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1. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

de Rábago, Eugenia Gonzalez, Blanco Morales, Elena Alonso, Fernández López, J. Carlos, Villar, Natividad Oreiro, Sandoval, Antonio Atanes, Blanco García, Francisco J., De Miquel, Cayetano Alegre, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, Torón, José García, Moreno Gil, María P., Mas, Antonio J., Espiño, Pilar, Ros, Inmaculada, Ibañez, Mónica, Murillo, Claudia, Piqueras, José A., Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Gutiérrez, Benjamín Fernández, Abasolo, Lydia, Fábregas, María D., Nolla, Joan M., Arias, Miriam García, García Vadillo, Jesús A., de Vicuña, Rosario García, Nebro, Antonio Fernández, Belmonte López, Maria Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, González, Ruth López, Garrido, Daniel Pielfort, Alvarez, Juana Sampedro, García Aparicio, Ángel María, Gómez, Rebeca Belmonte, Bautista, Pastora Granados, Sanz, Azucena Hernández, Sánchez González, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Zorzo, Fernando Jimenez, Ubeda, Eugenio Giménez, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Erausquin, Celia, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Lozano, Carlos Rodríguez, Herráez, Jesús Babío, López Longo, Francisco J., Gerona, Delia, Fernández, Carlos González, Carreño, Luis, Monteagudo, Indalecio, del Pino, Javier, Sánchez González, María Dolores, Corrales, Alfonso, Peiró, María Enriqueta, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, magro, Cesar, Escribano, Ana Ruibal, Expósito, Sergio Ros, Nievas, Ginés Sánchez, Navarro, Enrique Júdez, Fernández, Manuela Sianes, García Morales, María Ángeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, Alvarez, Beatriz González, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodríguez, Jiménez, Luis María, Redondo, Javier Rivera, Hernández, Teresa González, González Polo, Francisco J., Almagro, Raúl Menor, Moreno, José M., Serret, Emilio Giner, Barroso, Carla Lannuzzelli, Méndez, Laura Cebrián, Navío, María Teresa, Carballido, Cristina Fernández, Pagán, Encarnación, del Castillo, Pablo Mesa, Naredo, Esperanza, Cruz, Ana, Turrión, Ana, Mateo, Isabel, Sánchez, Julio, Galindo, María, González, Javier García, Collantes, Eduardo, Ruíz, Desireé, Font, Pilar, Bonilla, Gema, Meseguer, Antonio López, Moreno, Manuel J., Martínez, M<ce:sup loc='post">a</ce:sup> José Moreno, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Beteta, Linares, Luis F., Morcillo, Mercedes, González Gómez, María L., Aramburu, José M., Rivera, Natalia A., Berrizbeitia, Olaia Fernández, García Vivar, María Luz, Riera, Manel, León, Yolanda María, Maymó, Joan, Amirall, Miriam, Escolano, Silvia Iniesta, Serrano, Silvia Sánchez, Lis Bona, María Pilar, Fiter, Jordi, Melón, Julia Fernández, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquín, Bañegil, Inmaculada, Díaz, César, Valls, Ramón, Castellví, Iván, Bonet, María, Ruzafa, Estefania Moreno, Alen, Jaime Calvo, Sandoval, Trinidad Pérez, Evrard, Eva Revuelta, Godo, Javier R., Espartero, Cruz Fernández, Navarro Blasco, Francisco J., González, José Antonio, Miranda-Filloy, José A., García-Gómez, Carmen, Martín-Martínez, Maria A., Castañeda, Santos, Sanchez-Alonso, Fernando, Uriarte-Ecenarro, Miren, González-Juanatey, Carlos, Romera-Baures, Montserrat, Santos-Rey, José, Pinto-Tasende, José Antonio, Quesada-Masachs, Estefanía, Tornero-Molina, Jesús, Martínez-González, Olga, Cobo-Ibáñez, Tatiana, Chamizo-Carmona, Eugenio, Manrique-Arija, Sara, Fábregas-Canales, Dolores, Díaz-González, Federico, Llorca, Javier, and González-Gay, Miguel A.

Published
2017
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4. The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis

Author

de la Calle-Fabregat, Carlos, primary, Rodríguez-Ubreva, Javier, additional, Ciudad, Laura, additional, Ramírez, Julio, additional, Celis, Raquel, additional, Azuaga, Ana Belén, additional, Cuervo, Andrea, additional, Graell, Eduard, additional, Pérez-García, Carolina, additional, Díaz-Torné, César, additional, Salvador, Georgina, additional, Gómez-Puerta, José A., additional, Haro, Isabel, additional, Sanmartí, Raimon, additional, Cañete, Juan D., additional, and Ballestar, Esteban, additional

Published
2022
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5. The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis

Author

Calle-Fabregat, Carlos de la, Rodríguez-Ubreva, Javier, Ciudad, Laura, Ramírez, Julio, Celis, Raquel, Azuaga, Ana Belén, Cuervo, Andrea, Graell, Eduard, Pérez-García, Carolina, Díaz-Torné, César, Salvador, Georgina, Gómez-Puerta, José A., Haro Villar, Isabel, Sanmartí, Raimon, Cañete, Juan D., Ballestar, Esteban, Calle-Fabregat, Carlos de la, Rodríguez-Ubreva, Javier, Ciudad, Laura, Ramírez, Julio, Celis, Raquel, Azuaga, Ana Belén, Cuervo, Andrea, Graell, Eduard, Pérez-García, Carolina, Díaz-Torné, César, Salvador, Georgina, Gómez-Puerta, José A., Haro Villar, Isabel, Sanmartí, Raimon, Cañete, Juan D., and Ballestar, Esteban

Abstract

Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely associated with arthritis, are contributors and sensors of inflammation through epigenetic modifications. In this study, we investigated associations between clinical features and DNA methylation in blood and synovial fluid (SF) MOs in a prospective cohort of patients with early inflammatory arthritis. DNA methylation profiles of undifferentiated arthritis (UA) blood MOs exhibited marked alterations in comparison with those from healthy donors. We identified additional differences both in blood and SF MOs after comparing patients with UA grouped by their future outcomes, i.e., good versus poor. Patient profiles in subsequent visits revealed a reversion toward a healthy level in both groups, those requiring disease-modifying antirheumatic drugs and those who remitted spontaneously. Changes in disease activity between visits also affected DNA methylation, which was partially concomitant in the SF of UA and in blood MOs of patients with rheumatoid arthritis. Epigenetic similarities between arthritis types allow a common prediction of disease activity. Our results constitute a resource of DNA methylation-based biomarkers of poor prognosis, disease activity, and treatment efficacy for the personalized clinical management of early inflammatory arthritis.

