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3. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke

Author

Salsano Giancarlo, Salsano Antonio, Del Sette Bruno, D’Alonzo Alessio, Sassos Davide, Alexandre Andrea, Pedicelli Alessandro, Di Iorio Riccardo, Colò Francesca, and Castellan Lucio

Subjects
dmvo, endovascular therapy, ivt, acute ischemic stroke, Medicine
Abstract

In the absence of clinical trials, the benefit of endovascular therapy (EVT) on the treatment of acute ischemic stroke (AIS) with primary distal and medium vessel occlusions (DMVO) is still not well defined. The aim of the study is to evaluate EVT with or without intravenous thrombolysis (EVT ± IVT) in primary DMVO stroke in comparison with a control cohort treated with IVT alone.

Published
2024
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5. Impact of Surgeon Experience and Centre Volume on Outcome After Off-Pump Coronary Artery Bypass Surgery: Results From the European Multicenter Study on Coronary Artery Bypass Grafting (E-CABG) Registry

Author

Naito, Shiho, Demal, Till J., Sill, Björn, Reichenspurner, Hermann, Onorati, Francesco, Gatti, Giuseppe, Mariscalco, Giovanni, Faggian, Giuseppe, Salsano, Antonio, Santini, Francesco, Santarpino, Giuseppe, Zanobini, Marco, Musumeci, Francesco, Rubino, Antonino S., Bancone, Ciro, De Feo, Marisa, Nicolini, Francesco, Dalén, Magnus, Speziale, Giuseppe, Bounader, Karl, Mäkikallio, Timo, Tauriainen, Tuomas, Ruggieri, Vito G., Perrotti, Andrea, and Biancari, Fausto

Published
2023
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7. Treatment and outcomes of mechanical complications of acute myocardial infarction during the Covid-19 era: A comparison with the pre-Covid-19 period. A systematic review and meta-analysis

Author

Spadaccio Cristiano, Pisani Angelo, Salsano Antonio, Nenna Antonio, Fardman Alexander, D’Alessandro David, Santini Francesco, Gaudino Mario F. L., Sundt Thoralf M., and Rose David

Subjects
myocardial infarction, mechanical complications, covid-19, Medicine
Abstract

This study aims to compare treatments and outcomes of mechanical complications of acute myocardial infarction (MI) during the Covid-19 and in the pre-Covid-19 era. Electronic databases have been searched for MI mechanical complications during the Covid-19 era and in the previous period from January 1998 to January 2020 (pre-Covid-19 era), until October 2021. To perform a quantitative analysis of non-comparative series, a meta-analysis of proportion has been conducted. Early mortality after surgical treatment was 15.0% while it was significantly higher after conservative treatment (62.4%) (P = 0.026). Early mortality after surgical treatment was seemingly higher in the pre-Covid-19 era but the difference did not reach statistical significance (15.0% vs 38.9%; P = 0.13). Mortality in patients treated conservatively, or turned down for surgery, was lower during the Covid-19 pandemic (62.4% vs 97.7%; P = 0.001). The crude mean prevalence of the use rate of conservative or surgical treatment across the studies during Covid-19 and in the pre-Covid-19 era was comparable. The current increased incidence of MI mechanical complications might be a consequence of delayed presentation or restricted access to hospital facilities. Despite the general negative impact of Covid-19 on cardiac surgery volumes and outcomes and the apparent increase of the incidence of MI complications, the outcomes of their surgical and clinical treatment seem not to have been affected during the pandemic.

Published
2022
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8. Coronary Artery Bypass Grafting in Patients With High Risk of Bleeding

Author

Demal, Till J., Fehr, Samira, Mariscalco, Giovanni, Reiter, Beate, Bibiza, Eric, Reichenspurner, Hermann, Gatti, Giuseppe, Onorati, Francesco, Faggian, Giuseppe, Salsano, Antonio, Santini, Francesco, Perrotti, Andrea, Santarpino, Giuseppe, Zanobini, Marco, Saccocci, Matteo, Musumeci, Francesco, Rubino, Antonino S., De Feo, Marisa, Bancone, Ciro, Nicolini, Francesco, Dalén, Magnus, Maselli, Daniele, Bounader, Karl, Mäkikallio, Timo, Juvonen, Tatu, Ruggieri, Vito G., and Biancari, Fausto

Published
2022
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10. Surgical myocardial revascularization outcomes in Kawasaki disease: systematic review and meta-analysis

Author

Salsano Antonio, Liao Jingda, Miette Ambra, Capoccia Massimo, Mariscalco Giovanni, Santini Francesco, and Corno Antonio F.

Subjects
aorto-coronary bypass grafting, coronary artery aneurisms, kawasaki disease, surgical revascularization, Medicine
Abstract

Kawasaki disease (KD) is a systemic inflammatory condition occurring predominantly in children. Coronary artery bypass grafting (CABG) is performed in the presence of inflammation and aneurysms of the coronary arteries. The objectives of our study were to assess which CABG strategy provides better graft patency and early and long-term outcomes.

Published
2021
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11. Intestinal Microbiota and Derived Metabolites in Myocardial Fibrosis and Postoperative Atrial Fibrillation.

