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1. Italian guidelines for the management of irritable bowel syndrome in children and adolescents: Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM)

Author

Di Nardo, Giovanni, Barbara, Giovanni, Borrelli, Osvaldo, Cremon, Cesare, Giorgio, Valentina, Greco, Luigi, La Pietra, Michele, Marasco, Giovanni, Pensabene, Licia, Piccirillo, Marisa, Romano, Claudio, Salvatore, Silvia, Saviano, Michele, Stanghellini, Vincenzo, Strisciuglio, Caterina, Tambucci, Renato, Turco, Rossella, Zenzeri, Letizia, and Staiano, Annamaria

Published
2024
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3. Solving the multi-messenger puzzle of the AGN-starburst composite galaxy NGC 1068

Author

Eichmann, Björn, Oikonomou, Foteini, Salvatore, Silvia, Dettmar, Ralf-Jürgen, and Tjus, Julia Becker

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Multi-wavelength observations indicate that some starburst galaxies show a dominant non-thermal contribution from their central region. These active galactic nuclei (AGN)-starburst composites are of special interest, as both phenomena on their own are potential sources of highly-energetic cosmic rays and associated gamma-ray and neutrino emission. In this work, a homogeneous, steady-state two-zone multi-messenger model of the non-thermal emission from the AGN corona as well as the circumnuclear starburst region is developed and subsequently applied to the case of NGC 1068, which has recently shown some first indications of high-energy neutrino emission. Here, we show that the entire spectrum of multi-messenger data - from radio to gamma-rays including the neutrino constraint - can be described very well if both, starburst and AGN corona, are taken into account. Using only a single emission region is not sufficient.

Published
2022
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11. Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP)

Author

Isoldi, Sara, Di Nardo, Giovanni, Mallardo, Saverio, Parisi, Pasquale, Raucci, Umberto, Tambucci, Renato, Quitadamo, Paolo, Salvatore, Silvia, Felici, Enrico, Cisarò, Fabio, Pensabene, Licia, Banzato, Claudia, Strisciuglio, Caterina, Romano, Claudio, Fusco, Patrizia, Rigotti, Francesca, Sansotta, Naire, Caimmi, Silvia, Savasta, Salvatore, Zuin, Giovanna, Di Stefano, Marina, Provera, Silvia, Campanozzi, Angelo, Rossi, Paolo, Gatti, Simona, Corpino, Mara, Alvisi, Patrizia, Martelossi, Stefano, Suppiej, Agnese, Gandullia, Paolo, Verrotti, Alberto, Terrin, Gianluca, Pacenza, Caterina, Fornaroli, Fabiola, Comito, Donatella, D’Arrigo, Stefano, Striano, Pasquale, Raviglione, Federico, Carotenuto, Marco, Orsini, Alessandro, Belcastro, Vincenzo, Di Corcia, Giovanna, Raieli, Vincenzo, Ferilli, Michela Ada Noris, Ruscitto, Claudia, Spadoni, Elisabetta, Grosso, Salvatore, D’Alonzo, Renato, Papa, Amanda, Pavone, Piero, Meli, Mariaclaudia, Velardita, Mario, Mainetti, Martina, Vanacore, Nicola, and Borrelli, Osvaldo

Published
2022
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12. Epidemiological trends of pediatric IBD in Italy: A 10-year analysis of the Italian society of pediatric gastroenterology, hepatology and nutrition registry

Author

Accomando, Salvatore, Banzato, Claudia, Barera, Graziano, Brunero, Marco, Calvo, Pier Luigi, Campanozzi, Angelo, Cananzi, Mara, Corpino, Mara, Cozzali, Rita, De Angelis, Gianluigi, De Giacomo, Costantino, Dilillo, Dario, Felici, Enrico, Gatti, Simona, Motta, Valentina, Norsa, Lorenzo, Pavanello, Paolo Maria, Pession, Andrea, Provera, Silvia, Ravelli, Alberto, Ricci, Antonio Maria, Salvatore, Silvia, Strisciuglio, Caterina, Alvisi, Patrizia, Labriola, Flavio, Scarallo, Luca, Gandullia, Paolo, Knafelz, Daniela, Bramuzzo, Matteo, Zuin, Giovanna, Pastore, Maria Rosa, Illiceto, Maria Teresa, Miele, Erasmo, Graziano, Francesco, Romano, Claudio, Bartoletti, Daniela, Oliva, Salvatore, Arrigo, Serena, Bracci, Fiammetta, Renzo, Sara, Agrusti, Anna, Aloi, Marina, and Lionetti, Paolo

Published
2022
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13. No COVID‐19 pandemic impact on incidence and clinical presentation of celiac disease in Italian children.