Published
2022

6. The DNA Methylomes of Synovial and Peripheral Blood Monocytes Associate and Evolve With Prognosis and Treatment in Undifferentiated Arthritis

Author

de la Calle-Fabregat, Carlos, primary, Rodríguez-Ubreva, Javier, additional, Ciudad, Laura, additional, Ramírez, Julio, additional, Celis, Raquel, additional, Azuaga, Ana Belén, additional, Cuervo, Andrea M., additional, Graell, Eduard, additional, Pérez-García, Carolina, additional, Díaz-Torné, César, additional, Salvador, Georgina, additional, Gómez-Puerta, José A., additional, Haro, Isabel, additional, Sanmartí, Raimon, additional, Cañete, Juan D., additional, and Ballestar, Esteban, additional

Published
2022
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8. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk

Author

Julià, Antonio, Pinto, José Antonio, Gratacós, Jordi, Queiró, Rubén, Ferrándiz, Carlos, Fonseca, Eduardo, Montilla, Carlos, Torre-Alonso, Juan Carlos, Puig, Lluís, Pérez Venegas, José Javier, Fernández Nebro, Antonio, Fernández, Emilia, Muñoz-Fernández, Santiago, Daudén, Esteban, González, Carlos, Roig, Daniel, Sánchez Carazo, José Luís, Zarco, Pedro, Erra, Alba, López Estebaranz, José Luís, Rodríguez, Jesús, Ramírez, David Moreno, de la Cueva, Pablo, Vanaclocha, Francisco, Herrera, Enrique, Castañeda, Santos, Rubio, Esteban, Salvador, Georgina, Díaz-Torné, César, Blanco, Ricardo, Willisch Domínguez, Alfredo, Mosquera, José Antonio, Vela, Paloma, Tornero, Jesús, Sánchez-Fernández, Simón, Corominas, Héctor, Ramírez, Julio, López-Lasanta, María, Tortosa, Raül, Palau, Nuria, Alonso, Arnald, García-Montero, Andrés C, Gelpí, Josep Lluís, Codó, Laia, Day, Kenneth, Absher, Devin, Myers, Richard M, Cañete, Juan D, and Marsal, Sara

Published
2015
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9. PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis

Author

Julià, Antonio, Rodríguez, Jesús, Fernández-Sueiro, José Luis, Gratacós, Jordi, Queiró, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José Javier, Manrique-Arija, Sara, Muñoz-Fernández, Santiago, González, Carlos, Roig, Daniel, Zarco, Pedro, Erra, Alba, Castañeda, Santos, García, Alicia, Salvador, Georgina, Díaz-Torne, César, Blanco, Ricardo, Domínguez, Alfredo Willisch, Mosquera, José Antonio, Vela, Paloma, Tornero, Jesús, Sánchez-Fernández, Simón, Corominas, Héctor, Ramírez, Julio, Ávila, Gabriela, Alonso, Arnald, Tortosa, Raül, López-Lasanta, María, Cañete, Juan D, and Marsal, Sara

Published
2014
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10. Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?

Author

Sanmartí, Raimon, Frade-Sosa, Beatriz, Morlà, Rosa, Castellanos-Moreira, Raul, Cabrero-Villalba, Sonia, Ramirez, Julio, Salvador, Georgina, Haro Villar, Isabel, Cañete, Juan D., Sanmartí, Raimon, Frade-Sosa, Beatriz, Morlà, Rosa, Castellanos-Moreira, Raul, Cabrero-Villalba, Sonia, Ramirez, Julio, Salvador, Georgina, Haro Villar, Isabel, and Cañete, Juan D.

Abstract

Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.

Published
2021

12. Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis

Author

Ministerio de Economía y Competitividad (España), Castellanos-Moreira, Raul, Rodriguez-García, Sebastian C., Cabrero-Villalba, Sonia, Gómara Elena, María José, Salvador, Georgina, Ruiz-Esquide, Virginia, Ramírez, Julio, Inciarte-Mundo, José, Morlà, Rosa, García-Moreno, Cristina, Cuervo, Andrea, Gómez-Puerta, José A., Cañete, Juan D., Haro Villar, Isabel, Sanmartí, Raimon, Ministerio de Economía y Competitividad (España), Castellanos-Moreira, Raul, Rodriguez-García, Sebastian C., Cabrero-Villalba, Sonia, Gómara Elena, María José, Salvador, Georgina, Ruiz-Esquide, Virginia, Ramírez, Julio, Inciarte-Mundo, José, Morlà, Rosa, García-Moreno, Cristina, Cuervo, Andrea, Gómez-Puerta, José A., Cañete, Juan D., Haro Villar, Isabel, and Sanmartí, Raimon

Abstract

[Background]: A restricted response against citrullinated peptides/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide/protein antibodies (Anti-CarP) in patients with PR and RA., [Methods]: Cross-sectional study including 54 patients with pure PR and 53 patients with RA, matched by sex, age, disease duration and ACPA. Anti-CarP specificities were determined by home-made enzyme-linked immunosorbent assay tests using a synthetic chimeric fibrin/filaggrin homocitrullinated peptide (CFFHP) and fetal calf serum (FCS) homocitrullinated protein as antigens. IgG, IgA and IgM isotypes were measured., [Results]: Anti-CarP were positive (CFFHP or FCS) in 24% and 64% of patients with PR and RA, respectively (p < 0.005). All Anti-CarP isotype proportions were significantly lower in PR than in RA: Anti-CarP-IgG (24% versus 51%), Anti-CarP-IgA (7% versus 34%) and Anti-CarP-IgM (7% versus 36%). Mean titers of Anti-CarP isotypes were also lower in PR. In Anti-CarP positive patients, the isotype distribution differed between PR and RA: IgG Anti-CarP was used in all PR patients and in 79% of RA patients. By contrast, a significantly lower isotype usage of both IgA (31% versus 53%) and IgM (31% versus 56%) was observed in PR patients. No significant differences in clinical or demographic characteristics were observed according to Anti-CarP status in PR patients, except for a higher prevalence of ACPA and higher mean titers of ACPA and rheumatoid factor in Anti-CarP positive patients., [Conclusion]: Anti-CarP are found in patients with PR but in a lower proportion and with a different isotype usage from in RA, suggesting a distinct B cell response to homocitrullinated antigens in PR.

