030209 endocrinology & metabolism ,Hematology ,Odds ratio ,030204 cardiovascular system & hematology ,medicine.disease ,Obesity ,vitamin D deficiency ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Nephrology ,Internal medicine ,medicine ,Vitamin D and neurology ,Hemodialysis ,Metabolic syndrome ,education ,business - Abstract
Low vitamin D levels have been linked to metabolic syndrome in the general population. In the present study, the relationship between inadequate serum concentrations of vitamin D and metabolic syndrome in patients with end-stage renal disease undergoing hemodialysis was explored. In a cross-sectional setting, 145 patients undergoing maintenance hemodialysis were enrolled. Metabolic syndrome was defined using the International Diabetes Federation criteria. Serum concentration of 25(OH) vitamin D was determined by a commercially available enzyme immunosorbent assay method. The prevalence of metabolic syndrome was 53.1%. The prevalence rate of severe vitamin D deficiency ( 30 ng/mL) 29.0%. With the increasing number of metabolic abnormalities, vitamin D levels significantly decreased (P for trend = 0.028). Among the components of metabolic syndrome, vitamin D deficiency was significantly associated with central obesity (odds ratio [OR], 95% confident interval [CI] = 2.80, 1.11-7.04, P = 0.028). A positive, but nonsignificant association between vitamin D deficiency and raised fasting plasma glucose was noted (OR, 95% CI = 2.40, 0.94-6.11, P = 0.067). Both vitamin D deficiency and insufficiency were significantly associated with an increased likelihood of having metabolic syndrome (P < 0.05). In a final model controlling for age, sex, and parathyroid hormone levels, vitamin D deficiency increased the odds of having metabolic syndrome by more than threefold (OR, 95% CI = 3.26, 1.30-8.20, P = 0.012). Low levels of vitamin D are frequent among hemodialysis patients and are associated with the metabolic syndrome.
- Published
- 2015