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1. Parallel Statistical Model Checking for Safety Verification in Smart Grids

Author

Mancini, T., Mari, F., Melatti, I., Salvo, I., Tronci, E., Gruber, J. K., Hayes, B., Prodanovic, M., and Elmegaard, L.

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Distributed, Parallel, and Cluster Computing, 68Q60, I.6.3, J.2
Abstract

By using small computing devices deployed at user premises, Autonomous Demand Response (ADR) adapts users electricity consumption to given time-dependent electricity tariffs. This allows end-users to save on their electricity bill and Distribution System Operators to optimise (through suitable time-dependent tariffs) management of the electric grid by avoiding demand peaks. Unfortunately, even with ADR, users power consumption may deviate from the expected (minimum cost) one, e.g., because ADR devices fail to correctly forecast energy needs at user premises. As a result, the aggregated power demand may present undesirable peaks. In this paper we address such a problem by presenting methods and a software tool (APD-Analyser) implementing them, enabling Distribution System Operators to effectively verify that a given time-dependent electricity tariff achieves the desired goals even when end-users deviate from their expected behaviour. We show feasibility of the proposed approach through a realistic scenario from a medium voltage Danish distribution network., Comment: 6 pages, 1 figure. In SmartGridComm 2018. IEEE, 2018

Published
2021
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2. 1st Italian SMA Family Association Consensus Meeting:: Management and recommendations for respiratory involvement in spinal muscular atrophy (SMA) types I–III, Rome, Italy, 30–31 January 2015

Author

Agosto, C., Banfi, P., Baranello, G., Bignamini, E., Chiarini, M.B., Cutrera, R., D'amico, A., Dusio, M., Fanfulla, F., Garuti, G., Giretti, R., Gorni, K., Gregoretti, C., Luccoli, L., Messina, S., Pane, M., Pavone, M., Pedemonte, M., Pera, M.C., Piastra, M., Profazio, C., Rao, F., Salvo, I., Testa, R., Villanova, M., Sansone, V.A., Racca, F., Ottonello, G., Vianello, A., Berardinelli, A., Crescimanno, G., and Casiraghi, J.L.

Published
2015
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12. The CanMEDS scholar: the neglected competency in tomorrow's doctors

Author

Ologunde R, Di Salvo I, and Khajuria A

Subjects
Special aspects of education, LC8-6691, Medicine (General), R5-920
Abstract

Rele Ologunde,1 Ivana Di Salvo,2,3 Ankur Khajuria1 1Imperial College School of Medicine, Imperial College London, London, UK; 2Faculty of Medicine and Surgery, University of Pavia, Pavia, Italy; 3International Federation of Medical Students' Associations, Ferney-Voltaire, FranceIn 1996, the Royal College of Physicians and Surgeons of Canada proposed a competency-based framework describing the core competencies of specialist physicians, one of which was a scholar.1 The UK General Medical Council has since provided advice on developing teachers and trainers in undergraduate medical education.2 However, guidance about how to most effectively incorporate this advice into the medical curriculum remains unclear.

Published
2014

16. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

Author

Davidson, Aj, Frawley, G, Hardy, P, Arnup, Sj, Schuster, T, Lee, K, Hunt, Rw, Stargatt, R, Sheppard, S, Ormond, Gd, Hartmann, Pl, Takagi, Mj, Malarbi, S, Doyle, M, Ragg, P, Backstrom, M, Costi, D, von Ungern Sternberg, Bs, Wilton, Nc, Knottenbelt, G, Disma, NICOLA MASSIMO, Montobbio, G, Mameli, L, Tuo, P, Girbaldi, G, PINI PRATO, Alessio, Mattioli, Girolamo, Wolfler, A, Izzo, F, Salvo, I, Sonzogni, V, Locatelli, Bg, Khotcholava, M, de Graaff, Jc, van Gool, Jt, Numan, Sc, van Veldhuijzen, D, Kalkman, Cj, van Baar, Al, Steenis, Lj, Hagenaars, Jh, Absalom, Ar, Hoekstra, Fm, Volkers, M, Withington, D, Furue, K, Gaudreault, J, Mccann, Me, Berde, C, Soriano, S, Young, V, Sethna, N, Kovatsis, P, Cravero, J, Bellinger, D, Marmor, J, Lynn, A, Ivanova, I, Hunyady, A, Verma, S, Polaner, D, Thomas, J, Mueller, M, Haret, D, Szmuk, P, Steiner, J, Kravitz, B, Surantham, S, Hays, S, Taenzer, A, Maxwell, L, Williams, Rk, Morton, Ns, Bell, G, Dorris, L, Adey, C, Pownall, J, Bagshaw, O, Chisakuta, A, Eissa, A, Stoddart, P, Davis, A, Myles, P, Withngton, De, Degraaff, Jc, Bellinger, Dc, Wolf, A, Mcintosh, N, Carlin, J, Leslie, K, de Lima, J, Hammer, G, Field, D, Gebski, V, Tibboel, D., Development and Treatment of Psychosocial Problems, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
Male, Pediatrics, Hernia, Research Support, U.S. Gov't, P.H.S, CHILDREN, P.H.S, Bayley Scales of Infant Development, law.invention, Child Development, 0302 clinical medicine, Randomized controlled trial, 030202 anesthesiology, law, Medicine, Anesthesia, General anaesthesia, Non-U.S. Gov't, Child, BIRTH COHORT, Wechsler Preschool and Primary Scale of Intelligence, Research Support, Non-U.S. Gov't, Medicine (all), CHILDHOOD EXPOSURE, Age Factors, Wechsler Scales, Brain, Gestational age, General Medicine, Multicenter Study, Inguinal, Randomized Controlled Trial, Cohort, CLINICAL-RESEARCH, Female, Cohort study, medicine.medical_specialty, Spinal, Gestational Age, Anesthesia, General, Anesthesia, Spinal, Child, Preschool, Double-Blind Method, Hernia, Inguinal, Herniorrhaphy, Humans, Infant, Research Support, ACADEMIC-PERFORMANCE, N.I.H, DEVELOPING BRAIN, 03 medical and health sciences, Research Support, N.I.H., Extramural, EARLY EXPOSURE, 030225 pediatrics, Journal Article, Toddler, General, Preschool, business.industry, Extramural, LEARNING-DISABILITIES, CELL-DEATH, NEUROTOXICITY, U.S. Gov't, business
Abstract

