1. Early Clinical Infancy Outcomes for Microcephaly and/or Small for Gestational Age Zika-Exposed Infants
- Author
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Adachi, Kristina, Romero, Tahmineh, Nielsen-Saines, Karin, Pone, Sheila, Aibe, Mitsue, de Aguiar, Elisa Barroso, Sim, Myung, Brasil, Patricia, Zin, Andrea, Tsui, Irena, Gaw, Stephanie L, Halai, Umme-Aiman, Vasconcelos, Zilton, Pereira, Jose Paulo, Salles, Tania Saad, Barbosa, Claudia Neves, Portari, Elyzabeth, Cherry, James D, Pone, Marcos, and Moreira, Maria Elisabeth
- Subjects
Paediatrics ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Vector-Borne Diseases ,Preterm ,Low Birth Weight and Health of the Newborn ,Conditions Affecting the Embryonic and Fetal Periods ,Clinical Research ,Congenital Structural Anomalies ,Rare Diseases ,Infectious Diseases ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Brazil ,Female ,Gestational Age ,Humans ,Infant ,Microcephaly ,Pregnancy ,Pregnancy Complications ,Infectious ,Zika Virus ,Zika Virus Infection ,Zika ,congenital Zika syndrome ,microcephaly ,proportional microcephaly ,small for gestational age ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundZika-exposed infants with microcephaly (proportional or disproportional) and those who are small for gestational age without microcephaly should be closely followed, particularly their growth trajectories. They are at high risk of adverse outcomes in the first year of life.Antenatal Zika virus (ZIKV) exposure may lead to adverse infant outcomes including microcephaly and being small for gestational age (SGA). ZIKV-exposed infants with a diagnosis of microcephaly (proportional [PM] or disproportional [DM]) or SGA at birth were evaluated with anthropometric measurements and health outcomes.MethodsInfants had laboratory-confirmed ZIKV exposure in Brazil. PM, DM, or SGA classification was based on head circumference and weight. First-year growth parameters and clinical outcomes were recorded with analyses performed.ResultsAmong the 156 ZIKV-exposed infants, 14 (9.0%) were SGA, 13 (8.3%) PM, 13 (8.3%) DM, and 116 (74.4%) were neither SGA nor had microcephaly (NSNM). High rates of any neurologic, ophthalmologic, and hearing abnormalities were observed for PM (100%), DM (100%), and SGA (42.9%) vs NSNM infants (18.3%; P
- Published
- 2020