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1. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024
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2. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024
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3. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023
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4. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Published
2024

5. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, Szewczyk, Nathaniel, Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, and Szewczyk, Nathaniel

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

6. Planarian Mucus: A Novel Source of Pleiotropic Cytotoxic and Cytostatic Agents against Cancer Cells.

Author

Gambino, Gaetana, Da Pozzo, Eleonora, Salvetti, Alessandra, and Rossi, Leonardo

Subjects
BIOLOGICAL evolution, CANCER cell growth, REACTIVE oxygen species, METABOLITES, MUCUS
Abstract

Biological evolution has generated a vast array of natural compounds produced by organisms across all domains. Among these, secondary metabolites, selected to enhance an organism's competitiveness in its natural environment, make them a reservoir for discovering new compounds with cytotoxic activity, potentially useful as novel anticancer agents. Slime secretions, the first barrier between epithelial surfaces and the surrounding environment, frequently contain cytotoxic molecules to limit the growth of parasitic organisms. Planarians, freshwater Triclads, continuously secrete a viscous mucus with multiple physiological functions. The chemical composition of planarian mucus has been only partially elucidated, and there are no studies reporting its cytotoxic or cytostatic effects. In this study, we developed a protocol for collecting mucus from Dugesia japonica specimens and we demonstrated that it inhibits the growth of cancer cells by activating cytostatic and ROS-dependent cytotoxic mechanisms inducing lipid droplet accumulation and mitochondrial membrane reorganization. Although further research is needed to identify the specific chemicals responsible for the anticancer activity of planarian mucus, this work opens up numerous research avenues aimed at better understanding the mechanisms of action of this product for potential therapeutic applications. [ABSTRACT FROM AUTHOR]

Published
2024
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8. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J, Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

9. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, Monici, Monica, Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024

10. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

12. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

Published
2023

14. Starvation resistance in planarians: multiple strategies to get a thrifty phenotype.

Author

Gambino, Gaetana, Iacopetti, Paola, Ippolito, Chiara, Salvetti, Alessandra, and Rossi, Leonardo

Subjects
HOMEOSTASIS, STARVATION, PLURIPOTENT stem cells, PHENOTYPES, TRANSCRIPTION factors
Abstract

Starvation resistance is a life-saving mechanism for many organisms facing food availability fluctuation in the natural environment. Different strategies have been episodically identified for some model organisms, the first of which was the ability to suppress metabolic rate. Among the identified strategies, the ability of planarians to shrink their body under fasting conditions and revert the process after feeding (the growth-degrowth process) represents a fascinating mechanism to face long periods of fasting. The growth-degrowth process is strictly related to the capability of planarians to continuously maintain tissue homeostasis and body proportions even in challenging conditions, thanks to the presence of a population of pluripotent stem cells. Here, we take advantage of several previous studies describing the growth-degrowth process and of recent progress in the understanding of planarian homeostasis mechanisms, to identify tissueselective transcriptional downregulation as a driving strategy for the development of a thrifty phenotype, and the p53 transcription factor as a player in adjusting tissue homeostasis in accordance with food availability. [ABSTRACT FROM AUTHOR]

Published
2024
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18. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, Monici, Monica, Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, and Monici, Monica

Published
2023

19. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., Monici, Monica, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023

20. A Network of MicroRNAs and mRNAs Involved in Melanosome Maturation and Trafficking Defines the Lower Response of Pigmentable Melanoma Cells to Targeted Therapy

Author

Vitiello, Marianna, primary, Mercatanti, Alberto, additional, Podda, Maurizio Salvatore, additional, Baldanzi, Caterina, additional, Prantera, Antonella, additional, Sarti, Samanta, additional, Rizzo, Milena, additional, Salvetti, Alessandra, additional, Conte, Federica, additional, Fiscon, Giulia, additional, Paci, Paola, additional, and Poliseno, Laura, additional

Published
2023
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21. Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells

Author

Lenzi, Paola, primary, Busceti, Carla L., additional, Lazzeri, Gloria, additional, Ferese, Rosangela, additional, Biagioni, Francesca, additional, Salvetti, Alessandra, additional, Pompili, Elena, additional, De Franchis, Valerio, additional, Puglisi-Allegra, Stefano, additional, Frati, Alessandro, additional, Ferrucci, Michela, additional, and Fornai, Francesco, additional

