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34 results on '"Salvador, M.J."'

2. Early detection of interstitial lung disease in rheumatic diseases: A joint statement from the Portuguese Pulmonology Society, the Portuguese Rheumatology Society, and the Portuguese Radiology and Nuclear Medicine Society

Author

Morais, A., primary, Duarte, A.C., additional, Fernandes, M.O., additional, Borba, A., additional, Ruano, C., additional, Marques, I.D., additional, Calha, J., additional, Branco, J.C., additional, Pereira, J.M., additional, Salvador, M.J., additional, Bernardes, M., additional, Khmelinskii, N., additional, Pinto, P., additional, Pinto-Basto, R, additional, Freitas, S., additional, Campainha, S., additional, Alfaro, T., additional, and Cordeiro, A., additional

Published
2023
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6. La positivité des anticorps antinucléaires avant le traitement n’est pas associée au pire pronostic ni à un taux de switch plus élevé chez les patients atteints de polyarthrite rhumatoïde sous anti-TNFα

Author

Cunha, R., primary, Saraiva, L., additional, Brites, L., additional, Coutinho, M., additional, Salvador, M.J., additional, Santiago, M., additional, Aguiar, R., additional, Barcelos, A., additional, and Pereira da Silva, J.A., additional

Published
2020
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7. Trypanocidal and antimicrobial activities of Moquinia kingii

Author

Schinor, E.C., Salvador, M.J., Ito, I.Y., de Albuquerque, S., and Dias, D.A.

Subjects
Anti-infective agents -- Case studies -- Health aspects, Medicinal plants -- Case studies -- Health aspects, Trypanosoma cruzi -- Health aspects -- Case studies, Biological sciences, Health, Science and technology, Case studies, Health aspects
Abstract

Summary A chloroform crude extract (aerial part) and two compounds, apigenin (1) and cynaropicrin (2), isolated from Moquinia kingii were evaluated against Trypanosoma cruzi trypomastigotes in vitro. Antimicrobial activity was [...]

Published
2004

8. Bioactivity of crude extracts and some constituents of Blutaparon portulacoides (Amaranthaceae)

Author

Salvador, M.J., Ferreira, E.O., Pral, E.M.F., Alfieri, S.C., Albuquerque, S., Ito, I.Y., and Dias, D.A.

Subjects
Biological sciences, Health, Science and technology
Abstract

Summary Crude extracts (aerial parts and roots, both dried), methylenedioxyflavonol, and a mixture of acyl steryl glycosides isolated from BLUTAPARON portulacoides, were assayed for their toxicity against Trypanosoma cruzi trypomastigotes [...]