Author

Nenna, Antonio, Laudisio, Alice, Taffon, Chiara, Fogolari, Marta, Spadaccio, Cristiano, Ferrisi, Chiara, Loreni, Francesco, Giacinto, Omar, Mastroianni, Ciro, Barbato, Raffaele, Rose, David, Salsano, Antonio, Santini, Francesco, Angeletti, Silvia, Crescenzi, Anna, Antonelli Incalzi, Raffaele, Chello, Massimo, and Lusini, Mario

Subjects
MICROBIAL metabolites, TRANSFORMING growth factors-beta, RIGHT heart atrium, ATRIAL fibrillation, FIBROSIS, GUT microbiome, ENZYME-linked immunosorbent assay, GENE expression
Abstract

The high incidence of atrial fibrillation (AFib) following cardiac surgery (postoperative atrial fibrillation, POAF) relies on specific surgical features. However, in the setting of POAF, the role of the microbiome in the modulation of cardiac fibrosis is still not clear. This study aimed to analyze the effect of the microbiome and its main metabolic product (trimethylamine-N-oxide, TMAO) in the fibrosis of myocardial tissue, to investigate its role in POAF. Patients undergoing elective cardiac surgery with cardiopulmonary bypass, central atrio-caval cannulation and no history of AFib, were included. A fragment of the right atrium was analyzed for qualitative and mRNA-quantitative evaluation. A preoperative blood sample was analyzed with enzyme-linked immunosorbent assay (ELISA). A total of 100 patients have been included, with POAF occurring in 38%. Histologically, a higher degree of fibrosis, angiogenesis and inflammation has been observed in POAF. Quantitative evaluation showed increased mRNA expression of collagen-1, collagen-3, fibronectin, and transforming growth factor beta (TGFb) in the POAF group. ELISA analysis showed higher levels of TMAO, lipopolysaccharide and TGFb in POAF, with similar levels of sP-selectin and zonulin. TMAO ≥ 61.8 ng/mL (odds ratio, OR 2.88 [1.35–6.16], p = 0.006), preoperative hemoglobin < 13.1 g/dL (OR 2.37 [1.07–5.24], p = 0.033) and impaired right ventricular function (OR 2.38 [1.17–4.83], p = 0.017) were independent predictors of POAF. Also, TMAO was significantly associated with POAF by means of increased fibrosis. Gut microbiome product TMAO is crucial for myocardial fibrosis, which is a key factor for POAF. Patients in preoperative sinus rhythm who will develop POAF have increased genetic expression of pro-fibrotic genes and enhanced fibrosis in histological staining. Elevated TMAO level (≥61.8 ng/mL) is an independent risk factor for POAF. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Aortic Valve Replacement for Aortic Stenosis in Low-, Intermediate-, and High-Risk Patients: Preliminary Results From a Prospective Multicenter Registry

Author

Onorati, Francesco, Quintana, Eduard, El-Dean, Zein, Perrotti, Andrea, Sponga, Sandro, Ruggieri, Vito Giovanni, Rinaldi, Mauro, Milano, Aldo Domenico, Santini, Francesco, Chocron, Sidney, Livi, Ugolino, Salizzoni, Stefano, Loizzo, Tommaso, Salsano, Antonio, Di Cesare, Alessandro, Faggian, Giuseppe, Castella, Manuel, and Nicolini, Francesco

Published
2020
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14. Similar outcome of tricuspid valve repair and replacement for isolated tricuspid infective endocarditis

Author

Di Mauro, Michele, Bonalumi, Giorgia, Giambuzzi, Ilaria, Dato, Guglielmo Mario Actis, Centofanti, Paolo, Corte, Alessandro Della, Ratta, Ester Della, Cugola, Diego, Merlo, Maurizio, Santini, Francesco, Salsano, Antonio, Rinaldi, Mauro, Mancuso, Samuel, Cappabianca, Giangiuseppe, Beghi, Cesare, De Vincentiis, Carlo, Biondi, Andrea, Livi, Ugolino, Sponga, Sandro, Pacini, Davide, Murana, Giacomo, Scrofani, Roberto, Antona, Carlo, Cagnoni, Giovanni, Nicolini, Francesco, Benassi, Filippo, De Bonis, Michele, Pozzoli, Alberto, Pano, Marco, Nicolardi, Salvatore, Falcetta, Giosuè, Colli, Andrea, Musumeci, Francesco, Gherli, Riccardo, Vizzardi, Enrico, Salvador, Loris, Picichè, Marco, Paparella, Domenico, Margari, Vito, Troise, Giovanni, Villa, Emmanuel, Dossena, Yudit, Lucarelli, Carla, Onorati, Francesco, Faggian, Giuseppe, Mariscalco, Giovanni, Maselli, Daniele, Barili, Fabio, Parolari, Alessandro, and Lorusso, Roberto

Published
2022
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15. Enhanced recovery protocols after surgery: A systematic review and meta‐analysis of randomized trials in cardiac surgery

Author

Spadaccio, Cristiano, primary, Salsano, Antonio, additional, Pisani, Angelo, additional, Nenna, Antonio, additional, Nappi, Francesco, additional, Osho, Asishana, additional, D’Alessandro, David, additional, Sundt, Thoralf M., additional, Crestanello, Juan, additional, Engelman, Daniel, additional, and Rose, David, additional

Published
2024
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16. Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry

Author

Salsano, Antonio, primary, Di Mauro, Michele, additional, Labate, Laura, additional, Della Corte, Alessandro, additional, Lo Presti, Federica, additional, De Bonis, Michele, additional, Trumello, Cinzia, additional, Rinaldi, Mauro, additional, Cura Stura, Erik, additional, Actis Dato, Guglielmo, additional, Punta, Giuseppe, additional, Nicolini, Francesco, additional, Carino, Davide, additional, De Vincentiis, Carlo, additional, Garatti, Andrea, additional, Cappabianca, Giangiuseppe, additional, Musazzi, Andrea, additional, Cugola, Diego, additional, Merlo, Maurizio, additional, Pacini, Davide, additional, Folesani, Gianluca, additional, Sponga, Sandro, additional, Vendramin, Igor, additional, Pilozzi Casado, Alberto, additional, Rosato, Francesco, additional, Mikus, Elisa, additional, Savini, Carlo, additional, Onorati, Francesco, additional, Luciani, Giovanni Battista, additional, Scrofani, Roberto, additional, Epifani, Francesco, additional, Musumeci, Francesco, additional, Lio, Antonio, additional, Colli, Andrea, additional, Falcetta, Giosuè, additional, Nicolardi, Salvatore, additional, Zaccaria, Salvatore, additional, Vizzardi, Enrico, additional, Pantaleo, Antonio, additional, Minniti, Giuseppe, additional, Villa, Emmanuel, additional, Dalla Tomba, Margherita, additional, Pollari, Francesco, additional, Barili, Fabio, additional, Parolari, Alessandro, additional, Lorusso, Roberto, additional, and Santini, Francesco, additional

Published
2023
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19. Culture-negative infective endocarditis (CNIE): impact on postoperative mortality

Author

Salsano Antonio, Giacobbe Daniele Roberto, Del Puente Filippo, Natali Roberto, Miette Ambra, Moscatelli Sara, Perocchio Giacomo, Scarano Flavio, Porto Italo, Mariscalco Giovanni, Bassetti Matteo, and Santini Francesco

Subjects
cardiopulmonary bypass, endocarditis, heart valves, inflammation, Medicine
Abstract

Poor postoperative outcomes have been reported after surgery for infective endocarditis (IE). Whether the absence of positive cultures impacts the prognosis remains a matter of discussion. The aim of this study was to evaluate the impact of negative cultures on the prognosis of surgically treated IE.

Published
2020
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20. Perioperative Bleeding in Patients With Acute Coronary Syndrome Treated With Fondaparinux Versus Low-Molecular-Weight Heparin Before Coronary Artery Bypass Grafting

Author

Khodabandeh, Sorosh, Biancari, Fausto, Kinnunen, Eeva-Maija, Mariscalco, Giovanni, Airaksinen, Juhani, Gherli, Riccardo, Gatti, Giuseppe, Demal, Till, Onorati, Francesco, Faggian, Giuseppe, De Feo, Marisa, Santarpino, Giuseppe, Rubino, Antonino S., Maselli, Daniele, Salsano, Antonio, Nicolini, Francesco, Zanobini, Marco, Ruggieri, Vito G., Bounader, Karl, Perrotti, Andrea, and Dalén, Magnus

Published
2019
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21. Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting

Author

Ruggieri, Vito G., Bounader, Karl, Verhoye, Jean Philippe, Onorati, Francesco, Rubino, Antonino S., Gatti, Giuseppe, Tauriainen, Tuomas, De Feo, Marisa, Reichart, Daniel, Dalén, Magnus, Svenarud, Peter, Faggian, Giuseppe, Santarpino, Giuseppe, Maselli, Daniele, Gherli, Riccardo, Mariscalco, Giovanni, Salsano, Antonio, Nicolini, Francesco, Gherli, Tiziano, Saccocci, Matteo, Airaksinen, Juhani K.E., Chocron, Sidney, Perrotti, Andrea, and Biancari, Fausto

Published
2018
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22. Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Author

Salsano, Antonio, primary, Di Mauro, Michele, additional, Labate, Laura, additional, Della Corte, Alessandro, additional, Lo Presti, Federica, additional, De Bonis, Michele, additional, Trumello, Cinzia, additional, Rinaldi, Mauro, additional, Cura Stura, Erik, additional, Actis Dato, Guglielmo, additional, Punta, Giuseppe, additional, Nicolini, Francesco, additional, Carino, Davide, additional, De Vincentiis, Carlo, additional, Garatti, Andrea, additional, Cappabianca, Giangiuseppe, additional, Musazzi, Andrea M, additional, Cugola, Diego, additional, Merlo, Maurizio, additional, Pacini, Davide, additional, Folesani, Gianluca, additional, Sponga, Sandro, additional, Vendramin, Igor, additional, Pilozzi Casado, Alberto, additional, Rosato, Francesco, additional, Mikus, Elisa, additional, Savini, Carlo, additional, Onorati, Francesco, additional, Luciani, Giovanni Battista, additional, Scrofani, Roberto, additional, Epifani, Francesco, additional, Musumeci, Francesco, additional, Lio, Antonio, additional, Colli, Andrea, additional, Falcetta, Giosuè, additional, Nicolardi, Salvatore, additional, Zaccaria, Salvatore, additional, Vizzardi, Enrico, additional, Pantaleo, Antonio, additional, Minniti, Giuseppe, additional, Villa, Emmanuel, additional, Dalla Tomba, Margherita, additional, Pollari, Francesco, additional, Barili, Fabio, additional, Parolari, Alessandro, additional, Lorusso, Roberto, additional, and Santini, Francesco, additional

