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2. Évaluation de l’immunogénicité du programme d’essais cliniques sur la pegunigalsidase alfa : analyse intégrée des anticorps anti-médicaments de novo et renforcés par le traitement

Author

Salomone, F., primary, Bernat, J.A., additional, Hughes, D., additional, Linhart, A., additional, Hopkin, R.J., additional, Tøndel, C., additional, Warnock, D.G., additional, Rup, B., additional, Koulinska, I., additional, Rocco, R., additional, Alon, S., additional, Chertkoff, R., additional, Almon, E.B., additional, Sakov, A., additional, and Wallace, E.L., additional

Published
2024
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3. T.07.7: CHARACTERISTICS AND MANAGEMENT OF HEPATOCELLULAR CARCINOMA (HCC) IN SICILY: FIRST RESULTS OF THE HCC SICILY MULTIDISCIPLINARY NETWORK

Author

Celsa, C., primary, Cabibbo, G., additional, Ciccia, R., additional, Di Maria, G., additional, Pagano, D., additional, Miraglia, R., additional, Maruzzelli, L., additional, Bavetta, M.G., additional, Barcellona, M.R., additional, Cocuzza, C., additional, Tavarelli, M., additional, Filomia, R., additional, Pitrone, C., additional, Malizia, G., additional, Bertino, G., additional, Salomone, F., additional, Distefano, M., additional, Mitra, M., additional, Cartabellotta, F., additional, Giannitrapani, L., additional, Giuffrida, D., additional, Spada, M., additional, Alaimo, G., additional, Sambataro, D., additional, Sportato, G., additional, Grassini, M.V., additional, Cannella, R., additional, Antonucci, M., additional, D'Amato, F., additional, Capodicasa, L., additional, Grova, A., additional, Rao, S., additional, Salvato, M., additional, Cusimano, G., additional, Gaudioso, V., additional, Sparacino, A., additional, Mercurio, F., additional, Rizzo, G.E.M., additional, Picciotto, V., additional, Montenegro, R., additional, Arena, S., additional, Saitta, C., additional, Russello, M., additional, Fusco, G., additional, Di Marco, V., additional, Gruttadauria, S., additional, and Cammà, C., additional

Published
2024
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5. Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition

Author

Pozzi, D, Marchini, C, Cardarelli, F, Salomone, F, Coppola, S, Montani, M, Zabaleta, M Elexpuru, Digman, MA, Gratton, E, Colapicchioni, V, and Caracciolo, G

Subjects
Biological Sciences, Industrial Biotechnology, Nanotechnology, Bioengineering, Gene Therapy, Genetics, Biotechnology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, CHO Cells, Cations, Cricetinae, Cricetulus, DNA, Endosomes, Flow Cytometry, Gene Transfer Techniques, Genetic Therapy, Lipids, Liposomes, Nanocomposites, Nanostructures, Pinocytosis, Protamines, Lipoplex, Lipid nanoparticle, Transfection barrier, Gene delivery, Physical Sciences, Biological sciences, Physical sciences
Abstract

Here we present a quantitative mechanism-based investigation aimed at comparing the cell uptake, intracellular trafficking, endosomal escape and final fate of lipoplexes and lipid-protamine/deoxyribonucleic acid (DNA) (LPD) nanoparticles (NPs) in living Chinese hamster ovary (CHO) cells. As a model, two lipid formulations were used for comparison. The first formulation is made of the cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and the zwitterionic lipid dioleoylphosphocholine (DOPC), while the second mixture is made of the cationic 3β-[N-(N,N-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the zwitterionic helper lipid dioleoylphosphatidylethanolamine (DOPE). Our findings indicate that lipoplexes are efficiently taken up through fluid-phase macropinocytosis, while a less efficient uptake of LPD NPs occurs through a combination of both macropinocytosis and clathrin-dependent pathways. Inside the cell, both lipoplexes and LPD NPs are actively transported towards the cell nucleus, as quantitatively addressed by spatio-temporal image correlation spectroscopy (STICS). For each lipid formulation, LPD NPs escape from endosomes more efficiently than lipoplexes. When cells were treated with DOTAP-DOPC-containing systems the majority of the DNA was trapped in the lysosome compartment, suggesting that extensive lysosomal degradation was the rate-limiting factors in DOTAP-DOPC-mediated transfection. On the other side, escape from endosomes is large for DC-Chol-DOPE-containing systems most likely due to DOPE and cholesterol-like molecules, which are able to destabilize the endosomal membrane. The lipid-dependent and structure-dependent enhancement of transfection activity suggests that DNA is delivered to the nucleus synergistically: the process requires both the membrane-fusogenic activity of the nanocarrier envelope and the employment of lipid species with intrinsic endosomal rupture ability.

