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11. Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype.

Author

Rasaei, Niloufar, Fatemi, Seyedeh Fatemeh, Gholami, Fatemeh, Samadi, Mahsa, Mohammadian, Mohammad Keshavarz, Daneshzad, Elnaz, and Mirzaei, Khadijeh

Subjects
GENETIC risk score, BODY composition, ESSENTIAL fatty acids, DISEASE risk factors, NUTRITION
Abstract

Background: The growth in obesity and rates of abdominal obesity in developing countries is due to the dietary transition, meaning a shift from traditional, fiber-rich diets to Westernized diets high in processed foods, sugars, and unhealthy fats. Environmental changes, such as improving the quality of dietary fat consumed, may be useful in preventing or mitigating the obesity or unhealthy obesity phenotype in individuals with a genetic predisposition, although this has not yet been confirmed. Therefore, in this study, we investigated how dietary fat quality indices with metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUO) based on the Karelis criterion interact with genetic susceptibility in Iranian female adults. Methods: In the current cross-sectional study, 279 women with overweight or obesity participated. Dietary intake was assessed using a 147-item food frequency questionnaire and dietary fat quality was assessed using the cholesterol-saturated fat index (CSI) and the ratio of omega-6/omega-3 (N6/N3) essential fatty acids. Three single nucleotide polymorphisms-MC4R (rs17782313), CAV-1 (rs3807992), and Cry-1(rs2287161) were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and were combined to produce the genetic risk score (GRS). Body composition was evaluated using a multi-frequency bioelectrical impedance analyzer. Participants were divided into MHO or MUO phenotypes after the metabolic risk assessment based on the Karelis criteria. Results: We found significant interactions between GRS and N6/N3 in the adjusted model controlling for confounding factors (age, body mass index, energy, and physical activity) (β = 2.26, 95% CI: 0.008 to 4.52, P = 0.049). In addition, we discovered marginally significant interactions between GRS and N6/N3 in crude (β = 1.92, 95% CI: -0.06 to 3.91, P = 0.058) and adjusted (age and energy) (β = 2.00, 95% CI: -0.05 to 4.05, P = 0.057) models on the MUH obesity phenotype. However, no significant interactions between GRS and CSI were shown in both crude and adjusted models. Conclusion: This study highlights the importance of personalized nutrition and recommends further study of widely varying fat intake based on the findings on gene-N6/N3 PUFA interactions. [ABSTRACT FROM AUTHOR]

Published
2025
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16. Mechanisms of mGluR-dependent plasticity in hippocampal area CA2

Author

Samadi, Mahsa, Hales, Claire A., Lustberg, Daniel J., Farris, Shannon, Ross, Madeleine R., Zhao, Meilan, Hepler, John R., Harbin, Nicholas H., Robinson, Emma S. J., Banks, Paul J., Bashir, Zafar I., Dudek, Serena M., Samadi, Mahsa, Hales, Claire A., Lustberg, Daniel J., Farris, Shannon, Ross, Madeleine R., Zhao, Meilan, Hepler, John R., Harbin, Nicholas H., Robinson, Emma S. J., Banks, Paul J., Bashir, Zafar I., and Dudek, Serena M.

Abstract

Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the other CA subregions. Notably, this includes a lack of typical long-term potentiation of stratum radiatum synapses. CA2 neurons express high levels of several known and potential regulators of metabotropic glutamate receptor (mGluR)-dependent signaling including Striatal-Enriched Tyrosine Phosphatase (STEP) and several Regulator of G-protein Signaling (RGS) proteins, yet the functions of these proteins in regulating mGluR-dependent synaptic plasticity in CA2 are completely unknown. Thus, the aim of this study was to examine mGluR-dependent synaptic depression and to determine whether STEP and the RGS proteins RGS4 and RGS14 are involved. Using whole cell voltage-clamp recordings from mouse pyramidal cells, we found that mGluR agonist-induced long-term depression (mGluR-LTD) is more pronounced in CA2 compared with that observed in CA1. This mGluR-LTD in CA2 was found to be protein synthesis and STEP dependent, suggesting that CA2 mGluR-LTD shares mechanistic processes with those seen in CA1, but in addition, RGS14, but not RGS4, was essential for mGluR-LTD in CA2. In addition, we found that exogenous application of STEP could rescue mGluR-LTD in RGS14 KO slices. Supporting a role for CA2 synaptic plasticity in social cognition, we found that RGS14 KO mice had impaired social recognition memory as assessed in a social discrimination task. These results highlight possible roles for mGluRs, RGS14, and STEP in CA2-dependent behaviors, perhaps by biasing the dominant form of synaptic plasticity away from LTP and toward LTD in CA2.

