Search

Subjectivity in art stems from the freedom to embody the artist’s vision that stems from within him and not from the character and forms imposed on him byThe outside, and this is what the philosopher Croce sees that the artwork is a free creation whose source is the artist's self, not bound by laws.Subjectivity and subjectivity are a stimulating and active source within the creative process in the movements of modern painting in particular, and it is inherent to it.and transformed as an operating mechanism, due to the transformations in the systems formed for each direction and for eachSubjectivity is fixed as a visual conceptThe concept is intertwined by mixing it up with phenomena, functions, images, and connotations that mediate it with its relation to the invisible throughThe imaginary and its relation to concepts (ego, soul, mind, self) that overlap in creating a concept that works in different contexts.

Photography, as we know it today, was not invented on a specific date, but it went through gradual stages over the yearsOver the course of nearly a century and over these years, it is difficult to speak of a single "inventor" because there are so many photographs in my view.The types of processes that can be considered a “photograph” and the many different starting points for each type of technology. WherePhysics, chemistry, light science, agriculture, animal studies, and many intermediate industrial activities all had developments until they beganconverge upon photographic technology. This network of sciences and industries formed, and still is, a mixture of photographic technology and art.

SUMMARYThe thymus is essential for establishing adaptive immunity yet undergoes age-related atrophy leading to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capacity declines with age. Focusing on non-hematopoietic stromal cells, and using single-cell and spatial transcriptomics, lineage-tracing, and advanced imaging, we discovered two atypical thymic epithelial cell (TEC) states that emerged with age. Age-associated (aa)TECs formed atypical high-density epithelial clusters that were devoid of thymocytes, an accretion of non-functional thymic tissue that worsened with age and exhibited features of partial epithelial-to-mesenchymal transition (EMT).In silicointeraction analysis revealed that aaTEC emergence drew tonic signals from other TEC populations at baseline, acting as a sink for TEC growth factors. Following damage, aaTEC expanded substantially, further perturbing trophic pathways, and correlating with defective regeneration of the involuted thymus. These findings define a unique feature of thymic involution linked to immune aging.

Science is developing significantly in all fields, and of course this development serves the person, and the designer is always looking for everything new and modern that makes his design more successful. The more the designer introduces modern techniques to the design of the internal space, the more contemporary the space becomes, and saves a lot of time and effort, whether for him or for the occupant of the vacuum. Modern technology has provided many and many design solutions and produced spaces that are functionally and aesthetically successful. The world is now heading to the use of modern technologies and advanced technology that achieve savings, whether by energy or raw materials, which also serve the human need and fit with the internal void and its modern requirements and functions, keeping pace with progress and modernity, linking the present with the future, and integrating the originality of thought and environmental character with technology and development. The internal space becomes a smart space in which multiple systems of energy use, temperature control, lighting, sound and communications are compatible, as electronic systems are introduced that work to control different systems of lighting, air conditioning, energy, etc., hence the importance of the research as the research presents applications for the use of technology And modern technologies in interior architecture, and their impact on the concept and vocabulary of interior design.

Egypt’s landscape is changing rapidly and continuously and this is highly affecting the developing of the economy. No tools other than remote sensing for monitoring the land use is effective. Millions of land images are widely available today from the satellite images, these land images have to be classified into different categories to ensure proper land management and land decision making. Our main objective is to explore the use of deep learning for the land classification of Egypt’s remote sensing images. Our chapter exploits different deep convolutional neural network models to extract features from the images followed by category classification by supervised classifiers. We report at the end the accuracy and the performance comparisons between the different testing models on three different standard datasets and on Egypt’s land images. Standard datasets are used to fine-tune the classifier layers of the pre-trained CNN networks AlexNet, VGG16 and ResNet. In general the SVM classifier outperforms the other two tested classifiers (KNN and the Naive Bayes). The highest accuracy, 94.7%, achieved by ResNet model on the RS19 dataset. We obtained our dataset from Google Earth Engine from different parts of Egypt. The Egyptian dataset is used finally for testing without retraining the classifier layers to test the ability of the models for real-time applications. We achieved a highest accuracy of 60% with AlexNet.