Background Preclinical data suggest that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia can have an increased risk of poor neurodevelopmental outcome. We aimed to establish whether general anaesthesia in infancy has any effect on neurodevelopmental outcome. Here we report the secondary outcome of neurodevelopmental outcome at 2 years of age in the General Anaesthesia compared to Spinal anaesthesia (GAS) trial.Methods In this international assessor-masked randomised controlled equivalence trial, we recruited infants younger than 60 weeks postmenstrual age, born at greater than 26 weeks ' gestation, and who had inguinal herniorrhaphy, from 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and New Zealand. Infants were randomly assigned (1:1) to receive either awake-regional anaesthesia or sevoflurane-based general anaesthesia. Web-based randomisation was done in blocks of two or four and stratified by site and gestational age at birth. Infants were excluded if they had existing risk factors for neurological injury. The primary outcome of the trial will be the Wechsler Preschool and Primary Scale of Intelligence Third Edition (WPPSI-III) Full Scale Intelligence Quotient score at age 5 years. The secondary outcome, reported here, is the composite cognitive score of the Bayley Scales of Infant and Toddler Development III, assessed at 2 years. The analysis was as per protocol adjusted for gestational age at birth. A difference in means of five points (1/3 SD) was predefined as the clinical equivalence margin. This trial is registered with ANZCTR, number ACTRN12606000441516 and ClinicalTrials.gov, number NCT00756600.Findings Between Feb 9, 2007, and Jan 31, 2013, 363 infants were randomly assigned to receive awake-regional anaesthesia and 359 to general anaesthesia. Outcome data were available for 238 children in the awake-regional group and 294 in the general anaesthesia group. In the as-per-protocol analysis, the cognitive composite score (mean [SD]) was 98.6 (14.2) in the awake-regional group and 98.2 (14.7) in the general anaesthesia group. There was equivalence in mean between groups (awake-regional minus general anaesthesia 0.169, 95% CI-2.30 to 2.64). The median duration of anaesthesia in the general anaesthesia group was 54 min.Interpretation For this secondary outcome, we found no evidence that just less than 1 h of sevoflurane anaesthesia in infancy increases the risk of adverse neurodevelopmental outcome at 2 years of age compared with awake-regional anaesthesia.Funding Australia National Health and Medical Research Council (NHMRC), Health Technologies Assessment-National Institute for Health Research UK, National Institutes of Health, Food and Drug Administration, Australian and New Zealand College of Anaesthetists, Murdoch Childrens Research Institute, Canadian Institute of Health Research, Canadian Anesthesiologists ' Society, Pfizer Canada, Italian Ministry of Heath, Fonds NutsOhra, and UK Clinical Research Network (UKCRN).

Published
2016

17. Extracellular Vesicles Derived from Wharton's Jelly Mesenchymal Stem Cells Prevent and Resolve Programmed Cell Death Mediated by Perinatal Hypoxia-Ischemia in Neuronal Cells

Author

Philipp Schneider, Marianne Joerger-Messerli, Gierin Florence Thomi, Marialuigia Spinelli, Andreina Schoeberlein, di Salvo I, and Byron Oppliger

Subjects
0301 basic medicine, Programmed cell death, Biomedical Engineering, lcsh:Medicine, Caspase 3, 03 medical and health sciences, Extracellular Vesicles, Mice, Ischemia, Cell Line, Tumor, Wharton's jelly, In Situ Nick-End Labeling, Animals, Wharton Jelly, 610 Medicine & health, Hypoxia, Cells, Cultured, neuroregeneration, Neurons, Transplantation, Chemistry, lcsh:R, Mesenchymal stem cell, apoptosis, let-7-5p, Mesenchymal Stem Cells, Cell Biology, Articles, Neuroregeneration, Cell biology, MicroRNAs, 030104 developmental biology, Cell culture, Apoptosis, 570 Life sciences, biology, DNA fragmentation, oxygen–glucose deprivation/reoxygenation (OGD/R), neuroprotection, extracellular vesicles (EVs)
Abstract

Hypoxic-ischemic (HI) insult in the perinatal phase harbors a high risk of encephalopathy in the neonate. Brain cells undergo apoptosis, initiating neurodegeneration. So far, therapeutic approaches such as cooling remain limited. Transplantation of mesenchymal stem cells (MSCs) exhibits therapeutic success despite the short-time survival in the host brain, providing strong evidence that their beneficial effects are largely based on secreted factors, including extracellular vesicles (EVs). The aim of this study was to investigate the effects of human Wharton’s jelly MSC (hWJ-MSC)-derived EVs on neuroprotection and neuroregeneration, using an in vitro model of oxygen–glucose deprivation/reoxygenation (OGD/R) mimicking HI injury in the mouse neuroblastoma cell line neuro2a (N2a). hWJ-MSC-derived EVs were isolated from cell culture supernatants by multistep centrifugation and identified by endosomal marker expression and electron microscopy. OGD/R significantly increased DNA fragmentation and caspase 3 ( Casp3) transcription in N2a cells relative to undamaged cells. OGD/R-mediated DNA fragmentation and Casp3 expression could be prevented as well as resolved by the addition of hWJ-MSC-derived EV before and after OGD, respectively. hWJ-MSC-derived EV also tended to increase the phosphorylation of the B cell lymphoma 2 (Bcl2) family member Bcl-2-antagonist of cell death (BAD) in N2a cells, when added prior or post OGD, thereby inactivating the proapoptotic function of BAD. Fluorescence confocal microscopy revealed the close localization of hWJ-MSC-derived EVs to the nuclei of N2a cells. Furthermore, EVs released their RNA content into the cells. The expression levels of the microRNAs (miRs) let-7a and let-7e, known regulators of Casp3, were inversely correlated to Casp3. Our data suggest that hWJ-MSC-derived EVs have the potential to prevent and resolve HI-induced apoptosis in neuronal cells in the immature neonatal brain. Their antiapoptotic effect seems to be mediated by the transfer of EV-derived let-7-5p miR.

Published
2018

18. Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction

Author

Mancini, T, Mari, F, Massini, A, Melatti, I, Salvo, I, Sinisi, S, Tronci, Enrico; https://orcid.org/0000-0002-0377-3119, Ehrig, R, Röblitz, S, Leeners, Brigitte, Mancini, T, Mari, F, Massini, A, Melatti, I, Salvo, I, Sinisi, S, Tronci, Enrico; https://orcid.org/0000-0002-0377-3119, Ehrig, R, Röblitz, S, and Leeners, Brigitte

Abstract

In Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.

Published
2018

19. Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Author

Barbero, F, Russo, L, Vitali, M, Piella, J, Salvo, I, Borrajo, M, Busquets-Fité, M, Grandori, R, Bastús, N, Casals, E, Puntes, V, Borrajo, ML, Bastús, NG, Barbero, F, Russo, L, Vitali, M, Piella, J, Salvo, I, Borrajo, M, Busquets-Fité, M, Grandori, R, Bastús, N, Casals, E, Puntes, V, Borrajo, ML, and Bastús, NG

Abstract

The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.