Published
2002

9. What have multicentre registries across the world taught us about the disease features of systemic sclerosis?.

Author

Iannone F., Schett G., Distler J.H., Meroni P., Zeni S., Mouthon L., De Keyser F., Smith V., Cantatore F.P., Corrado A., Ullman S., Iversen L., Pozzi M.R., Eyerich K., Hein R., Knott E., Szechinski J., Wiland P., Szmyrka-Kaczmarek M., Sokolik R., Morgiel E., Krummel-Lorenz B., Saar P., Aringer M., Gunther C., Anic B., Baresic M., Mayer M., Radominski S.C., de Souza Muller C., Azevedo V.F., Agachi S., Groppa L., Chiaburu L., Russu E., Zenone T., Stebbings S., Highton J., Stamp L., Chapman P., O'Donnell J., Solanki K., Doube A., Veale D., O'Rourke M., Loyo E., Rosato E., Pisarri S., Tanaseanu C.-M., Popescu M., Dumitrascu A., Tiglea I., Chirieac R., Ancuta C., Furst D.E., Kafaja S., Garcia de la Pena Lefebvre P., Rubio S.R., Exposito M.V., Sibilia J., Chatelus E., Gottenberg J.E., Chifflot H., Litinsky I., Venalis A., Butrimiene I., Venalis P., Rugiene R., Karpec D., Kerzberg E., Montoya F., Cosentino V., Low A.H.L., Teng G., Chan G., Lim A.Y.N., Ng S.C., Kowal-Bielecka O., Proudman S.M., Huq M., Stevens W., Wilson M.E., Sahhar J., Baron M., Hudson M., Allanore Y., Distler O., Bielecka O.K., Matucci-Cerinic M., H.L. Low A., Teng G.G., Law W.G., Santosa A., Nikpour M., Hill C., Lester S., Nash P., Ngian G.-S., Proudman S., Rischmueller M., Roddy J., Strickland G., Thakkar V., Walker J., Zochling J., Pope J., Markland J., Robinson D., Jones N., Khalidi N., Docherty P., Kaminska E., Masetto A., Sutton E., Mathieu J.-P., Ligier S., Grodzicky T., LeClercq S., Thorne C., Gyger G., Smith D., Fortin P.R., Larche M., Abu-Hakima M., Rodriguez-Reyna T.S., Cabral A.R., Fritzler M., Avouac J., Walker U.A., Guiducci S., Riemekasten G., Air P., Hachulla E., Valentini G., Carreira P.E., Cozzi F., Gurman A.B., Braun-Moscovici Y., Damjanov N., Ananieva L.P., Scorza R., Jimenez S., Busquets J., Li M., Muller-Ladner U., Maurer B., Tyndall A., Lapadula G., Becvar R., Sierakowsky S., Cutolo M., Sulli A., Cuomo G., Vettori S., Rednic S., Nicoara I., Vlachoyiannopoulos P., Montecucco C., Caporali R., Novak S., Czirjak L., Varju C., Chizzolini C., Kucharz E.J., Kotulska A., Kopec-Medrek M., Widuchowska M., Rozman B., Mallia C., Coleiro B., Gabrielli A., Farge D., Hij A., Hesselstrand R., Scheja A., Wollheim F., Martinovic D., Govoni M., Lo Monaco A., Hunzelmann N., Pellerito R., Bambara L.M., Caramaschi P., Black C., Denton C., Henes J., Santamaria V.O., Heitmann S., Krasowska D., Seidel M., Oleszowsky M., Burkhardt H., Himsel A., Salvador M.J., Stamenkovic B., Stankovic A., Tikly M., Starovoytova M.N., Engelhart M., Strauss G., Nielsen H., Damgaard K., Szucs G., Mendoza A.Z., de la Puente Buijdos C., Giraldo W.A.S., Midtvedt O., Garen T., Launay D., Valesini G., Riccieri V., Ionescu R.M., Opris D., Groseanu L., Wigley F.M., Mihai C.M., Cornateanu R.S., Ionitescu R., Gherghe A.M., Gorga M., Dobrota R., Bojinca M., Iannone F., Schett G., Distler J.H., Meroni P., Zeni S., Mouthon L., De Keyser F., Smith V., Cantatore F.P., Corrado A., Ullman S., Iversen L., Pozzi M.R., Eyerich K., Hein R., Knott E., Szechinski J., Wiland P., Szmyrka-Kaczmarek M., Sokolik R., Morgiel E., Krummel-Lorenz B., Saar P., Aringer M., Gunther C., Anic B., Baresic M., Mayer M., Radominski S.C., de Souza Muller C., Azevedo V.F., Agachi S., Groppa L., Chiaburu L., Russu E., Zenone T., Stebbings S., Highton J., Stamp L., Chapman P., O'Donnell J., Solanki K., Doube A., Veale D., O'Rourke M., Loyo E., Rosato E., Pisarri S., Tanaseanu C.-M., Popescu M., Dumitrascu A., Tiglea I., Chirieac R., Ancuta C., Furst D.E., Kafaja S., Garcia de la Pena Lefebvre P., Rubio S.R., Exposito M.V., Sibilia J., Chatelus E., Gottenberg J.E., Chifflot H., Litinsky I., Venalis A., Butrimiene I., Venalis P., Rugiene R., Karpec D., Kerzberg E., Montoya F., Cosentino V., Low A.H.L., Teng G., Chan G., Lim A.Y.N., Ng S.C., Kowal-Bielecka O., Proudman S.M., Huq M., Stevens W., Wilson M.E., Sahhar J., Baron M., Hudson M., Allanore Y., Distler O., Bielecka O.K., Matucci-Cerinic M., H.L. Low A., Teng G.G., Law W.G., Santosa A., Nikpour M., Hill C., Lester S., Nash P., Ngian G.-S., Proudman S., Rischmueller M., Roddy J., Strickland G., Thakkar V., Walker J., Zochling J., Pope J., Markland J., Robinson D., Jones N., Khalidi N., Docherty P., Kaminska E., Masetto A., Sutton E., Mathieu J.-P., Ligier S., Grodzicky T., LeClercq S., Thorne C., Gyger G., Smith D., Fortin P.R., Larche M., Abu-Hakima M., Rodriguez-Reyna T.S., Cabral A.R., Fritzler M., Avouac J., Walker U.A., Guiducci S., Riemekasten G., Air P., Hachulla E., Valentini G., Carreira P.E., Cozzi F., Gurman A.B., Braun-Moscovici Y., Damjanov N., Ananieva L.P., Scorza R., Jimenez S., Busquets J., Li M., Muller-Ladner U., Maurer B., Tyndall A., Lapadula G., Becvar R., Sierakowsky S., Cutolo M., Sulli A., Cuomo G., Vettori S., Rednic S., Nicoara I., Vlachoyiannopoulos P., Montecucco C., Caporali R., Novak S., Czirjak L., Varju C., Chizzolini C., Kucharz E.J., Kotulska A., Kopec-Medrek M., Widuchowska M., Rozman B., Mallia C., Coleiro B., Gabrielli A., Farge D., Hij A., Hesselstrand R., Scheja A., Wollheim F., Martinovic D., Govoni M., Lo Monaco A., Hunzelmann N., Pellerito R., Bambara L.M., Caramaschi P., Black C., Denton C., Henes J., Santamaria V.O., Heitmann S., Krasowska D., Seidel M., Oleszowsky M., Burkhardt H., Himsel A., Salvador M.J., Stamenkovic B., Stankovic A., Tikly M., Starovoytova M.N., Engelhart M., Strauss G., Nielsen H., Damgaard K., Szucs G., Mendoza A.Z., de la Puente Buijdos C., Giraldo W.A.S., Midtvedt O., Garen T., Launay D., Valesini G., Riccieri V., Ionescu R.M., Opris D., Groseanu L., Wigley F.M., Mihai C.M., Cornateanu R.S., Ionitescu R., Gherghe A.M., Gorga M., Dobrota R., and Bojinca M.

