1. Antidotes for Acute Bismuth Intoxication
- Author
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Mark A. Basinger, Mark M. Jones, and Sam. A. McCroskey
- Subjects
Male ,Chemistry ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Bismuth poisoning ,Antidotes ,Penicillamine ,chemistry.chemical_element ,Pharmacology ,Toxicology ,Phosphonate ,Median lethal dose ,Bismuth ,Mice ,chemistry.chemical_compound ,Acute Disease ,Toxicity ,medicine ,Animals ,Chelation ,Antidote ,Chelating Agents ,medicine.drug - Abstract
Nine chelating agents were tested as antidotes for acute bismuth intoxication in mice. Of these, those with sulfhydryl groups, adjacent aromatic hydroxy groups or appropriately positioned phosphonate groups proved themselves to be effective antidotes. Of the compounds currently approved for therapeutic use, D-penicillamine was the most effective.
- Published
- 1983
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