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1. First constraints on general neutrino interactions based on KATRIN data

Author

Aker, M., Batzler, D., Beglarian, A., Beisenkötter, J., Biassoni, M., Bieringer, B., Biondi, Y., Block, F., Bornschein, B., Bornschein, L., Böttcher, M., Carminati, M., Chatrabhuti, A., Chilingaryan, S., Daniel, B. A., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Fengler, C., Fiorini, C., Formaggio, J. A., Forstner, C., Fränkle, F. M., Gagliardi, G., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gutknecht, N., Hannen, V., Hasselmann, L., Helbing, K., Henke, H., Heyns, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Huber, A., Jansen, A., Khosonthongkee, K., Köhler, C., Köllenberger, L., Kopmann, A., Kovač, N., La Cascio, L., Lasserre, T., Lauer, J., Le, T. L., Lebeda, O., Lehnert, B., Li, G., Lokhov, A., Machatschek, M., Mark, M., Marsteller, A., McMichael, K., Melzer, C., Mertens, S., Mohanty, S., Mostafa, J., Müller, K., Nava, A., Neumann, H., Niemes, S., Onillon, A., Parno, D. S., Pavan, M., Pinsook, U., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodenbeck, C., Röllig, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schlösser, K., Schlösser, M., Schlüter, L., Schneidewind, S., Schrank, M., Schürmann, J., Schütz, A. K., Schwemmer, A., Schwenck, A., Seeyangnok, J., Šefčík, M., Siegmann, D., Simon, F., Songwadhana, J., Spanier, F., Spreng, D., Sreethawong, W., Steidl, M., Štorek, J., Stribl, X., Sturm, M., Suwonjandee, N., Jerome, N. Tan, Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadorozhny, S., and Zeller, G.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The precision measurement of the tritium $\beta$-decay spectrum performed by the KATRIN experiment provides a unique way to search for general neutrino interactions (GNI). All theoretical allowed GNI terms involving neutrinos are incorporated into a low-energy effective field theory, and can be identified by specific signatures in the measured tritium $\beta$-spectrum. In this paper an effective description of the impact of GNI on the $\beta$-spectrum is formulated and the first constraints on the effective GNI parameters are derived based on the 4 million electrons collected in the second measurement campaign of KATRIN in 2019. In addition, constraints on selected types of interactions are investigated, thereby exploring the potential of KATRIN to search for more specific new physics cases, including a right-handed W boson, a charged Higgs or leptoquarks.

Published
2024

2. Measurement of the electric potential and the magnetic field in the shifted analysing plane of the KATRIN experiment

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Beisenkötter, J., Biassoni, M., Bieringer, B., Biondi, Y., Block, F., Bobien, S., Böttcher, M., Bornschein, B., Bornschein, L., Caldwell, T. S., Carminati, M., Chatrabhuti, A., Chilingaryan, S., Daniel, B. A., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Fengler, C., Fiorini, C., Formaggio, J. A., Forstner, C., Fränkle, F. M., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Hasselmann, L., Haußmann, N., Helbing, K., Heyns, S., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Khosonthongkee, K., Köhler, C., Köllenberger, L., Kopmann, A., Kovač, N., Krause, H., La Cascio, L., Lasserre, T., Lauer, J., Le, T. L., Lebeda, O., Lehnert, B., Li, G., Lokhov, A., Machatschek, M., Mark, M., Marsteller, A., Martin, E. L., McMichael, K., Melzer, C., Mertens, S., Mohanty, S., Mostafa, J., Müller, K., Nava, A., Neumann, H., Niemes, S., Parno, D. S., Pavan, M., Pinsook, U., Poon, A. W. P., Poyato, J. M. L., Pozzi, S., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodenbeck, C., Röllig, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schürmann, J., Schütz, A. K., Schwemmer, A., Schwenck, A., Šefčík, M., Siegmann, D., Simon, F., Spanier, F., Spreng, D., Sreethawong, W., Steidl, M., Štorek, J., Stribl, X., Sturm, M., Suwonjandee, N., Jerome, N. Tan, Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Weinheimer, C., Welte, S., Wendel, J., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadorozhny, S., and Zeller, G.

Subjects
Physics - Instrumentation and Detectors
Abstract

The projected sensitivity of the effective electron neutrino-mass measurement with the KATRIN experiment is below 0.3 eV (90 % CL) after five years of data acquisition. The sensitivity is affected by the increased rate of the background electrons from KATRIN's main spectrometer. A special shifted-analysing-plane (SAP) configuration was developed to reduce this background by a factor of two. The complex layout of electromagnetic fields in the SAP configuration requires a robust method of estimating these fields. We present in this paper a dedicated calibration measurement of the fields using conversion electrons of gaseous $^\mathrm{83m}$Kr, which enables the neutrino-mass measurements in the SAP configuration., Comment: 19 pages, 11 figures