Abstract

Introduction: The aim of this study is to compare the clinical features, mortality and causes of death of systemic sclerosis (SSc) patients in four large multicentre registries. Method(s): Patients seen at least once in the Australian Scleroderma Cohort Study (ASCS) (n = 1714), the Canadian Scleroderma Research Group (CSRG) (n = 1628), the European League Against Rheumatism Scleroderma Trials and Research (EUSTAR) Network (n = 13,996) and the Systemic Sclerosis Cohort in Singapore (SCORE) (n = 500) before August 2016 were included. Clinical manifestations and survival in cohorts and disease subtypes were compared. Result(s): Among 17,838 SSc patients, most were female (86.1%), Caucasian (84.6%) and had the limited cutaneous subtype (lcSSc) (65.0%). The anti-centromere autoantibody was the most prevalent (37.6%). More patients in SCORE had the diffuse subtype (dcSSc) (49.3%) and Scl-70 autoantibody (38.8%) (p<0.001). Patients with dcSSc were more likely to be younger and male (p<0.001) and have shorter disease duration, more calcinosis, tendon friction rubs and synovitis (all p<0.001). Interstitial lung disease (ILD) occurred more frequently in dcSSc but prevalence of pulmonary arterial hypertension (PAH) was similar in both subtypes. More deaths occurred among SCORE patients who had the shortest median survival (p<0.001). The survival of patients with early disease, males and those with dcSSc was shorter than that of patients with prevalent disease, female gender and lcSSc, respectively. SSc-related complications accounted for more than 50% of deaths, with PAH and ILD being the most common. Conclusion(s): This meta-cohort of SSc patients, the largest reported to date, provides insights into the impact of race and sex on disease manifestations and survival and confirms the early mortality in this disease.Copyright © 2017 Wichtig International

Published
2018

10. Update of EULAR recommendations for the treatment of systemic sclerosis

Author

Kowal-Bielecka, O. Fransen, J. Avouac, J. Becker, M. Kulak, A. Allanore, Y. Distler, O. Clements, P. Cutolo, M. Czirjak, L. Damjanov, N. Del Galdo, F. Denton, C.P. Distler, J.H.W. Foeldvari, I. Figelstone, K. Frerix, M. Furst, D.E. Guiducci, S. Hunzelmann, N. Khanna, D. Matucci-Cerinic, M. Herrick, A.L. Van Den Hoogen, F. Van Laar, J.M. Riemekasten, G. Silver, R. Smith, V. Sulli, A. Tarner, I. Tyndall, A. Welling, J. Wigley, F. Valentini, G. Walker, U.A. Zulian, F. Müller-Ladner, U. EUSTAR Coauthors Daikeler, T. Lanciano, E. Becvár, R. Tomcik, M. Gińdzieńska-Sieskiewicz, E. Cuomo, G. Iudici, M. Rednic, S. Vlachoyiannopoulos, P.G. Caporali, R. Carreira, P.E. Novak, S. Minier, T. Kucharz, E.J. Gabrielli, A. Moroncini, G. Airo', P. Hesselstrand, R. Martinovic, D. Radic, M. Marasovic-Krstulovic, D. Braun-Moscovici, Y. Balbir-Gurman, A. Lo Monaco, A. Caramaschi, P. Morovic-Vergles, J. Henes, J. Ortiz Santamaria, V. Heitmann, S. Krasowska, D. Seidel, M.F. Hasler, P. Pereira Da Silva, J.A. Salvador, M.J. Stamenkovic, B. Stankovic, A. Tikly, M. Ananieva, L.P. Beretta, L. Szucs, G. Szamosi, S. de la Puente Bujidos, C. Midtvedt, Ø. Hoffmann-Vold, A.-M. Launay, D. Hachulla, E. Riccieri, V. Ionescu, R. Opris, D. Mihai, C. Herrgott, I. Beyer, C. Ingegnoli, F. von Mühlen, C.A. Alegre-Sancho, J.J. Beltrán-Catalán, E. Aringer, M. Fantana, J. Leuchten, N. Tausche, A.-K. De Langhe, E. Vanthuyne, M. Anic, B. Barešic, M. Mayer, M. Üprus, M. Otsa, K. Yavuz, S. Granel, B. Azevedo, V.F. Muller, C. Jimenez, S.A. Popa, S. Agachi, S. Zenone, T. Stebbings, S. Dockerty, J. Vacca, A. Schollum, J. Veale, D.J. Toloza, S. Xu, D. Olas, J. Rosato, E. Foti, R. Adler, S. Dan, D. Wiesik-Szewczyk, E. Olesińska, M. Kayser, C. Fathi, N. de la Peña Lefebvre, P.G. Imbert, B.