Author

Guacci, Pietro, Ballabio, Claudia, Folegatti, Alice, Giancotti, Laura, Scordo, Alessia, Pensabene, Licia, Parma, Barbara, Selicorni, Angelo, Luini, Chiara, Agosti, Massimo, and Salvatore, Silvia

Subjects
CHILD patients, PEDIATRIC gastroenterology, ITALIANS, SYMPTOMS, JUVENILE diseases, CELIAC disease
Abstract

Aim: We aimed to evaluate the impact of Coronavirus Disease‐19 (COVID‐19) pandemic on the incidence and clinical presentation of celiac disease (CD) in children. Methods: The diagnoses of CD were compared between the COVID‐19 pandemic (from April 2020 to March 2022) and the pre‐pandemic period (from April 2018 to March 2020) in three Italian Paediatric Gastroenterology centres (Varese, Como, Catanzaro). Electronic patient records were reviewed and additional information were collected through parental interview. The diagnosis of CD was made according to ESPGHAN criteria. SARS‐CoV‐2 infection was diagnosed based on pre‐vaccination positive serum antibodies or nasopharyngeal swabs. Z test and chi‐square were used for statistical analysis. Results: The overall number of paediatric diagnosis of CD did not differ between the two years pre‐pandemic and pandemic periods (177 and 172 cases) in the three Italian participating centres. Clinical presentation of CD was also similar throughout the study periods. SARS‐CoV‐2 infection has been documented in 10.6% of children but only in 5.8% of these occurred before CD diagnosis. Conclusion: Different to what reported for other autoimmune diseases, the incidence and presenting symptoms of CD in our paediatric population did not change during the COVID‐19 pandemic compared to the previous 2 years. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Pre-, and Postbiotics: A Multi-Country Multi-Center Prospective Randomized Controlled Study in Infants with Regurgitation

Author

Salvatore, Silvia, primary, Klymenko, Viktoriia, additional, Karpushenko, Yuliia, additional, Durczak-Hilleman, Maria, additional, Loboda, Andrii, additional, Petrashenko, Viktoriia, additional, Olechowski, Wiesław, additional, Lista, Gianluca, additional, Meneghin, Fabio, additional, Amodio, Sonia, additional, Bongers, Anke, additional, Ludwig, Thomas, additional, and Vandenplas, Yvan, additional

Published
2024
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17. Synbiotics in the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications

Author

Hojsak, Iva, Kolaček, Sanja, Mihatsch, Walter, Mosca, Alexis, Shamir, Raanan, Szajewska, Hania, Vandenplas, Yvan, van den Akker, Chris H. P., Berni Canani, Roberto, Dinleyici, Ener Cagri, Domellof, Magnus, van Goudoever, Johannes B., Guarino, Alfredo, Gutierrez-Castrellon, Pedro, Indrio, Flavia, Orel, Rok, Salvatore, Silvia, and Weizman, Zvi

Published
2023
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18. Contributors