Published
2024

3. Direct neutrino-mass measurement based on 259 days of KATRIN data

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Beisenkötter, J., Biassoni, M., Bieringer, B., Biondi, Y., Block, F., Bobien, S., Böttcher, M., Bornschein, B., Bornschein, L., Caldwell, T. S., Carminati, M., Chatrabhuti, A., Chilingaryan, S., Daniel, B. A., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Fengler, C., Fiorini, C., Formaggio, J. A., Forstner, C., Fränkle, F. M., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Gutknecht, N., Hannen, V., Hasselmann, L., Haußmann, N., Helbing, K., Henke, H., Heyns, S., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Khosonthongkee, K., Kleifges, M., Klein, M., Kohpeiß, J., Köhler, C., Köllenberger, L., Kopmann, A., Kovač, N., Kovalík, A., Krause, H., La Cascio, L., Lasserre, T., Lauer, J., Le, T., Lebeda, O., Lehnert, B., Li, G., Lokhov, A., Machatschek, M., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mohanty, S., Mostafa, J., Müller, K., Nava, A., Neumann, H., Niemes, S., Onillon, A., Parno, D. S., Pavan, M., Pinsook, U., Poon, A. W. P., Poyato, J. M. Lopez, Pozzi, S., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schnurr, U., Schrank, M., Schürmann, J., Schütz, A., Schwemmer, A., Schwenck, A., Šefčík, M., Siegmann, D., Simon, F., Spanier, F., Spreng, D., Sreethawong, W., Steidl, M., Štorek, J., Stribl, X., Sturm, M., Suwonjandee, N., Jerome, N. Tan, Telle, H. H., Thorne, L. A., Thümmler, T., Tirolf, S., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Weinheimer, C., Welte, S., Wendel, J., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadorozhny, S., and Zeller, G.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The fact that neutrinos carry a non-vanishing rest mass is evidence of physics beyond the Standard Model of elementary particles. Their absolute mass bears important relevance from particle physics to cosmology. In this work, we report on the search for the effective electron antineutrino mass with the KATRIN experiment. KATRIN performs precision spectroscopy of the tritium $\beta$-decay close to the kinematic endpoint. Based on the first five neutrino-mass measurement campaigns, we derive a best-fit value of $m_\nu^{2} = {-0.14^{+0.13}_{-0.15}}~\mathrm{eV^2}$, resulting in an upper limit of $m_\nu < {0.45}~\mathrm{eV}$ at 90 % confidence level. With six times the statistics of previous data sets, amounting to 36 million electrons collected in 259 measurement days, a substantial reduction of the background level and improved systematic uncertainties, this result tightens KATRIN's previous bound by a factor of almost two., Comment: 61 pages, 20 figures, 2 tables

Published
2024

4. Search for Lorentz-invariance violation with the first KATRIN data

Author

Aker, M, Batzler, D, Beglarian, A, Behrens, J, Berlev, A, Besserer, U, Bieringer, B, Block, F, Bobien, S, Bornschein, B, Bornschein, L, Böttcher, M, Brunst, T, Caldwell, TS, Carney, RMD, Chilingaryan, S, Choi, W, Debowski, K, Descher, M, Barrero, D Díaz, Doe, PJ, Dragoun, O, Drexlin, G, Edzards, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Felden, A, Formaggio, JA, Fränkle, FM, Franklin, GB, Friedel, F, Fulst, A, Gauda, K, Gavin, AS, Gil, W, Glück, F, Grössle, R, Gumbsheimer, R, Hannen, V, Haußmann, N, Helbing, K, Hickford, S, Hiller, R, Hillesheimer, D, Hinz, D, Höhn, T, Houdy, T, Huber, A, Jansen, A, Karl, C, Kellerer, J, Kleifges, M, Klein, M, Köhler, C, Köllenberger, L, Kopmann, A, Korzeczek, M, Kovalík, A, Krasch, B, Krause, H, La Cascio, L, Lasserre, T, Le, TL, Lebeda, O, Lehnert, B, Lokhov, A, Machatschek, M, Malcherek, E, Mark, M, Marsteller, A, Martin, EL, Melzer, C, Mertens, S, Mostafa, J, Müller, K, Neumann, H, Niemes, S, Oelpmann, P, Parno, DS, Poon, AWP, Poyato, JML, Priester, F, Ráliš, J, Ramachandran, S, Robertson, RGH, Rodejohann, W, Rodenbeck, C, Röllig, M, Röttele, C, Ryšavý, M, Sack, R, Saenz, A, Salomon, R, Schäfer, P, Schimpf, L, Schlösser, M, Schlösser, K, and Schlüter, L

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

Some extensions of the Standard Model of particle physics allow for Lorentz invariance and charge-parity-time invariance violations. In the neutrino sector strong constraints have been set by neutrino-oscillation and time-of-flight experiments. However, some Lorentz-invariance-violating parameters are not accessible via these probes. In this work, we focus on the parameters (aof(3))00, (aof(3))10, and (aof(3))11 which would manifest themselves in a nonisotropic β-decaying source as a sidereal oscillation and an overall shift of the spectral endpoint. Based on the data of the first scientific run of the KATRIN experiment, we set the first 90% confidence-level limit on |(aof(3))11| of

Published
2023

5. Search for keV-scale Sterile Neutrinos with first KATRIN Data

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Bieringer, B., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Böttcher, M., Brunst, T., Caldwell, T. S., Carney, R. M. D., Chilingaryan, S., Choi, W., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., La Cascio, L., Lasserre, T., Le, T. L., Lebeda, O., Lehnert, B., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Neumann, H., Niemes, S., Oelpmann, P., Parno, D. S., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schimpf, L., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schwemmer, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Hernández, A. P. Vizcaya, Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., and Zeller, G.

Subjects
Nuclear Experiment
Abstract

In this work we present a keV-scale sterile-neutrino search with the first tritium data of the KATRIN experiment, acquired in the commissioning run in 2018. KATRIN performs a spectroscopic measurement of the tritium $\beta$-decay spectrum with the main goal of directly determining the effective electron anti-neutrino mass. During this commissioning phase a lower tritium activity facilitated the search for sterile neutrinos with a mass of up to $1.6\, \mathrm{keV}$. We do not find a signal and set an exclusion limit on the sterile-to-active mixing amplitude of down to $\sin^2\theta < 5\cdot10^{-4}$ ($95\,\%$ C.L.), improving current laboratory-based bounds in the sterile-neutrino mass range between 0.1 and $1.0\, \mathrm{keV}$.