Published
2023
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24. Autopsy Study of Testicles in COVID-19: Upregulation of Immune-Related Genes and Downregulation of Testis-Specific Genes

Author

Basolo, Alessio, primary, Poma, Anello Marcello, additional, Macerola, Elisabetta, additional, Bonuccelli, Diana, additional, Proietti, Agnese, additional, Salvetti, Alessandra, additional, Vignali, Paola, additional, Torregrossa, Liborio, additional, Evangelisti, Laura, additional, Sparavelli, Rebecca, additional, Giannini, Riccardo, additional, Ugolini, Clara, additional, Basolo, Fulvio, additional, Santini, Ferruccio, additional, and Toniolo, Antonio, additional

Published
2022
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25. Autopsy Study of Testicles in COVID-19: Upregulation of Immune-Related Genes and Downregulation of Testis-Specific Genes.

Author

Basolo, Alessio, Poma, Anello Marcello, Macerola, Elisabetta, Bonuccelli, Diana, Proietti, Agnese, Salvetti, Alessandra, Vignali, Paola, Torregrossa, Liborio, Evangelisti, Laura, Sparavelli, Rebecca, Giannini, Riccardo, Ugolini, Clara, Basolo, Fulvio, Santini, Ferruccio, and Toniolo, Antonio

Subjects
DOWNREGULATION, TESTICULAR diseases, COVID-19 testing
Abstract

Context: Infection by SARS-CoV-2 may be associated with testicular dysfunction that could affect male fertility. Objective: Testicles of fatal COVID-19 cases were investigated to detect virus in tissue and to evaluate histopathological and transcriptomic changes. Methods: Three groups were compared: (a) uninfected controls (subjects dying of trauma or sudden cardiac death; n= 10); (b) subjects dying of COVID-19 (virus-negative in testes; n= 15); (c) subjects dying of COVID-19 (virus-positive in testes; n= 9). SARS-CoV-2 genome and nucleocapsid antigen were probed using RT-PCR, in situ hybridization, and immunohistochemistry (IHC). Infiltrating leukocytes were typed by IHC. mRNA transcripts of immune-related and testis-specific genes were quantified using the nCounter method. Results: SARS-CoV-2 was detected in testis tissue of 9/24 (37%) COVID-19 cases accompanied by scattered T-cell and macrophage infiltrates. Size of testicles and counts of spermatogenic cells were not significantly different among groups. Analysis of mRNA transcripts showed that in virus-positive testes immune processes were activated (interferon-alpha and -gamma pathways). By contrast, transcription of 12 testis-specific genes was downregulated, independently of virus positivity in tissue. By IHC, expression of the luteinizing hormone/choriogonadotropin receptor was enhanced in virus-positive compared to virus-negative testicles, while expression of receptors for androgens and the follicle-stimulating hormone were not significantly different among groups. Conclusion: In lethal COVID-19 cases, infection of testicular cells is not uncommon. Viral infection associates with activation of interferon pathways and downregulation of testis-specific genes involved in spermatogenesis. Due to the exceedingly high numbers of infected people in the pandemic, the impact of virus on fertility should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland

Author

Poma, Anello Marcello, primary, Proietti, Agnese, additional, Macerola, Elisabetta, additional, Bonuccelli, Diana, additional, Conti, Marco, additional, Salvetti, Alessandra, additional, Dolo, Vincenza, additional, Chillà, Andrea, additional, Basolo, Alessio, additional, Santini, Ferruccio, additional, Toniolo, Antonio, additional, and Basolo, Fulvio, additional

Published
2022
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29. Supplementary Figure 1 and 2 from Cell quiescence in planarian stem cells, interplay between p53 and nutritional stimuli

Author

Gambino, Gaetana, Iacopetti, Paola, Guidi, Patrizia, Ippolito, Chiara, Linsalata, Stefania, Salvetti, Alessandra, and Rossi, Leonardo

Abstract

Cell quiescence appeared early in evolution as an adaptive response to adverse conditions, i.e. nutrient depletion. In metazoans, quiescence has been enrolled in additional purposes like tissue homeostasis, which is made possible by the presence of adult stem cells (ASCs). Cell-cycle control machinery is a common hub for quiescence entrance, and evidence indicates a role for p53 in establishing the quiescent state of undamaged cells. Mechanisms responsible for waking up quiescent cells remain elusive and nutritional stimulus, as a legacy of its original role, still appears to be a player in quiescence exit. Planarians, rich in ASCs, represent a suitable system in which we characterized a quiescent population of ASCs, the dorsal midline cord (DMC) cells, exhibiting unique transcriptional features and maintained quiescent by p53 and awakened upon feeding. The function of DMC cells is puzzling and we speculate that DMC cells, despite retaining ancient properties, might represent a functional drift in which quiescence has been recruited to provide evolutionary advantages.