Author

Abrams, Elissa M., primary, Agostoni, Carlo, additional, Andreae, Doerthe A., additional, Berti, Cristiana, additional, Bhutta, Zulfiqar A., additional, Burton, Mark A., additional, Catassi, Carlo, additional, Closa-Monasterolo, Ricardo, additional, Cusick, Sarah E., additional, Dattilo, Anne M., additional, Subias, Joaquin Escribano, additional, Pallas, Natalia Ferré, additional, Fisher, Jennifer Orlet, additional, Fleischer, David M., additional, Georgieff, Michael K., additional, Giannì, Maria Lorella, additional, Godfrey, Keith M., additional, Guz-Mark, Anat, additional, Hart, Tricia L., additional, Iglesia, Edward G.A., additional, Kalhoff, Hermann, additional, Kalliomäki, Marko, additional, Kersting, Mathilde, additional, Kris-Etherton, Penny M., additional, Lafeber, Harrie N., additional, Laitinen, Kirsi, additional, Lassi, Zohra S., additional, Lillycrop, Karen A., additional, Lionetti, Elena, additional, Moreno, Veronica Luque, additional, Mokkala, Kati, additional, Morniroli, Daniela, additional, Mosca, Fabio, additional, Nowak-Wegrzyn, Anna, additional, O’Neill, Lynda M., additional, Oken, Emily, additional, Padhani, Zahra A., additional, Perng, Wei, additional, Petersen, Kristina S., additional, Sundseth Ross, Erin, additional, Ruys, Charlotte A., additional, Saavedra, Jose M., additional, Salam, Rehana A., additional, Salvatore, Silvia, additional, Shamir, Raanan, additional, van de Lagemaat, Monique, additional, van den Akker, Chris H.P., additional, van Goudoever, Johannes B., additional, Vandenplas, Yvan, additional, Vickers, Mark H., additional, and Vizzari, Giulia, additional

Published
2022
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20. Editorial: Probiotics in Children Health

Author

Baldassarre Maria Elisabetta, Laforgia Nicola, Campeotto Florence, and Salvatore Silvia

Subjects
probiotics, children, health, neurocognitive abilities, preterm/full term infants, Pediatrics, RJ1-570
Published
2022
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25. Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications

Author

Indrio, Flavia, primary, Dinleyici, Ener Cagri, additional, Berni Canani, Roberto, additional, Domellöf, Magnus, additional, Francavilla, Ruggiero, additional, Guarino, Alfredo, additional, Gutierrez Castrellon, Pedro, additional, Orel, Rok, additional, Salvatore, Silvia, additional, Van den Akker, Chris H. P., additional, and Weizman, Zvi, additional

Published
2024
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29. CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML

Author

Salomé, Bérengère, Gomez-Cadena, Alejandra, Loyon, Romain, Suffiotti, Madeleine, Salvestrini, Valentina, Wyss, Tania, Vanoni, Giulia, Ruan, Dan Fu, Rossi, Marianna, Tozzo, Alessandra, Tentorio, Paolo, Bruni, Elena, Riether, Carsten, Jacobsen, Eva-Maria, Jandus, Peter, Conrad, Curdin, Hoenig, Manfred, Schulz, Ansgar, Michaud, Katarzyna, Della Porta, Matteo Giovanni, Salvatore, Silvia, Ho, Ping-Chih, Gfeller, David, Ochsenbein, Adrian, Mavilio, Domenico, Curti, Antonio, Marcenaro, Emanuela, Steinle, Alexander, Horowitz, Amir, Romero, Pedro, Trabanelli, Sara, and Jandus, Camilla

Published
2019
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31. Esophageal pH-impedance monitoring in children: position paper on indications, methodology and interpretation by the SIGENP working group

Author

Quitadamo, Paolo, Tambucci, Renato, Mancini, Valentina, Cristofori, Fernanda, Baldassarre, Mariella, Pensabene, Licia, Francavilla, Ruggiero, Di Nardo, Giovanni, Caldaro, Tamara, Rossi, Paolo, Mallardo, Saverio, Maggiora, Elena, Staiano, Annamaria, Cresi, Francesco, Salvatore, Silvia, and Borrelli, Osvaldo

Published
2019
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32. Neonatal Antibiotics and Prematurity Are Associated with an Increased Risk of Functional Gastrointestinal Disorders in the First Year of Life

Author

Salvatore, Silvia, Baldassarre, Maria Elisabetta, Di Mauro, Antonio, Laforgia, Nicola, Tafuri, Silvio, Bianchi, Francesco Paolo, Dattoli, Enzo, Morando, Lucia, Pensabene, Licia, Meneghin, Fabio, Dilillo, Dario, Mancini, Valentina, Talarico, Valentina, Tandoi, Francesco, Zuccotti, Gianvincenzo, and Agosti, Massimo

Published
2019
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33. Study on Nocturnal Infant Crying Evaluation (NICE) and Reflux Disease (RED).