Published
2023
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23. Lactate-Based Difference as a Determinant of Outcomes following Surgery for Type A Acute Aortic Dissection: A Multi-Centre Study

Author

Nappi, Francesco, primary, Alzamil, Almothana, additional, Salsano, Antonio, additional, Avtaar Singh, Sanjeet Singh, additional, Gambardella, Ivancarmine, additional, Santini, Francesco, additional, Fiore, Antonio, additional, Perocchio, Giacomo, additional, Demondion, Pierre, additional, Mesnildrey, Patrick, additional, Schoell, Thibaut, additional, Bonnet, Nicolas, additional, and Leprince, Pascal, additional

Published
2023
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24. Lactate-Based Difference as a Determinant of Outcomes Following Surgery for Type A Acute Aortic Dissection: A LASSO Regression Multicenter Study

Author

Nappi, Francesco, primary, Alzamil, Almothana, additional, Salsano, Antonio, additional, Avtaar Singh, Sanjeet Singh, additional, Gambardella, Ivancarmine, additional, Santini, Francesco, additional, Fiore, Antonio, additional, Perocchio, Giacomo, additional, Demondion, Pierre, additional, Mesnildrey, Patrick, additional, Schoell, Thibaut, additional, Bonnet, Nicolas, additional, and Leprince, Pascal, additional

Published
2023
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25. Extracorporeal Membrane Oxygenation for COVID-19 respiratory distress syndrome: an Italian Society for Cardiac Surgery Report

Author

Loforte, Antonio, Di Mauro, Michele, Pellegrini, Carlo, Monterosso, Christian, Pelenghi, Stefano, Degani, Antonella, Rinaldi, Mauro, Cura Stura, Erik, Sales, Gabriele, Montrucchio, Giorgia, Mangino, Domenico, Terrini, Alberto, Pacini, Davide, Affronti, Alessandro, Tarzia, Vincenzo, Bottio, Tomaso, Pantaleo, Antonio, Donatelli, Francesco, Miceli, Antonio, Santini, Francesco, Salsano, Antonio, Colli, Andrea, Ravenni, Giacomo, Montalto, Andrea, Musumeci, Francesco, Salvador, Loris, Gerosa, Gino, Parolari, Alessandro, and Picichè, Marco

Published
2021
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27. Prognostic Impact of Asymptomatic Carotid Artery Stenosis in Patients Undergoing Coronary Artery Bypass Grafting

Author

Santarpino, Giuseppe, Nicolini, Francesco, De Feo, Marisa, Dalén, Magnus, Fischlein, Theodor, Perrotti, Andrea, Reichart, Daniel, Gatti, Giuseppe, Onorati, Francesco, Franzese, Ilaria, Faggian, Giuseppe, Bancone, Ciro, Chocron, Sidney, Khodabandeh, Sorosh, Rubino, Antonino S., Maselli, Daniele, Nardella, Saverio, Gherli, Riccardo, Salsano, Antonio, Zanobini, Marco, Saccocci, Matteo, Bounader, Karl, Rosato, Stefano, Tauriainen, Tuomas, Mariscalco, Giovanni, Airaksinen, Juhani, Ruggieri, Vito G., and Biancari, Fausto

Published
2018
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28. Utility of glycated hemoglobin screening in patients undergoing elective coronary artery surgery: Prospective, cohort study from the E-CABG registry

Author

Nicolini, Francesco, Santarpino, Giuseppe, Gatti, Giuseppe, Reichart, Daniel, Onorati, Francesco, Faggian, Giuseppe, Dalén, Magnus, Khodabandeh, Sorosh, Fischlein, Theodor, Maselli, Daniele, Nardella, Saverio, Rubino, Antonino S., De Feo, Marisa, Salsano, Antonio, Gherli, Riccardo, Mariscalco, Giovanni, Kinnunen, Eeva-Maija, Ruggieri, Vito G., Bounader, Karl, Saccocci, Matteo, Chocron, Sidney, Airaksinen, Juhani, Perrotti, Andrea, and Biancari, Fausto

Published
2018
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29. A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE

Author

Di Mauro, Michele, Dato, Guglielmo Mario Actis, Barili, Fabio, Gelsomino, Sandro, Santè, Pasquale, Corte, Alessandro Della, Carrozza, Antonio, Ratta, Ester Della, Cugola, Diego, Galletti, Lorenzo, Devotini, Roger, Casabona, Riccardo, Santini, Francesco, Salsano, Antonio, Scrofani, Roberto, Antona, Carlo, Botta, Luca, Russo, Claudio, Mancuso, Samuel, Rinaldi, Mauro, De Vincentiis, Carlo, Biondi, Andrea, Beghi, Cesare, Cappabianca, Giangiuseppe, Tarzia, Vincenzo, Gerosa, Gino, De Bonis, Michele, Pozzoli, Alberto, Nicolini, Francesco, Benassi, Filippo, Rosato, Francesco, Grasso, Elena, Livi, Ugolino, Sponga, Sandro, Pacini, Davide, Di Bartolomeo, Roberto, De Martino, Andrea, Bortolotti, Uberto, Onorati, Francesco, Faggian, Giuseppe, Lorusso, Roberto, Vizzardi, Enrico, Di Giammarco, Gabriele, Marinelli, Daniele, Villa, Emmanuel, Troise, Giovanni, Picichè, Marco, Musumeci, Francesco, Paparella, Domenico, Margari, Vito, Tritto, Francesco, Damiani, Girolamo, Scrascia, Giuseppe, Zaccaria, Salvatore, Renzulli, Attilio, Serraino, Giuseppe, Mariscalco, Giovanni, Maselli, Daniele, Foschi, Massimiliano, Parolari, Alessandro, and Nappi, Giannantonio

Published
2017
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30. The impact of minor blood transfusion on the outcome after coronary artery bypass grafting

Author

Kinnunen, Eeva-Maija, Zanobini, Marco, Onorati, Francesco, Brascia, Debora, Mariscalco, Giovanni, Franzese, Ilaria, Ruggieri, Vito G., Bounader, Karl, Perrotti, Andrea, Musumeci, Francesco, Santarpino, Giuseppe, Maselli, Daniele, Nardella, Saverio, Gulbins, Helmut, Gherli, Riccardo, Rubino, Antonino S., Mignosa, Carmelo, De Feo, Marisa, Gatti, Giuseppe, Santini, Francesco, Salsano, Antonio, Dalén, Magnus, Saccocci, Matteo, Reichart, Daniel, Faggian, Giuseppe, Gherli, Tiziano, Nicolini, Francesco, and Biancari, Fausto

Published
2017
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31. Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry.

Author

Salsano, Antonio, Di Mauro, Michele, Labate, Laura, Della Corte, Alessandro, Lo Presti, Federica, De Bonis, Michele, Trumello, Cinzia, Rinaldi, Mauro, Cura Stura, Erik, Actis Dato, Guglielmo, Punta, Giuseppe, Nicolini, Francesco, Carino, Davide, De Vincentiis, Carlo, Garatti, Andrea, Cappabianca, Giangiuseppe, Musazzi, Andrea, Cugola, Diego, Merlo, Maurizio, and Pacini, Davide

Subjects
*AORTIC valve transplantation, *ENDOCARDITIS, *PROSTHETIC heart valves, *INFECTIVE endocarditis, *AORTIC valve, *OVERALL survival
Abstract

Background: Infective endocarditis (IE) is a serious disease, and in many cases, surgery is necessary. Whether the type of prosthesis implanted for aortic valve replacement (AVR) for IE impacts patient survival is a matter of debate. The aim of the present study is to quantify differences in long-term survival and recurrence of endocarditis AVR for IE according to prosthesis type among patients aged 40 to 65 years. Methods: This was an analysis of the INFECT-REGISTRY. Trends in proportion to the use of mechanical prostheses versus biological ones over time were tested by applying the sieve bootstrapped t-test. Confounders were adjusted using the optimal full-matching propensity score. The difference in overall survival was compared using the Cox model, whereas the differences in recurrence of endocarditis were evaluated using the Gray test. Results: Overall, 4365 patients were diagnosed and operated on for IE from 2000 to 2021. Of these, 549, aged between 40 and 65 years, underwent AVR. A total of 268 (48.8%) received mechanical prostheses, and 281 (51.2%) received biological ones. A significant trend in the reduction of implantation of mechanical vs. biological prostheses was observed during the study period (p < 0.0001). Long-term survival was significantly higher among patients receiving a mechanical prosthesis than those receiving a biological prosthesis (hazard ratio [HR] 0.546, 95% CI: 0.322–0.926, p = 0.025). Mechanical prostheses were associated with significantly less recurrent endocarditis after AVR than biological prostheses (HR 0.268, 95%CI: 0.077–0.933, p = 0.039). Conclusions: The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after a mechanical aortic valve prosthesis implant for IE in middle-aged patients. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Postoperative Quality of Life After Full-sternotomy and Ministernotomy Aortic Valve Replacement

Author

Perrotti, Andrea, primary, Francica, Alessandra, additional, Monaco, Francesco, additional, Quintana, Edward, additional, Sponga, Sandro, additional, El-Dean, Zein, additional, Salizzoni, Stefano, additional, Loizzo, Tommaso, additional, Salsano, Antonio, additional, Di Cesare, Alessandro, additional, Benassi, Filippo, additional, Castella, Manuel, additional, Rinaldi, Mauro, additional, Chocron, Sidney, additional, Vendramin, Igor, additional, Faggian, Giuseppe, additional, Santini, Francesco, additional, Nicolini, Francesco, additional, Milano, Aldo Domenico, additional, Ruggieri, Vito Giovanni, additional, and Onorati, Francesco, additional

Published
2023
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36. Sex-Based Difference in Aortic Dissection Outcomes: A Multicenter Study

Author

Nappi, Francesco, primary, Petiot, Sandra, additional, Salsano, Antonio, additional, Avtaar Singh, Sanjeet Singh, additional, Berger, Joelle, additional, Kostantinou, Marisa, additional, Bonnet, Severine, additional, Gambardella, Ivancarmine, additional, Biancari, Fausto, additional, Almazil, Almothana, additional, Santini, Francesco, additional, Chaara, Rim, additional, and Fiore, Antonio, additional

Published
2023
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38. Revascularization of Occluded Right Coronary Artery and Outcome After Coronary Artery Bypass Grafting.