Published
2022

6. Search for Lorentz-Invariance Violation with the first KATRIN data

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Bieringer, B., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Böttcher, M., Brunst, T., Caldwell, T. S., Carney, R. M. D., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., La Cascio, L., Lasserre, T., Le, T. L., Lebeda, O., Lehnert, B., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Neumann, H., Niemes, S., Oelpmann, P., Parno, D. S., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schimpf, L., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schwemmer, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Hernández, A. P. Vizcaya, Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wickles, J., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., and Zeller, G.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Some extensions of the Standard Model of Particle Physics allow for Lorentz invariance and Charge-Parity-Time (CPT)-invariance violations. In the neutrino sector strong constraints have been set by neutrino-oscillation and time-of-flight experiments. However, some Lorentz-invariance-violating parameters are not accessible via these probes. In this work, we focus on the parameters $(a_{\text{of}}^{(3)})_{00}$, $(a_{\text{of}}^{(3)})_{10}$ and $(a_{\text{of}}^{(3)})_{11}$ which would manifest themselves in a non-isotropic beta-decaying source as a sidereal oscillation and an overall shift of the spectral endpoint. Based on the data of the first scientific run of the KATRIN experiment, we set the first limit on $\left|(a_{\text{of}}^{(3)})_{11}\right|$ of $< 3.7\cdot10^{-6}$ GeV at 90\% confidence level. Moreover, we derive new constraints on $(a_{\text{of}}^{(3)})_{00}$ and $(a_{\text{of}}^{(3)})_{10}$.

Published
2022
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7. Search for keV-scale sterile neutrinos with the first KATRIN data

Author

Aker, M, Batzler, D, Beglarian, A, Behrens, J, Berlev, A, Besserer, U, Bieringer, B, Block, F, Bobien, S, Bornschein, B, Bornschein, L, Böttcher, M, Brunst, T, Caldwell, TS, Chilingaryan, S, Choi, W, Debowski, K, Descher, M, Barrero, D Díaz, Doe, PJ, Dragoun, O, Drexlin, G, Edzards, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Felden, A, Formaggio, JA, Fränkle, FM, Franklin, GB, Friedel, F, Fulst, A, Gauda, K, Gavin, AS, Gil, W, Glück, F, Grössle, R, Gumbsheimer, R, Hannen, V, Haußmann, N, Helbing, K, Hickford, S, Hiller, R, Hillesheimer, D, Hinz, D, Höhn, T, Houdy, T, Huber, A, Jansen, A, Karl, C, Kellerer, J, Kleifges, M, Klein, M, Köhler, C, Köllenberger, L, Kopmann, A, Korzeczek, M, Kovalík, A, Krasch, B, Krause, H, La Cascio, L, Lasserre, T, Le, TL, Lebeda, O, Lehnert, B, Lokhov, A, Machatschek, M, Malcherek, E, Mark, M, Marsteller, A, Martin, EL, Melzer, C, Mertens, S, Mostafa, J, Müller, K, Neumann, H, Niemes, S, Oelpmann, P, Parno, DS, Poon, AWP, Poyato, JML, Priester, F, Ráliš, J, Ramachandran, S, Robertson, RGH, Rodejohann, W, Rodenbeck, C, Röllig, M, Röttele, C, Ryšavý, M, Sack, R, Saenz, A, Salomon, R, Schäfer, P, Schimpf, L, Schlösser, M, Schlösser, K, Schlüter, L, and Schneidewind, S

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

In this work we present a keV-scale sterile-neutrino search with a low-tritium-activity data set of the KATRIN experiment, acquired in a commissioning run in 2018. KATRIN performs a spectroscopic measurement of the tritium β -decay spectrum with the main goal of directly determining the effective electron anti-neutrino mass. During this commissioning phase a lower tritium activity facilitated the measurement of a wider part of the tritium spectrum and thus the search for sterile neutrinos with a mass of up to 1.6keV . We do not find a signal and set an exclusion limit on the sterile-to-active mixing amplitude of sin 2θ< 5 × 10 - 4 (95 % C.L.) at a mass of 0.3 keV. This result improves current laboratory-based bounds in the sterile-neutrino mass range between 0.1 and 1.0 keV.

Published
2023

8. KATRIN: Status and Prospects for the Neutrino Mass and Beyond

Author

Aker, M., Balzer, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Biassoni, M., Bieringer, B., Block, F., Bobien, S., Bombelli, L., Bormann, D., Bornschein, B., Bornschein, L., Böttcher, M., Brofferio, C., Bruch, C., Brunst, T., Caldwell, T. S., Carminati, M., Carney, R. M. D., Chilingaryan, S., Choi, W., Cremonesi, O., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Fink, D., Fiorini, C., Formaggio, J. A., Forstner, C., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grande, A., Grössle, R., Gugiatti, M., Gumbsheimer, R., Hannen, V., Hartmann, J., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., King, P., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Lasserre, T., La Cascio, L., Lebeda, O., Lechner, P., Lehnert, B., Le, T. L., Lokhov, A., Machatschek, M., Malcherek, E., Manfrin, D., Mark, M., Marsteller, A., Martin, E. L., Mazzola, E., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Nava, A., Neumann, H., Niemes, S., Oelpmann, P., Onillon, A., Parno, D. S., Pavan, M., Pigliafreddo, A., Poon, A. W. P., Poyato, J. M. L., Pozzi, S., Priester, F., Puritscher, M., Radford, D. C., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R. W. J., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schneidewind, S., Schrank, M., Schütz, A. K., Schwemmer, A., Sedlak, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Spreng, D., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trigilio, P., Urban, K., Valerius, K., Vénos, D., Hernández, A. P. Vizcaya, Voigt, P., Weinheimer, C., Weiss, E., Welte, S., Wendel, J., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wunderl, L., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., and Zeller, G.