Published
2020

13. Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis

Author

Castellanos-Moreira, Raul, primary, Rodriguez-Garcia, Sebastian C., additional, Cabrera-Villalba, Sonia, additional, Gomara, María José, additional, Salvador, Georgina, additional, Ruiz-Esquide, Virginia, additional, Ramirez, Julio, additional, Inciarte-Mundo, Jose, additional, Morla, Rosa, additional, Garcia-Moreno, Cristina, additional, Cuervo, Andrea, additional, Gómez-Puerta, Jose A., additional, Cañete, Juan D., additional, Haro, Isabel, additional, and Sanmarti, Raimon, additional

Published
2020
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14. Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

Author

Martin-Martinez, M. A., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Garcia-Gomez, C., Lopez-Gonzalez, R., Babio-Herraiz, J., Juan-Mas, A., Moreno-Gil, M. P., Sanchez-Gonzalez, C. O., Romera-Baures, M., Pinto-Tasende, J. A., Tornero-Molina, J., Fabregas-Canales, D., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Quesada, Estefania, Steiner, Martina, Munoz, Santiago, Cobo, Tatiana, Gamero, Fernando, Garcia Toron, Jose, Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Pina, Jose M., Nolla, Joan M., Garcia Arias, Miriam, Garcia Vadillo, Jesus A., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Manrique Arija, Sara, Belmonte Lopez, Maria A., Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Pielfort Garrido, Daniel, Garcia Aparicio, Angel M., Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Bachiller, Javier, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Garcia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria A., Labiano Bastero, Isabel, Garcia Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Jimenez, Luis M., Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Navio, Maria T., Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Maria Jose, Beteta Fernandez, Maria D., Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria L., Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria P., Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Gonzalez, Jose A., and Miranda-Filloy, Jose A.

Subjects
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, incidence, cohort study, CARMA project, cardiovascular diseases
Abstract

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

Published
2019

16. Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies

Author

Canete, Juan D., Martinez, Susana E., Farres, Jaume, Sanmarti, Raimon, Blay, Maite, Gomez, Antoni, Salvador, Georgina, and Munoz-Gomez, Jose

Subjects
Rheumatoid arthritis -- Physiological aspects, Cytokines -- Physiological aspects, Health
Abstract

Th1 expression is greater than Th2 expression in the joints of patients with rheumatoid arthritis. This confirms that Th1 expression is inflammatory, whereas Th2 expression is anti-inflammatory.

Published
2000

17. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

Author

Aterido, Adrià, primary, Cañete, Juan D, additional, Tornero, Jesús, additional, Ferrándiz, Carlos, additional, Pinto, José Antonio, additional, Gratacós, Jordi, additional, Queiró, Rubén, additional, Montilla, Carlos, additional, Torre-Alonso, Juan Carlos, additional, Pérez-Venegas, José J, additional, Fernández Nebro, Antonio, additional, Muñoz-Fernández, Santiago, additional, González, Carlos M, additional, Roig, Daniel, additional, Zarco, Pedro, additional, Erra, Alba, additional, Rodríguez, Jesús, additional, Castañeda, Santos, additional, Rubio, Esteban, additional, Salvador, Georgina, additional, Díaz-Torné, Cesar, additional, Blanco, Ricardo, additional, Willisch Domínguez, Alfredo, additional, Mosquera, José Antonio, additional, Vela, Paloma, additional, Sánchez-Fernández, Simon Angel, additional, Corominas, Héctor, additional, Ramírez, Julio, additional, de la Cueva, Pablo, additional, Fonseca, Eduardo, additional, Fernández, Emilia, additional, Puig, Lluis, additional, Dauden, Esteban, additional, Sánchez-Carazo, José Luís, additional, López-Estebaranz, José Luís, additional, Moreno, David, additional, Vanaclocha, Francisco, additional, Herrera, Enrique, additional, Blanco, Francisco, additional, Fernández‐Gutiérrez, Benjamín, additional, González, Antonio, additional, Pérez-García, Carolina, additional, Alperi‐López, Mercedes, additional, Olivé Marques, Alejandro, additional, Martínez‐Taboada, Víctor, additional, González-Álvaro, Isidoro, additional, Sanmartí, Raimon, additional, Tomás Roura, Carlos, additional, García-Montero, Andrés C, additional, Bonàs-Guarch, Sílvia, additional, Mercader, Josep Maria, additional, Torrents, David, additional, Codó, Laia, additional, Gelpí, Josep Lluís, additional, López-Corbeto, Mireia, additional, Pluma, Andrea, additional, López-Lasanta, Maria, additional, Tortosa, Raül, additional, Palau, Nuria, additional, Absher, Devin, additional, Myers, Richard, additional, Marsal, Sara, additional, and Julià, Antonio, additional

Published
2018
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18. Ultrasound findings in palindromic rheumatism

Author

Sanmarti, Raimon, primary, Ramírez, Julio, additional, Castellanos-Moreira, Raul, additional, Cabrera-Villalba, Sonia Raquel, additional, Ruiz-Esquide, Virginia, additional, and Salvador, Georgina, additional

Published
2018
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19. Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis

Author

Cabrera-Villalba, Sonia, primary, Gomara, María José, additional, Cañete, Juan D., additional, Ramírez, Julio, additional, Salvador, Georgina, additional, Ruiz-Esquide, Virginia, additional, Hernández, Maria Victoria, additional, Inciarte-Mundo, José, additional, Haro, Isabel, additional, and Sanmartí, Raimon, additional