Published
2023

17. Mechanisms of mGluR‐dependent plasticity in hippocampal area CA2

Author

Samadi, Mahsa, primary, Hales, Claire A., additional, Lustberg, Daniel J., additional, Farris, Shannon, additional, Ross, Madeleine R., additional, Zhao, Meilan, additional, Hepler, John R., additional, Harbin, Nicholas H., additional, Robinson, Emma S. J., additional, Banks, Paul J., additional, Bashir, Zafar I., additional, and Dudek, Serena M., additional

Published
2023
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23. Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder

Author

Mohammadzadeh Honarvar, Niyaz, primary, Samadi, Mahsa, additional, Seyedi Chimeh, Marzieh, additional, Gholami, Fatemeh, additional, Bahrampour, Niki, additional, Jalali, Mahmoud, additional, Effatpanah, Mohammad, additional, Yekaninejad, Mir Saeid, additional, Abdolahi, Mina, additional, and Chamari, Maryam, additional

Published
2022
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24. Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Author

Rasaei, Niloufar, primary, Asbaghi, Omid, additional, Samadi, Mahsa, additional, Setayesh, Leila, additional, Bagheri, Reza, additional, Gholami, Fatemeh, additional, Soveid, Neda, additional, Casazza, Krista, additional, Wong, Alexei, additional, Suzuki, Katsuhiko, additional, and Mirzaei, Khadijeh, additional

Published
2021
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27. Young Adult Experience in an Outpatient Interdisciplinary Palliative Care Cancer Clinic

Author

Avery, Jonathan, primary, Mosher, Pamela J., additional, Kassam, Alisha, additional, Srikanthan, Amirrtha, additional, D’Agostino, Norma, additional, Zimmermann, Camilla, additional, Castaldo, Yan, additional, Aubrey, Rachel, additional, Rodrigues, Caroline M., additional, Thavaratnam, Adrian, additional, Samadi, Mahsa, additional, Al-Awamer, Ahmed, additional, and Gupta, Abha, additional

Published
2020
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28. Evaluation of an Educational Whiteboard Video to Introduce Fertility Preservation to Female Adolescents and Young Adults With Cancer

Author

Greenspoon, Talia, primary, Charow, Rebecca, additional, Papadakos, Janet, additional, Samadi, Mahsa, additional, Maloney, Anne Marie, additional, Paulo, Chelsea, additional, Forcina, Victoria, additional, Chen, Li, additional, Thavaratnam, Adrian, additional, Mitchell, Laura, additional, Lorenzo, Armando, additional, and Gupta, Abha A., additional

Published
2020
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29. “It’s More Difficult…”: Clinicians’ Experience Providing Palliative Care to Adolescents and Young Adults Diagnosed With Advanced Cancer

Author

Avery, Jonathan, primary, Geist, Arielle, additional, D’Agostino, Norma Mammone, additional, Kawaguchi, Sarah K., additional, Mahtani, Ramona, additional, Mazzotta, Paolo, additional, Mosher, Pamela J., additional, al-Awamer, Ahmed, additional, Kassam, Alisha, additional, Zimmermann, Camilla, additional, Samadi, Mahsa, additional, Tam, Seline, additional, Srikanthan, Amirrtha, additional, and Gupta, Abha, additional

Published
2020
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30. The Effect of Vitamin D3 Supplementation on Serum BDNF, Dopamine, and Serotonin in Children with Attention-Deficit/Hyperactivity Disorder

Author

Seyedi, Marzieh, primary, Gholami, Fatemeh, additional, Samadi, Mahsa, additional, Djalali, Mahmoud, additional, Effatpanah, Mohammad, additional, Yekaninejad, Mir Saeed, additional, Hashemi, Rezvan, additional, Abdolahi, Mina, additional, Chamari, Maryam, additional, and Honarvar, Niyaz Mohammadzadeh, additional

Published
2019
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32. Using a video to introduce fertility preservation to women with cancer.

Author

Gupta, Abha A., primary, Lenton-Brym, Talia, additional, Charow, Rebecca, additional, Paulo, Chelsea, additional, Samadi, Mahsa, additional, Forcina, Victoria, additional, Chen, Shian Li, additional, Thavaratnam, Adrian, additional, Mitchell, Laura, additional, Lorenzo, Armando J., additional, and Papadakos, Janet, additional

Published
2019
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