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13. Gestione del paziente con sovrappeso e obesità.

Author

Giovannini, Marcello, Maffeis, Claudio, Molinari, Enrico, Scaglioni, Silvia, and Salvioni, Michela

Abstract

Copyright of Salute & Equilibrio Nutrizionale is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2006
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14. PPAR-2 Pro12Ala Variant, Insulin Resistance and Plasma Long-chain Polyunsaturated Fatty Acids in Childhood Obesity

Author

SCAGLIONI, SILVIA, VERDUCI, ELVIRA, SALVIONI, MICHELA, BIONDI, MARIA LUISA, RADAELLI, GIOVANNI, AGOSTONI, CARLO, and GIOVANNINI, MARCELLO

Abstract

Pro12Ala variant of peroxisome-proliferator-activated receptor-gamma2 (PPAR-2) may be linked to insulin sensitivity. This study examined whether an association of PPAR-2 Pro12Ala with insulin resistance and plasma LCPUFAs may exist in obese children. One hundred and forty Italian normolipidemic obese children (58 girls and 82 boys, mean age SD, 10.2 2.7 y) entered the study. Obesity was defined according to International Obesity Task Force. BMI Z-scores were calculated. Fasting blood glucose, insulin, lipids and plasma fatty acids were measured. Insulin resistance was estimated by the homeostatic model assessment (HOMA-IR). The frequency of Ala allele was 9%. Mean SD values of fasting insulin and HOMA-IR in Pro/Pro versusPro12Ala groups were: 19.3 10.6 versus14.1 10.4 U/mL (p0.017) and 4.2 2.3 versus3.0 2.3 (p0.022). Mean SD values of plasma C20:3n-9 and of C20:4n-6, C20:5n-3, C22:6n-3 and n-6/n-3 LCPUFA in phospholipds in Pro/Pro versusPro12Ala groups were: 0.15 0.07 versus0.12 0.08 % (p0.014), 8.9 1.9 versus10.2 2.6 % (p0.023), 0.34 0.15 versus0.42 0.11 % (p0.005), 2.1 0.9 versus2.6 0.9 % (p0.032) and 4.8 1.2 versus4.2 0.7 (p0.017). Pro12Ala may be associated with higher insulin sensitivity and higher LCPUFAs, particularly n-3, levels in plasma phosholipids of obese children.

Published
2006
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15. PPAR-gamma2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity.

Author

Scaglioni S, Verduci E, Salvioni M, Biondi ML, Radaelli G, Agostoni C, and Giovannini M

Subjects
Alanine chemistry, Alanine genetics, Child, Female, Gene Frequency, Humans, Male, Phospholipids blood, Polymorphism, Genetic, Proline chemistry, Proline genetics, Fatty Acids, Unsaturated blood, Insulin Resistance genetics, Obesity diagnosis, PPAR gamma genetics
Abstract

Pro12Ala variant of peroxisome-proliferator-activated receptor-gamma2 (PPAR-gamma2) may be linked to insulin sensitivity. This study examined whether an association of PPAR-gamma2 Pro12Ala with insulin resistance and plasma LCPUFAs may exist in obese children. One hundred and forty Italian normolipidemic obese children (58 girls and 82 boys, mean age [SD], 10.2 [2.7] y) entered the study. Obesity was defined according to International Obesity Task Force. BMI Z-scores were calculated. Fasting blood glucose, insulin, lipids and plasma fatty acids were measured. Insulin resistance was estimated by the homeostatic model assessment (HOMA-IR). The frequency of Ala allele was 9%. Mean [SD] values of fasting insulin and HOMA-IR in Pro/Pro versus Pro12Ala groups were: 19.3 [10.6] versus 14.1 [10.4] microU/mL (p = 0.017) and 4.2 [2.3] versus 3.0 [2.3] (p = 0.022). Mean [SD] values of plasma C20:3n-9 and of C20:4n-6, C20:5n-3, C22:6n-3 and n-6/n-3 LCPUFA in phospholipds in Pro/Pro versus Pro12Ala groups were: 0.15 [0.07] versus 0.12 [0.08] % (p = 0.014), 8.9 [1.9] versus 10.2 [2.6] % (p = 0.023), 0.34 [0.15] versus 0.42 [0.11] % (p = 0.005), 2.1 [0.9] versus 2.6 [0.9] % (p = 0.032) and 4.8 [1.2] versus 4.2 [0.7] (p = 0.017). Pro12Ala may be associated with higher insulin sensitivity and higher LCPUFAs, particularly n-3, levels in plasma phosholipids of obese children.

Published
2006
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