Published
2017
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20. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

García-Gómez, Carmen, primary, Martín-Martínez, Maria A., additional, Castañeda, Santos, additional, Sanchez-Alonso, Fernando, additional, Uriarte-Ecenarro, Miren, additional, González-Juanatey, Carlos, additional, Romera-Baures, Montserrat, additional, Santos-Rey, José, additional, Pinto-Tasende, José Antonio, additional, Quesada-Masachs, Estefanía, additional, Tornero-Molina, Jesús, additional, Martínez-González, Olga, additional, Cobo-Ibáñez, Tatiana, additional, Chamizo-Carmona, Eugenio, additional, Manrique-Arija, Sara, additional, Fábregas-Canales, Dolores, additional, Díaz-González, Federico, additional, Llorca, Javier, additional, González-Gay, Miguel A., additional, de Rábago, Eugenia Gonzalez, additional, Blanco Morales, Elena Alonso, additional, Fernández López, J. Carlos, additional, Villar, Natividad Oreiro, additional, Sandoval, Antonio Atanes, additional, Blanco García, Francisco J., additional, De Miquel, Cayetano Alegre, additional, González Fernández, María J., additional, Codina, Ramón Huguet, additional, Yoldi, Beatriz, additional, Ramentol, Mercedes, additional, Ávila, Gabriela, additional, Barril, Sara Marsal, additional, Steiner, Martina, additional, Muñoz, Santiago, additional, Gamero, Fernando, additional, Torón, José García, additional, Moreno Gil, María P., additional, Mas, Antonio J., additional, Espiño, Pilar, additional, Ros, Inmaculada, additional, Ibañez, Mónica, additional, Murillo, Claudia, additional, Piqueras, José A., additional, Sanmartí, Raimon, additional, Berman, Horacio, additional, Cabrera, Sonia, additional, Ruiz, Virginia, additional, Patón, Oscar Fontseré, additional, Gutiérrez, Benjamín Fernández, additional, Abasolo, Lydia, additional, Fábregas, María D., additional, Nolla, Joan M., additional, Arias, Miriam García, additional, García Vadillo, Jesús A., additional, de Vicuña, Rosario García, additional, Nebro, Antonio Fernández, additional, Belmonte López, Maria Angeles, additional, Ureña, Inmaculada, additional, Irigoyen, María V., additional, Cagigal, Virginia Coret, additional, González, Ruth López, additional, Garrido, Daniel Pielfort, additional, Alvarez, Juana Sampedro, additional, García Aparicio, Ángel María, additional, Gómez, Rebeca Belmonte, additional, Bautista, Pastora Granados, additional, Sanz, Azucena Hernández, additional, Sánchez González, Carmen O., additional, Bachiller, Javier, additional, Zea, Antonio, additional, Manero, Francisco J., additional, Zorzo, Fernando Jimenez, additional, Ubeda, Eugenio Giménez, additional, Gracía, Jesús Marzo, additional, Audera, Chesús Beltrán, additional, Medrano, Marta, additional, Pecondón, Ángela, additional, Erausquin, Celia, additional, Ojeda, Soledad, additional, Quevedo, Juan Carlos, additional, Francisco, Félix, additional, Lozano, Carlos Rodríguez, additional, Herráez, Jesús Babío, additional, López Longo, Francisco J., additional, Gerona, Delia, additional, Fernández, Carlos González, additional, Carreño, Luis, additional, Monteagudo, Indalecio, additional, del Pino, Javier, additional, Sánchez González, María Dolores, additional, Corrales, Alfonso, additional, Peiró, María Enriqueta, additional, Senabre, José M., additional, Rosas, José C., additional, Rotés, Isabel, additional, Moreno, Estefanía, additional, Erra, Alba, additional, Grado, Dolors, additional, Calvo, Javier, additional, Rueda, Amalia, additional, Möller, Ingrid, additional, Rodríguez, Isabel, additional, Barbadillo, Carmen, additional, Raya, Enrique, additional, Morales, Pilar, additional, Nieto, Ana, additional, Jiménez, Inmaculada, additional, magro, Cesar, additional, Escribano, Ana Ruibal, additional, Expósito, Sergio Ros, additional, Nievas, Ginés Sánchez, additional, Navarro, Enrique Júdez, additional, Fernández, Manuela Sianes, additional, García Morales, María Ángeles, additional, Bastero, Isabel Labiano, additional, Consuegra, Gloria García, additional, Palmou, Natalia, additional, Pardo, Silvia Martínez, additional, Pujol, Manel, additional, Alonso, Elena Riera, additional, Salvador, Georgina, additional, Alvarez, Beatriz González, additional, Cantabrana, Alberto, additional, Bustabad, Sagrario, additional, Delgado, Esmeralda, additional, Muñoz, Alejandro, additional, Montero, Sergio Rodríguez, additional, Jiménez, Luis María, additional, Redondo, Javier Rivera, additional, Hernández, Teresa González, additional, González Polo, Francisco J., additional, Almagro, Raúl Menor, additional, Moreno, José M., additional, Serret, Emilio Giner, additional, Barroso, Carla Lannuzzelli, additional, Méndez, Laura Cebrián, additional, Navío, María Teresa, additional, Carballido, Cristina Fernández, additional, Pagán, Encarnación, additional, del Castillo, Pablo Mesa, additional, Naredo, Esperanza, additional, Cruz, Ana, additional, Turrión, Ana, additional, Mateo, Isabel, additional, Sánchez, Julio, additional, Galindo, María, additional, González, Javier García, additional, Collantes, Eduardo, additional, Ruíz, Desireé, additional, Font, Pilar, additional, Bonilla, Gema, additional, Meseguer, Antonio López, additional, Moreno, Manuel J., additional, Martínez, Ma José Moreno, additional, Fernández, Ma Dolores Beteta, additional, Linares, Luis F., additional, Morcillo, Mercedes, additional, González Gómez, María L., additional, Aramburu, José M., additional, Rivera, Natalia A., additional, Berrizbeitia, Olaia Fernández, additional, García Vivar, María Luz, additional, Riera, Manel, additional, León, Yolanda María, additional, Maymó, Joan, additional, Amirall, Miriam, additional, Escolano, Silvia Iniesta, additional, Serrano, Silvia Sánchez, additional, Lis Bona, María Pilar, additional, Fiter, Jordi, additional, Melón, Julia Fernández, additional, Espadaler, Luis, additional, Maiz, Olga, additional, Belzunegui, Joaquín, additional, Bañegil, Inmaculada, additional, Díaz, César, additional, Valls, Ramón, additional, Castellví, Iván, additional, Bonet, María, additional, Ruzafa, Estefania Moreno, additional, Alen, Jaime Calvo, additional, Sandoval, Trinidad Pérez, additional, Evrard, Eva Revuelta, additional, Godo, Javier R., additional, Espartero, Cruz Fernández, additional, Navarro Blasco, Francisco J., additional, González, José Antonio, additional, and Miranda-Filloy, José A., additional