Subjects
Nuclear Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to measure a high-precision integral spectrum of the endpoint region of T2 beta decay, with the primary goal of probing the absolute mass scale of the neutrino. After a first tritium commissioning campaign in 2018, the experiment has been regularly running since 2019, and in its first two measurement campaigns has already achieved a sub-eV sensitivity. After 1000 days of data-taking, KATRIN's design sensitivity is 0.2 eV at the 90% confidence level. In this white paper we describe the current status of KATRIN; explore prospects for measuring the neutrino mass and other physics observables, including sterile neutrinos and other beyond-Standard-Model hypotheses; and discuss research-and-development projects that may further improve the KATRIN sensitivity., Comment: Contribution to Snowmass 2021. 70 pages excluding references; 35 figures. Author list updated June 2023

Published
2022
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9. An active transverse energy filter to differentiate low energy particles with large pitch angles in a strong magnetic field

Author

Gauda, K., Schneidewind, S., Drexlin, G., Fulst, A., Hannen, V., König, T., Lokhov, A., Oelpmann, P., Ortjohann, H. -W., Pernice, W., Robertson, R. G. H., Salomon, R. W. J., Stappers, M., and Weinheimer, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present the idea and proof of principle measurements for an angular-selective active filter for charged particles. The motivation for the setup arises from the need to distinguish background electrons from signal electrons in a spectrometer of MAC-E filter type. While a large fraction of the background electrons exhibit predominantly small angles relative to the magnetic guiding field (corresponding to a low amount of kinetic energy in the motion component transverse to the field lines, in the following referred to as transverse energy) and pass the filter mostly unhindered, signal electrons from an isotropically emitting source interact with the active filter and are detected. The concept is demonstrated using a microchannel plate (MCP) as an active filter element. When correctly aligned with the magnetic field, electrons with a small transverse energy pass the channels of the MCP without interaction while electrons with large transverse energies hit the channel walls and trigger an avalanche of secondary electrons that is subsequently detected. Due to several drawbacks of MCPs for an actual transverse energy filter, an alternative detection technique using microstructured Si-PIN diodes is proposed., Comment: 9 pages, 7 figures

Published
2022
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10. New Constraint on the Local Relic Neutrino Background Overdensity with the First KATRIN Data Runs

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Bieringer, B., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Böttcher, M., Brunst, T., Caldwell, T. S., Carney, R. M. D., Chilingaryan, S., Choi, W., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, F., Kellerer, J., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., La Cascio, L., Lasserre, T., Le, T. L., Lebeda, O., Lehnert, B., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Neumann, H., Niemes, S., Oelpmann, P., Parno, D. S., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schimpf, L., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schwemmer, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Hernández, A. P. Vizcaya, Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., and Zeller, G.

Subjects
Nuclear Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

We report on the direct cosmic relic neutrino background search from the first two science runs of the KATRIN experiment in 2019. Beta-decay electrons from a high-purity molecular tritium gas source are analyzed by a high-resolution MAC-E filter around the kinematic endpoint at 18.57 keV. The analysis is sensitive to a local relic neutrino overdensity of 9.7e10 (1.1e11) at a 90% (95%) confidence level. A fit of the integrated electron spectrum over a narrow interval around the kinematic endpoint accounting for relic neutrino captures in the Tritium source reveals no significant overdensity. This work improves the results obtained by the previous kinematic neutrino mass experiments at Los Alamos and Troitsk. We furthermore update the projected final sensitivity of the KATRIN experiment to <1e10 at 90% confidence level, by relying on updated operational conditions., Comment: 7 pages, 7 figures

Published
2022
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11. Improved eV-scale Sterile-Neutrino Constraints from the Second KATRIN Measurement Campaign

Author

Aker, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Bieringer, B., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Böttcher, M., Brunst, T., Caldwell, T. S., Carney, R. M. D., Chilingaryan, S., Choi, W., Debowski, K., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., La Cascio, L., Lasserre, T., Le, T. L., Lebeda, O., Lehnert, B., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Neumann, H., Niemes, S., Oelpmann, P., Parno, D. S., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schimpf, L., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schwemmer, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Hernández, A. P. Vizcaya, Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., and Zeller, G.

Subjects
High Energy Physics - Experiment
Abstract

We present the results of the light sterile neutrino search from the second KATRIN measurement campaign in 2019. Approaching nominal activity, $3.76 \times 10^6$ tritium $\beta$-electrons are analyzed in an energy window extending down to $40\,$eV below the tritium endpoint at $E_0 = 18.57\,$keV. We consider the $3\nu+1$ framework with three active and one sterile neutrino flavor. The analysis is sensitive to a fourth mass eigenstate $m_4^2\lesssim1600\,$eV$^2$ and active-to-sterile mixing $|U_{e4}|^2 \gtrsim 6 \times 10^{-3}$. As no sterile-neutrino signal was observed, we provide improved exclusion contours on $m_4^2$ and $|U_{e4}|^2$ at $95\,$% C.L. Our results supersede the limits from the Mainz and Troitsk experiments. Furthermore, we are able to exclude the large $\Delta m_{41}^2$ solutions of the reactor antineutrino and gallium anomalies to a great extent. The latter has recently been reaffirmed by the BEST collaboration and could be explained by a sterile neutrino with large mixing. While the remaining solutions at small $\Delta m_{41}^2$ are mostly excluded by short-baseline reactor experiments, KATRIN is the only ongoing laboratory experiment to be sensitive to relevant solutions at large $\Delta m_{41}^2$ through a robust spectral shape analysis., Comment: 14 pages, 8 figures, 2 tables

Published
2022
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12. New Constraint on the Local Relic Neutrino Background Overdensity with the First KATRIN Data Runs

Author

Aker, M, Batzler, D, Beglarian, A, Behrens, J, Berlev, A, Besserer, U, Bieringer, B, Block, F, Bobien, S, Bornschein, B, Bornschein, L, Böttcher, M, Brunst, T, Caldwell, TS, Carney, RMD, Chilingaryan, S, Choi, W, Debowski, K, Descher, M, Barrero, D Díaz, Doe, PJ, Dragoun, O, Drexlin, G, Edzards, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Felden, A, Formaggio, JA, Fränkle, FM, Franklin, GB, Friedel, F, Fulst, A, Gauda, K, Gavin, AS, Gil, W, Glück, F, Grössle, R, Gumbsheimer, R, Hannen, V, Haußmann, N, Helbing, K, Hickford, S, Hiller, R, Hillesheimer, D, Hinz, D, Höhn, T, Houdy, T, Huber, A, Jansen, A, Karl, C, Kellerer, F, Kellerer, J, Kleifges, M, Klein, M, Köhler, C, Köllenberger, L, Kopmann, A, Korzeczek, M, Kovalík, A, Krasch, B, Krause, H, La Cascio, L, Lasserre, T, Le, TL, Lebeda, O, Lehnert, B, Lokhov, A, Machatschek, M, Malcherek, E, Mark, M, Marsteller, A, Martin, EL, Melzer, C, Mertens, S, Mostafa, J, Müller, K, Neumann, H, Niemes, S, Oelpmann, P, Parno, DS, Poon, AWP, Poyato, JML, Priester, F, Ráliš, J, Ramachandran, S, Robertson, RGH, Rodejohann, W, Rodenbeck, C, Röllig, M, Röttele, C, Ryšavý, M, Sack, R, Saenz, A, Salomon, R, Schäfer, P, Schimpf, L, Schlösser, M, and Schlösser, K