Published
2014

6. Prognostic relevance of Platelet-to-Lymphocyte Ratio in patients with Muscle-Invasive Bladder Cancer Patients: real world data from a retrospective multicenter analysis

Author

Pecoraro, G., primary, Scagliarini, S., additional, Puglia, L., additional, Alberico, G., additional, Amato, A.R., additional, Migliaccio, F., additional, Di Costanzo, F., additional, Ribera, D., additional, Verde, A., additional, D’Ambrosio, A., additional, Buonaiuto, R., additional, Salomone, F., additional, Viggiano, A., additional, Peddio, A., additional, Romano, F.J., additional, Servetto, A., additional, Bianco, R., additional, and Formisano, L., additional

Published
2023
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7. Inadequate PROs and HRQoL reporting in phase III advanced genitourinary tumors RCTs

Author

Di Costanzo, F., primary, Salomone, F., additional, VItale, F., additional, Amato, A.R., additional, Alberico, G., additional, Migliaccio, F., additional, Pecoraro, G., additional, Verde, A., additional, Ribera, D., additional, D’Ambrosio, A., additional, Napolitano, F., additional, Scagliarini, S., additional, Rossetti, S., additional, Puglia, L., additional, Di Napoli, M., additional, Crocetto, F., additional, Bianco, R., additional, Servetto, A., additional, and Formisano, L., additional

Published
2023
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9. SIRT5 rs12216101 T>G variant is associated with oxidative stress and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease

Author

Salomone, F., primary, Pipitone, R.M., additional, Longo, M., additional, Malvestiti, F., additional, Casirati, E., additional, Distefano, A., additional, Amorini, M., additional, Volti, G. Li, additional, Ciociola, E., additional, Lazzarino, G., additional, Craxì, A., additional, Fracanzani, A.L., additional, Dongiovanni, P., additional, Valenti, L., additional, Petta, S., additional, and Grimaudo, S., additional

Published
2023
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10. 51P Efficacy of PARP inhibitors in patients with advanced high grade serous ovarian cancer according to BRCA domain mutations

Author

Buonaiuto, R., primary, Neola, G., additional, Parola, S., additional, Cefaliello, A., additional, Pecoraro, G., additional, Grieco, A., additional, Flauto, F., additional, Amato, A.R., additional, Lamia, M.R., additional, Salomone, F., additional, Caltavituro, A., additional, Pepe, F., additional, Malapelle, U., additional, Ventriglia, J., additional, Pignata, S., additional, and De Angelis, C., additional

Published
2023
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12. 1232P Assessing uncertainty and vulnerability of clinical trials with immune-checkpoint inhibitors and chemotherapy (ICI+CT) in early stage non-small cell lung cancer (NSCLC) by informative censoring and survival inferred fragility index (SIFI).

Author

Nuccio, A., Salomone, F., Viscardi, G., Venanzi, F.M., Bulotta, A., Ogliari, F.R., Oresti, S., Riva, S.T., Mollica, L., Viganò, M.G., Passaretti, F., Ravasi, M., Papotto, L., Ferrara, M., Ricciuti, B., Veronesi, G., Cascone, T., Garassino, M.C., Torri, V., and Ferrara, R.

Subjects
*NON-small-cell lung carcinoma, *IMMUNE checkpoint inhibitors, *CLINICAL trials, *CENSORSHIP, *CANCER chemotherapy
Published
2024
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19. Efficacy and safety of pangenotypic DAAs for chronic HCV infection: real-world data from the RESIST-HCV cohort

Author

Salomone, F., primary, Cacciola, I., additional, Petta, S., additional, Calvaruso, V., additional, Micek, A., additional, Madonia, S., additional, Grova, M., additional, Distefano, M., additional, Cannavò, M., additional, Di Rosolini, M.A., additional, Digiacomo, A., additional, Di Lorenzo, F., additional, Bertino, G., additional, Licata, A., additional, Latteri, F., additional, Benanti, F., additional, Averna, A., additional, Guarneri, L., additional, Scalisi, I., additional, Iacobello, C., additional, Montineri, A., additional, Colletti, P., additional, Cartabellotta, F., additional, Davì, A., additional, Russello, M., additional, Scifo, G., additional, Squadrito, G., additional, Raimondo, G., additional, Craxì, A., additional, and Di Marco, V., additional

Published
2022
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20. Gamma Glutamyl Transferase as a marker of risk of progression to cirrhosis in patients with Primary Biliary Cholangitis