Published
2017

20. Pharmacokinetic Profile of Isoflurane in Children

Author

Torri, G., Salvo, I., Righi, P., Calderini, E., Bordoli, W., Bergmann, H., editor, Brückner, J. B., editor, Gemperle, M., editor, Henschel, W. F., editor, Mayrhofer, O., editor, Meßmer, K., editor, Peter, K., editor, Lawin, Peter, editor, Van Aken, Hugo, editor, and Puchstein, Christoph, editor

Published
1986
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21. Nationwide study of headache pain in Italy shows that pain assessment is still inadequate in paediatric emergency care

Author

Benini, Franca, Piga, Simone, Zangardi, Tiziana, Messi, Gianni, Tomasello, Caterina, Pirozzi, Nicola, Cuttini, Marina, ocerino, A, Crichiutti, G, Barbi, E, Biban, P, Ghizzi, C, Benedetti, M, rrighini, A, Podestà, A F, Scalfaro, C, Stringhi, C, Rotta, S, Salvo, I R Di, Fossali, E, rbino, A, Taglietto, M, Marciano, C, Piccotti, E, Manfredini, L, Mannelli, F, Messeri, A, Cardoni, G, Piattellini, G M, Midulla, F, Chiaretti, A, Campa, A, Borrometi, F, Maremonti, P, Grandolfo, Rita, Fucà, F, and Parrino, R

Subjects
Male, Emergency Medical Services, Pediatrics, hospitals pediatric, 0302 clinical medicine, Pain assessment, Emergency medical services, Medicine, hospital, Child, hospitals general, Pain Measurement, Headache, Regular Article, quality indicators, General Medicine, Hospitals, Pediatric, health care, Italy, Child, Preschool, Practice Guidelines as Topic, Female, Emergency care, Guideline Adherence, Emergency Service, Hospital, medicine.medical_specialty, Adolescent, Pain, Hospitals, General, Disease cluster, preschool, 03 medical and health sciences, 030225 pediatrics, child, emergency care, headache, pain assessment, pain management, adolescent, emergency medical services, emergency service, hospital, female, guideline adherence, humans, male, pain measurement, pediatrics, practice guidelines as topic, retrospective studies, triage, perinatology and child health, Humans, Online Only Articles, Quality Indicators, Health Care, Retrospective Studies, emergency service, business.industry, Retrospective cohort study, Odds ratio, Emergency department, Triage, Pain management, Pediatrics, Perinatology and Child Health, Emergency medicine, Observational study, business, 030217 neurology & neurosurgery, Regular Articles
Abstract

Aim Italian national guidelines on pain management were published in 2010, but there is little information on how effective pain management is in paediatric emergency care, with other countries reporting poor levels. Using headache as an indicator, we described pain assessment in Italian emergency departments and identified predictors of algometric scale use. Methods All Italian paediatric and maternal and child hospitals participated, plus four general hospitals. Data on all children aged 4–14 years admitted during a one-month period with headache as their chief complaint were abstracted from clinical records. Multivariable analyses identified predictors of algometric assessment, taking into account the cluster study design. Results We studied 470 admissions. During triage, pain was assessed using a standardised scale (41.5%), informally (15.5%) or was not recorded (42.9%). Only 32.1% of the children received analgesia in the emergency department. The odds ratios for predictors of algometric assessment were non-Italian nationality (3.6), prehospital medication (1.8), admission to a research hospital (7.3) and a more favourable nurses-to-admissions ratio of 10.8 for the highest versus lowest tertile. Conclusion Despite national guidelines, paediatric pain assessment in Italian emergency care was suboptimal. Hospital variables appeared to be stronger predictors of adequate assessment than patient characteristics.

Published
2016

23. Recommendations for anesthesia and sedation in nonoperating room locations [Raccomandazioni per l'esecuzione dell'anestesia e della sedazione al di fuori dei blocchi operatori]

Author

Calderini, E., Accorsi, A., Adrario, E., Bettelli, G., Cornara, G., Gasperi, A., Della Rocca, G., Di Castri, D., Frova, G., Gregorini, P., Iapichino, G., Landoni, G., Lombardo, G., Mondello, E., Paolillo, G. M., Peduto, V. A., Petrini, F., Piazza, L., Pierdominici, S., Pietropaoli, P., Rosi, R., Salvo, I., Santagostino, R., Savoia, G., Serafini, G., maurizio solca, Stella, L., Tavola, M., Torri, G., Tufano, R., Vesconi, S., Zoia, E., Zuccoli, P., Calderini, E, Accorsi, A, Adrario, E, Bettelli, G, Cornara, G, De Gasperi, A, Della Rocca, G, Di Castri, D, Frova, G, Gregorini, P, Iapichino, G, Landoni, Giovanni, Lombardo, G, Mondello, E, Paolillo G., M, Peduto V., A, Petrini, F, Piazza, L, Pierdominici, S, Pietropaoli, P, Rosi, R, Salvo, I, Santagostino, R, Savoia, G, Serafini, G, Solca, M, Stella, L, Tavola, M, Torri, G, Tufano, R, Vesconi, S, Zoia, E, Zuccoli, P., Calderini, E., Accorsi, A., Adrario, E., Bettelli, G., Cornara, G., De Gasperi, A., Della Rocca, G., Di Castri, D., Frova, G., Gregorini, P., Iapichino, G., Landoni, G., Lombardo, G., Mondello, E., Paolillo, G. M., Peduto, V. A., Petrini, F., Piazza, L., Pierdominici, S., Pietropaoli, P., Rosi, R., Salvo, I., Santagostino, R., Savoia, G., Serafini, G., Solca, M., Stella, L., Tavola, M., Torri, G., Tufano, Rosalba, Vesconi, S., and Zoia, E.

Published
2005

25. Longitudinal assessment of Upper Limb function in DMD patients: 12 month changes

Author

Sansone, V. A., Racca, F., Ottonello, G., Vianello, A., Berardinelli, A., Crescimanno, G., Agosto, C., Banfi, P., Baranello, G., Bignamini, E., Chiarini, M. B., Cutrera, R., D'Amico, A., Dusio, M., Fanfulla, F., Garuti, G., Giretti, R., Goorni, K., Gregoretti, C., Luccoli, L., Messina, Sonia, Pane, M., Pavone, M., Pedemonte, M., Pera, M. C., Piastra, M., Profazio, Claudia, Rao, F., Salvo, I., Testa, R., Villanova, M., and Casiraghi, J. L.