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, KATRIN Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

We report on the direct search for cosmic relic neutrinos using data acquired during the first two science campaigns of the KATRIN experiment in 2019. Beta-decay electrons from a high-purity molecular tritium gas source are analyzed by a high-resolution MAC-E filter around the end point at 18.57 keV. The analysis is sensitive to a local relic neutrino overdensity ratio of η

Published
2022

13. Improved eV-scale sterile-neutrino constraints from the second KATRIN measurement campaign

Author

Aker, M, Batzler, D, Beglarian, A, Behrens, J, Berlev, A, Besserer, U, Bieringer, B, Block, F, Bobien, S, Bornschein, B, Bornschein, L, Böttcher, M, Brunst, T, Caldwell, TS, Carney, RMD, Chilingaryan, S, Choi, W, Debowski, K, Descher, M, Barrero, D Díaz, Doe, PJ, Dragoun, O, Drexlin, G, Edzards, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Felden, A, Formaggio, JA, Fränkle, FM, Franklin, GB, Friedel, F, Fulst, A, Gauda, K, Gavin, AS, Gil, W, Glück, F, Grössle, R, Gumbsheimer, R, Hannen, V, Haußmann, N, Helbing, K, Hickford, S, Hiller, R, Hillesheimer, D, Hinz, D, Höhn, T, Houdy, T, Huber, A, Jansen, A, Karl, C, Kellerer, J, Kleifges, M, Klein, M, Köhler, C, Köllenberger, L, Kopmann, A, Korzeczek, M, Kovalík, A, Krasch, B, Krause, H, La Cascio, L, Lasserre, T, Le, TL, Lebeda, O, Lehnert, B, Lokhov, A, Machatschek, M, Malcherek, E, Mark, M, Marsteller, A, Martin, EL, Melzer, C, Mertens, S, Mostafa, J, Müller, K, Neumann, H, Niemes, S, Oelpmann, P, Parno, DS, Poon, AWP, Poyato, JML, Priester, F, Ráliš, J, Ramachandran, S, Robertson, RGH, Rodejohann, W, Rodenbeck, C, Röllig, M, Röttele, C, Ryšavý, M, Sack, R, Saenz, A, Salomon, R, Schäfer, P, Schimpf, L, Schlösser, M, Schlösser, K, and Schlüter, L

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract

We present the results of the light sterile neutrino search from the second Karlsruhe Tritium Neutrino (KATRIN) measurement campaign in 2019. Approaching nominal activity, 3.76×106 tritium β-electrons are analyzed in an energy window extending down to 40 eV below the tritium end point at E0=18.57 keV. We consider the 3ν+1 framework with three active and one sterile neutrino flavors. The analysis is sensitive to a fourth mass eigenstate m42≲1600 eV2 and active-to-sterile mixing |Ue4|2≳6×10-3. As no sterile-neutrino signal was observed, we provide improved exclusion contours on m42 and |Ue4|2 at 95% C.L. Our results supersede the limits from the Mainz and Troitsk experiments. Furthermore, we are able to exclude the large Δm412 solutions of the reactor antineutrino and gallium anomalies to a great extent. The latter has recently been reaffirmed by the BEST Collaboration and could be explained by a sterile neutrino with large mixing. While the remaining solutions at small Δm412 are mostly excluded by short-baseline reactor experiments, KATRIN is the only ongoing laboratory experiment to be sensitive to relevant solutions at large Δm412 through a robust spectral shape analysis.

Published
2022

15. POS0378 HETEROZYGOUS LOSS-OF-FUNCTION RELA MUTATIONS LEAD TO SYSTEMIC LUPUS ERYTHEMATOSUS OR AUTOINFLAMMATORY SYNDROME

Author

Riller, Q., primary, Barnabei, L., additional, Rodrigo-Riestra, M., additional, Stolzenberg, M. C., additional, Pelle, O., additional, Delage, L., additional, Becquard, T., additional, Courteille, C., additional, Marchais, M., additional, De Cevins, C., additional, Brunaud, C., additional, Magerus, A., additional, Luka, M., additional, Sorin, B., additional, Boussard, C., additional, Salomon, R., additional, Ménager, M., additional, Hié, M., additional, Neven, B., additional, Baud, V., additional, Skokowa, J., additional, Sogkas, G., additional, Jamilloux, Y., additional, Merlin, E., additional, Belot, A., additional, Picard, C., additional, Boursier, G., additional, Riviere, E., additional, Georgin-Lavialle, S., additional, Quartier, P., additional, Bader-Meunier, B., additional, Fischer, A., additional, Miner, J. J., additional, and Rieux-Laucat, F., additional

Published
2024
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17. Hybrid matrix method for stable numerical analysis of the propagation of Dirac electrons in gapless bilayer graphene superlattices

