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196 results on '"Salmi, Toivo T."'

14. Metabolic characterization of childhood brain tumors: comparison of (18)F-fluorodeoxyglucose and (11)C-methionine positron emission tomography

Author

Utriainen, Meri, Metsahonkala, Liisa, Salmi, Toivo T., Utriainen, Tapio, Kalimo, Hannu, Pihko, Helena, Makipernaa, Anne, Harila-Saari, Arja, Jyrkkio, Sirkku, Laine, Jukka, Nagren, Kjell, and Minn, Heikki

Subjects
Brain tumors -- Identification and classification, Brain tumors -- Physiological aspects, PET imaging -- Methods, PET imaging -- Evaluation, Brain cancer -- Diagnosis, Cancer in children -- Diagnosis, Health
Published
2002

15. Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia

Author

Kahkonen, Meri, Metsahonkala, Liisa, Minn, Heikki, Utriainen, Tapio, Korhonen, Tapio, Norvasuo-Heila, Marja-Kaisu, Harila-Saari, Arja, Aarimaa, Tuula, Suhonen-Polvi, Hanna, Ruotsalainen, Ulla, Solin, Olof, and Salmi, Toivo T.

Subjects
Lymphoblastic leukemia in children -- Care and treatment, Radiotherapy -- Health aspects, Glucose metabolism -- Health aspects, Health
Published
2000

16. Military service of male survivors of childhood malignancies

Author

Lahteenmaki, Paivi M., Salmi, Heikki A., Salmi, Toivo T., Helenius, Hans, Makipernaa, Anne, Lanning, Marjatta, Perkkio, Mikko, and Siimes, Martti A.

Subjects
Cancer survivors -- Behavior, Draft -- Analysis, Health
Published
1999

18. Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma

Author

Isola Jorma, Pelliniemi Tarja-Terttu, Kalimo Hannu, Salmi Toivo T, Jokilammi Anne, Korja Miikka, Rantala Immo, Haapasalo Hannu, and Finne Jukka

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblastoma is unclear. Methods A tumor tissue microarray (TMA) of 36 paraffin-embedded neuroblastoma samples was utilized to detect polySia-NCAM expression with a polySia-binding fluorescent fusion protein, and polySia-NCAM expression was compared with clinical stage, age, MYCN amplification status, histology (INPC), and proliferation index (PI). Results PolySia-NCAM-positive neuroblastoma patients had more often metastases at diagnosis, and polySia-NCAM expression associated with advanced disease (P = 0.047). Most interestingly, absence of polySia-NCAM-expressing tumor cells in TMA samples, however, was a strong unfavorable prognostic factor for overall survival in advanced disease (P = 0.0004), especially when MYCN was not amplified. PolySia-NCAM-expressing bone marrow metastases were easily detected in smears, aspirates and biopsies. Conclusion PolySia-NCAM appears to be a new clinically significant molecular marker in neuroblastoma, hopefully with additional value in neuroblastoma risk stratification.

Published
2009
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19. Recovery of blood B-lymphocytes and serum immunoglobulins after chemotherapy for childhood acute lymphoblastic leukemia

Author

Alanko, Soile, Pelliniemi, Tarja-Terttu, and Salmi, Toivo T.

Subjects
Lymphocytic leukemia, Chemotherapy, Combination -- Physiological aspects, B cells -- Physiological aspects, Immunoglobulins -- Physiological aspects, Lymphoblastic leukemia in children -- Research, Health
Abstract

Recovery of humoral immunity after cessation of chemotherapy for childhood acute lymphoblastic leukemia (ALL) was investigated by determining blood leukocyte, lymphocyte and B-lymphocyte, and serum immunoglobulin (Ig) levels and IgG subclasses at 0, 1, 3, 6, 9, and 12 months after cessation of chemotherapy for ALL in 14 patients. Blood B-lymphocytes were analyzed with the use of flow cytometry and monoclonal CD20 antibody. At cessation of chemotherapy, the amount of blood B-lymphocytes was subnormal in most patients but increased to normal levels in 1 month after therapy was discontinued. The recovery of serum Ig, which reflect B-cell function, was slower, but occurred by 6 months after therapy was discontinued in most patients. The authors conclude that by 6 months after cessation of chemotherapy for ALL, a sufficiently functioning immune system by these parameters is established and that prophylactic antibiotics can be withdrawn and immunizations started. Cancer 1992; 69:1481-1486.

Published
1992

22. Disc degeneration in young gymnasts: a magnetic resonance imaging study

Author

Tertti, Minna, Paajanen, Hannu, Kujala, Urho M., Alanen, Anu, Salmi, Toivo T., and Kormano, Martti

Subjects
Gymnasts -- Injuries, Magnetic resonance imaging, Spine -- Injuries, Intervertebral disk -- Injuries, Gymnastics -- Health aspects, Spinal cord -- Abnormalities, Health, Sports and fitness
Published
1990

24. Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.