Published
2015

26. EMpowerment of PArents in THe Intensive Care Questionnaire: Translation and Validation in Italian PICUs

Author

Wolfler, A., Giannini, A., Finistrella, M., Salvo, I., Calderini, E., Frasson, G., Dall Oglio, I., Di Furia, M., Iuzzolino, R., Musicco, M., Latour, Jos, Wolfler, A., Giannini, A., Finistrella, M., Salvo, I., Calderini, E., Frasson, G., Dall Oglio, I., Di Furia, M., Iuzzolino, R., Musicco, M., and Latour, Jos

Abstract

Objectives: To translate and validate the EMpowerment of PArents in THe Intensive Care questionnaire to measure parent satisfaction and experiences in Italian PICUs. Design: Prospective, multicenter study. Setting: Four medical/surgical Italian PICUs in three tertiary hospitals. Patients: Families of children, 0-16 years old, admitted to the PICUs were invited to participate. Inclusion criteria were PICU length of stay greater than 24 hours and good comprehension of Italian language by parents/guardians. Exclusion criteria were readmission within 6 months and parents of a child who died in the PICU. Interventions: Distribution, at PICU discharge, of the EMpowerment of PArents in THe Intensive Care questionnaire with 65 items divided into five domains and a six-point rating scale: 1 "certainly no" to 6 "certainly yes." Measurements and Main Results: Back and forward translations of the EMpowerment of PArents in THe Intensive Care questionnaire between Dutch (original version) and Italian languages were deployed. Cultural adaptation of the instrument was confirmed by a consultation with a representative parent group (n = 10). Totally, 150 of 190 parents (79%) participated in the study. On item level, 12 statements scored a mean below 5.0. The Cronbach's [alpha], measured for internal consistency, on domain level was between 0.67 and 0.96. Congruent validity was measured by correlating the five domains with four gold standard satisfaction measures and showed adequate correlations (rs, 0.41-0.71; p < 0.05). No significant differences occurred in the nondifferential validity testing between three children's characteristics and the domains; excepting parents with a child for a surgical and planned admission were more satisfied on information and organization issues.Conclusions: The Italian version of the EMpowerment of PArents in THe Intensive Care questionnaire has satisfactory reliability and validity estimates and seems to be appropriate for Italian PICU setting. It is

Published
2016

27. Pediatric intensive care unit admission criteria for haematooncological patients: A basis for clinical guidelines implementation

Author

Piastra, M, Fognani, G, Franceschi, A, Pietrini, D, Tornesello, A, Ingelmo, P, Locatelli, F, Pession, A, Cogo, P, Cesaro, S, Conio, A, Grossetti, R, Ottonello, G, Gallini, C, Racca, F, Ferrero, F, Calderini, E, Chidini, G, Wolfler, A, Salvo, I, Lamperti, M, Codazzi, D, Fumagalli, R, Molinaro, Mg, Carnevale, L, Pettenazzo, A, Biban, P, Furlan, S, Savron, F, Pagni, R, Baroncini, S, Calamandrei, M, Marano, M, Stoppa, F, Pirozzi, N, Chiusolo, F, De Luca, D, Stival, E, Marzano, L, Caliandro, F, Conti, G, Testa, R, Savoia, G, Guddo, A, Gitto, Eloisa, Melchionda, G, Del Gaudio, A, Caione, R., Piastra, M, Fognani, G, Franceschi, A, Pietrini, D, Tornesello, A, Ingelmo, P, Locatelli, F, Pession, A, Cogo, P, Cesaro, S, Conio, A, Grossetti, R, Ottonello, G, Gallini, C, Racca, F, Ferrero, F, Calderini, E, Chidini, G, Wolfler, A, Salvo, I, Lamperti, M, Codazzi, D, Fumagalli, R, Molinaro, M, Carnevale, L, Pettenazzo, A, Biban, P, Furlan, S, Savron, F, Pagni, R, Baroncini, S, Calamandrei, M, Marano, M, Stoppa, F, Pirozzi, N, Chiusolo, F, De Luca, D, Stival, E, Marzano, L, Caliandro, F, Conti, G, Testa, R, Savoia, G, Guddo, A, Gitto, E, Melchionda, G, Del Gaudio, A, and Caione, R

Subjects
medicine.medical_specialty, lcsh:Medicine, Case Report, critically ill, Children, Critically ill, Intensive Care, Malignancy, Pediatric intensive care unit admission criteria, Pediatrics, law.invention, law, Critical care nursing, Intensive care, medicine, Intensive care medicine, Pediatric intensive care unit, business.industry, Septic shock, lcsh:R, lcsh:RJ1-570, Cancer, lcsh:Pediatrics, MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, medicine.disease, Intensive care unit, Respiratory failure, business
Abstract

Cancer remains a major death cause in children, though outcomes have considerably improved over the past decades (1-3). Outcomes for children diagnosed with cancer have changed since ’70 from 80% mortality to 80% survival (2), while children with solid tumors 5-year survival has been reported as 67%, cure rates for childhood leukemia now approach 90% [4-5). Moreover, hematopoietic stem cell transplantation (HSCT) indications are still expanding for both malignant and non-malignant diseases.

Published
2011

28. Long-term home ventilation of children in Italy: A national survey

Author

Racca, Federico, Berta, G, Sequi, M, Bignamini, E, Capello, Elena, Cutrera, R, Ottonello, G, Ranieri, Vito Marco, Salvo, I, Testa, R, Wolfler, A, Bonati, M, Anna, Costantino, Raffaella, Pagni, Anna Maria Miorelli, Paolo, Castaldi, Mariano, Cabras, Bruno, Dengo, Augusto, Biasini, Francesco, Morandi, Carlo, Minetti, Giancarlo, Ottonello, Paolo, Banfi, Maurizio, Bonati, Edoardo, Calderini, Edi, Prandi, Ida, Salvo, Marco, Sequi, Andrea, Wolfler, Marco, Zucconi, Giuseppe, Fiorentino, Antonio, Maddalena, Raffaele, Testa, Grazia, Crescimanno, Anna, Guddo, Livio, Carnevale, Andrea, Vianello, Giancarlo, Piccinini, Valter, Bottari, Maurizio, Corbari, Renato, Cutrera, Martino, Pavone, Berta, Giacomo, Elisabetta, Bignamini, Elena, Capello, DEL SORBO, Lorenzo, Cesare, Gregoretti, Maria, Maspoli, Fabrizio, Racca, Ranieri, Marco V., Antonio, Peratoner, Monica, Benedetti, Racca F, Berta G, Sequi M, Bignamini E, Capello E, Cutrera R, Ottonello G, RANIERI, VITO MARCO, Salvo I, Testa R, Wolfler A, Bonati M, on Anna Costantino, Raffaella Pagni, Anna Maria Miorelli, Paolo Castaldi, Mariano Cabra, Bruno Dengo, Augusto Biasini, Francesco Morandi, Carlo Minetti, Giancarlo Ottonello, Paolo Banfi, Maurizio Bonati, Edoardo Calderini, Edi Prandi, Ida Salvo, Marco Sequi, Andrea Wolfler, Marco Zucconi, Giuseppe Fiorentino, Antonio Maddalena, Raffaele Testa, Grazia Crescimanno, Anna Guddo, Livio Carnevale, Andrea Vianello, Giancarlo Piccinini, Valter Bottari, Maurizio Corbari, Renato Cutrera, Martino Pavone, Giacomo Berta, Elisabetta Bignamini, Elena Capello, Lorenzo Del Sorbo, Cesare Gregoretti, Maria Maspoli, Fabrizio Racca, Marco V. Ranieri, Antonio Peratoner, and Monica Benedetti