Author

Briones-Torres, J. A., Pernas-Salomón, R., Pérez-Álvarez, R., and Rodríguez-Vargas, I.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Gapless bilayer graphene (GBG), like monolayer graphene, is a material system with unique properties, such as anti-Klein tunneling and intrinsic Fano resonances. These properties rely on the gapless parabolic dispersion relation and the chiral nature of bilayer graphene electrons. In addition, propagating and evanescent electron states coexist inherently in this material, giving rise to these exotic properties. In this sense, bilayer graphene is unique, since in most material systems in which Fano resonance phenomena are manifested an external source that provides extended states is required. However, from a numerical standpoint, the presence of evanescent-divergent states in the eigenfunctions linear superposition representing the Dirac spinors, leads to a numerical degradation (the so called $\Omega$d problem) in the practical applications of the standard Coefficient Transfer Matrix ($K$) method used to study charge transport properties in Bilayer Graphen based multi-barrier systems. We present here a straightforward procedure based in the hybrid compliance-stiffness matrix method ($H$) that can overcome this numerical degradation. Our results show that in contrast to standard matrix method, the proposed $H$ method is suitable to study the transmission and transport properties of electrons in GBG superlattice since it remains numerically stable regardless the size of the superlattice and the range of values taken by the input parameters: the energy and angle of the incident electrons, the barrier height and the thickness and number of barriers. We show that the matrix determinant can be used as a test of the numerical accuracy in real calculations.

Published
2015
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18. Relations between transfer matrices and numerical stability analysis to avoid the $\Omega d$ problem

Author

Pérez-Álvarez, R., Pernas-Salomón, R., and Velasco, V. R.

Subjects
Mathematical Physics, 34L16
Abstract

The transfer matrix method is usually employed to study problems described by $N$ equations of matrix Sturm-Liouville (MSL) kind. In some cases a numerical degradation (the so called $\Omega d$ problem) appears thus impairing the performance of the method. We present here a procedure that can overcome this problem in the case of multilayer systems having piecewise constant coefficients. This is performed by studying the relations between the associated transfer matrix and other transfer matrix variants. In this way it was possible to obtain the matrices which can overcome the $\Omega d$ problem in the general case and then in problems which are particular cases of the general one. In this framework different strategies are put forward to solve different boundary condition problems by means of these numerically stable matrices. Numerical and analytic examples are presented to show that these stable variants are more adequate than other matrix methods to overcome the $\Omega d$ problem. Due to the ubiquity of the MSL system, these results can be applied to the study of many elementary excitations in multilayer structures., Comment: 23 pages, 2 figures

Published
2015
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26. Performance of alkali-activated slag individually incorporated with two nanozinc sources

Author

Hussein Al-kroom, Mohamed Abd Elrahman, Mohammed A. Arif, Aya H. Mohammed, Salomon R. Vasquez-Garcia, and Hamdy A. Abdel-Gawwad

Subjects
Health, Toxicology and Mutagenesis, Environmental Chemistry, General Medicine, Pollution
Abstract

The role of nanozinc source (nanohydrozincite: nHZ; nanozinc oxide: nZO) on the performance of alkali-activated slag (AAS) was explored for the first time in the present work. The results showed that nHZ with different contents (0.5, 1.0, and 1.5 wt%) retards the early hydration rate of AAS, whereas nZO showed the lowest retardation effect. Zn(OH)

Published
2022

28. ImmunoInertial microfluidics: A novel strategy for isolation of small EV subpopulations

Author

Razavi Bazaz, S, Zhand, S, Salomon, R, Beheshti, EH, Jin, D, Warkiani, ME, Razavi Bazaz, S, Zhand, S, Salomon, R, Beheshti, EH, Jin, D, and Warkiani, ME

Abstract

Cancer-specific small extracellular vesicles (sEVs), known as exosomes, have shown a great promise to serve as novel biomarkers for cancer diagnosis and prognosis in liquid biopsies. However, the high heterogeneity of sEVs posed great technical challenges to acquiring their molecular information. A simple and reproducible method for isolating subpopulations of sEVs can significantly enhance the detection and stratification of these circulating biomarkers and their function. This study used the synergic effects of the immunoaffinity-based approach and inertial microfluidics (ImmunoInertial microfluidics) to isolate specific subpopulations of sEVs. At first, the cancer cell-derived sEVs were captured on microbeads of varying sizes which were functionalized with specific capture antibodies such as epithelial cell adhesion molecule (EpCAM), epidermal growth factor receptor (EGFR), and the programmed death-ligand 1 (PD-L1), facilitating the selective capture of sEVs. The sEVs-bearing microbeads were subsequently introduced to a series of inertial microfluidic channels, called iZExoSub (inertial zigzag microfluidics for exosome subpopulation separation), for size-based bead separation. Results revealed more than 90% efficiency in sEVs subpopulation separation, further proved via flow cytometry analysis data. Our approach is capable of selective isolation and quantitative detection of important biomarkers from sEVs subpopulations with high sensitivity and low cost and has the capacity to process samples of varying volumes, ranging from µL up to mL continuously. This system can outperform FACS machines in terms of sample throughput by orders of magnitudes. In addition, this study emphasized the necessity of using a consistent sEV marker (as capture and detector) across different samples for accurate assessment of subpopulations.

Published
2023

29. A Method for Rapid, Quantitative Evaluation of Particle Sorting in Microfluidics Using Basic Cytometry Equipment.

Author

Salomon, R, Razavi Bazaz, S, Li, W, Gallego-Ortega, D, Jin, D, Warkiani, ME, Salomon, R, Razavi Bazaz, S, Li, W, Gallego-Ortega, D, Jin, D, and Warkiani, ME

Abstract

This paper describes, in detail, a method that uses flow cytometry to quantitatively characterise the performance of continuous-flow microfluidic devices designed to separate particles. Whilst simple, this approach overcomes many of the issues with the current commonly utilised methods (high-speed fluorescent imaging, or cell counting via either a hemocytometer or a cell counter), as it can accurately assess device performance even in complex, high concentration mixtures in a way that was previously not possible. Uniquely, this approach takes advantage of pulse processing in flow cytometry to allow quantitation of cell separation efficiencies and resulting sample purities on both single cells as well as cell clusters (such as circulating tumour cell (CTC) clusters). Furthermore, it can readily be combined with cell surface phenotyping to measure separation efficiencies and purities in complex cell mixtures. This method will facilitate the rapid development of a raft of continuous flow microfluidic devices, will be helpful in testing novel separation devices for biologically relevant clusters of cells such as CTC clusters, and will provide a quantitative assessment of device performance in complex samples, which was previously impossible.

