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186 results on '"Salvatori, L."'

2. MEMS Mirror Manufacturing and Testing for Innovative Space Applications

Author

Bagolini, A., Boscardin, M., Dell'Agnello, S., Monache, G. Delle, Emilio, M. Di Paolo, Porcelli, L., Salvatori, L., and Tibuzzi, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors, Physics - Optics
Abstract

In the framework of the GLARE-X (Geodesy via LAser Ranging from spacE X) project, led by INFN and funded for the years 2019-2021, aiming at significantly advance space geodesy, one shows the initial activities carried out in 2019 in order to manufacture and test adaptive mirrors. This specific article deals with manufacturing and surface quality measurements of the passive substrate of 'candidate' MEMS (Micro-Electro-Mechanical Systems) mirrors for MRRs (Modulated RetroReflectors); further publications will show the active components. The project GLARE-X was approved by INFN for the years 2019-2021: it involves several institutions, including, amongst the other, INFN-LNF and FBK. GLARE-X is an innovative R&D activity, whose at large space geodesy goals will concern the following topics: inverse laser ranging (from a laser terminal in space down to a target on a planet), laser ranging for debris removal and iterative orbit correction, development of high-end ToF (Time of Flight) electronics, manufacturing and testing of MRRs for space, and provision of microreflectors for future NEO (Near Earth Orbit) cubesats. This specific article summarizes the manufacturing and surface quality measurements activities performed on the passive substrate of 'candidate' MEMS mirrors, which will be in turn arranged into MRRs. The final active components, to be realized by 2021, will inherit the manufacturing characteristics chosen thanks to the presented (and further) testing campaigns, and will find suitable space application to NEO, Moon, and Mars devices, like, for example, cooperative and active lidar scatterers for laser altimetry and lasercomm support., Comment: 9 pages, 5 figures

Published
2020

8. Monitoraggio dinamico di ponti mediante reti wireless di sensori

Author

Marra A. M., Morano G., Nicese B., Salvatori L., Spinelli P., Girardi M., Padovani C., and Pellegrini D.

Subjects
Wireless sensors, Dynamic tests, Operational Modal Analysis, Bridges
Abstract

Report finale del progetto "Monitoraggio dinamico di ponti mediante reti wireless di sensori" (MOODWISE).

Published
2023

14. Social inequalities in the metropolitan area of Rome. A multidisciplinary analysis of the urban segregation of the 'formerly-Bastogi' compound

Author

Iorio, S, Salvatori, L M, Barnocchi, A, Battisti, A, Rinaldi, A, Marceca, M, Ricotta, G, Brandimarte, A M, Baglio, G, Gazzaniga, V, and Paglione, L

Subjects
urban divide, Urban Population, rome suburb, Social Determinants of Health, Interdisciplinary Research, Rome, urban inequalities, social determinants, Health Status Disparities, spatial segregation, Age Distribution, Socioeconomic Factors, Residence Characteristics, Surveys and Questionnaires, Humans, Built Environment, City Planning, Sex Distribution
Abstract

This study tries to evaluate, through a multidisciplinary approach, the relationship between urban structure, isolation and distribution of social determinants of health, in the so-called "formerly-Bastogi, a compound, with more than 1,500 inhabitants, located in north-western Rome, Italy.The architectural-urban analysis, conducted through site visits and evaluations of urban situation, showed how strongly the compound is isolated from the neighbourhoods, and structurally degraded. The socio-demographic analysis, based on the National Census data, showed significant differences in the distribution of the social determinants of health between "formerly-Bastogi" and the surrounding areas.The area under study appears to be isolated from the surrounding urban space, both because of social and architectural factors. This situation could have some association with inhabitants' health.If our preliminary investigation was useful for a diagnosis of the situation, a more complete - qualitative and quantitative - investigation of the context will be needed to plan appropriate multidisciplinary health-promoting interventions.