Published
2017
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21. Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross‐Sectional Study

Author

Fernández‐Carballido, Cristina, Martín‐Martínez, María A., García‐Gómez, Carmen, Castañeda, Santos, González‐Juanatey, Carlos, Sánchez‐Alonso, Fernando, García de Vicuña, Rosario, Erausquin‐Arruabarrena, Celia, López‐Longo, Javier, Sánchez, María D., Corrales, Alfonso, Quesada‐Masachs, Estefanía, Chamizo, Eugenio, Barbadillo, Carmen, Bachiller‐Corral, Javier, Cobo‐Ibañez, Tatiana, Turrión, Ana, Giner, Emilio, Llorca, Javier, González‐Gay, Miguel A., Gonzalez de Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernández Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco García, Francisco J., Alegre De Miquel, Cayetano, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, García Torón, José, Espino, Pilar, Ros, Inmaculada, Ibáñez, Mónica, Murillo, Claudia, Molina, Jesús Tornero, Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Fernández Gutierrez, Benjamín, Abasolo, Lydia, Pina, Jose Manuel, Nolla, Joan M., García Arias, Miriam, Uriarte‐Ecenarro, Mirem, García Vadillo, Jesús A., Fernández Nebro, Antonio, Manrique Arija, Sara, Belmonte López, María Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, Garrido, Daniel Pielfort, García Aparicio, Angel María, Belmonte Gómez, Rebeca, Bautista, Pastora Granados, Hernandez Sanz, Azucena, Manero, Francisco J., Jimenez Zorzo, Fernando, Giménez Ubeda, Eugenio, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Rodríguez Lozano, Carlos, Gerona, Delia, González Fernández, Carlos, Carreño, Luis, Monteagudo, Indalecio, Pino, Javier, Peiró, María Enriqueta, Fernández‐Carballido, Cristina, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Expósito, Sergio Ros, Sánchez Nievas, Ginés, Navarro, Enrique Júdez, Sianes Fernández, Manuela, García Morales, María Angeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, González Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodriguez, and Jimenez, Luis María

Abstract

To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This was a cross‐sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0–27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and Pvalues. We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28‐ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = –0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.

Published
2020
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22. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.

Author

Aterido, Adrià, Cañete, Juan D., Tornero, Jesús, Ferrándiz, Carlos, Pinto, José Antonio, Gratacós, Jordi, Queiró, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José J., Nebro, Antonio Fernández, Muñoz-Fernández, Santiago, González, Carlos M., Roig, Daniel, Zarco, Pedro, Erra, Alba, Rodríguez, Jesús, Castañeda, Santos, Rubio, Esteban, and Salvador, Georgina

Abstract

Objective: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis affecting up to 30% of patients with psoriasis (Ps). To date, most of the known risk loci for PsA are shared with Ps, and identifying disease-specific variation has proven very challenging. The objective of the present study was to identify genetic variation specific for PsA.Methods: We performed a genome-wide association study in a cohort of 835 patients with PsA and 1558 controls from Spain. Genetic association was tested at the single marker level and at the pathway level. Meta-analysis was performed with a case-control cohort of 2847 individuals from North America. To confirm the specificity of the genetic associations with PsA, we tested the associated variation using a purely cutaneous psoriasis cohort (PsC, n=614) and a rheumatoid arthritis cohort (RA, n=1191). Using network and drug-repurposing analyses, we further investigated the potential of the PsA-specific associations to guide the development of new drugs in PsA.Results: We identified a new PsA risk single-nucleotide polymorphism at B3GNT2 locus (p=1.10e-08). At the pathway level, we found 14 genetic pathways significantly associated with PsA (pFDR<0.05). From these, the glycosaminoglycan (GAG) metabolism pathway was confirmed to be disease-specific after comparing the PsA cohort with the cohorts of patients with PsC and RA. Finally, we identified candidate drug targets in the GAG metabolism pathway as well as new PsA indications for approved drugs.Conclusion: These findings provide insights into the biological mechanisms that are specific for PsA and could contribute to develop more effective therapies. [ABSTRACT FROM AUTHOR]

Published
2019
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23. Diagnostic and Therapeutic Delay of Rheumatoid Arthritis and its Relationship With Health Care Devices in Catalonia. The AUDIT Study

Author

Corominas, Hèctor, primary, Narváez, Javier, additional, Díaz-Torné, César, additional, Salvador, Georgina, additional, Gomez-Caballero, María Eugenia, additional, de la Fuente, Diana, additional, Campoy, Ester, additional, Roig-Vilaseca, Daniel, additional, Clavaguera, Teresa, additional, Morlà, Rosa, additional, Torrente-Segarra, Vicenç, additional, Arasa, Xavier, additional, Gomez-Puerta, José Alfredo, additional, Möller, Ingrid, additional, Alegre, Cayetano, additional, Graell, Eduard, additional, Ponce, Andrés, additional, Lisbona, María Pilar, additional, Pérez-Garcia, Carolina, additional, Fíguls, Ramon, additional, Sirvent, Elena, additional, Poca, Violan, additional, and Sanmartí, Raimon, additional

