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Background: Patients undergoing CABG often experience a varied series of discomfort symptoms post hospital dischargeinclude; shortness of breath, chest pain or angina pain, incisional pain, atrial fibrillation fatigue, leg swelling, sleep quality, loss of appetite, anxiety and depression. Specific educational program regarding symptoms management strategies (SMS) are used to improve patient outcome, therefore patients' compliance with this programis very essential to relief, manage it. Aim: to evaluate the effect of an educational program for patients post CABS on the compliance with (SMS). Design: a quasi-experimental design. Setting: conducted at outpatient clinics in Cardio Thoracic Academy at Ain Shams Hospital. Subject: a purposive sample of (150) patients post CABG were recruited. Tools: demographic, medical data, Cardiac Symptoms Survey (CSS) and compliance scale are used. Results: The subjects were complaint towards (SMS) pre-program (12.7%) changed to (83.3%) post program. As evidence, 53.3% of the subjects who had sever level of perception of symptoms pre, changed to 5.3% post. Moreover, (62.7%, 59.4% respectively) of the subjects who had sever level of frequency, severity of symptoms pre changed to (4 %, 2.7% respectively) post. In addition, (57.3% respectively) of the subjects who had sever level of interference with physical activity, enjoyment of life pre, changed to (4%,4% respectively) post. Conclusion: Educational program showed positive effect on the subjects experienced discomfort symptoms post CABG and their compliance towards the management strategies. [ABSTRACT FROM AUTHOR]