Published
2019

17. The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells

Author

Favia, A., Salvatori, L., Nanni, Simona, Iwamoto-Stohl, L. K., Valente, S., Mai, A., Scagnoli, F., Fontanella, R. A., Totta, P., Nasi, S., Illi, B., Nanni S. (ORCID:0000-0002-3320-1584), Favia, A., Salvatori, L., Nanni, Simona, Iwamoto-Stohl, L. K., Valente, S., Mai, A., Scagnoli, F., Fontanella, R. A., Totta, P., Nasi, S., Illi, B., and Nanni S. (ORCID:0000-0002-3320-1584)

Abstract

Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respectively. They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glioblastoma multiforme (GBM) which presents largely deregulated Myc activity. Previously, we demonstrated that PRMT5 associates with Myc in GBM cells, modulating, at least in part, its transcriptional properties. Here we show that Myc/PRMT5 protein complex includes PRMT1, in both HEK293T and glioblastoma stem cells (GSCs). We demonstrate that Myc is both asymmetrically and symmetrically dimethylated by PRMT1 and PRMT5, respectively, and that these modifications differentially regulate its stability. Moreover, we show that the ratio between symmetrically and asymmetrically dimethylated Myc changes in GSCs grown in stem versus differentiating conditions. Finally, both PRMT1 and PRMT5 activity modulate Myc binding at its specific target promoters. To our knowledge, this is the first work reporting R asymmetrical and symmetrical dimethylation as novel Myc post-translational modifications, with different functional properties. This opens a completely unexplored field of investigation in Myc biology and suggests symmetrically dimethylated Myc species as novel diagnostic and prognostic markers and druggable therapeutic targets for GBM.

Published
2019

18. Knowledge, attitude, barriers, professional behaviour and possible interventions: a survey on healthcareassociated infections among the healthcare workers of an intensive care unit in a large teaching hospital in Rome.

Author

Angelozzi, A., Caminada, S., Dorelli, B., Sindoni, A., Baccolini, V., Di Paolo, C., Mele, A., Salvatori, L. M., Alessandri, F., Marzuillo, C., De Vito, C., Tellan, G., De Giusti, M., and Villari, P.

Subjects
MEDICAL personnel, COVID-19 pandemic, HOSPITAL care, INTENSIVE care units, DISEASE prevalence
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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26. Next-generation laser retroreflectors for GNSS, solar system exploration, geodesy, gravitational physics and earth observation

Author

Dell’Agnello, S., primary, Boni, A., primary, Cantone, C., primary, Tibuzzi, M., primary, Vittori, R., primary, Bianco, G., primary, Mondaini, C., primary, Tuscano, P., primary, Ciocci, E., primary, Martini, M., primary, Patrizi, G., primary, Delle Monache, G., primary, Currie, D., primary, Intaglietta, N., primary, Salvatori, L., primary, Lops, C., primary, Contessa, S., primary, Porcelli, L., primary, and Maiello, M., primary

Published
2018
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28. Next-generation laser retroreflectors for precision tests of general relativity

Author

Ciocci, Emanuele, primary, Martini, Manuele, additional, Contessa, Simone dell’Agnello S., additional, Monache, G. Delle, additional, Boni, A., additional, Porcelli, L., additional, Patrizi, G., additional, Tibuzzi, M., additional, Lops, C., additional, Intaglietta, N., additional, Tuscano, P., additional, Salvatori, L., additional, Maiello, M., additional, Mondaini, C., additional, Chandler, J.F., additional, Currie, D., additional, and Bianco, G., additional

Published
2017
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31. Thermal-vacuum optical characterization of next-generation lunar laser retroreflectors

Author

Mondaini, C., primary, Bianco, G., additional, Boni, A., additional, Ciocci, E., additional, Contessa, S., additional, Currie, D., additional, Dell'Agnello, S., additional, Delle Monache, G., additional, Intaglietta, N., additional, Maiello, M., additional, Martini, M., additional, Patrizi, G., additional, Porcelli, L., additional, Salvatori, L., additional, Tibuzzi, M., additional, Tuscano, P., additional, and Vittori, R., additional

Published
2016
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37. Laser ranging positioning metrology for Galileo and the Moon