Author

Biancari, Fausto, Dalén, Magnus, Tauriainen, Tuomas, Gatti, Giuseppe, Salsano, Antonio, Santini, Francesco, Feo, Marisa De, Zhang, Qiyao, Mazzaro, Enzo, Franzese, Ilaria, Bancone, Ciro, Zanobini, Marco, Mäkikallio, Timo, Saccocci, Matteo, Francica, Alessandra, Onorati, Francesco, El-Dean, Zein, and Mariscalco, Giovanni

Subjects
CORONARY artery bypass, CORONARY arteries, PROPENSITY score matching, CORONARY artery disease, MYOCARDIAL infarction
Abstract

Objectives The aim of the present study was to evaluate the results of isolated coronary artery bypass grafting (CABG) with or without revascularization of the occluded right coronary artery (RCA). Methods Patients undergoing isolated CABG were included in a prospective European multicenter registry. Outcomes were adjusted for imbalance in preoperative variables with propensity score matching analysis. Late outcomes were evaluated with Kaplan–Meier's method and competing risk analysis. Results Out of 2,948 included in this registry, 724 patients had a total occlusion of the RCA and were the subjects of this analysis. Occluded RCA was not revascularized in 251 (34.7%) patients with significant variability between centers. Among 245 propensity score-matched pairs, patients with and without revascularization of occluded RCA had similar early outcomes. The nonrevascularized RCA group had increased rates of 5-year all-cause mortality (17.7 vs. 11.7%, p = 0.039) compared with patients who had their RCA revascularized. The rates of myocardial infarction and repeat revascularization were only numerically increased but contributed to a significantly higher rate of MACCE (24.7 vs. 15.7%, p = 0.020) at 5 year among patients with nonrevascularized RCA. Conclusion In this multicenter study, one-third of totally occluded RCAs was not revascularized during isolated CABG for multivessel coronary artery disease. Failure to revascularize an occluded RCA in these patients increased the risk of all-cause mortality and MACCEs at 5 years. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Impact of Surgeon Experience and Centre Volume on Outcome After Off-Pump Coronary Artery Bypass Surgery: Results from the European Multicenter Study on Coronary Artery Bypass Grafting (E-CABG) Registry

Author

Naito, Shiho, primary, Demal, Till J., additional, Sill, Björn, additional, Reichenspurner, Hermann, additional, Onorati, Francesco, additional, Gatti, Giuseppe, additional, Mariscalco, Giovanni, additional, Faggian, Giuseppe, additional, Salsano, Antonio, additional, Santini, Francesco, additional, Santarpino, Giuseppe, additional, Zanobini, Marco, additional, Musumeci, Francesco, additional, Rubino, Antonino S., additional, Bancone, Ciro, additional, De Feo, Marisa, additional, Nicolini, Francesco, additional, Dalén, Magnus, additional, Speziale, Giuseppe, additional, Bounader, Karl, additional, Mäkikallio, Timo, additional, Tauriainen, Tuomas, additional, Ruggieri, Vito G., additional, Perrotti, Andrea, additional, and Biancari, Fausto, additional

Published
2022
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41. Late Myocardial Infarction and Repeat Revascularization after Coronary Artery Bypass Grafting in Patients with Prior Percutaneous Coronary Intervention

Author

Biancari, Fausto, primary, Salsano, Antonio, additional, Santini, Francesco, additional, De Feo, Marisa, additional, Dalén, Magnus, additional, Zhang, Qiyao, additional, Gatti, Giuseppe, additional, Mazzaro, Enzo, additional, Franzese, Ilaria, additional, Bancone, Ciro, additional, Zanobini, Marco, additional, Tauriainen, Tuomas, additional, Mäkikallio, Timo, additional, Saccocci, Matteo, additional, Francica, Alessandra, additional, Rosato, Stefano, additional, El-Dean, Zein, additional, Onorati, Francesco, additional, and Mariscalco, Giovanni, additional

Published
2022
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42. Prior Percutaneous Coronary Intervention and Mortality in Patients Undergoing Surgical Myocardial Revascularization: Results From the E-CABG (European Multicenter Study on Coronary Artery Bypass Grafting) With a Systematic Review and Meta-Analysis

Author

Mariscalco, Giovanni, Rosato, Stefano, Serraino, Giuseppe F., Maselli, Daniele, Dalén, Magnus, Airaksinen, Juhani K.E., Reichart, Daniel, Zanobini, Marco, Onorati, Francesco, De Feo, Marisa, Gherli, Riccardo, Santarpino, Giuseppe, Rubino, Antonino S., Gatti, Giuseppe, Nicolini, Francesco, Santini, Francesco, Perrotti, Andrea, Bruno, Vito D., Ruggieri, Vito G., Biancari, Fausto, Ahmed, Aamer, Masala, Nicola, Dominici, Carmelo, Nardella, Saverio, Khodabandeh, Sorosh, Svenarud, Peter, Gulbins, Helmut, Saccocci, Matteo, Faggian, Giuseppe, Franzese, Ilaria, Bancone, Ciro, Della Ratta, Ester E., Musumeci, Francesco, Gazdag, Laszlo, Fischlein, Theodor, Mignosa, Carmelo, Pappalardo, Aniello, Gherli, Tiziano, Salsano, Antonio, Olivieri, Guido, Bounader, Karl, Verhoye, Jean P., Chocron, Sidney, Tauriainen, Tuomas, and Kinnunen, Eeva-Maija