Author

Calvaruso, V., primary, Saitta, C., additional, Russello, M., additional, Fichera, A., additional, Bertino, G., additional, Bueti, FM., additional, Bronte, F., additional, Di Stefano, M., additional, Giacchetto, M., additional, Salomone, F., additional, Madonia, S., additional, Cadamuro, L., additional, Franzè, MS., additional, Licata, A., additional, Alaimo, G., additional, Pitrone, C., additional, Minissale, M., additional, Sapienza, M., additional, Cannavò, M.R., additional, Cartabellotta, F., additional, Raimondo, G., additional, Craxì, A., additional, and Di Marco, V., additional

Published
2022
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23. SIRT5 rs12216101 T>G variant is associated with fibrosis severity in patients with non-alcoholic fatty liver disease

Author

Salomone, F., primary, Grimaudo, S., additional, Malvestiti, F., additional, Pipitone, R.M., additional, Distefano, A., additional, Baselli, G., additional, Pennisi, G., additional, Dongiovanni, P., additional, Fracanzani, A.L., additional, Li Volti, G., additional, Craxì, A., additional, Romeo, S., additional, Valenti, L., additional, and Petta, S., additional

Published
2021
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24. Endoscopic bariatric and metabolic therapies for non-alcoholic fatty liver disease: Evidence and perspectives

Author

Salomone, F., Sharaiha, R. Z., Boskoski, Ivo, Boskoski I. (ORCID:0000-0001-8194-2670), Salomone, F., Sharaiha, R. Z., Boskoski, Ivo, and Boskoski I. (ORCID:0000-0001-8194-2670)

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in industrialized countries because of the worldwide epidemic of obesity. Beyond metabolic complications, a subset of patients with NAFLD develop non-alcoholic steatohepatitis (NASH) with fibrosis, which is emerging as a leading cause of liver transplantation due to progression to cirrhosis and cancer. For these reasons, NAFLD is considered a public health burden. In recent years endoscopic bariatric and metabolic therapies (EBMT) have emerged as safe and effective for the treatment of obesity and type 2 diabetes mellitus. EBMT include gastric and duodenal devices and techniques such as intragastric balloons, endoscopic sleeve gastroplasty, endoscopic small bowel by-pass and duodenal mucosal resurfacing. Observational studies and pilot trials have revealed beneficial effects of EBMT on NAFLD as assessed by non-invasive parameters or histology. In this review we summarise current evidence for the efficacy and safety of EBMT in obese patients with NAFLD and examine future clinical applications.

Published
2020

31. From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy

Author

Bianco, F., primary, Ricci, F., additional, Catozzi, C., additional, Murgia, X., additional, Schlun, M., additional, Bucholski, A., additional, Hetzer, U., additional, Bonelli, S., additional, Lombardini, M., additional, Pasini, E., additional, Nutini, M., additional, Pertile, M., additional, Minocchieri, S., additional, Simonato, M., additional, Rosa, B., additional, Pieraccini, G., additional, Moneti, G., additional, Lorenzini, L., additional, Catinella, S., additional, Villetti, G., additional, Civelli, M., additional, Pioselli, B., additional, Cogo, P., additional, Carnielli, V., additional, Dani, C., additional, and Salomone, F., additional

Published
2019
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34. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies

Author

Marventano, S, Salomone, F, Godos, J, Pluchinotta, F, Del Rio, D, Mistretta, Antonio, Grosso, G., and Grosso, Giuseppe

Subjects
0301 basic medicine, Liver Cirrhosis, medicine.medical_specialty, tea, MEDLINE, coffee, Critical Care and Intensive Care Medicine, Coffee, metabolic syndrome, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, Non-alcoholic Fatty Liver Disease, Internal medicine, NAFLD, Caffeine, medicine, Odds Ratio, Humans, Metabolic Syndrome, 030109 nutrition & dietetics, Nutrition and Dietetics, Tea, business.industry, NAFLD, Metabolic syndrome, Coffee, Tea, Meta-analysis, Fatty liver, medicine.disease, Confidence interval, Diet, meta-analysis, Meta-analysis, Endocrinology, chemistry, Relative risk, 030211 gastroenterology & hepatology, Steatohepatitis, Metabolic syndrome, business
Abstract