Published
2022
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30. Cover Image

Author

Salvetti, Alessandra, primary, Degl'Innocenti, Andrea, additional, Gambino, Gaetana, additional, Loon, Jack J.W.A., additional, Ippolito, Chiara, additional, Ghelardoni, Sandra, additional, Ghigo, Eric, additional, Leoncino, Luca, additional, Prato, Mirko, additional, Rossi, Leonardo, additional, and Ciofani, Gianni, additional

Published
2021
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32. Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology

Author

Ballarin, Loriano, primary, Karahan, Arzu, additional, Salvetti, Alessandra, additional, Rossi, Leonardo, additional, Manni, Lucia, additional, Rinkevich, Baruch, additional, Rosner, Amalia, additional, Voskoboynik, Ayelet, additional, Rosental, Benyamin, additional, Canesi, Laura, additional, Anselmi, Chiara, additional, Pinsino, Annalisa, additional, Tohumcu, Begüm Ece, additional, Jemec Kokalj, Anita, additional, Dolar, Andraž, additional, Novak, Sara, additional, Sugni, Michela, additional, Corsi, Ilaria, additional, and Drobne, Damjana, additional

Published
2021
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35. Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect

Author

Salvetti, Alessandra, primary, Degl'Innocenti, Andrea, additional, Gambino, Gaetana, additional, Loon, Jack J.W.A., additional, Ippolito, Chiara, additional, Ghelardoni, Sandra, additional, Ghigo, Eric, additional, Leoncino, Luca, additional, Prato, Mirko, additional, Rossi, Leonardo, additional, and Ciofani, Gianni, additional

Published
2021
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40. Djeyes absent (Djeya) controls prototypic planarian eye regeneration by cooperating with the transcription factor Djsix-1

Author

Mannini, Linda, Rossi, Leonardo, Deri, Paolo, Gremigni, Vittorio, Salvetti, Alessandra, Salo, Emili, and Batistoni, Renata

Subjects
Central nervous system -- Research, Biological sciences
Abstract

A conserved network of nuclear proteins is crucial to eye formation in both vertebrates and invertebrates. The finding that freshwater planarians can regenerate eyes without the contribution of Pax6 suggests that alternative combinations of regulatory elements may control the morphogenesis of the prototypic planarian eye. To further dissect the molecular events controlling eye regeneration in planarians, we investigated the role of eyes absent (Djeya) and six-1 (Djsix-1) genes in Dugesiajaponica. These genes are expressed in both regenerating eyes and in differentiated photoreeeptors of intact adults. Through RNAi studies, we show that Djsix-1 and Djeya are both critical for the regeneration of normal eyes in planarians and genetically cooperate in vivo to establish correct eye cell differentiation. We further demonstrate that the genetic interaction is mediated by physical interaction between the evolutionarily conserved domains of these two proteins. These data indicate that planarians use cooperatively Djsix-1 and Djeya for the proper specification of photoreceptors, implicating that the mechanism involving their evolutionarily conserved domains can be very ancient. Finally, both Djsix-1 and Djeya double-stranded RNA are substantially more effective at producing no-eye phenotypes in the second round of regeneration. This is probably due to the significant plasticity of the planarian model system, based on the presence of a stable population of totipotent stem cells, which ensure the rapid cell turnover of all differentiated cell types. Keywords: Planarians; Regeneration; Eye; Central nervous system; Eyes absent; six-l; RNAi; In situ hybridization

Published
2004

42. “Candidatus Trichorickettsia mobilis”, a Rickettsiales bacterium, can be transiently transferred from the unicellular eukaryote Paramecium to the planarian Dugesia japonica

Author

Modeo, Letizia, primary, Salvetti, Alessandra, additional, Rossi, Leonardo, additional, Castelli, Michele, additional, Szokoli, Franziska, additional, Krenek, Sascha, additional, Serra, Valentina, additional, Sabaneyeva, Elena, additional, Di Giuseppe, Graziano, additional, Fokin, Sergei I., additional, Verni, Franco, additional, and Petroni, Giulio, additional