Subjects
integumentary system, skin and connective tissue diseases
Abstract

The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc. © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Published
2017

11. Mapping and predicting mortality from systemic sclerosis

Author

Elhai, M. Meune, C. Boubaya, M. Avouac, J. Hachulla, E. Balbir-Gurman, A. Riemekasten, G. Airò, P. Joven, B. Vettori, S. Cozzi, F. Ullman, S. Czirják, L. Tikly, M. Müller-Ladner, U. Caramaschi, P. Distler, O. Iannone, F. Ananieva, L.P. Hesselstrand, R. Becvar, R. Gabrielli, A. Damjanov, N. Salvador, M.J. Riccieri, V. Mihai, C. Szücs, G. Walker, U.A. Hunzelmann, N. Martinovic, D. Smith, V. Müller, C.D.S. Montecucco, C.M. Opris, D. Ingegnoli, F. Vlachoyiannopoulos, P.G. Stamenkovic, B. Rosato, E. Heitmann, S. Distler, J.H.W. Zenone, T. Seidel, M. Vacca, A. Langhe, E.D. Novak, S. Cutolo, M. Mouthon, L. Henes, J. Chizzolini, C. Mühlen, C.A.V. Solanki, K. Rednic, S. Stamp, L. Anic, B. Santamaria, V.O. Santis, M.D. Yavuz, S. Sifuentes-Giraldo, W.A. Chatelus, E. Stork, J. Laar, J.V. Loyo, E. De La Peña Lefebvre, P.G. Eyerich, K. Cosentino, V. Alegre-Sancho, J.J. Kowal-Bielecka, O. Rey, G. Matucci-Cerinic, M. Allanore, Y.

Abstract

Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 and 2011, we examined the death certificates of all French patients with SSc to determine causes of death. Then we examined causes of death and developed a score associated with all-cause mortality from the international European Scleroderma Trials and Research (EUSTAR) database. Candidate prognostic factors were tested by Cox proportional hazards regression model by single variable analysis, followed by a multiple variable model stratified by centres. The bootstrapping technique was used for internal validation. Results We identified 2719 French certificates of deaths related to SSc, mainly from cardiac (31%) and respiratory (18%) causes, and an increase in SSc-specific mortality over time. Over a median follow-up of 2.3 years, 1072 (9.6%) of 11 193 patients from the EUSTAR sample died, from cardiac disease in 27% and respiratory causes in 17%. By multiple variable analysis, a risk score was developed, which accurately predicted the 3-year mortality, with an area under the curve of 0.82. The 3-year survival of patients in the upper quartile was 53%, in contrast with 98% in the first quartile. Conclusion Combining two complementary and detailed databases enabled the collection of an unprecedented 3700 deaths, revealing the major contribution of the cardiopulmonary system to SSc mortality. We also developed a robust score to risk-stratify these patients and estimate their 3-year survival. With the emergence of new therapies, these important observations should help caregivers plan and refine the monitoring and management to prolong these patients' survival. ©Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Published
2017

15. OP0112 Effect of Comedication with Conventional Synthetic Dmards on Tnf Inhibitors-Retention in Patients with Spondyloarthritis: A Prospective Cohort

Author

Sepriano, A., primary, Ramiro, S., additional, van der Heijde, D., additional, Άvila-Ribeiro, P., additional, Fonseca, R., additional, Borges, J., additional, Teixeira, L., additional, Carvalho, P., additional, Cerqueira, M., additional, Neves, J., additional, Meirinhos, T., additional, Barcelos, A., additional, Sequeira, G., additional, Salvador, M.J., additional, Canas da Silva, J.A., additional, Santos, H., additional, Bernardes, M., additional, Vieira-Sousa, E., additional, Canhão, H., additional, Branco, J., additional, Pimentel-Santos, F., additional, and Landewé, R., additional

Published
2016
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16. OP0022 Juvenile Idiopathic Arthritis in Adulthood: Clinical Pattern and Long-Term Outcomes of 512 Patients

Author

Oliveira Ramos, F., primary, Eusébio, M., additional, Martins, F., additional, Cordeiro, I., additional, Mourão, A.F., additional, Salvador, M.J., additional, Cerqueira, M., additional, Brito, I., additional, Lucas, R., additional, Canhão, H., additional, Santos, M.J., additional, Melo Gomes, J.A., additional, and Fonseca, J.E., additional

Published
2015
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17. SAT0065 Pain and Anxiety are the Major Predictors of Discrepancies Between Patients' and Physicians' Perception of Disease Activity in Rheumatoid Arthritis

Author

Duarte, C., primary, Ferreira, R., additional, Batista, S., additional, Medeiros, C., additional, Sousa, J., additional, Eugenio, G., additional, Ferreira, J., additional, Costa, C., additional, Carvalho, P., additional, Coutinho, M., additional, Salvador, M.J., additional, and Silva, J.A., additional

Published
2015
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19. Clinical risk assessment of organ manifestations in systemic sclerosis: A report from the EULAR Scleroderma Trials and Research group database