Author

Carabelli, Greta, Binotto, Ivan, Armano, Chiara, Bertù, Lorenza, Luini, Chiara, Nosetti, Luana, Agosti, Massimo, and Salvatore, Silvia

Subjects
ALGINATES, CRYING in children, INFANT psychology, MULTIPLE regression analysis, SEX distribution, QUESTIONNAIRES, DISEASE prevalence, DESCRIPTIVE statistics, CHI-squared test, AGE distribution, MILK, BIOELECTRIC impedance, INFANT formulas, LARYNGOSCOPY, FAILURE to thrive syndrome, STATISTICS, ANALYSIS of variance, PATIENT monitoring, ANTHROPOMETRY, CONFIDENCE intervals, POLYSOMNOGRAPHY, GASTROESOPHAGEAL reflux, DIET, DEMOGRAPHY, SYMPTOMS
Abstract

Background: Nocturnal infant crying is often empirically treated with acid suppressants. The aim of this study was to evaluate the prevalence and characteristics of gastroesophageal reflux (GER) in infants with unexplained persistent crying. Methods: We enrolled all infants (0–12 months) referred for suspected GER disease who underwent esophageal impedance–pH monitoring (MII-pH) for unexplained persistent crying not improved by parental reassurance, dietary modification or alginate. Gastrointestinal malformation/surgery, neurological impairment and infections were exclusion criteria. Demographic and anthropometric parameters, GER symptoms and questionnaires (I-GERQ-R) and MII-pH data were recorded and analyzed. Normal MII-pH was defined when acid exposure was <3%, symptom index was <50% and symptom association probability was <95%. Acid exposure >5% and >10% was also considered. Statistical analysis was performed using Chi-Square and univariate and multivariable regression analysis. Results: We included 50 infants (median age 3.5 months) who fulfilled the study criteria: 30 (60%) had normal MII-pH. I-GERQ-R score was abnormal in 33 (66%) infants, and 21/33 (64%) had normal MII-pH (p = 0.47). In the 26 (52%) infants with nocturnal crying, MII-pH was normal in 16 (54%) (p = 0.82). Associated regurgitation (>3 or >10 episodes/die) did not predict abnormal MII-pH (p = 0.74, p = 0.82, respectively). Univariate and multivariable regression analysis did not identify any clinical variable significantly associated with abnormal MII-pH. Conclusions: Infants with persistent unexplained and nocturnal crying should not be empirically treated with acid inhibitors. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Cow’s Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6–12 months: a cross-sectional study

Author

Jankiewicz, Mateusz, primary, Ahmed, Fatme, additional, Bajerova, Katerina, additional, Carvajal Roca, Maria Eva, additional, Dupont, Christophe, additional, Huysentruyt, Koen, additional, Kuitunen, Mikael, additional, Meyer, Rosan, additional, Pancheva, Rouzha, additional, Koninckx, Carmen Ribes, additional, Salvatore, Silvia, additional, Shamir, Raanan, additional, Staiano, Annamaria, additional, Vandenplas, Yvan, additional, and Szajewska, Hania, additional

Published
2023
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40. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Kafritsa, Panayota, Brusa, Sandra, Campanozzi, Angelo, Romano, Claudio, Salvatore, Silvia, Kotzakioulafi, Evelina, Barrio, Josefa, Cilleruelo, Maria Luz, Juste, Mercedes, Gutiérrez-Junquera, Carolina, Trbojević, Tena, Ivković, Lana, Scarpato, Elena, Kolacek, Sanja, Jojkic-Pavkov, Danijela, Konjik, Vlatka, Živković, Nataša, Roman, Enriqueta, Kostovski, Aco, Zdraveska, Nikolina, Altamimi, Eyad, Papadopoulou, Alexandra, Karagiozoglou-Lampoudi, Thomai, Shamir, Raanan, Bar Lev, Michal Rozenfeld, Koleilat, Aziz, Mneimneh, Sirin, Bruzzese, Dario, Leis, Rosaura, and Staiano, Annamaria

Published
2018
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46. Prevalence and Risk Factors of Functional Gastrointestinal Disorders: A Cross-Sectional Study in Italian Infants and Young Children

Author

Scarpato, Elena, Salvatore, Silvia, Romano, Claudio, Bruzzese, Dario, Ferrara, Dante, Inferrera, Ramona, Zeevenhooven, Judith, Steutel, Nina F., Benninga, Marc A., Staiano, Annamaria, Scarpato, Elena, Salvatore, Silvia, Romano, Claudio, Bruzzese, Dario, Ferrara, Dante, Inferrera, Ramona, Zeevenhooven, Judith, Steutel, Nina F, Benninga, Marc A, Staiano, Annamaria, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development