Subjects
Male, Time Factors, Adolescent, Home Care Services, Respiration, Artificial, Patient Discharge, House Calls, Age Distribution, n/a, Italy, Child, Preschool, Surveys and Questionnaires, Humans, Female, Child, Respiratory Insufficiency, Demography, Monitoring, Physiologic
Abstract

BACKGROUND: Improved technology, as well as professional and parental awareness, enable many ventilator-dependent children to live at home. However, the profile of this growing population, the quality and adequacy of home care, and patients' needs still require thorough assessment. OBJECTIVES: To define the characteristics of Italian children receiving long-term home mechanical ventilation (HMV) in Italy. METHODS: A detailed questionnaire was sent to 302 National Health Service hospitals potentially involved in the care of HVM in children (aged

Published
2011

29. Invasive and non-invasive long-term mechanical ventilation in Italian Children

Author

Racca, F., Bonati, M., Del Sorbo, L., Berta, G., Sequi, M., Capello, E. C., Wolfler, A., Salvo, I., Bignamini, E., Ottonello, G., Cutrera, R., Paolo Biban, Benini, F., Ranieri, V. M., Racca F., Bonati M., Del Sorbo L., Berta G., Sequi M., Capello E. C., Wolfler A., Salvo I., Bignamini E., Ottonello G., Cutrera R., Biban P., Benini F., and RANIERI, VITO MARCO

Subjects
Male, Adolescent, Age Factors, Infant, Newborn, Infant, Respiration, Artificial, Respiratory Function Tests, Logistic Models, Tracheostomy, n/a, Italy, Child, Preschool, Data Interpretation, Statistical, Health Care Surveys, Surveys and Questionnaires, Humans, Female, Child, Ventilator Weaning
Abstract

BACKGROUND: To date, few studies have been published regarding the number of children in Italy who require long-term mechanical ventilation (LTV) and their underlying diagnoses, ventilatory needs and hospital discharge rate. METHODS: A preliminary national postal survey was conducted and identified 535 children from 57 centers. Detailed data were then obtained for 378 children from 30 centers. RESULTS: The estimated prevalence in Italy of this population was 4.3/100000. The majority of children (72.2%) were followed in pediatric units. The primary physicians who cared for these patients were either pediatric intensivists or pediatric pulmonologists. Neurological patients (78.2% of cases) represented the principal disorder category. 57.2% of the patients were non-invasively ventilated, with a nasal mask being the most common interface (85% of cases). The presence of clinical symptoms that were associated with abnormal findings on diagnostic testing was the primary indication for ventilatory support, whereas weaning failure was the primary indication for tracheotomy. Invasive ventilation was significantly related to younger age, longer daily hours on ventilation and cerebral palsy. Ventilatory modes with guaranteed minimal tidal volume were more often used in patients with tracheotomy. Despite their age, illness severity and need for technological care, 98% of the study population were successfully home discharged. CONCLUSION: Managing pediatric home LTV requires tremendous effort on the part of the patient's family and places a significant strain on community financial resources. In particular, neurological patients require more health care than patients in other categories. To further improve the quality of care for these patients, it is essential to establish a dedicated national database.

Published
2011

31. AN INTEGRATIVE APPROACH FOR MODEL DRIVEN COMPUTATION OF TREATMENTS IN REPRODUCTIVE MEDICINE

Author

EHRIG, R., primary, DIERKES, T., additional, SCHÄFER, S., additional, RÖBLITZ, S., additional, TRONCI, E., additional, MANCINI, T., additional, SALVO, I., additional, ALIMGUZHIN, V., additional, MARI, F., additional, MELATTI, I., additional, MASSINI, A., additional, KRÜGER, T.H.C., additional, EGLI, M., additional, ILLE, F., additional, and LEENERS, B., additional

Published
2016
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32. Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial.

Author

Giribaldi G., Polaner D., Thomas J., Meuller M., Haret D., Szmuk P., Steiner J., Davidson A.J., Morton N.S., Arnup S.J., De Graaff J.C., Disma N., Withington D.E., Frawley G., Hunt R.W., Hardy P., Khotcholava M., Von Ungern Sternberg B.S., Wilton N., Tuo P., Salvo I., Ormond G., Stargatt R., Locatelli B.G., McCann M.E., Lee K., Sheppard S., Hartmann P., Ragg P., Backstrom M., Costi D., Von Ungern-Sternberg B.S., Knottenbelt G., Montobbio G., Mameli L., Prato A.P., Mattioli G., Wolfler A., Izzo F., Sonzogni V., Van Gool J.T.D.G., Numan S.C., Kalkman C.J., Hagenaars J.H.M., Absalom A.R., Hoekstra F.M., Volkers M.J., Furue K., Gaudreault J., Berde C., Soriano S., Young V., Sethna N., Kovatsis P., Cravero J.P., Bellinger D., Marmor J., Lynn A., Ivanova I., Hunyady A., Verma S., Kravitz B., Suresh S., Hays S.R., Taenzer A.H., Maxwell L.G., Williams R.K., Bell G.T., Dorris L., Adey C., Bagshaw O., Chisakuta A., Eissa A., Stoddart P., Davis A., Myles P., Wolf A., McIntosh N., Carlin J., Leslie K., De Lima J., Hammer G., Field D., Gebski V., Tibboel D., Giribaldi G., Polaner D., Thomas J., Meuller M., Haret D., Szmuk P., Steiner J., Davidson A.J., Morton N.S., Arnup S.J., De Graaff J.C., Disma N., Withington D.E., Frawley G., Hunt R.W., Hardy P., Khotcholava M., Von Ungern Sternberg B.S., Wilton N., Tuo P., Salvo I., Ormond G., Stargatt R., Locatelli B.G., McCann M.E., Lee K., Sheppard S., Hartmann P., Ragg P., Backstrom M., Costi D., Von Ungern-Sternberg B.S., Knottenbelt G., Montobbio G., Mameli L., Prato A.P., Mattioli G., Wolfler A., Izzo F., Sonzogni V., Van Gool J.T.D.G., Numan S.C., Kalkman C.J., Hagenaars J.H.M., Absalom A.R., Hoekstra F.M., Volkers M.J., Furue K., Gaudreault J., Berde C., Soriano S., Young V., Sethna N., Kovatsis P., Cravero J.P., Bellinger D., Marmor J., Lynn A., Ivanova I., Hunyady A., Verma S., Kravitz B., Suresh S., Hays S.R., Taenzer A.H., Maxwell L.G., Williams R.K., Bell G.T., Dorris L., Adey C., Bagshaw O., Chisakuta A., Eissa A., Stoddart P., Davis A., Myles P., Wolf A., McIntosh N., Carlin J., Leslie K., De Lima J., Hammer G., Field D., Gebski V., and Tibboel D.