Author

Martini, M., primary, Dell'Agnello, S., additional, Delle Monache, G., additional, Vittori, R., additional, Boni, A., additional, Cantone, C., additional, Ciocci, E., additional, Patrizi, G., additional, Tibuzzi, M., additional, Bianco, G., additional, Intaglietta, N., additional, Salvatori, L., additional, Lops, C., additional, Contessa, S., additional, Porcelli, L., additional, Mondaini, C., additional, Tuscano, P., additional, Maiello, M., additional, Currie, D., additional, and Chandler, J. F., additional

Published
2015
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38. Advanced Laser Retroreflectors for Astrophysics and Space Science

Author

Agnello, S. Dell’, primary, Monache, G. Delle, additional, Vittori, R., additional, Boni, A., additional, Cantone, C., additional, Ciocci, E., additional, Martini, M., additional, Patrizi, G., additional, Tibuzzi, M., additional, Bianco, G., additional, Currie, D., additional, Intaglietta, N., additional, Salvatori, L., additional, Lops, C., additional, Contessa, S., additional, Porcelli, L., additional, Mondaini, C., additional, Tuscano, P., additional, and Maiello, M., additional

Published
2015
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39. Nonylphenol polyethoxylate degradation in aqueous waste by the use of biofilm bioreactors

Author

Di Gioia D., Sciubba L., Bertin L., Barberio C., Salvatori L., Frassinetti S., and Fava F.

Subjects
Packed bed bioreactors, FISH, Biofilm, Nonylphenol ethoxylates, Wastewater
Abstract

An aerobic bacterial consortium (Consortium A) was recently obtained from textile wastewater and was capable of degrading 4-nonylphenol and nonylphenol polyethoxylates (NPnEOs). In the perspective of developing a biotechnological process for the treatment of effluents from activated sludge plants fed with NPnEO contaminated wastewater, the capability of Consortium A of biodegrading an industrial mixture of NPnEOs in the physiological condition of immobilized cells was investigated. Two identically configured packed bed reactors were developed by immobilizing the consortium on silica beads or granular activated carbon. Both reactors were tested in batch and continuous mode by feeding them with water supplemented with NPnEOs. The two reactors were monitored through chemical, microbiological and molecular integrated methodology. Active biofilms were generated on both immobilization supports. Both reactors displayed comparable NPnEO mineralization under batch and continuous conditions. FISH analyses evidenced that the biofilms evolved with time by changing the reactor operation mode and the organic load. Taken together, the data collected in this study provide a preliminary strong indication on the feasibility of Consortium A-based biofilm technology for the decontamination of NPnEO containing effluents.

Published
2009

41. Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells

Author

Salvatori L, Caporuscio F, Coroniti G, Starace G, Frati L, Russo MA, and Petrangeli E.

Subjects
hormones, hormone substitutes, and hormone antagonists
Abstract

In previous studies on HeLa cells we demonstrated estrogen-responsiveness of the epidermal growth factor receptor (EGFR) gene, as 17beta-estradiol (E(2)) and selective estrogen receptor modulators (SERMs) genistein (G), daidzein (D), and 4-hydroxytamoxifen (4OH-T) modulated its transcription in a ligand- and estrogen receptor (ER) isoform-specific way. This study describes further investigations into the role of ERs in mediating the effects induced by E(2) and SERMs on EGFR expression, and the relationship between the actions of ERs and EGFR in U2OS osteosarcoma cells stably expressing ERalpha or ERbeta. Cell number and DNA content determination revealed that E(2), G, and D inhibited proliferation and cell cycle progression and promoted apoptosis in both cell lines. In parallel, changes in cell morphology typical of osteoblast maturation were observed via optical microscopy. Consistently, quantitative PCR and Western blot analysis showed an up-regulation of markers of osteoblast differentiation and bone repair, and a decrease in EGFR expression. The transfection of specific antisense (AS) oligonucleotides strengthened our hypothesis that EGFR reduction caused changes in the proliferation/differentiation pattern comparable to those induced by ER ligands. The link between the ER and EGFR pathways was confirmed by treatment with 4OH-T, which decreased the EGFR level and produced differentiation effects via ERalpha, but induced both EGFR expression and proliferation effects via ERbeta. In conclusion, we show that also in U2OS cells, E(2) and SERMs are able to modulate the expression of the EGFR gene and can affect events strictly controlled by its signaling pathway, such as the maturation of osteoblasts.

Published
2009

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