Published
2016
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24. Retraso diagnóstico y terapéutico de la artritis reumatoide y su relación con dispositivos asistenciales en Catalunya. Estudio AUDIT

Author

Corominas, Hèctor, primary, Narváez, Javier, additional, Díaz-Torné, César, additional, Salvador, Georgina, additional, Gomez-Caballero, María Eugenia, additional, de la Fuente, Diana, additional, Campoy, Ester, additional, Roig-Vilaseca, Daniel, additional, Clavaguera, Teresa, additional, Morlà, Rosa, additional, Torrente-Segarra, Vicenç, additional, Arasa, Xavier, additional, Gomez-Puerta, José Alfredo, additional, Möller, Ingrid, additional, Alegre, Cayetano, additional, Graell, Eduard, additional, Ponce, Andrés, additional, Lisbona, María Pilar, additional, Pérez-Garcia, Carolina, additional, Fíguls, Ramon, additional, Sirvent, Elena, additional, Poca, Violan, additional, and Sanmartí, Raimon, additional

Published
2016
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25. A deletion atADAMTS9-MAGI1locus is associated with psoriatic arthritis risk

Author

Julià, Antonio, primary, Pinto, José Antonio, additional, Gratacós, Jordi, additional, Queiró, Rubén, additional, Ferrándiz, Carlos, additional, Fonseca, Eduardo, additional, Montilla, Carlos, additional, Torre-Alonso, Juan Carlos, additional, Puig, Lluís, additional, Pérez Venegas, José Javier, additional, Fernández Nebro, Antonio, additional, Fernández, Emilia, additional, Muñoz-Fernández, Santiago, additional, Daudén, Esteban, additional, González, Carlos, additional, Roig, Daniel, additional, Sánchez Carazo, José Luís, additional, Zarco, Pedro, additional, Erra, Alba, additional, López Estebaranz, José Luís, additional, Rodríguez, Jesús, additional, Ramírez, David Moreno, additional, de la Cueva, Pablo, additional, Vanaclocha, Francisco, additional, Herrera, Enrique, additional, Castañeda, Santos, additional, Rubio, Esteban, additional, Salvador, Georgina, additional, Díaz-Torné, César, additional, Blanco, Ricardo, additional, Willisch Domínguez, Alfredo, additional, Mosquera, José Antonio, additional, Vela, Paloma, additional, Tornero, Jesús, additional, Sánchez-Fernández, Simón, additional, Corominas, Héctor, additional, Ramírez, Julio, additional, López-Lasanta, María, additional, Tortosa, Raül, additional, Palau, Nuria, additional, Alonso, Arnald, additional, García-Montero, Andrés C, additional, Gelpí, Josep Lluís, additional, Codó, Laia, additional, Day, Kenneth, additional, Absher, Devin, additional, Myers, Richard M, additional, Cañete, Juan D, additional, and Marsal, Sara, additional

Published
2015
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27. Is There Subclinical Synovitis in Patients with Palindromic Rheumatism in the Intercritical Period? A Clinical and Ultrasonographic Study According to Anticitrullinated Protein Antibody Status

Author

Cabrera-Villalba, Sonia, primary, Ramirez, Julio, additional, Salvador, Georgina, additional, Ruiz-Esquide, Virginia, additional, Hernández, M. Victoria, additional, Inciarte-Mundo, José, additional, Gómez-Puerta, José A., additional, Cañete, Juan D., additional, and Sanmarti, Raimon, additional

Published
2014
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28. Palindromic Rheumatism with Positive Anticitrullinated Peptide/Protein Antibodies Is Not Synonymous with Rheumatoid Arthritis. A Longterm Followup Study

Author

SANMARTÍ, RAIMON, primary, CABRERA-VILLALBA, SONIA, additional, GÓMEZ-PUERTA, JOSÉ A., additional, RUIZ-ESQUIDE, VIRGINIA, additional, HERNÁNDEZ, M. VICTORIA, additional, SALVADOR, GEORGINA, additional, RAMIREZ, JULIO, additional, VIÑAS, ODETTE, additional, and CAÑETE, JUAN D., additional

Published
2012
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29. Diagnosis of tuberculosis infection by tuberculin skin test and a whole-blood interferon-γ release assay in patients considered for anti–tumor necrosis factor-α therapy

Author

Casas, Susana, primary, Andreu, Ana, additional, Juanola, Xavier, additional, Bordas, Xavier, additional, Alcaide, Fernando, additional, Moure, Raquel, additional, Anibarro, Luis, additional, Cuchí, Eva, additional, Esteve, Maria, additional, Ortiz, Vera, additional, Guerra, Maria Rosario, additional, Rodríguez, Jesus, additional, Reina, Delia, additional, Salvador, Georgina, additional, Guardiola, Jordi, additional, Surís, Xavier, additional, Pascual, Maria Angeles, additional, Martí, Carmina, additional, Martínez-Lacasa, Xavier, additional, Cuquet, Jordi, additional, Gonzalez, Lucia, additional, and Santin, Miguel, additional

Published
2011
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30. PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis.

Author

Juli, Antonio, Rodríguez, Jesús, Fernández-Sueiro, José Luis, Gratacós, Jordi, Queir, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José Javier, Manrique-Arija, Sara, Muñoz-Fernández, Santiago, González, Carlos, Roig, Daniel, Zarco, Pedro, Erra, Alba, Castañeda, Santos, García, Alicia, Salvador, Georgina, Díaz-Torne, César, Blanco, Ricardo, and Domínguez, Alfredo Willisch

Abstract

Aim: Variation at PDE3A-SLCO1C1 locus has been recently associated with the response to anti-TNF therapy in rheumatoid arthritis. We undertook the present study to determine whether PDE3A-SLCO1C1 is also associated with the response to anti-TNF therapy in psoriatic arthritis. Patients & methods: Genomic DNA was obtained from 81 psoriatic arthritis patients that had been treated with anti-TNF therapy. PDE3A-SLCO1C1 SNP rs3794271 was genotyped using Taqman realt-time PCR. The clinical response to anti-TNF therapy was measured as the change from baseline in the level of disease activity according to the DAS28 score. Results: A significant association between rs3794271 and anti-TNF response in psoriatic arthritis was found (beta = -0.71; p = 0.0036). Conclusion: PDE3A-SLCO1C1 locus is also associated with response to anti-TNF therapy in psoriatic arthritis. Original submitted 12 May 2014; Revision submitted 18 August 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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33. Validity, reproducibility, and responsiveness of a twelvejoint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis

Author

Naredo, Esperanza, Rodríguez, Manuel, Campos, Cristina, Rodríguezheredia, José Manuel, Medina, Julio A., Giner, Emilio, Martínez, Olga, Toyos, Francisco Javier, Ruíz, Teresa, Ros, Inmaculada, Pujol, Manuel, Miquel, Xavier, García, Luz, Aznar, Juan José, Chamizo, Eugenio, Páez, Manuel, Morales, Pilar, Rueda, Amalia, Tuneu, Roser, Corominas, Hector, de Agustín, Juan José, Moragues, Carmen, Mínguez, Dolores, Willisch, Alfredo, Gonzálezcruz, Isabel, Aragón, Angel, Iglesias, Gerardo, Armas, Carlos, Pablo valdazo, Juan, Vargas, Carmen, Calvoalén, Jaime, Juanmas, Antonio, Salvador, Georgina, Puigdollers, Angels, Galíndez, Eva, Garrido, Noemi, Salaberri, José, Raya, Enrique, Salles, Meritxell, Díaz, César, Cuadra, José luis, and Garrido, Jesús

Abstract

ObjectiveTo investigate the validity, reproducibility, and responsiveness of a simplified power Doppler ultrasound PDUS assessment of joint inflammation compared with a comprehensive 44joint PDUS assessment in patients with rheumatoid arthritis RA who started therapy with a biologic agent.MethodsA total of 160 patients with active RA who started a biologic agent were prospectively recruited in 18 Spanish centers. The patients underwent clinical and laboratory assessment and blinded PDUS examination at baseline and 6 months. A PDUS examination of 128 synovial sites in 44 joints was performed. US synovitis and PD signal were semiquantitatively graded from 1 to 3 in all synovial sites. US count and index for synovitis and PD signal were obtained. PDUS intraobserver and interobserver reliability were evaluated. A process of data reduction based on the frequency of involvement of synovial sites by both synovitis and PD signal was conducted. Construct and discriminant validity of a simplified PDUS assessment was investigated.ResultsA PDUS simplified assessment including 24 synovial sites from 12 joints detected 100 of patients with synovitis and 91 of patients with PD signal. There was a highly significant correlation between the 44joint count and index for synovitis and PD signal and the 12joint count and index for synovitis and PD signal at baseline and 6 months r 0.84–0.90, P< 0.0005. The smallest detectable difference was lower than the mean change in simplified PDUS variables.ConclusionA 12joint PDUS assessment of RA joint inflammation may be a valid, feasible method for multicenter monitoring of therapeutic response to biologic agents.

Published
2008
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35. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C., Martin-Martinez, M. A., Fernandez-Carballido, C., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Gonzalez-Fernandez, M. J., Sanmarti, R., Garcia-Vadillo, J. A., Fernandez-Gutierrez, B., Garcia-Arias, M., Manero, F. J., Senabre, J. M., Rueda-Cid, A., Ros-Exposito, S., Pina-Salvador, J. M., Erra-Duran, A., Moller-Parera, I., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Munoz, Santiago, Gamero, Fernando, Garcia Toron, Jose, Moreno Gil, Maria P., Mas, Antonio J., Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Piqueras, Jose A., Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Fabregas, Maria D., Romera Baures, Montserrat, Nolla, Joan M., Gonzalez-Alvaro, Isidoro, Tomero Muriel, Eva G., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Belmonte Lopez, Maria Angeles, Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Lopez Gonzalez, Ruth, Pielfort Garrido, Daniel, Sampedro Alvarez, Juana, Garcia Aparicio, Angel Maria, Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Sanchez Gonzalez, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Gracia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Babio Herraez, Jesus, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Carreno, Luis, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria Angeles, Labiano Bastero, Isabel, Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Maria Jimenez, Luis, Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Teresa Navio, Maria, Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Mateo, Isabel, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Ma Jose, Beteta Fernandez, Ma Dolores, Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Aramburu, Jose M., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria Luz, Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria Pilar, Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Antonio Gonzalez, Jose, and Miranda-Filloy, Jose A.

Subjects
psoriatic arthritis, lipids, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

36. Cross-sectional Study and Mendelian Randomization Analysis of Diet in Six Prevalent Autoimmune Diseases

Author

Julia, Antonio, Martinez, Sergio H., Tornero, Jesus, Canete, Juan, Fernandez-Nebro, Antonio, Blanco, Francisco J., Rodriguez, Jesus, Javier Lopez-Longo, Francisco, Fernandez-Gutierrez, Benjamin, Gratacos, Jordi, Perez Venegas, Jose J., Perez, Carolina, Rubén Queiro, Olive-Marques, Alejandro, Alperi-Lopez, Mercedes, Montilla, Carlos, Luis Andreu, Jose, Carlos Torre-Alonso, Juan, Angeles Aguirre-Zamorano, Ma, Corominas, Hector, Vela, Paloma, Martinez-Taboada, Victor, Marique, Sara, Nolla, Joan M., Gonzalez, Isidoro, Munoz-Fernandez, Santiago, Marenco La Fuente, Jose Luis, Gonzalez, Carlos, Zea, Antonio, Lopez Lasanta, Maria, Roig, Daniel, Maria Pego-Reigosa, Jose, Lopez Corbeto, Mireia, Zarco, Pedro, Freire Gonzalez, Mercedes, Erra, Alba, Diez, Elvira, Castaneda, Santos, Rodriguez, Esther, Garcia, Alicia, Carreira, Patricia, Salvador, Georgina, Blanco, Ricardo, Diaz-Torne, Cesar, Willisch Dominguez, Alfredo, Antonio Mosquera, Joan, Sanchez-Fernandez, Simon, Ramirez, Julio, and Marsal, Sara

39. Non-adherence to subcutaneous biological medication in patients with rheumatoid arthritis: a multicentre, non-interventional study.

