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A treatment regimen with an ointment containing simvastatin 2% and 5% cholesterol was offered to the patients. Areas treated with simvastatin/cholesterol ointment are encircled in white, and the CO2 laser-treated area in Case 2 is marked circled in blue. gl In Case 1, there was only minor improvement after 1 month use of the simvastatin/cholesterol ointment (Fig. An excellent response to topical therapy of four congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome patients with an increased concentration of simvastatin ointment. [Extracted from the article]

Pathogenetic-based topical treatment with statins that target the mevalonate pathway and cholesterol biosynthesis was recently shown to be effective in disseminated porokeratosis.8 Here we performed molecular genetic analysis of skin samples of eight patients with disseminated porokeratosis. (a) Before treatment, the patient presented porokeratotic lesions on the arms and legs. Two novel SSH1 mutations in Chinese patients with disseminated superficial actinic porokeratosis and immunohistochemical analysis of anti-Slingshot homolog 1 antibody in one typical patient. [Extracted from the article]