Author

Meeths, Marie, Chiang, Samuel C C, Wood, Stephanie M, Entesarian, Miriam, Schlums, Heinrich, Bang, Benedicte, Nordenskjöld, Edvard, Björklund, Caroline, Jakovljevic, Gordana, Jazbec, Janez, Hasle, Henrik, Holmqvist, Britt-Marie, Rajic, Ljubica, Pfeifer, Susan, Rosthøj, Steen, Sabel, Magnus, Salmi, Toivo T, Stokland, Tore, Winiarski, Jacek, Ljunggren, Hans-Gustaf, Fadeel, Bengt, Nordenskjöld, Magnus, Henter, Jan-Inge, Bryceson, Yenan T, Meeths, Marie, Chiang, Samuel C C, Wood, Stephanie M, Entesarian, Miriam, Schlums, Heinrich, Bang, Benedicte, Nordenskjöld, Edvard, Björklund, Caroline, Jakovljevic, Gordana, Jazbec, Janez, Hasle, Henrik, Holmqvist, Britt-Marie, Rajic, Ljubica, Pfeifer, Susan, Rosthøj, Steen, Sabel, Magnus, Salmi, Toivo T, Stokland, Tore, Winiarski, Jacek, Ljunggren, Hans-Gustaf, Fadeel, Bengt, Nordenskjöld, Magnus, Henter, Jan-Inge, and Bryceson, Yenan T

Abstract

Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal recessive, often-fatal hyperinflammatory disorder. Mutations in PRF1, UNC13D, STX11, and STXBP2 are causative of FHL2, 3, 4, and 5, respectively. In a majority of suspected FHL patients from Northern Europe, sequencing of exons and splice sites of such genes required for lymphocyte cytotoxicity revealed no or only monoallelic UNC13D mutations. Here, in 21 patients, we describe 2 pathogenic, noncoding aberrations of UNC13D. The first is a point mutation localized in an evolutionarily conserved region of intron 1. This mutation selectively impairs UNC13D transcription in lymphocytes, abolishing Munc13-4 expression. The second is a 253-kb inversion straddling UNC13D, affecting the 3'-end of the transcript and likewise abolishing Munc13-4 expression. Carriership of the intron 1 mutation was found in patients across Europe, whereas carriership of the inversion was limited to Northern Europe. Notably, the latter aberration represents the first description of an autosomal recessive human disease caused by an inversion. These findings implicate an intronic sequence in cell-type specific expression of Munc13-4 and signify variations outside exons and splice sites as a common cause of FHL3. Based on these data, we propose a strategy for targeted sequencing of evolutionary conserved noncoding regions for the diagnosis of primary immunodeficiencies.

Published
2011
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25. Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D

Author

Meeths, Marie, primary, Chiang, Samuel C. C., additional, Wood, Stephanie M., additional, Entesarian, Miriam, additional, Schlums, Heinrich, additional, Bang, Benedicte, additional, Nordenskjöld, Edvard, additional, Björklund, Caroline, additional, Jakovljevic, Gordana, additional, Jazbec, Janez, additional, Hasle, Henrik, additional, Holmqvist, Britt-Marie, additional, Rajić, Ljubica, additional, Pfeifer, Susan, additional, Rosthøj, Steen, additional, Sabel, Magnus, additional, Salmi, Toivo T., additional, Stokland, Tore, additional, Winiarski, Jacek, additional, Ljunggren, Hans-Gustaf, additional, Fadeel, Bengt, additional, Nordenskjöld, Magnus, additional, Henter, Jan-Inge, additional, and Bryceson, Yenan T., additional

Published
2011
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30. Vincristine treatment of acute lymphoblastic leukemia induces transient autonomic cardioneuropathy

Author

Hirvonen, Harri E., Salmi, Toivo T., Heinonen, Esa, Antila, Kari J. K.J., and Valimaki, Ilkka A.T.

Subjects
Vincristine -- Adverse and side effects, Chemotherapy -- Complications, Arrhythmia -- Measurement, Nervous system, Autonomic -- Injuries, Lymphoblastic leukemia in children -- Complications, Peripheral nerve diseases -- Research, Health
Abstract

Many drugs used to manage pediatric leukemia have highly toxic side-effects. In the case of vincristine, neurotoxicity (damage to nerve cells and nerve function) is a potentially serious side effect that may limit the dose of the drug. Symptoms of neurotoxicity are motor dysfunction, muscle weakness, muscle pain, and paresthesia (numbness and tingling). Vincristine treatment for acute lymphoblastic leukemia (characterized by immature while blood cells, lymphocytes and lymphoblasts) may cause neurotoxic side-effects on cardiac function by inducing cardioneuropathy (impairment of the nerves that innervate the heart). Researchers studied the heart rate variability (HRV) of nine children being treated with vincristine for acute lymphoblastic leukemia. Evidence strongly suggests that vincristine severely limited vagal nerve conduction (a nerve involved in contractions of the heart). Researchers advocate close monitoring of the autonomic nervous system among children undergoing therapy with vincristine (the autonomic nervous system effects involuntary body functions, such as heart function). The authors conclude that HRV is a suitable means of monitoring autonomic neurotoxicity.

Published
1989

31. Respiratory Viral Infections in Children With Leukemia

Author

Koskenvuo, Minna, primary, Möttönen, Merja, additional, Rahiala, Jaana, additional, Saarinen-Pihkala, Ulla M., additional, Riikonen, Pekka, additional, Waris, Matti, additional, Ziegler, Thedi, additional, Uhari, Matti, additional, Salmi, Toivo T., additional, and Ruuskanen, Olli, additional

Published
2008
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35. Mixed Bacterial-Viral Infections in Septic Children With Leukemia

Author

Koskenvuo, Minna, primary, Möttönen, Merja, additional, Rahiala, Jaana, additional, Saarinen-Pihkala, Ulla M., additional, Riikonen, Pekka, additional, Waris, Matti, additional, Ziegler, Thedi, additional, Uhari, Matti, additional, Ruuskanen, Olli, additional, and Salmi, Toivo T., additional

Published
2007
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45. Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia

Author

K�hk�nen, Meri, primary, Mets�honkala, Liisa, additional, Minn, Heikki, additional, Utriainen, Tapio, additional, Korhonen, Tapio, additional, Norvasuo-Heil�, Marja-Kaisu, additional, Harila-Saari, Arja, additional, ��rimaa, Tuula, additional, Suhonen-Polvi, Hanna, additional, Ruotsalainen, Ulla, additional, Solin, Olof, additional, and Salmi, Toivo T., additional

Published
2000
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