Author

Walker, U.A. Tyndall, A. Czirják, L. Denton, C. Farge-Bancel, D. Kowal-Bielecka, O. Müller-Ladner, U. Bocelli-Tyndall, C. Matucci-Cerinic, M. Riemekasten, G. Brückner, C. Airó, P. Scarsi, M. Scorza, R. Beretta, L. Cozzi, F. Tiso, F. Vonk, M.C. Van Den Hoogen, F.H.J. Wigley, F.M. Hummers, L. Nevskaya, T. Ananieva, L. Miniati, I. Tartaglia, N. Lomater, C. Balbir-Gurman, A. Braun-Moscovici, Y. Bambara, L.M. Caramaschi, P. Valentini, G. Ruocco, L. Krieg, T. Hunzelmann, N. Varjú, C. Carriera, P.E. Joven, B. Iannone, F. Lapadula, G. Kahan, A. Allanore, Y. Gabrielli, A. Imperatore, M. Scheja, A. Wollheim, F. Damjanov, N. Ostojic, P. Saar, P. Tarner, I.H. Kötter, I. Bombardieri, S. Bazzichi, L. Del Papa, N. Comina, D.P. Lo Monaco, A. La Corte, R. Hachulla, E. Launay, D. Distler, O. Ciurea, A. Sierakowski, S. Mitchell, H. Silver, R.M. Krasowska, D. Michalska-Jakubus, M. Tikly, M. Aboo, N. Worm, M. Klaus, P. Rovenský, J. Lukáčová, O. Rozman, B. Sipek, A. Clemente-Coelho, P. Shoenfeld, Y. Langewitch, P. Da Silva José, A.P. Salvador, M.J. Kuhn, A. Erdmann, G. Bečvář, R. Friedl, E. Graninger, W. Riccieri, V. Caporali, R. Montecucco, C. Vlachoyiannopoulos, P. Distler, M. Reich, K. Majdan, M. Wielosz, E. Rednic, S. Van Laar, J.M. Heitmann, S. Bruckner, A. Himsel, A. Riemann, J. Meyringer, R. Müller, A. Martinovic, D. Radic, M. Sticherling, M. Szekanecz, Z. Szücs, G. Giacomelli, R. Marrelli, A. Stamenkovic, B. Stankovic, A. Aringer, M. Smolen, J.S. Kucharz, E.J. Kotulska, A.T. Jablonska, S. Blasczik, M. Jun, J.-B. Mallia, C. Coleiro, B. Santamaria, V.O. Hinrichs, R. Nielsen, H. Cossutta, R. Ionescu, R. Opris, D. Steinbrink, K. Grundt, B. Bajocchi, G. Jiří, Š. Lefebvre, P.G.D.L.P. Zea Mendoza, A.C. Ribi, C. Chizzolini, C. Wisłowska, M. Novak, S. Indiveri, F. Jacobsen, S. Frandsen, P.B. Gorska, I.Z. Tore Gran, J. Midtvedt, Ø. Ramos, F.O. Rajcevska, L.D. Bozinovski, G. Schöffel, D. Sunderkötter, C. Böhm, M. Morović-Vergles, J. Čulo, M.-I. Cutolo, M. Sulli, A. Derk, C.T. Jimenez, S.A. Siakka, P. Søndergaard, K. Stengaard-Pedersen, K. Cabane, J. Tiev, K.P. Mihai, C. Sfrent-Cornateanu, R. Jendro, M. Tuvik, P. Antivalle, M. Randisi, G. Seidel, M. Clarenbach, R. Simsek, I. Dinc, A. Inanc, M. Capraru, M.S. Capraru, D. Bañegil, I. Richter, J. Alhasani, S. Földvari, I. Pinto, S. Brandão, F. Mas, A.J.

Subjects
integumentary system, skin and connective tissue diseases
Abstract

Background: Systemic sclerosis (SSc) is a multisystem autoimmune disease, which is classified into a diffuse cutaneous (dcSSc) and a limited cutaneous (IcSSc) subset according to the skin involvement. In order to better understand the vascular, immunological and fibrotic processes of SSc and to guide its treatment, the EULAR Scleroderma Trials And Research (EUSTAR) group was formed in June 2004. Aims and methods: EUSTAR collects prospectively the Minimal Essential Data Set (MEDS) on all sequential patients fulfilling the American College of Rheumatology diagnostic criteria in participating centres. We aimed to characterise demographic, clinical and laboratory characteristics of disease presentation in SSc and analysed EUSTAR baseline visits. Results: In April 2006, a total of 3656 patients (1349 with dcSSc and 2101 with IcSSc) were enrolled in 102 centres and 30 countries. 1330 individuals had autoantibodies against Scl70 and 1106 against anticentromere antibodies. 87% of patients were women. On multivariate analysis, scleroderma subsets (dcSSc vs IcSSc), antibody status and age at onset of Raynaud's phenomenon, but not gender, were found to be independently associated with the prevalence of organ manifestations. Autoantibody status in this analysis was more closely associated with clinical manifestations than were SSc subsets. Conclusion: dcSSc and IcSSc subsets are associated with particular organ manifestations, but in this analysis the clinical distinction seemed to be superseded by an antibody-based classification in predicting some scleroderma complications. The EUSTAR MEDS database facilitates the analysis of clinical patterns in SSc, and contributes to the standardised assessment and monitoring of SSc internationally.