Abstract

Background: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. Method(s): Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. Result(s): Three hundred sixty-three patients were assigned to RA and 359 to GA. Overall, the incidence of apnea (0 to 12 h) was similar between arms (3% in RA and 4% in GA arms; odds ratio [OR], 0.63; 95% CI, 0.31 to 1.30, P = 0.2133); however, the incidence of early apnea (0 to 30 min) was lower in the RA arm (1 vs. 3%; OR, 0.20; 95% CI, 0.05 to 0.91; P = 0.0367). The incidence of late apnea (30 min to 12 h) was 2% in both RA and GA arms (OR, 1.17; 95% CI, 0.41 to 3.33; P = 0.7688). The strongest predictor of apnea was prematurity (OR, 21.87; 95% CI, 4.38 to 109.24), and 96% of infants with apnea were premature. Conclusion(s): RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period. Cardiorespiratory monitoring should be used for all ex-premature infants.Copyright © 2015, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved.

Published
2015

33. Predictors of Failure of Awake Regional Anesthesia for Neonatal Hernia Repair: Data from the General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes.

Author

Van Gool J.T.D.G., Frawley G., Bell G., Disma N., Withington D.E., De Graaff J.C., Morton N.S., McCann M.E., Arnup S.J., Bagshaw O., Wolfler A., Bellinger D., Davidson A.J., Hardy P., Hunt R.W., Stargatt R., Ormond G., Hartmann P., Ragg P., Backstrom M., Costi D., Von Ungern-Sternberg B.S., Wilton N., Knottenbelt G., Montobbio G., Mameli L., Tuo P., Giribaldi G., Prato A.P., Mattioli G., Izzo F., Salvo I., Sonzogni V., Locatelli B.G., Khotcholava M., Numan S.C., Kalkman C.J., Hagenaars J.H.M., Absalom A.R., Hoekstra F.M., Volkers M.J., Furue K., Gaudreault J., Berde C., Soriano S., Young V., Sethna N., Kovatsis P., Cravero J.P., Marmor J., Lynn A., Ivanova I., Hunyady A., Verma S., Polaner D., Thomas J., Meuller M., Haret D., Suresh S., Hays S.R., Taenzer A.H., Maxwell L.G., Williams R.K., Bell G.T., Dorris L., Adey C., Chisakuta A., Eissa A., Stoddart P., Davis A., Myles P., Wolf A., Carlin J., Leslie K., De Lima J., Field D., Gebski V., Tibboel D., Szmuk P., Steiner J., Kravitz B., Van Gool J.T.D.G., Frawley G., Bell G., Disma N., Withington D.E., De Graaff J.C., Morton N.S., McCann M.E., Arnup S.J., Bagshaw O., Wolfler A., Bellinger D., Davidson A.J., Hardy P., Hunt R.W., Stargatt R., Ormond G., Hartmann P., Ragg P., Backstrom M., Costi D., Von Ungern-Sternberg B.S., Wilton N., Knottenbelt G., Montobbio G., Mameli L., Tuo P., Giribaldi G., Prato A.P., Mattioli G., Izzo F., Salvo I., Sonzogni V., Locatelli B.G., Khotcholava M., Numan S.C., Kalkman C.J., Hagenaars J.H.M., Absalom A.R., Hoekstra F.M., Volkers M.J., Furue K., Gaudreault J., Berde C., Soriano S., Young V., Sethna N., Kovatsis P., Cravero J.P., Marmor J., Lynn A., Ivanova I., Hunyady A., Verma S., Polaner D., Thomas J., Meuller M., Haret D., Suresh S., Hays S.R., Taenzer A.H., Maxwell L.G., Williams R.K., Bell G.T., Dorris L., Adey C., Chisakuta A., Eissa A., Stoddart P., Davis A., Myles P., Wolf A., Carlin J., Leslie K., De Lima J., Field D., Gebski V., Tibboel D., Szmuk P., Steiner J., and Kravitz B.

Abstract

Background: Awake regional anesthesia (RA) is a viable alternative to general anesthesia (GA) for infants undergoing lower abdominal surgery. Benefits include lower incidence of postoperative apnea and avoidance of anesthetic agents that may increase neuroapoptosis and worsen neurocognitive outcomes. The General Anesthesia compared to Spinal anesthesia study compares neurodevelopmental outcomes after awake RA or GA in otherwise healthy infants. The aim of the study is to describe success and failure rates of RA and report factors associated with failure. Method(s): This was a nested cohort study within a prospective, randomized, controlled, observer-blind, equivalence trial. Seven hundred twenty-two infants 60 weeks or less postmenstrual age scheduled for herniorrhaphy under anesthesia were randomly assigned to receive RA (spinal, caudal epidural, or combined spinal caudal anesthetic) or GA with sevoflurane. The data of 339 infants, where spinal or combined spinal caudal anesthetic was attempted, were analyzed. Possible predictors of failure were assessed including patient factors, technique, experience of site and anesthetist, and type of local anesthetic. Result(s): RA was sufficient for the completion of surgery in 83.2% of patients. Spinal anesthesia was successful in 86.9% of cases and combined spinal caudal anesthetic in 76.1%. Thirty-four patients required conversion to GA, and an additional 23 patients (6.8%) required brief sedation. Bloody tap on the first attempt at lumbar puncture was the only risk factor significantly associated with block failure (odds ratio = 2.46). Conclusion(s): The failure rate of spinal anesthesia was low. Variability in application of combined spinal caudal anesthetic limited attempts to compare the success of this technique to spinal alone.Copyright © 2015, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved.

Published
2015

34. Evolution of Noninvasive Mechanical Ventilation Use: A Cohort Study Among Italian PICUs

Author

Wolfler, A, Calderini, E, Iannella, E, Conti, Giorgio, Biban, P, Dolcini, A, Pirozzi, N, Racca, F, Pettenazzo, A, Salvo, I, Conti, G (ORCID:0000-0002-8566-9365), Wolfler, A, Calderini, E, Iannella, E, Conti, Giorgio, Biban, P, Dolcini, A, Pirozzi, N, Racca, F, Pettenazzo, A, Salvo, I, and Conti, G (ORCID:0000-0002-8566-9365)

Abstract

To assess how clinical practice of noninvasive ventilation has evolved in the Italian PICUs.

Published
2015

35. Continuous positive airway pressure with helmet versus mask in infants with bronchiolitis: an RCT

Author

Chidini, G, Piastra, M, Marchesi, T, De Luca, D, Napolitano, L, Salvo, I, Wolfler, A, Pelosi, P, Damasco, M, Conti, Giorgio, Calderini, E., Piastra, M (ORCID:0000-0002-3144-8970), Conti, Giorgio (ORCID:0000-0002-8566-9365), Chidini, G, Piastra, M, Marchesi, T, De Luca, D, Napolitano, L, Salvo, I, Wolfler, A, Pelosi, P, Damasco, M, Conti, Giorgio, Calderini, E., Piastra, M (ORCID:0000-0002-3144-8970), and Conti, Giorgio (ORCID:0000-0002-8566-9365)

Abstract

Noninvasive continuous positive airway pressure (CPAP) is usually applied with a nasal or facial mask to treat mild acute respiratory failure (ARF) in infants. A pediatric helmet has now been introduced in clinical practice to deliver CPAP. This study compared treatment failure rates during CPAP delivered by helmet or facial mask in infants with respiratory syncytial virus-induced ARF.