There are many aesthetic and creative values in our heritage, Egypt is the cradle of civilizations and the Egyptian people as longas the whole world is concerned with the basic elements of civilization and the Egyptian identity has been influenced by othercivilizations, but it always returns to its Egypt, so the Egyptian designer must adhere to his identity and work to confirm it in mostof his designs, so he must It creates other goals for the design related to cultural communication and the transfer of ideas andmeanings, as the designer works to formulate semantic symbols extracted from the cultural and civilizational heritage andcomponents of the environment and intellectual trends, so the design fits into the user's thought and culture, so our popular heritageis the true image of what the ancestors created and where their feelings were mixed with nature Surrounding them as if they werepart of it, so their heritage fulfilled all their needs, so they lived their lives in harmony with their environment.

Chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) are myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap disorders characterized by monocytosis, myelodysplasia, and a characteristic hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). Currently, there are no available disease-modifying therapies for CMML, nor are there preclinical models that fully recapitulate the unique features of CMML. Through use of immunocompromised mice with transgenic expression of human GM-CSF, interleukin-3, and stem cell factor in a NOD/SCID-IL2Rγnull background (NSGS mice), we demonstrate remarkable engraftment of CMML and JMML providing the first examples of serially transplantable and genetically accurate models of CMML. Xenotransplantation of CD34+ cells (n = 8 patients) or unfractionated bone marrow (BM) or peripheral blood mononuclear cells (n = 10) resulted in robust engraftment of CMML in BM, spleen, liver, and lung of recipients (n = 82 total mice). Engrafted cells were myeloid-restricted and matched the immunophenotype, morphology, and genetic mutations of the corresponding patient. Similar levels of engraftment were seen upon serial transplantation of human CD34+ cells in secondary NSGS recipients (2/5 patients, 6/11 mice), demonstrating the durability of CMML grafts and functionally validating CD34+ cells as harboring the disease-initiating compartment in vivo. Successful engraftments of JMML primary samples were also achieved in all NSGS recipients (n = 4 patients, n = 12 mice). Engraftment of CMML and JMML resulted in overt phenotypic abnormalities and lethality in recipients, which facilitated evaluation of the JAK2/FLT3 inhibitor pacritinib in vivo. These data reveal that NSGS mice support the development of CMML and JMML disease-initiating and mature leukemic cells in vivo, allowing creation of genetically accurate preclinical models of these disorders.

The terrestrial blood feeding leeches of family Haemadipsidae are abundant throughout the Indo-Pacific, a region which encompasses many of the world’s biodiversity hotspots. Haemadipsids have been shown to retain high-quality host DNA in their guts on the order of months and have been targeted as tools for vertebrate biodiversity assessment in tropical rainforests, where species are difficult to monitor. Complementing prior mammal-specific 16S mtDNA data, the 12S mtDNA locus optimized for tetrapods was employed to assign identities to leech hosts. Through traditional Sanger sequencing of each blood meal for each of 16S and 12S mitochondrial regions, we find a 41% increase in the diversity of taxa detected using both loci than of using 16S alone. In addition to mammalian diversity assigned through sequencing of 16S, the host identities determined through sequencing of both loci inform the diversity of sampled localities as well as the foraging behavior of the leeches themselves. We present evidence for generalist foraging among the terrestrial leeches of Madagascar (Chtonobdella fallax), with data suggesting mammals, birds, amphibians, and reptiles as viable leech hosts.

Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a ubiquitously expressed transcription factor that is well known for its role in regulating the cellular redox pathway. Although there is mounting evidence suggesting a critical role for Nrf2 in hematopoietic stem cells and innate leukocytes, little is known about its involvement in T-cell biology. In this study, we identified a novel role for Nrf2 in regulating alloreactive T-cell function during allogeneic hematopoietic cell transplantation (allo-HCT). We observed increased expression and nuclear translocation of Nrf2 upon T-cell activation in vitro, especially in CD4+ donor T cells after allo-HCT. Allo-HCT recipients of Nrf2−/− donor T cells had significantly less acute graft-versus-host disease (GVHD)-induced mortality, morbidity, and pathology. This reduction in GVHD was associated with the persistence of Helios+ donor regulatory T cells in the allograft, as well as defective upregulation of the gut-homing receptor LPAM-1 on alloreactive CD8+ T cells. Additionally, Nrf2−/− donor CD8+ T cells demonstrated intact cytotoxicity against allogeneic target cells. Tumor-bearing allo-HCT recipients of Nrf2−/− donor T cells had overall improved survival as a result of preserved graft-versus-tumor activity and reduced GVHD activity. Our findings characterized a previously unrecognized role for Nrf2 in T-cell function, as well as revealed a novel therapeutic target to improve the outcomes of allo-HCT.