Published
2007

20. AB0653 Retention Rate and Predictive Factors of Tnf-α Inhibitor Discontinuation in Patients with Ankylosing Spondylitis - Results from the Rheumatic Diseases Portuguese Register Reuma.Pt

Author

Sepriano, A.R., primary, Araujo, F., additional, Aguiar, R., additional, Vieira, R., additional, Sousa, E., additional, Pimentel-Santos, F., additional, Sequeira, G., additional, Canhão, H., additional, Santos, H., additional, Garcia, J., additional, Pereira Silva, J.A., additional, Canas Silva, J., additional, Miranda, L., additional, Oliveira, M., additional, Salvador, M.J., additional, Bernardes, M., additional, Monteiro, P., additional, Nόvoa, T., additional, and Branco, J., additional

Published
2014
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21. AB0660 Predictive Factors of Treatment Response to A Second Tnf-α Inhibitor in Patients with Ankylosing Spondylitis - Results from the Portuguese Register Reuma.Pt

Author

Araújo, F., primary, Sepriano, A., additional, Madureira, P., additional, Aguiar, R., additional, Bernardo, A., additional, Silva, C., additional, Sousa, E., additional, Santos, F., additional, Sequeira, G., additional, Canhão, H., additional, Santos, H., additional, Garcia, J., additional, Pereira Silva, J.A., additional, Canas Silva, J., additional, Oliveira, M., additional, Salvador, M.J., additional, Nero, P., additional, Monteiro, P., additional, Nόvoa, T., additional, and Branco, J., additional

Published
2014
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24. Preliminary criteria for the very early diagnosis of systemic sclerosis: Results of a Delphi consensus study from EULAR scleroderma trials and research group

Author

UCL - (MGD) Service de rhumatologie, Avouac, J., Fransen, J., Walker, U.A., Riccieri, V., Smith, V., Muller, C., Miniati, I., Tarner, I.H., Bellando Randone, S., Cutolo, M., Allanore, Y., Distler, O., Valentini, G., Czirjak, L., Müller-Ladner, U., Furst, D.E., Tyndall, A., Matucci-Cerinic, M., De Keyser, F., Sulli, A., Pizzorni, C., Maurer, B., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P., Riemekasten, G., Rednic, S., Nicoara, I., Caporali, R., Štork, J., Inanc, M., Carreira, P., Novak, S., Varju, C., Chizzolini, C., Ribi, C., Kucharz, E.J., Kotulska, A., Widuchowska, M., Richter, J., Sipek-Dolnicar, A., Rozman, B., Gabrielli, A., Moroncini, G., Farge, D., Durant, C., Kiener, H.P., Rath, E., Airo, P., Wollheim, F.A., Hunzelmann, N., Bombardieri, S., Della Rossa, A., Bazzichi, L., Pellerito, R., Saracco, M., Denton, C., Vonk, M., Van Den Hoogen, F., Damjanov, N., Kötter, I., Heitmann, S., Seidel, M., Hasler, P., Van Laar, J.M., Salvador, M.J., Pereira Da Silva, J.A., Jacobsen, S., Worm, M., Kuhn, A., Nevskaya, T., Nasonov, E.L., Scorza, R., Nielsen, H., Silver, R.M., Hachulla, E., Launay, D., Valesini, G., Ionescu, R., Opris, D., Del Papa, N., Maglione, W., Comina, D., Udrea, G., Ciurtin, C., Ionitescu, R., Mihai, C., Sunderkötter, C., Jun, J.-B., Derk, C., Alhasani, S., Alhajjar, L., Ton, E., Seibold, J., Nash, P., Mouthon, L., Von Mühlen, C.A., Krummel-Lorenz, B., Eilbacher, P., Westhovens, R., De Langhe, E., Mayer, M., Anic, B., Baresic, M., Stoeckl, F., Üprus, M., Popa, S., Buslau, M., Granel, B., Zenone, T., Mathieu, A., Vacca, A., Amerio, P., Tourinho, T., Lonzetti, L., Lemos Lopes, M., De Souza, R., Vealex, D., Caramaschi, P., Balbir-Gurman, A., Braun, Y., Ullman, S., Szmyrka-Kaczmarek, M., Morgiel, E., Vanthuyne, Marie, Meurer, M., Rehberger, P., Müller, C., Sampaio-Barros, P., UCL - (MGD) Service de rhumatologie, Avouac, J., Fransen, J., Walker, U.A., Riccieri, V., Smith, V., Muller, C., Miniati, I., Tarner, I.H., Bellando Randone, S., Cutolo, M., Allanore, Y., Distler, O., Valentini, G., Czirjak, L., Müller-Ladner, U., Furst, D.E., Tyndall, A., Matucci-Cerinic, M., De Keyser, F., Sulli, A., Pizzorni, C., Maurer, B., Sierakowsky, S., Kowal-Bielecka, O., Coelho, P., Riemekasten, G., Rednic, S., Nicoara, I., Caporali, R., Štork, J., Inanc, M., Carreira, P., Novak, S., Varju, C., Chizzolini, C., Ribi, C., Kucharz, E.J., Kotulska, A., Widuchowska, M., Richter, J., Sipek-Dolnicar, A., Rozman, B., Gabrielli, A., Moroncini, G., Farge, D., Durant, C., Kiener, H.P., Rath, E., Airo, P., Wollheim, F.A., Hunzelmann, N., Bombardieri, S., Della Rossa, A., Bazzichi, L., Pellerito, R., Saracco, M., Denton, C., Vonk, M., Van Den Hoogen, F., Damjanov, N., Kötter, I., Heitmann, S., Seidel, M., Hasler, P., Van Laar, J.M., Salvador, M.J., Pereira Da Silva, J.A., Jacobsen, S., Worm, M., Kuhn, A., Nevskaya, T., Nasonov, E.L., Scorza, R., Nielsen, H., Silver, R.M., Hachulla, E., Launay, D., Valesini, G., Ionescu, R., Opris, D., Del Papa, N., Maglione, W., Comina, D., Udrea, G., Ciurtin, C., Ionitescu, R., Mihai, C., Sunderkötter, C., Jun, J.-B., Derk, C., Alhasani, S., Alhajjar, L., Ton, E., Seibold, J., Nash, P., Mouthon, L., Von Mühlen, C.A., Krummel-Lorenz, B., Eilbacher, P., Westhovens, R., De Langhe, E., Mayer, M., Anic, B., Baresic, M., Stoeckl, F., Üprus, M., Popa, S., Buslau, M., Granel, B., Zenone, T., Mathieu, A., Vacca, A., Amerio, P., Tourinho, T., Lonzetti, L., Lemos Lopes, M., De Souza, R., Vealex, D., Caramaschi, P., Balbir-Gurman, A., Braun, Y., Ullman, S., Szmyrka-Kaczmarek, M., Morgiel, E., Vanthuyne, Marie, Meurer, M., Rehberger, P., Müller, C., and Sampaio-Barros, P.