Published
2018
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45. Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry

Author

Kong, William K F, primary, Salsano, Antonio, additional, Giacobbe, Daniele Roberto, additional, Popescu, Bogdan A, additional, Laroche, Cécile, additional, Duval, Xavier, additional, Schueler, Robert, additional, Moreo, Antonella, additional, Colonna, Paolo, additional, Piper, Cornelia, additional, Calvo-Iglesias, Francisco, additional, Badano, Luigi P, additional, Srdanovic, Ilija, additional, Boutoille, David, additional, Huttin, Olivier, additional, Stöhr, Elisabeth, additional, Timóteo, Ana Teresa, additional, Vaskelyte, Jolanta Justina, additional, Sadeghpour, Anita, additional, Tornos, Pilar, additional, Abid, Leila, additional, Poh, Kian Keong, additional, Habib, Gilbert, additional, and Lancellotti, Patrizio, additional

Published
2022
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46. Clinical profile and outcome of recurrent infective endocarditis

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Citro, Rodolfo, Chan, Kwan-Leung, Miglioranza, Marcelo Haertel, Laroche, Cécile, Benvenga, Rossella Maria, Furnaz, Shumaila, Magne, Julien, Olmos, Carmen, Paelinck, Bernard P., Pasquet, Agnès, Piper, Cornelia, Salsano, Antonio, Savouré, Arnaud, Park, Seung Woo, Szymański, Piotr, Tattevin, Pierre, Vallejo Camazon, Nuria, Lancellotti, Patrizio, Habib, Gilbert, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Citro, Rodolfo, Chan, Kwan-Leung, Miglioranza, Marcelo Haertel, Laroche, Cécile, Benvenga, Rossella Maria, Furnaz, Shumaila, Magne, Julien, Olmos, Carmen, Paelinck, Bernard P., Pasquet, Agnès, Piper, Cornelia, Salsano, Antonio, Savouré, Arnaud, Park, Seung Woo, Szymański, Piotr, Tattevin, Pierre, Vallejo Camazon, Nuria, Lancellotti, Patrizio, and Habib, Gilbert

Abstract

Aims Purpose of this study is to compare the clinical course and outcome of patients with recurrent versus first-episode infective endocarditis (IE). Methods Patients with recurrent and first-episode IE enrolled in the EUROpean ENDOcarditis (EURO-ENDO) registry including 156 centres were identified and compared using propensity score matching. Recurrent IE was classified as relapse when IE occurred ≤6 months after a previous episode or reinfection when IE occurred >6 months after the prior episode. Results 3106 patients were enrolled: 2839 (91.4%) patients with first-episode IE (mean age 59.4 (±18.1); 68.3% male) and 267 (8.6%) patients with recurrent IE (mean age 58.1 (±17.7); 74.9% male). Among patients with recurrent IE, 13.2% were intravenous drug users (IVDUs), 66.4% had a repaired or replaced valve with the tricuspid valve being more frequently involved compared with patients with first-episode IE (20.3% vs 14.1%; p=0.012). In patients with a first episode of IE, the aortic valve was more frequently involved (45.6% vs 39.5%; p=0.061). Recurrent relapse and reinfection were 20.6% and 79.4%, respectively. Staphylococcus aureus was the microorganism most frequently observed in both groups (p=0.207). There were no differences in in-hospital and post-hospitalisation mortality between recurrent and first-episode IE. In patients with recurrent IE, in-hospital mortality was higher in IVDU patients. Independent predictors of poorer in-hospital and 1-year outcome, including the occurrence of cardiogenic and septic shock, valvular disease severity and failure to undertake surgery when indicated, were similar for recurrent and first-episode IE. Conclusions In-hospital and 1-year mortality was similar in patients with recurrent and first-episode IE who shared similar predictors of poor outcome.