Published
2023

35. An active transverse energy filter to differentiate low energy particles with large pitch angles in a strong magnetic field

Author

Gauda, K., primary, Schneidewind, S., additional, Drexlin, G., additional, Fulst, A., additional, Hannen, V., additional, König, T., additional, Lokhov, A., additional, Oelpmann, P., additional, Ortjohann, H.-W., additional, Pernice, W., additional, Robertson, R. G. H., additional, Salomon, R. W. J., additional, Stappers, M., additional, and Weinheimer, C., additional

Published
2022
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36. KATRIN: status and prospects for the neutrino mass and beyond

Author

Aker, M, primary, Balzer, M, additional, Batzler, D, additional, Beglarian, A, additional, Behrens, J, additional, Berlev, A, additional, Besserer, U, additional, Biassoni, M, additional, Bieringer, B, additional, Block, F, additional, Bobien, S, additional, Bombelli, L, additional, Bormann, D, additional, Bornschein, B, additional, Bornschein, L, additional, Böttcher, M, additional, Brofferio, C, additional, Bruch, C, additional, Brunst, T, additional, Caldwell, T S, additional, Carminati, M, additional, Carney, R M D, additional, Chilingaryan, S, additional, Choi, W, additional, Cremonesi, O, additional, Debowski, K, additional, Descher, M, additional, Díaz Barrero, D, additional, Doe, P J, additional, Dragoun, O, additional, Drexlin, G, additional, Edzards, F, additional, Eitel, K, additional, Ellinger, E, additional, Engel, R, additional, Enomoto, S, additional, Felden, A, additional, Fink, D, additional, Fiorini, C, additional, Formaggio, J A, additional, Forstner, C, additional, Fränkle, F M, additional, Franklin, G B, additional, Friedel, F, additional, Fulst, A, additional, Gauda, K, additional, Gavin, A S, additional, Gil, W, additional, Glück, F, additional, Grande, A, additional, Grössle, R, additional, Gugiatti, M, additional, Gumbsheimer, R, additional, Hannen, V, additional, Hartmann, J, additional, Haußmann, N, additional, Helbing, K, additional, Hickford, S, additional, Hiller, R, additional, Hillesheimer, D, additional, Hinz, D, additional, Höhn, T, additional, Houdy, T, additional, Huber, A, additional, Jansen, A, additional, Karl, C, additional, Kellerer, J, additional, King, P, additional, Kleifges, M, additional, Klein, M, additional, Köhler, C, additional, Köllenberger, L, additional, Kopmann, A, additional, Korzeczek, M, additional, Kovalík, A, additional, Krasch, B, additional, Krause, H, additional, Lasserre, T, additional, La Cascio, L, additional, Lebeda, O, additional, Lechner, P, additional, Lehnert, B, additional, Le, T L, additional, Lokhov, A, additional, Machatschek, M, additional, Malcherek, E, additional, Manfrin, D, additional, Mark, M, additional, Marsteller, A, additional, Martin, E L, additional, Mazzola, E, additional, Melzer, C, additional, Mertens, S, additional, Mostafa, J, additional, Müller, K, additional, Nava, A, additional, Neumann, H, additional, Niemes, S, additional, Oelpmann, P, additional, Onillon, A, additional, Parno, D S, additional, Pavan, M, additional, Pigliafreddo, A, additional, Poon, A W P, additional, Poyato, J M L, additional, Pozzi, S, additional, Priester, F, additional, Puritscher, M, additional, Radford, D C, additional, Ráliš, J, additional, Ramachandran, S, additional, Robertson, R G H, additional, Rodejohann, W, additional, Rodenbeck, C, additional, Röllig, M, additional, Röttele, C, additional, Ryšavý, M, additional, Sack, R, additional, Saenz, A, additional, Salomon, R W J, additional, Schäfer, P, additional, Schimpf, L, additional, Schlösser, K, additional, Schlösser, M, additional, Schlüter, L, additional, Schneidewind, S, additional, Schrank, M, additional, Schütz, A-K, additional, Schwemmer, A, additional, Sedlak, A, additional, Šefčík, M, additional, Sibille, V, additional, Siegmann, D, additional, Slezák, M, additional, Spanier, F, additional, Spreng, D, additional, Steidl, M, additional, Sturm, M, additional, Telle, H H, additional, Thorne, L A, additional, Thümmler, T, additional, Titov, N, additional, Tkachev, I, additional, Trigilio, P, additional, Urban, K, additional, Valerius, K, additional, Vénos, D, additional, Vizcaya Hernández, A P, additional, Voigt, P, additional, Weinheimer, C, additional, Welte, S, additional, Wendel, J, additional, Wiesinger, C, additional, Wilkerson, J F, additional, Wolf, J, additional, Wunderl, L, additional, Wüstling, S, additional, Wydra, J, additional, Xu, W, additional, Zadoroghny, S, additional, and Zeller, G, additional

Published
2022
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40. Touch-EE-to-Grasp-AI

Author

Salomon, R., Krumpholz, B., Ionescu, Adrian M., editor, Declercq, Michel, editor, Kayal, Maher, editor, and Leblebici, Yusuf, editor

Published
2004
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42. Improved eV-scale sterile-neutrino constraints from the second KATRIN measurement campaign