Abstract

Objective: To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc). Methods: A list of items provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to a Delphi exercise among 110 experts in the field of SSc. In round 1, experts were asked to choose the items they considered as the most important for the very early diagnosis of SSc. In round 2, experts were asked to reconsider the items accepted after the first stage. In round 3, the clinical relevance of selected items and their importance as measures that would lead to an early referral process were rated using appropriateness scores. Results: Physicians from 85 EUSTAR centres participated in the study and provided an initial list of 121 items. After three Delphi rounds, the steering committee, with input from external experts, collapsed the 121 items into three domains containing seven items, developed as follows: skin domain (puffy fingers/puffy swollen digits turning into sclerodactily);vascular domain (Raynaud's phenomenon, abnormal capillaroscopy with scleroderma pattern) and laboratory domain (antinuclear, anticentromere and antitopoisomerase-I antibodies). Finally, the whole assembly of EUSTAR centres ratified with a majority vote the results in a final face-to-face meeting. Conclusion: The three Delphi rounds allowed us to identify the items considered by experts as necessary for the very early diagnosis of SSc. The validation of these items to establish diagnostic criteria is currently ongoing in a prospective observational cohort.

Published
2011

31. SRTXRF Analysis in Different Pharmaceutical Forms of Diclofenac Sodium.

Author

Zucchi, O.L. A. D., Schiavetto, I.A., Salvador, M.J., and Moreira, S.

Subjects
SODIUM, DRUGS, PHARMACEUTICAL industry, SOLID dosage forms, X-ray spectroscopy, ANTI-inflammatory agents
Abstract

The quality of medicine depends upon the production processes and on chemical, physical, and physical-chemical properties of the drug (i.e., the active ingredient) and pharmaceutical excipients used in the formulation. The presence of impurities can inhibit the process of dissolution of medicine and the formulation components, among them metals, can be associated with the clinical effectiveness and bioavailability. The purpose of this work was to verify the presence of trace metals in different batches and pharmaceutical forms of diclofenac sodium using synchrotron radiation total reflection X-ray fluorescence analysis (SRTXRF). Different batches of medicines from six laboratories were analyzed. The results indicated variation in individual masses of the commercial medicine and in the nature and concentrations of the trace elements detected. Elements measured include Al, Si, P, S, Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Br, Rb, and Sr. The SRTXRF shows high sensitivity for the elements considered; it is, therefore, ideal for elemental characterization in solid pharmaceutical products. [ABSTRACT FROM AUTHOR]

Published
2005
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32. Determination of Trace Elements in Alternanthera brasiliana and Pfaffia glabrata by SRTXRF: Application in Environmental Pollution Control.

Author

Salvador, M.J., Moreira, S., Dias, D.A., and Zucchi, O.L. A. D.

Subjects
*ALTERNANTHERA, *TRACE elements, *POLLUTION, *AMARANTHACEAE, *SYNCHROTRON radiation, *X-ray spectroscopy
Abstract

Aiming at environmental control, we report the use of synchrotron radiation total reflection x-ray fluorescence (SRTXRF) analysis as a technique for trace elements determination in plants. The analyses were performed in two species (total plant) of Amaranthaceae family: Alternanthera brasiliana from four sites and Pfaffia glabrata from a single site. Some elements, such as P, S, K, Ca, Mn, Fe, Cu, Zn, Sr, and Pb were detected in all samples, and the elements Cl, Ti, Cr, Co, Ni, Br, Rb, Sr, Cd, Sn, Sb, and Ba were detected in some samples. The limit of detection (LOD) varied from 0.315 (Cu) to 121.4 (P) µg g−1. [ABSTRACT FROM AUTHOR]

Published
2004
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33. In vitro Antimicrobial Activity of Crude Extracts and Isolated Constituents of Alternanthera maritima.

Author

Salvador, M.J., Zucchi, O.L.A.D., Candido, R.C., Ito, I.Y., and Dias, D.A.

