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Your search keyword '"Salvador Aguilar-Rosas"' showing total 2 results
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2 results on '"Salvador Aguilar-Rosas"'

1. 1350 Neo-open reading frame peptides as a source of highly immunogenic neoantigens for mRNA therapeutic cancer vaccines

Author

Michael Martin, Regina Heidenreich, Wigard Kloosterman, Hugo Olsman, Katka Franke, Ronja Isabelle Mülfarth, Salvador Aguilar-Rosas, Mark Pieterse, Jamie Langelaar, Wim van Esch, Renee van Schreurs, Lisa van der Made, Bob Löwenberg, Ronald Plasterk, and Janna Krüger

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2023
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2. Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis

Author

Emmanuel Rojas-Morales, Virginia Sedeño-Monge, Julio Reyes-Leyva, Casandra Lucrecia Solis-Morales, Francisca Sosa-Jurado, Gerardo Santos-López, Raul Arcega-Revilla, Juan Carlos Pérez-García, Salvador Aguilar-Rosas, and Verónica Vallejo-Ruiz

Subjects
Adult, Male, Multiple Sclerosis, Adolescent, medicine.medical_treatment, Immunology, Statistics as Topic, Inflammation, Suppressor of Cytokine Signaling Proteins, Statistics, Nonparametric, Disability Evaluation, Young Adult, Immune system, Suppressor of Cytokine Signaling 1 Protein, medicine, Immunology and Allergy, Humans, SOCS3, Retrospective Studies, Autoimmune disease, Suppressor of cytokine signaling 1, business.industry, Multiple sclerosis, Middle Aged, medicine.disease, Cytokine, Cross-Sectional Studies, Neurology, Gliosis, Suppressor of Cytokine Signaling 3 Protein, Case-Control Studies, Leukocytes, Mononuclear, Female, Neurology (clinical), medicine.symptom, business
Abstract

Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Because the suppressors of cytokine signaling (Socs) regulate the immune response, we quantified SOCS1 and SOCS3 transcription in peripheral blood leukocytes of patients with MS. SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08±0.02 vs. 1.02±0.23; p=0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76±0.66 vs. 1.03±0.27; p=0.0008). Our results showed an imbalance of SOCS1 and SOCS3 transcription in MS patients, and a moderated negative correlation between them (Spearman's r=-0.57; p=0.0003).

Published
2014

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