Author

KATRIN Collaboration, Aker, M., Batzler, D., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Bieringer, B., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Böttcher, M., Brunst, T., Caldwell, T. S., Carney, R. M. D., Chilingaryan, S., Choi, W., Debowski, K., Descher, M., Díaz Barrero, D., Doe, P. J., Dragoun, O., Drexlin, G., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Gauda, K., Gavin, A. S., Gil, W., Glück, F., Grössle, R., Gumbsheimer, R., Hannen, V., Haußmann, N., Helbing, K., Hickford, S., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Houdy, T., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kleifges, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., La Cascio, L., Lasserre, T., Le, T. L., Lebeda, O., Lehnert, B., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Melzer, C., Mertens, S., Mostafa, J., Müller, K., Neumann, H., Niemes, S., Oelpmann, P., Parno, D. S., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ráliš, J., Ramachandran, S., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Salomon, R., Schäfer, P., Schimpf, L., Schlösser, M., Schlösser, K., Schlüter, L., Schneidewind, S., Schrank, M., Schwemmer, A., Šefčík, M., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Urban, K., Valerius, K., Vénos, D., Vizcaya Hernández, A. P., Weinheimer, C., Welte, S., Wendel, J., Wetter, M., Wiesinger, C., Wilkerson, J. F., Wolf, J., Wüstling, S., Wydra, J., Xu, W., Zadoroghny, S., Zeller, G., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), KATRIN, and UAM. Departamento de Química Física Aplicada

Subjects
Antineutrinos, gallium, data analysis method, Physics, neutrino: mass difference, shape analysis, FOS: Physical sciences, anomaly, Reactor, Química, neutrino: sterile, KATRIN, Neutrino Oscillations, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), tritium: semileptonic decay, neutrino: flavor, antineutrino: nuclear reactor, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], spectral, ddc:530, neutrino: mixing, experimental results
Abstract

We present the results of the light sterile neutrino search from the second KATRIN measurement campaign in 2019. Approaching nominal activity, $3.76 \times 10^6$ tritium $\beta$-electrons are analyzed in an energy window extending down to $40\,$eV below the tritium endpoint at $E_0 = 18.57\,$keV. We consider the $3\nu+1$ framework with three active and one sterile neutrino flavor. The analysis is sensitive to a fourth mass eigenstate $m_4^2\lesssim1600\,$eV$^2$ and active-to-sterile mixing $|U_{e4}|^2 \gtrsim 6 \times 10^{-3}$. As no sterile-neutrino signal was observed, we provide improved exclusion contours on $m_4^2$ and $|U_{e4}|^2$ at $95\,$% C.L. Our results supersede the limits from the Mainz and Troitsk experiments. Furthermore, we are able to exclude the large $\Delta m_{41}^2$ solutions of the reactor antineutrino and gallium anomalies to a great extent. The latter has recently been reaffirmed by the BEST collaboration and could be explained by a sterile neutrino with large mixing. While the remaining solutions at small $\Delta m_{41}^2$ are mostly excluded by short-baseline reactor experiments, KATRIN is the only ongoing laboratory experiment to be sensitive to relevant solutions at large $\Delta m_{41}^2$ through a robust spectral shape analysis., Comment: 14 pages, 8 figures, 2 tables

Published
2022

43. Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications.

Author

Radfar, P, Aboulkheyr Es, H, Salomon, R, Kulasinghe, A, Ramalingam, N, Sarafraz-Yazdi, E, Thiery, JP, Warkiani, ME, Radfar, P, Aboulkheyr Es, H, Salomon, R, Kulasinghe, A, Ramalingam, N, Sarafraz-Yazdi, E, Thiery, JP, and Warkiani, ME

Abstract

Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation using single-cell analysis, enables researchers to gain crucial information on metastatic mechanisms and the genomic alterations responsible for drug resistance, empowering treatment, and management of cancer. Despite a plethora of CTC isolation technologies, careful attention to the strengths and weaknesses of each method should be considered in order to isolate these rare cells. Here, we provide an overview of cutting-edge technologies used for single-cell isolation and analysis of CTCs. Additionally, we highlight the biological features, clinical application, and the therapeutic potential of CTCs and CTC clusters using single-cell analysis platforms for cancer management.

Published
2022

45. Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles.

Author

Razavi Bazaz, S, Mihandust, A, Salomon, R, Joushani, HAN, Li, W, A Amiri, H, Mirakhorli, F, Zhand, S, Shrestha, J, Miansari, M, Thierry, B, Jin, D, Ebrahimi Warkiani, M, Razavi Bazaz, S, Mihandust, A, Salomon, R, Joushani, HAN, Li, W, A Amiri, H, Mirakhorli, F, Zhand, S, Shrestha, J, Miansari, M, Thierry, B, Jin, D, and Ebrahimi Warkiani, M

Abstract

Separation and enrichment of target cells prior to downstream analyses is an essential pre-treatment step in many biomedical and clinical assays. Separation techniques utilizing simple, cost-effective, and user-friendly devices are highly desirable, both in the lab and at the point of need. Passive microfluidic approaches, especially inertial microfluidics, fit this brief perfectly and are highly desired. Using an optimized additive manufacturing technique, we developed a zigzag microchannel for rigid inertial separation and enrichment, hereafter referred to as Z-RISE. We empirically showed that the Z-RISE device outperforms equivalent devices based on curvilinear (sinusoidal), asymmetric curvilinear, zigzag with round corners, or square-wave formats and modelled this behavior to gain a better understanding of the physics underpinning the improved focusing and separation performance. The comparison between rigid and soft zigzag microchannels reveals that channel rigidity significantly affects and enhances the focusing performance of the microchannel. Compared to other serpentine microchannels, zigzag microfluidics demonstrates superior separation and purity efficiency due to the sudden channel cross-section expansion at the corners. Within Z-RISE, particles are aligned in either double-side or single-line focusing positions. The transition of particles from a double-focusing line to a single focusing line introduced a new phenomenon referred to as the plus focusing position. We experimentally demonstrated that Z-RISE could enrich leukocytes and their subtypes from diluted and RBC lysed blood while depleting dead cells, debris, and RBCs. Z-RISE was also shown to yield outstanding particle or cell concentration with a concentration efficiency of more than 99.99%. Our data support the great potential of Z-RISE for applications that involve particle and cell manipulations and pave the way for commercialization perspective in the near future.

Published
2022

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