Summary Background & aims Diet plays a role in the onset and progression of metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). We aimed to systematically review and perform quantitative analyses of results from observational studies on coffee/tea consumption and NAFLD or MetS. Methods A Medline and Embase search was performed to retrieve articles published up to March 2015. We used a combination of the keywords “coffee”, “caffeine”, “tea”, “non-alcoholic fatty liver disease”, “non-alcoholic steatohepatitis”, “metabolic syndrome”. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated by random-effects model. Results Seven studies assessed coffee consumption in NAFLD patients. Fibrosis scores were reported in four out of seven; all four studies revealed an inverse association of coffee intake with fibrosis severity, although the lack of comparable exposure and outcomes did not allow to perform pooled analysis. Seven studies met the inclusion criteria to be included in the meta-analysis on coffee consumption and MetS. Individuals consuming higher quantities of coffee were less like to have MetS (RR = 0.87, 95% CI: 0.79–0.96). However, the association of coffee and individual components of MetS was not consistent across the studies. Pooled analysis of six studies exploring the association between tea consumption and MetS resulted in decreased odds of MetS for individuals consuming more tea (RR = 0.83, 95% CI: 0.73–0.95). Conclusions Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis. Both coffee and tea consumption are associated with less likelihood of having MetS but further research with better designed studies is needed.

Published
2015

35. Cancer cell targeting of lipid gene vectors by protein corona

Author

Caracciolo, G., Pozzi, D., ANNA LAURA CAPRIOTTI, Cavaliere, C., Cardarelli, F., Bifone, A., Bardi, G., Salomone, F., Laganà, A., Caracciolo, G., Pozzi, D., Capriotti, A. L., Cavaliere, C., Cardarelli, F., Bifone, A., Bardi, Giuseppe, Salomone, F., and Laganà, A.

Subjects
Lipoplexe, Protein corona, Cationic liposome, Ceramics and Composite, DNA, Gene delivery, Surfaces, Coatings and Films
Abstract

In this study we exposed 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/DNA lipoplexes to different concentrations of human plasma (HP). Liquid chromatography-tandem mass spectrometry showed that the adsorbed protein corona is rich in vitronectin, a major ligand for α vβ 3 or α vβ 5 integrins. To investigate whether the protein corona could dictate a selective access to cells expressing vitronectin receptors, highly-metastatic MDA-MB-435S cells that express high levels of α vβ 3 and α vβ 5 integrins, were used as experimental model. Non-metastatic MCF7 cells that do not express α vβ 3 and express reduced levels of α vβ 5 integrins were used as a reference. After exposure to HP, the cellular uptake of lipoplexes in MDA-MB-435S cells was more than 2-fold larger than that of bare ones, while complexes could not enter MCF7 cells remaining largely accumulated at the plasma membrane. Collectively our data suggest that the protein corona can be used as a novel tool for cancer cell targeting.

Published
2012

39. Alteration in lipid metabolism after an oral fat load in patients with NAFLD

Author

Mezzabotta, Lavinia, Vanni, Ester, Rosso, Chiara, Gaggini, M., Gambino, Roberto, Buzzigoli, E., Saponaro, C., Ciociaro, D., Abate, Maria Lorena, Saba, F., Salomone, F., Caviglia, GIAN PAOLO, Carenzi, Silvia, Smedile, Antonina, Rizzetto, Mario, Cassader, Maurizio, Gastaldelli, A., and Bugianesi, Elisabetta

Published
2014

46. Tegola bicomponente con o senza modulo fotovoltaico

Author

BUONO M, CAPECE A, DE CRISTOFALO S, FIORENTINO C, SALOMONE F, VACCARO G., SIBILIO, Sergio, Buono, M, Capece, A, DE CRISTOFALO, S, Fiorentino, C, Salomone, F, Sibilio, Sergio, and Vaccaro, G.

Published
2008

49. Effect of cholesterol on the transfection efficiency of DOTAP-containing lipoplexes

Author

Pozzi, D., Cardarelli, F., Salomone, F., Marchini, C., Heinz Amenitsch, Caracciolo, G., Pozzi, Daniela, Cardarelli, Francesco, Salomone, Fabrizio, Marchini, Cristina, Amenitsch, Heinz, and Caracciolo, Giulio

Subjects
lipoplexes, transfection efficiency, cationic liposome, cholesterol, confocal microscopy, Confocal microscopy, Lipoplexe, Cholesterol, lipids (amino acids, peptides, and proteins), Cationic liposome, Transfection efficiency, Biotechnology
Abstract

Most lipid formulations need cholesterol for efficient transfection, but the precise motivation remains unclear. Here, we have investigated the effect of cholesterol on the transfection efficiency (TE) of cationic liposomes made of l, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) and dioleoylphosphocholine (DOPC) in Chinese hamster ovary cells. The transfection mechanisms of cholesterol-containing lipoplexes have been investigated by TE, synchrotron small angle X-ray scattering (SAXS) and laser scanning confocal microscopy (LSCM) experiments. We prove that cholesterol-containing lipoplexes enter the cells using different endocytosis pathways. Formulations with high cholesterol content efficienlty escape from endosomes. These studies will contribute to the rational design of novel lipid nanocarriers with superior TE.

Published
2013

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