Author

Calvo-Alén J, Monteagudo I, Salvador G, Vázquez-Rodríguez TR, Tovar-Beltrán JV, Vela P, Maceiras F, Bustabad S, Román-Ivorra JA, Díaz-Miguel C, Rosas J, Raya E, Carmona L, Cea-Calvo L, Arteaga MJ, Fernández S, and Marras C

Subjects
Adult, Aged, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid psychology, Biological Products adverse effects, Chi-Square Distribution, Drug Administration Schedule, Drug Prescriptions, Female, Humans, Infusions, Subcutaneous, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Factors, Spain, Surveys and Questionnaires, Time Factors, Treatment Outcome, Antirheumatic Agents administration & dosage, Arthritis, Rheumatoid drug therapy, Biological Products administration & dosage, Medication Adherence
Abstract

Objectives: To evaluate non-adherence to prescribed subcutaneous biologicals in rheumatoid arthritis (RA) patients in Spain., Methods: ARCO (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs) was a multicentre, non-interventional retrospective study involving 42 rheumatology clinics from representative hospitals throughout Spain. The primary objective was to assess the percentage of patients (aged ≥18 years with an established RA diagnosis) with non-adherence to prescribed subcutaneous biologicals using clinical records and hospital pharmacy dispensing logs as the primary information sources. Adherence was assessed using the Medication Possession Ratio (MPR). Additionally, patients completed the Morisky-Green Medication Adherence Questionnaire., Results: A total of 364 patients (77.5% females, mean age 54.9 years, median RA duration since diagnosis 7.8 years) were enrolled in ARCO. Non-adherence (MPR ≤80%) was reported in 52/363 evaluable patients (14.3%), and was lower in patients receiving initial monthly drug administration (6.4%) than with weekly (17.4%; p=0.034) or every two weeks (14.4%; p=0.102) administration. By multivariate analysis, non-adherence was positively associated with RA duration above the median and with using induction doses. Monthly administration, compared to weekly administration, was inversely associated with non-adherence. Age, gender, order of administration, and changes in the interval of administration, showed no association with non-adherence. Compared with the MPR, the Morisky-Green questionnaire performed poorly in detecting non-adherence., Conclusions: Non-adherence to the prescribed subcutaneous biological drug occurred in 14.3% of patients with RA. Patients using the most convenient administration period (i.e. monthly) had better adherence than those using more frequent dosing schedules.

Published
2017

40. Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis.

Author

Naredo E, Rodríguez M, Campos C, Rodríguez-Heredia JM, Medina JA, Giner E, Martínez O, Toyos FJ, Ruíz T, Ros I, Pujol M, Miquel X, García L, Aznar JJ, Chamizo E, Páez M, Morales P, Rueda A, Tuneu R, Corominas H, de Agustín JJ, Moragues C, Mínguez D, Willisch A, González-Cruz I, Aragón A, Iglesias G, Armas C, Pablo Valdazo J, Vargas C, Calvo-Alén J, Juan-Mas A, Salvador G, Puigdollers A, Galíndez E, Garrido N, Salaberri J, Raya E, Salles M, Díaz C, Cuadra JL, and Garrido J

Subjects
Adult, Aged, Aged, 80 and over, Arthritis diagnostic imaging, Female, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Arthritis, Rheumatoid diagnostic imaging, Ultrasonography, Doppler
Abstract

Objective: To investigate the validity, reproducibility, and responsiveness of a simplified power Doppler ultrasound (PDUS) assessment of joint inflammation compared with a comprehensive 44-joint PDUS assessment in patients with rheumatoid arthritis (RA) who started therapy with a biologic agent., Methods: A total of 160 patients with active RA who started a biologic agent were prospectively recruited in 18 Spanish centers. The patients underwent clinical and laboratory assessment and blinded PDUS examination at baseline and 6 months. A PDUS examination of 128 synovial sites in 44 joints was performed. US synovitis and PD signal were semiquantitatively graded from 1 to 3 in all synovial sites. US count and index for synovitis and PD signal were obtained. PDUS intraobserver and interobserver reliability were evaluated. A process of data reduction based on the frequency of involvement of synovial sites by both synovitis and PD signal was conducted. Construct and discriminant validity of a simplified PDUS assessment was investigated., Results: A PDUS simplified assessment including 24 synovial sites from 12 joints detected 100% of patients with synovitis and 91% of patients with PD signal. There was a highly significant correlation between the 44-joint count and index for synovitis and PD signal and the 12-joint count and index for synovitis and PD signal at baseline and 6 months (r = 0.84-0.90, P < 0.0005). The smallest detectable difference was lower than the mean change in simplified PDUS variables., Conclusion: A 12-joint PDUS assessment of RA joint inflammation may be a valid, feasible method for multicenter monitoring of therapeutic response to biologic agents.

Published
2008
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41. Palindromic rheumatism and other relapsing arthritis.

Author

Sanmarti R, Cañete JD, and Salvador G

Subjects
Arthritis complications, Arthritis immunology, Diagnosis, Differential, Familial Mediterranean Fever diagnosis, Humans, Hydrarthrosis diagnosis, Hyperlipidemias diagnosis, Recurrence, Rheumatic Diseases complications, Rheumatic Diseases immunology, Whipple Disease diagnosis, Whipple Disease immunology, Arthritis pathology, Rheumatic Diseases pathology
Abstract

Patients with recurrent or relapsing arthritis are frequently seen in rheumatological practice. Besides crystal arthritis, the most frequent cause of recurrent arthritis, there are several diseases that may present clinically as intermittent mono- or polyarthritis. Palindromic rheumatism is the paradigm of this type of condition, but other diseases such as systemic autoinflammatory disorders (periodic fever syndromes), Whipple's disease, arthritis associated with hyperlipidemia, intermittent hydrarthrosis and other diseases should be taken into account in the differential diagnosis of patients with recurrent arthritis. In this chapter, we discuss recent developments in these diseases with special emphasis on palindromic rheumatism, a common condition whose close relationship with rheumatoid arthritis remains intriguing.

Published
2004
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