Subjects
Rome IV criteria, Pediatrics, Perinatology and Child Health, Gastroenterology, Epidemiologic study, Constipation, Infant colic, Formula feeding
Abstract

Objectives: Reports of prevalence of functional gastrointestinal disorders (FGIDs) in infants/toddlers are widely variable. Reasons for this variability are not yet fully understood. The objective of this study is to estimate the prevalence of FGIDs according to Rome IV criteria and to evaluate associated factors, in Italian infants and toddlers. Methods: Subjects aged 0-48 months were enrolled by general pediatricians from 3 Italian regions. Parents or legal guardians were administered questionnaires including information about the child, the family, and GI symptoms according to Rome IV criteria. Results: Five hundred eight infants aged 0-12 months [mean age 4.4 ? 3.4 months; females (F) 40.9%], and 268 children aged 13-48 months (mean age 30.8 ? 10.7 months; F 44.4%) were included. In infants, prevalence of FGIDs was 21.1%, and the most prevalent FGID was infant colic (9.3%). In toddlers, prevalence of FGIDs was 19.6%, with functional constipation being the most frequent disorder (16.1%). In infants, multivariable analysis found that being older, being the only child, and living in a rural environment were associated with a lower rate of FGIDs. Prevalence was, in contrast, higher in infants fed with formula. Conclusions: One out of 5 Italian infants and young children is affected by at least 1 FGID. The most frequent FGID in infants is infant colic, while in toddlers this is functional constipation. In infants, prevalence of FGIDs is lower if the subject has no siblings, and in children living in a rural environment, while formula feeding represents a risk factor for FGIDs occurrence.

Published
2023

48. Prevalence of Non-erosive Esophageal Phenotypes in Children: A European Multicenter Study

Author

Blasi, Elisa, primary, Stefanelli, Ettore, additional, Tambucci, Renato, additional, Salvatore, Silvia, additional, Angelis, Paola De, additional, Quitadamo, Paolo, additional, Pacchiarotti, Claudia, additional, Nardo, Giovanni Di, additional, Crocco, Fanj, additional, Felici, Enrico, additional, Giorgio, Valentina, additional, Staropoli, Nicoletta, additional, Sestito, Simona, additional, Saliakellis, Efstratios, additional, Borrelli, Osvaldo, additional, and Pensabene, Licia, additional

Published
2023
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49. Probiotics for the management of pediatric gastrointestinal disorders : position paper of the ESPGHAN special interest group on gut microbiota and modifications

Author

Szajewska, Hania, Berni Canani, Roberto, Domellöf, Magnus, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Lo Vecchio, Andrea, Mihatsch, Walter A., Mosca, Alexis, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van den Akker, Chris H P, van Goudoever, Johannes B., Vandenplas, Yvan, Weizman, Zvi, Szajewska, Hania, Berni Canani, Roberto, Domellöf, Magnus, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Lo Vecchio, Andrea, Mihatsch, Walter A., Mosca, Alexis, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van den Akker, Chris H P, van Goudoever, Johannes B., Vandenplas, Yvan, and Weizman, Zvi

Abstract

BACKGROUND: Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are widely used despite uncertainty regarding their efficacy and discordant recommendations about their use. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Gut Microbiota and Modifications provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. METHODS: All systematic reviews and/or meta-analyses, as well as subsequently published randomized controlled trials (RCTs) (until December 2021), that compared the use of probiotics in all delivery vehicles and formulations, at any dose, with no probiotic (ie, placebo or no treatment), were eligible for inclusion. The recommendations were formulated only if at least 2 RCTs on a similar well-defined probiotic strain were available. The modified Delphi process was used to establish consensus on the recommendations. RESULTS: Recommendations for the use of specific probiotic strains were made for the management of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. CONCLUSIONS: Despite evidence to support the use of specific probiotics in some clinical situations, further studies confirming the effect(s) and defining the type, dose, and timing of probiotics are still often required. The use of probiotics with no documented health benefits should be discouraged.

Published
2023
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