Subjects
*ALTERNANTHERA, *ANTI-infective agents, *MICROORGANISMS, *INFECTION, *GRAM-negative bacteria, *BIOLOGICAL assay
Abstract

The antimicrobial activity of ethanolic extracts (aerial parts and roots), fractions and isolated compounds of Alternanthera maritima (Mart.) St. Hil. (Amaranthaceae) were evaluated against microorganisms involved in human infections. These bioassays were conducted using thirty strains including Gram-positive and Gram-negative bacteria, yeasts and dermatophytes. The minimum inhibitory concentrations (MIC) values for isolated constituents varied from 25 to 500 µg/ml. Bioassay-guided fractionation, purification and isolation were performed by chromatographic methods and the structures of isolated compounds were established by analysis of chemical and spectral evidences (UV, IR, NMR and ES-MS). The following bioactive compounds were isolated: steroids (stigmasterol 1 , β-sitosterol 2 , campesterol 3 , spinasterol 4 and Δ 7 stigmastenol 5 ), organic acids (palmitic 6 and vanillic 13 acids), saponins (stigmasterol 7 and Δ 7 stigmastenol-3- O -β-D-glucopyranosides 8 , β-sitosterol 9 and spinasterol-3- O -α-D-glucopyranosides 10 ), flavonoid aglycones (quercetin 3-methyl ether 11 and kaempferol 12 ) and flavonoid glycosides (vitexin 14 , isovitexin 15 , isorhamnetin-3- O -robinobioside 16 and quercetin-3- O -rutinoside 17 ). The results were analyzed statistically by cluster analysis and principal components analysis. [ABSTRACT FROM AUTHOR]

Published
2004
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34. ESC Guidelines on the management of cardiovascular diseases during pregnancy

Author

European Society of Gynecology, Association for European Paediatric Cardiology, German Society for Gender Medicine, Authors/Task Force Members, Regitz Zagrosek V., Blomstrom Lundqvist C., Cifkova R., Ferreira R., Foidart J. M., Gibbs J. S., Gohlke Baerwolf C., Gorenek B., Iung B., Kirby M., Maas A. H., Morais J., Nihoyannopoulos P., Pieper P. G., Presbitero P., Roos Hesselink J. W., Schaufelberger M., Seeland U., Torracca L, ESC Committee for Practice Guidelines, Bax J., Auricchio A., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck Brentano C., Hasdai D., Hoes A., Knuuti J., Kolh P., McDonagh T., Moulin C., Poldermans D., Popescu B. A., Reiner Z., Sechtem U., Sirnes P. A., Torbicki A., Vahanian A., Windecker S., Document Reviewers, Aguiar C., Al Attar N., Garcia A. A., Antoniou A., Coman I., Elkayam U., Gomez Sanchez M. A., Gotcheva N., Hilfiker Kleiner D., Kiss R. G., Kitsiou A., Konings K. T., Lip G. Y., Manolis A., Mebaaza A., Mintale I., Morice M. C., Mulder B. J., Pasquet A., Price S., Priori S. G., Salvador M. J., Shotan A., Silversides C. K., Skouby S. O., Stein J. I., Tornos P., Vejlstrup N., Walker F., Warnes C., BORGHI, CLAUDIO, European Society of Gynecology, Association for European Paediatric Cardiology, German Society for Gender Medicine, Authors/Task Force Members, Regitz-Zagrosek V., Blomstrom Lundqvist C., Borghi C., Cifkova R., Ferreira R., Foidart J.M., Gibbs J.S., Gohlke-Baerwolf C., Gorenek B., Iung B., Kirby M., Maas A.H., Morais J., Nihoyannopoulos P., Pieper P.G., Presbitero P., Roos-Hesselink J.W., Schaufelberger M., Seeland U., Torracca L, ESC Committee for Practice Guidelines, Bax J., Auricchio A., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck-Brentano C., Hasdai D., Hoes A., Knuuti J., Kolh P., McDonagh T., Moulin C., Poldermans D., Popescu B.A., Reiner Z., Sechtem U., Sirnes P.A., Torbicki A., Vahanian A., Windecker S., and Document Reviewers, Baumgartner H., Deaton C., Aguiar C., Al-Attar N., Garcia A.A., Antoniou A., Coman I., Elkayam U., Gomez-Sanchez M.A., Gotcheva N., Hilfiker-Kleiner D., Kiss R.G., Kitsiou A., Konings K.T., Lip G.Y., Manolis A., Mebaaza A., Mintale I., Morice M.C., Mulder B.J., Pasquet A., Price S., Priori S.G., Salvador M.J., Shotan A., Silversides C.K., Skouby S.O., Stein J.I., Tornos P., Vejlstrup N., Walker F., Warnes C.

Subjects
Counseling, Prenatal Diagnosi, Pregnancy Complications, Cardiovascular, Heart failure, Abortion, Induced, Prenatal Care, Venous Thromboembolism, Guideline, Cardiovascular disease, Aortic Disease, Valvular heart disease, Management, Congential heart disease, Heart Disease, Cardiovascular Agent, Pregnancy, Hypertension, Pregnancy Complications, Infectiou, Female, Cardiology and Cardiovascular Medicine, Arrhythmia, Risk assessment, Human
Abstract

not available

Published
2011

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