Published
2015

36. 1st Italian SMA Family Association Consensus Meeting

Author

Sansone, V.A., primary, Racca, F., additional, Ottonello, G., additional, Vianello, A., additional, Berardinelli, A., additional, Crescimanno, G., additional, Casiraghi, J.L., additional, Agosto, C., additional, Banfi, P., additional, Baranello, G., additional, Bignamini, E., additional, Chiarini, M.B., additional, Cutrera, R., additional, D'amico, A., additional, Dusio, M., additional, Fanfulla, F., additional, Garuti, G., additional, Giretti, R., additional, Gorni, K., additional, Gregoretti, C., additional, Luccoli, L., additional, Messina, S., additional, Pane, M., additional, Pavone, M., additional, Pedemonte, M., additional, Pera, M.C., additional, Piastra, M., additional, Profazio, C., additional, Rao, F., additional, Salvo, I., additional, Testa, R., additional, and Villanova, M., additional

Published
2015
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37. Model based design of control software for nonlinear discrete time hybrid systems

Author

Alimguzhin, V., Mari, F., Melatti, I., Salvo, I., and Tronci, E.

Abstract

Many Embedded Systems are indeed Software Based Control Systems, that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of embedded systems control software. This paper addresses control software synthesis for discrete time nonlinear hybrid systems. We present a methodology to over approximate the dynamics of a discrete time nonlinear hybrid system H by means of a discrete time linear hybrid system L_H, in such a way that controllers for L_H are guaranteed to be controllers for H. We present experimental results on control software synthesis for the inverted pendulum, a challenging and meaningful control problem.

Published
2013

38. Guidelines for completing the Perioperative Anesthesia Record

Author

Calderini, E., Accorsi, A., Adrario, E., Bettelli, G., Carrani, L., Cornara, G., De Gasperi, A., Della Rocca, G., Di Castri, D., Frova, G., Gregorini, P., Iapichino, G., Landoni, G., Lombardo, G., Mondello, E., Paolillo, G. M., Peduto, V. A., Petrini, F., Piazza, L., Pierdominici, S., Pietropaoli, Paolo, Rosi, R., Salvo, I., Santagostino, R., Savoia, G., Serafini, G., Solca, M., Stella, L., Tavola, M., Torri, G., Tufano, R., Vesconi, S., Zoia, E., Zuccoli, P., Siaarti Study Group For Safety In Anesthesia, Intensive, Care, E., Calderini, A., Accorsi, E., Adrario, G., Bettelli, L., Carrani, G., Cornara, A., De Gasperi, G., Della Rocca, D., Di Castri, G., Frova, P., Gregorini, G., Iapichino, G., Landoni, G., Lombardo, E., Mondello, G. M., Paolillo, V. A., Peduto, F., Petrini, L., Piazza, S., Pierdominici, P., Pietropaoli, R., Rosi, I., Salvo, R., Santagostino, G., Savoia, G., Serafini, M., Solca, L., Stella, M., Tavola, G., Torri, Tufano, Rosalba, S., Vesconi, E., Zoia, P., Zuccoli, S. I., A., Intensive, Care, Calderini, E, Accorsi, A, Adrario, E, Bettelli, G, Carrani, L, Cornara, G, De Gasperi, A, Della Rocca, G, Di Castri, D, Frova, G, Gregorini, P, Iapichino, G, Landoni, G, Lombardo, G, Mondello, E, Paolillo, G M, Peduto, V A, Petrini, F, Piazza, L, Pierdominici, S, Pietropaoli, P, Rosi, R, Salvo, I, Santagostino, R, Savoia, G, Serafini, G, Solca, M, Stella, L, Tavola, M, Torri, G, Tufano, R, Vesconi, S, Zoia, E, and Zuccoli, P

Subjects
Medical Record, Anesthesia, Medical Records, Perioperative Care
Published
2002

39. Abnormalities of acid–base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients

Author

Lorioli, L., primary, Cicalese, M.P., additional, Silvani, P., additional, Assanelli, A., additional, Salvo, I., additional, Mandelli, A., additional, Fumagalli, F., additional, Fiori, R., additional, Ciceri, F., additional, Aiuti, A., additional, Sessa, M., additional, Roncarolo, M.G., additional, Lanzani, C., additional, and Biffi, A., additional

Published
2015
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40. Patient-specific models from inter-patient biological models and clinical records

Author

Tronci, E, Mancini, T, Salvo, I, Sinsi, S, Mari, F, Melatti, I, Massini, A, Davì, F, Dierkes, T, Ehrig, R, Röblitz, S, Leeners, B, Krüger, T H C, Egli, M, Ille, F, Tronci, E, Mancini, T, Salvo, I, Sinsi, S, Mari, F, Melatti, I, Massini, A, Davì, F, Dierkes, T, Ehrig, R, Röblitz, S, Leeners, B, Krüger, T H C, Egli, M, and Ille, F

Published
2014

41. Recommendations for airway control and difficult airway management in thoracic aneshtesia and lung separation procedures

Author

Merli, G, Guarino, A., Della Rocca, G, Frova, G, Petrini, F, Sorbello, M, Coccia, C, Accorsi, A, Adrario, E, Agro, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Biolcati, F, Cafaggi, C, Cattano, D, Chinelli, E, Collavo, T, Corbanese, U, Corso, R, di Filippo, A, di Giacinto, I, Donato, P, Facco, E, Favaro, R, Ferraro, F, Finco, G, Galante, D, Gattinoni, L, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Ian-Nuzzi, E, Ivani, G, Ledda, G, Marchi, A, Mattioli, V, Menarini, M, Miceli, L, Mondello, E, Morossi, M, Oligeri, M, Pala, F, Pesetti, B, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, G, Rosi, R, Salvo, I, Santangelo, E, Sarti, A, Scoponi, M, Serafini, G, Tana, F, Tufano, R, Vesconi, S, Villani, A, and Zauli, M.