Published
2022

47. Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry

Author

Kong, W, Salsano, A, Giacobbe, D, Popescu, B, Laroche, C, Duval, X, Schueler, R, Moreo, A, Colonna, P, Piper, C, Calvo-Iglesias, F, Badano, L, Srdanovic, I, Boutoille, D, Huttin, O, Stöhr, E, Timóteo, A, Vaskelyte, J, Sadeghpour, A, Tornos, P, Abid, L, Poh, K, Habib, G, Lancellotti, P, Kong, William K F, Salsano, Antonio, Giacobbe, Daniele Roberto, Popescu, Bogdan A, Laroche, Cécile, Duval, Xavier, Schueler, Robert, Moreo, Antonella, Colonna, Paolo, Piper, Cornelia, Calvo-Iglesias, Francisco, Badano, Luigi, Srdanovic, Ilija, Boutoille, David, Huttin, Olivier, Stöhr, Elisabeth, Timóteo, Ana Teresa, Vaskelyte, Jolanta Justina, Sadeghpour, Anita, Tornos, Pilar, Abid, Leila, Poh, Kian Keong, Habib, Gilbert, Lancellotti, Patrizio, Kong, W, Salsano, A, Giacobbe, D, Popescu, B, Laroche, C, Duval, X, Schueler, R, Moreo, A, Colonna, P, Piper, C, Calvo-Iglesias, F, Badano, L, Srdanovic, I, Boutoille, D, Huttin, O, Stöhr, E, Timóteo, A, Vaskelyte, J, Sadeghpour, A, Tornos, P, Abid, L, Poh, K, Habib, G, Lancellotti, P, Kong, William K F, Salsano, Antonio, Giacobbe, Daniele Roberto, Popescu, Bogdan A, Laroche, Cécile, Duval, Xavier, Schueler, Robert, Moreo, Antonella, Colonna, Paolo, Piper, Cornelia, Calvo-Iglesias, Francisco, Badano, Luigi, Srdanovic, Ilija, Boutoille, David, Huttin, Olivier, Stöhr, Elisabeth, Timóteo, Ana Teresa, Vaskelyte, Jolanta Justina, Sadeghpour, Anita, Tornos, Pilar, Abid, Leila, Poh, Kian Keong, Habib, Gilbert, and Lancellotti, Patrizio

Abstract

AIM: Fatality of infective endocarditis (IE) is high worldwide, and its diagnosis remains a challenge. The objective of the present study was to compare the clinical characteristics and outcomes of patients with culture-positive (CPIE) vs. culture-negative IE (CNIE). METHODS AND RESULTS: This was an ancillary analysis of the ESC-EORP EURO-ENDO registry. Overall, 3113 patients who were diagnosed with IE during the study period were included in the present study. Of these, 2590 (83.2%) had CPIE, whereas 523 (16.8%) had CNIE. As many as 1488 (48.1%) patients underwent cardiac surgery during the index hospitalization, 1259 (48.8%) with CPIE and 229 (44.5%) with CNIE. The CNIE was a predictor of 1-year mortality [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.04-1.56], whereas surgery was significantly associated with survival (HR 0.49, 95% CI 0.41-0.58). The 1-year mortality was significantly higher in CNIE than CPIE patients in the medical subgroup, but it was not significantly different in CNIE vs. CPIE patients who underwent surgery. CONCLUSION: The present analysis of the EURO-ENDO registry confirms a higher long-term mortality in patients with CNIE compared with patients with CPIE. This difference was present in patients receiving medical therapy alone and not in those who underwent surgery, with surgery being associated with reduced mortality. Additional efforts are required both to improve the aetiological diagnosis of IE and identify CNIE cases early before progressive disease potentially contraindicates surgery.

Published
2022

48. Prosthetic valve endocarditis: predictors of early outcome of surgical therapy. A multicentric study

Author

Luciani, Nicola, Mossuto, Eugenio, Ricci, Davide, Luciani, Marco, Russo, Marco, Salsano, Antonio, Pozzoli, Alberto, Pierri, Michele D., D’Onofrio, Augusto, Chiariello, Giovanni A., Glieca, Franco, Canziani, Alberto, Rinaldi, Mauro, Nardi, Paolo, Milazzo, Valentina, Trecarichi, Enrico M., Santini, Francesco, De Bonis, Michele, Torracca, Lucia, Bizzotto, Eleonora, and Tumbarello, Mario

Published
2017
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49. Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low‐risk patients

Author

Kinnunen, EevaMaija, De Feo, Marisa, Reichart, Daniel, Tauriainen, Tuomas, Gatti, Giuseppe, Onorati, Francesco, Maschietto, Luca, Bancone, Ciro, Fiorentino, Francesca, Chocron, Sidney, Bounader, Karl, Dalén, Magnus, Svenarud, Peter, Faggian, Giuseppe, Franzese, Ilaria, Santarpino, Giuseppe, Fischlein, Theodor, Maselli, Daniele, Dominici, Carmelo, Nardella, Saverio, Gherli, Riccardo, Musumeci, Francesco, Rubino, Antonino S., Mignosa, Carmelo, Mariscalco, Giovanni, Serraino, Filiberto G., Santini, Francesco, Salsano, Antonio, Nicolini, Francesco, Gherli, Tiziano, Zanobini, Marco, Saccocci, Matteo, Ruggieri, Vito G., Philippe Verhoye, Jean, Perrotti, Andrea, and Biancari, Fausto

Published
2017
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50. Clinical profile and outcome of recurrent infective endocarditis

Author

Citro, Rodolfo, primary, Chan, Kwan-Leung, additional, Miglioranza, Marcelo Haertel, additional, Laroche, Cécile, additional, Benvenga, Rossella Maria, additional, Furnaz, Shumaila, additional, Magne, Julien, additional, Olmos, Carmen, additional, Paelinck, Bernard P., additional, Pasquet, Agnès, additional, Piper, Cornelia, additional, Salsano, Antonio, additional, Savouré, Arnaud, additional, Park, Seung Woo, additional, Szymański, Piotr, additional, Tattevin, Pierre, additional, Vallejo Camazon, Nuria, additional, Lancellotti, Patrizio, additional, and Habib, Gilbert, additional

Published
2022
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