Published
2020
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46. Planarian Stem Cell Heterogeneity

Author

Salvetti, Alessandra and Leonardo, Rossi

Subjects
Pluripotent Stem Cells, Animals, Regeneration, Planarians
Abstract

Planarian (Platyhelminthes, Triclads) are free-living flatworms endowed with extraordinary regenerative capabilities, i.e., the ability to rebuild any missing body parts also from small fragments. Planarian regenerative capabilities fascinated scientific community since early 1800, including high-standing scientists such as J.T. Morgan and C. M. Child. Today, it is known that planarian regeneration is due to the presence of a wide population of stem cells, the so-called neoblasts. However, the understanding of the nature of cells orchestrating planarian regeneration was a long journey, and several questions still remain unanswered. In this chapter, beginning from the definition of the classical concept of neoblast, we review progressive discoveries that have brought to the modern view of these cells as a highly heterogeneous population of stem cells including pluripotent stem cells and undifferentiated populations of committed progenies.

Published
2019

47. Planarian Stem Cell Heterogeneity

Author

Salvetti Alessandra and Leonardo Rossi

Subjects
Genetics and Molecular Biology (all), Piwi, Population, Flatworms, Piwi-interacting RNA, Stem cells, σ-Neoblasts, Biology, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Regeneration, 030212 general & internal medicine, Induced pluripotent stem cell, education, ζ-Neoblasts, education.field_of_study, Planarian, Clonogenic neoblast, Regeneration (biology), Neoblast, biology.organism_classification, Committed progeny, Tetraspanin, Platyhelminthes, Biochemistry, Genetics and Molecular Biology (all), Cell biology, Heterogeneous population, Stem cell
Abstract

Planarian (Platyhelminthes, Triclads) are free-living flatworms endowed with extraordinary regenerative capabilities, i.e., the ability to rebuild any missing body parts also from small fragments. Planarian regenerative capabilities fascinated scientific community since early 1800, including high-standing scientists such as J.T. Morgan and C. M. Child. Today, it is known that planarian regeneration is due to the presence of a wide population of stem cells, the so-called neoblasts. However, the understanding of the nature of cells orchestrating planarian regeneration was a long journey, and several questions still remain unanswered. In this chapter, beginning from the definition of the classical concept of neoblast, we review progressive discoveries that have brought to the modern view of these cells as a highly heterogeneous population of stem cells including pluripotent stem cells and undifferentiated populations of committed progenies.

Published
2019

50. Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae

Author

Backovic Ana, Cervelli Tiziana, Salvetti Alessandra, Zentilin Lorena, Giacca Mauro, and Galli Alvaro

Subjects
Microbiology, QR1-502
Abstract

Abstract Background The budding yeast Saccharomyces cerevisiae supports replication of many different RNA or DNA viruses (e.g. Tombusviruses or Papillomaviruses) and has provided means for up-scalable, cost- and time-effective production of various virus-like particles (e.g. Human Parvovirus B19 or Rotavirus). We have recently demonstrated that S. cerevisiae can form single stranded DNA AAV2 genomes starting from a circular plasmid. In this work, we have investigated the possibility to assemble AAV capsids in yeast. Results To do this, at least two out of three AAV structural proteins, VP1 and VP3, have to be simultaneously expressed in yeast cells and their intracellular stoichiometry has to resemble the one found in the particles derived from mammalian or insect cells. This was achieved by stable co-transformation of yeast cells with two plasmids, one expressing VP3 from its natural p40 promoter and the other one primarily expressing VP1 from a modified AAV2 Cap gene under the control of the inducible yeast promoter Gal1. Among various induction strategies we tested, the best one to yield the appropriate VP1:VP3 ratio was 4.5 hour induction in the medium containing 0.5% glucose and 5% galactose. Following such induction, AAV virus like particles (VLPs) were isolated from yeast by two step ultracentrifugation procedure. The transmission electron microscopy analysis revealed that their morphology is similar to the empty capsids produced in human cells. Conclusions Taken together, the results show for the first time that yeast can be used to assemble AAV capsid and, therefore, as a genetic system to identify novel cellular factors involved in AAV biology.

Published
2012
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