Published
2009

42. Recommendations for airway control and difficult airway management in thoracic anesthesia and lung separation procedures

Author

Merli, Guarino, Della, R, Frova, Petrini, Sorbello, Coccia, Accorsi, Adrario, Agro, Amicucci, Antonelli, Azzeri, Baroncini, Bettelli, Biolcati, Cafaggi, Cattano, Chinelli, Collavo, Corbanese, Corso, Filippo, D, Giacinto, D, Donato, Facco, Favaro, Ferraro, Finco, G, Galante, D, Gattinoni, L, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Ian-Nuzzi, E, Ivani, G, Ledda, G, Marchi, A, Mattioli, V, Menarini, M, Miceli, L, Mondello, E, Morossi, M, Oligeri, M, Pala, F, Pesetti, B, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, G, Rosi, R, Salvo, I, Santangelo, E, Sarti, A, Scoponi, M, Serafini, G, Tana, Tufano, R, Vesconi, S, Villani, A, and Zauli, M

Subjects
Settore MED/38
Published
2009

43. Recommendations for airway control and difficult airway management in thoracic anesthesia and lung separation procedures

Author

Accorsi, A, Adrario, E, Agrò, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Biolcati, F, Cafaggi, C, Cattano, D, Chinelli, E, Collavo, T, Corbanese, U, Corso, Ruggero Massimo, Della Rocca, G, Di Filippo, Alessandro, Di Giacinto, I, Donato, P, Facco, E, Favaro, R, Ferraro, F, Finco, G, Frova, G, Galante, D, Gattinoni, L, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Iannuzzi, E, Ivani, G, Ledda, G, Marchi, A, Mattioli, V, Menarini, M, Merli, G, Miceli, L, Mondello, E, Morossi, M, Oligeri, M, Pala, F, Pesetti, B, Petrini, F, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, G, Rosi, R, Salvo, I, Santangelo, E, Sarti, A, Scoponi, M, Serafini, G, Sorbello, Massimiliano, Tana, F, Tufano, R, Vesconi, S, Villani, A, and Zauli, M.

Subjects
Anesthesia, General, Humans, Lung, Respiration, Artificial, Thoracic Surgical Procedures
Published
2009

44. Incidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey. Intensive Care Medicine

Author

Wolfler, A, Silvani, P, Musicco, M, Antonelli, M, Salvo, I, and Italian Pediat Sepsis Study Grp.

Abstract

Objectives: The objective was to assess the incidence of sepsis, severe sepsis and septic shock and their mortality in Italian Pediatric Intensive Care Units (PICUs). Design: This is a prospective, observational, multi-center, 1-year study. Setting: Fifteen medical-surgical PICUs participated in this study. Patients: Two-thousand and seven hundred and forty-one children (2,741), aged 0-16 years, who were consecutively admitted in the participating PICUs, from 1 March 2004 to 28 February 2005, were enrolled in the study. Interventions: There were no interventions in this study. Measurements and main results: Data on infection, systemic inflammatory response syndrome (SIRS), severe sepsis and septic shock were collected using criteria defined by Proulx in 1996. Sepsis-related diagnosis was stratified for five age groups (neonates, infant, preschool, school, adolescent) and type of admission (medical, surgical, trauma). The presence of existing comorbidities has been considered for children with and without sepsis diagnosis. The results showed a lower overall incidence of sepsis, severe sepsis and septic shock (7.9, 1.6 and 2.1%, respectively) if compared with other studies. Children with sepsis diagnosis had a higher morbidity and higher mortality than those without sepsis. Severe sepsis and septic shock had a mortality rate of 17.7 and 50.8%, respectively. Mortality is significantly higher for children with existing comorbidities than those without existing comorbidities. Conclusions: Septic shock mortality is still high in Italian PICUs and attempts to improve medical treatment are necessary. We suggest that application of the new definitions for sepsis diagnosis and diffusion of guidelines for early recognition and aggressive treatment of severe sepsis and septic shock in Italy represent a high priority to reduce mortality. Descriptor: The descriptor is pediatrics.

Published
2008

47. Recommendations for airway control and difficult airway management

Author

Petrini, F., Accorsi, A., Adrario, E., Agro, F., Amicucci, G., Antonelli, M., Azzeri, F., Baroncini, S., Bettelli, G., Cafaggi, C., Cattano, D., Chinelli, E., Corbanese, U., Corso, R., Della Puppa, A., Di Filippo, A., Facco, E., Favaro, Roberto, Favero, R., Frova, G., Giunta, F., Giurati, G., Giusti, F., Guarino, A., Iannuzzi, E., Ivani, G., Mazzon, D., Menarini, M., Merli, G., Mondello, E., Muttini, S., Nardi, G., Pigna, A., Pittoni, G., Ripamonti, D., Rosa, Giovanni, Rosi, R., Salvo, I., Sarti, A., Serafini, G., Servadio, G., Sgandurra, A., Sorbello, M., Tana, F., Tufano, R., Vesconi, S., Villani, A., Zauli, M., vie Aeree Difficili Gruppo Di Studio Siaarti, Sarnepi Task Force, Irc E., F., Petrini, A., Accorsi, E., Adrario, F., Agrò, G., Amicucci, M., Antonelli, F., Azzeri, S., Baroncini, G., Bettelli, C., Cafaggi, D., Cattano, E., Chinelli, U., Corbanese, R., Corso, A., Della Puppa, A., Di Filippo, E., Facco, R., Favaro, R., Favero, G., Frova, F., Giunta, G., Giurati, F., Giusti, A., Guarino, E., Iannuzzi, G., Ivani, D., Mazzon, M., Menarini, G., Merli, E., Mondello, S., Muttini, G., Nardi, A., Pigna, G., Pittoni, D., Ripamonti, G., Rosa, R., Rosi, I., Salvo, A., Sarti, G., Serafini, G., Servadio, A., Sgandurra, M., Sorbello, F., Tana, Tufano, Rosalba, S., Vesconi, A., Villani, M., Zauli, Gruppo di, Studio, and I. R., C.

Subjects
pediatric patient, vie aeree, Laryngoscopy, Intubation, Intratracheal, Humans, Anesthesia, Inhalation, Intraoperative Complications, Algorithms
Published
2005

48. Recommendations for airway control and difficult airway management. Minerva Anestesiol. 2005 Nov;71(11):617-57

Author

Petrini, F, Accorsi, A, Adrario, E, Agro, F, Amicucci, G, Antonelli, M, Azzeri, F, Baroncini, S, Bettelli, G, Cafaggi, C, Cattano, D, Chinelli, E, Corbanese, U, Corso, R, DELLA PUPPA, A, DI FILIPPO, A, Facco, E, Favaro, Roberto, Favero, R, Frova, G, Giunta, F, Giurati, G, Giusti, F, Guarino, A, Iannuzzi, E, Ivani, G, Mazzon, D, Menarini, M, Merli, G, Mondello, E, Muttini, S, Nardi, G, Pigna, A, Pittoni, G, Ripamonti, D, Rosa, Giovanni, Rosi, R, Salvo, I, Sarti, A, Serafini, G, Servadio, G, Sgandurra, A, Sorbello, M, Tana, F, Tufano, R, Vesconi, S, Villani, A, Zauli, M, GRUPPO DI STUDIO SIAARTI VIE AEREE, Difficili, Sarnepi, IRC E., and Task, Force

Published
2005

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